Plcb1 (phospholipase C, beta 1) - Rat Genome Database

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Gene: Plcb1 (phospholipase C, beta 1) Mus musculus
Analyze
Symbol: Plcb1
Name: phospholipase C, beta 1
RGD ID: 735582
MGI Page MGI
Description: Enables lamin binding activity and phosphatidylinositol phospholipase C activity. Involved in several processes, including positive regulation of cell cycle process; regulation of cellular macromolecule biosynthetic process; and regulation of trans-synaptic signaling. Located in several cellular components, including chromatin; glutamatergic synapse; and nuclear speck. Part of protein-containing complex. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study Alzheimer's disease and schizophrenia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 12 and myelodysplastic syndrome. Orthologous to human PLCB1 (phospholipase C beta 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; 3110043I21Rik; AI132408; mKIAA0581; phosphoinositide phospholipase C; phosphoinositide phospholipase C-beta-1; phospholipase C-beta-1; phospholipase C-beta-1a; PLC-154; PLC-beta-1; Plcb
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392134,628,084 - 135,317,178 (+)NCBIGRCm39mm39
GRCm39 Ensembl2134,627,987 - 135,317,178 (+)Ensembl
GRCm382134,786,164 - 135,475,258 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2134,786,067 - 135,475,258 (+)EnsemblGRCm38mm10GRCm38
MGSCv372134,611,900 - 135,300,994 (+)NCBIGRCm37mm9NCBIm37
MGSCv362134,477,971 - 135,163,863 (+)NCBImm8
Celera2135,990,426 - 136,678,579 (+)NCBICelera
Cytogenetic Map2F3NCBI
cM Map265.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(R)-noradrenaline  (ISO)
1,2-dichloroethane  (EXP)
1-(3-chlorophenyl)piperazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dihydroxyphenylethyleneglycol  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
acrylonitrile  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alprazolam  (ISO)
aluminium trifluoride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aristolochic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
barium(0)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
Candesartan cilexetil  (ISO)
carbachol  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
chrysene  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP)
D-glucose  (ISO)
D-glyceraldehyde  (ISO)
desipramine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fipronil  (ISO)
fluoxetine  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
genistein  (EXP,ISO)
glucose  (ISO)
glyceraldehyde  (ISO)
glyphosate  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
morphine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (ISO)
oxytocin  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
Phenelzine  (ISO)
phenylephrine  (ISO)
phenylpropanolamine  (EXP)
PhIP  (ISO)
pirinixic acid  (EXP)
poly(I:C)  (EXP)
prazosin  (ISO)
progesterone  (ISO)
quercetin  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (EXP)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of meiosis involved in egg activation  (IDA)
brain development  (ISO,NAS)
cell adhesion  (IC)
cellular response to fluoride  (ISO)
cellular response to glyceraldehyde  (ISO)
cellular response to ionomycin  (ISO)
cellular response to vasopressin  (ISO)
cerebral cortex development  (IMP)
erythrocyte differentiation  (TAS)
fat cell differentiation  (IDA)
G protein-coupled acetylcholine receptor signaling pathway  (IMP)
G2/M transition of mitotic cell cycle  (IDA,NAS)
glutamate receptor signaling pathway  (IMP)
inositol trisphosphate metabolic process  (ISO)
insulin receptor signaling pathway  (TAS)
insulin-like growth factor receptor signaling pathway  (IDA)
interleukin-1-mediated signaling pathway  (ISO)
interleukin-12-mediated signaling pathway  (ISO)
interleukin-15-mediated signaling pathway  (ISO)
intracellular signal transduction  (IEA)
learning  (ISO)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
macrophage differentiation  (NAS)
memory  (IBA,IMP,ISO)
mRNA processing  (TAS)
negative regulation of monocyte extravasation  (IDA)
negative regulation of transcription, DNA-templated  (IDA)
oocyte maturation  (NAS)
phosphatidylinositol catabolic process  (ISO)
phosphatidylinositol metabolic process  (ISO)
phosphatidylinositol-mediated signaling  (IBA)
positive regulation of acrosome reaction  (IMP)
positive regulation of CD24 production  (IDA)
positive regulation of developmental growth  (IMP)
positive regulation of embryonic development  (IMP)
positive regulation of G1/S transition of mitotic cell cycle  (IDA)
positive regulation of interleukin-12 production  (IMP)
positive regulation of JNK cascade  (ISO)
positive regulation of myoblast differentiation  (IDA)
positive regulation of sodium:proton antiporter activity  (NAS)
positive regulation of transcription, DNA-templated  (IDA)
postsynaptic modulation of chemical synaptic transmission  (EXP,IDA,IMP)
regulation of cell cycle  (IEA)
regulation of establishment of endothelial barrier  (IMP)
regulation of fertilization  (IMP)
regulation of G protein-coupled receptor signaling pathway  (IMP)
regulation of retrograde trans-synaptic signaling by endocanabinoid  (IMP)
response to monosaccharide  (ISO)
response to organonitrogen compound  (ISO)
response to peptide hormone  (ISO)
signal transduction  (TAS)

Cellular Component
chromatin  (IDA)
cytoplasm  (IBA,IDA,ISO)
cytosol  (ISO)
GABA-ergic synapse  (IMP)
glutamatergic synapse  (EXP,IDA,IMP)
membrane  (ISO)
myelin sheath  (HDA)
nuclear speck  (IBA,IDA,ISO)
nucleus  (IDA,ISO,NAS)
plasma membrane  (TAS)
protein-containing complex  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
Alzheimer's disease pathway  (IEA)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
Chagas disease pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
endothelin signaling pathway  (ISO)
Entamoebiasis pathway  (IEA)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
glutamate signaling pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
Huntington's disease pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
inositol phosphate metabolic pathway  (IEA)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term depression  (IEA)
long term potentiation  (IEA)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway  (IEA)
phosphoinositide metabolic pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
protein kinase C (PKC) signaling pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sleeping sickness pathway  (IEA)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)
Wnt signaling pathway  (IEA)

References

Additional References at PubMed
PMID:2033248   PMID:7642703   PMID:7916325   PMID:8617512   PMID:8672127   PMID:8687404   PMID:8739298   PMID:8889548   PMID:9159640   PMID:9187110   PMID:9305844   PMID:9444325  
PMID:9753089   PMID:9762362   PMID:10349636   PMID:10609087   PMID:10913438   PMID:11042159   PMID:11076861   PMID:11224545   PMID:11464583   PMID:11471062   PMID:11487662   PMID:12031797  
PMID:12123715   PMID:12364493   PMID:12477932   PMID:12860966   PMID:14499343   PMID:14681479   PMID:15174099   PMID:15474310   PMID:15572359   PMID:15664177   PMID:15702972   PMID:15749982  
PMID:15849202   PMID:15864321   PMID:16141072   PMID:16141073   PMID:16210321   PMID:16330775   PMID:16339037   PMID:16405873   PMID:16538662   PMID:16602821   PMID:16951552   PMID:17022104  
PMID:17114649   PMID:17620288   PMID:17634366   PMID:17634444   PMID:17667964   PMID:17696993   PMID:17725492   PMID:17925404   PMID:17961538   PMID:18287559   PMID:18493969   PMID:18690108  
PMID:18692062   PMID:18799693   PMID:18836131   PMID:18957514   PMID:18973591   PMID:19028838   PMID:19159640   PMID:19236734   PMID:19342451   PMID:19385066   PMID:19687358   PMID:19729020  
PMID:19850892   PMID:20392936   PMID:21677750   PMID:21873635   PMID:21974932   PMID:22103416   PMID:22171034   PMID:23295235   PMID:23478264   PMID:23503970   PMID:23665500   PMID:24227722  
PMID:25268789   PMID:25550457   PMID:25916683   PMID:25918049   PMID:26079812   PMID:26217938   PMID:26731530   PMID:26796250   PMID:27342861   PMID:27353086   PMID:27507650   PMID:27563828  
PMID:27653213   PMID:27776973   PMID:28578927   PMID:28671696   PMID:30270038   PMID:30517689   PMID:30562941   PMID:31040226   PMID:31268747   PMID:32325033  


Genomics

Comparative Map Data
Plcb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392134,628,084 - 135,317,178 (+)NCBIGRCm39mm39
GRCm39 Ensembl2134,627,987 - 135,317,178 (+)Ensembl
GRCm382134,786,164 - 135,475,258 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2134,786,067 - 135,475,258 (+)EnsemblGRCm38mm10GRCm38
MGSCv372134,611,900 - 135,300,994 (+)NCBIGRCm37mm9NCBIm37
MGSCv362134,477,971 - 135,163,863 (+)NCBImm8
Celera2135,990,426 - 136,678,579 (+)NCBICelera
Cytogenetic Map2F3NCBI
cM Map265.66NCBI
PLCB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl208,077,251 - 8,968,360 (+)EnsemblGRCh38hg38GRCh38
GRCh38208,132,266 - 8,884,900 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37208,112,913 - 8,865,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36208,061,296 - 8,813,547 (+)NCBINCBI36hg18NCBI36
Build 34208,061,295 - 8,813,547NCBI
Celera208,182,881 - 8,935,778 (+)NCBI
Cytogenetic Map20p12.3NCBI
HuRef208,064,325 - 8,817,514 (+)NCBIHuRef
CHM1_1208,113,481 - 8,866,748 (+)NCBICHM1_1
Plcb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23122,059,968 - 122,772,896 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl3128,155,069 - 128,419,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03127,721,244 - 128,419,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03134,211,557 - 134,908,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43122,797,718 - 123,523,675 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13122,703,321 - 123,430,863 (+)NCBI
Celera3120,808,920 - 121,513,252 (+)NCBICelera
Cytogenetic Map3q36NCBI
Plcb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541518,210,662 - 18,915,158 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541518,210,608 - 18,915,099 (+)NCBIChiLan1.0ChiLan1.0
PLCB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1207,887,773 - 8,636,019 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl207,887,960 - 8,636,019 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0208,106,665 - 8,858,572 (+)NCBIMhudiblu_PPA_v0panPan3
PLCB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12413,337,285 - 13,996,218 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2413,322,296 - 13,995,539 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2413,161,289 - 13,837,418 (-)NCBI
ROS_Cfam_1.02413,744,297 - 14,413,598 (-)NCBI
UMICH_Zoey_3.12413,354,731 - 14,024,546 (-)NCBI
UNSW_CanFamBas_1.02413,455,648 - 14,132,727 (-)NCBI
UU_Cfam_GSD_1.02413,793,592 - 14,463,037 (-)NCBI
Plcb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640162,117,602 - 162,822,762 (-)NCBI
SpeTri2.0NW_00493648510,548,966 - 11,254,139 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1717,007,261 - 17,745,312 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11717,007,197 - 17,745,314 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21719,691,473 - 19,950,043 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLCB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,242,601 - 29,994,238 (-)NCBI
ChlSab1.1 Ensembl229,242,425 - 29,496,793 (-)Ensembl
Vero_WHO_p1.0NW_02366607114,560,873 - 15,334,958 (+)NCBI
Plcb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247419,030,817 - 9,859,597 (+)NCBI

Position Markers
D2Mit191  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382135,005,372 - 135,005,478UniSTSGRCm38
MGSCv372134,831,108 - 134,831,214UniSTSGRCm37
Celera2136,209,381 - 136,209,487UniSTS
Cytogenetic Map2F3UniSTS
cM Map276.7UniSTS
Whitehead Genetic261.2UniSTS
D2Mit208  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382135,280,668 - 135,280,855UniSTSGRCm38
MGSCv372135,106,404 - 135,106,591UniSTSGRCm37
Celera2136,484,191 - 136,484,378UniSTS
Cytogenetic Map2F3UniSTS
cM Map276.7UniSTS
Whitehead Genetic260.1UniSTS
Whitehead/MRC_RH21629.3UniSTS
D2Mit223  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382134,987,411 - 134,987,508UniSTSGRCm38
MGSCv372134,813,147 - 134,813,244UniSTSGRCm37
Celera2136,191,476 - 136,191,573UniSTS
Cytogenetic Map2F3UniSTS
cM Map276.7UniSTS
Whitehead Genetic261.2UniSTS
Whitehead_YAC2 UniSTS
D2Mit400  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382135,413,882 - 135,413,981UniSTSGRCm38
MGSCv372135,239,618 - 135,239,717UniSTSGRCm37
Celera2136,617,404 - 136,617,503UniSTS
Cytogenetic Map2F3UniSTS
cM Map261.2UniSTS
Whitehead Genetic261.2UniSTS
Whitehead/MRC_RH21655.01UniSTS
Whitehead_YAC2 UniSTS
AI132408  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382135,474,779 - 135,475,053UniSTSGRCm38
MGSCv372135,300,515 - 135,300,789UniSTSGRCm37
Celera2136,678,100 - 136,678,374UniSTS
Cytogenetic Map2F3UniSTS
cM Map276.7UniSTS
Whitehead/MRC_RH21655.01UniSTS
Plcb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F3UniSTS
cM Map276.7UniSTS
cM Map276.7UniSTS
D2Dcr79  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382134,949,670 - 134,949,788UniSTSGRCm38
MGSCv372134,775,406 - 134,775,524UniSTSGRCm37
Celera2136,153,832 - 136,153,948UniSTS
Cytogenetic Map2F3UniSTS
cM Map2 UniSTS
D2Dcr80  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382135,280,685 - 135,280,788UniSTSGRCm38
MGSCv372135,106,421 - 135,106,524UniSTSGRCm37
Celera2136,484,208 - 136,484,311UniSTS
Cytogenetic Map2F3UniSTS
cM Map2 UniSTS
PMC123676P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382135,416,275 - 135,416,695UniSTSGRCm38
MGSCv372135,242,011 - 135,242,431UniSTSGRCm37
Celera2136,619,797 - 136,620,213UniSTS
Cytogenetic Map2F3UniSTS
cM Map276.7UniSTS
D3Wox22  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382135,473,953 - 135,474,157UniSTSGRCm38
MGSCv372135,299,689 - 135,299,893UniSTSGRCm37
Celera2136,677,288 - 136,677,478UniSTS
Cytogenetic Map2F3UniSTS
cM Map276.7UniSTS
Plcb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F3UniSTS
Plcb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F3UniSTS
cM Map276.7UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284182854148680255Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284182854148825550Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294400000154400000Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100993579134993788Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2101112449135112609Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2101112449135112609Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2101112449135112609Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102800000160100000Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103265371167370436Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106391660140391809Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107413756141413756Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110647738144647887Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2111085773154512747Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111331784145331901Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111331784145331901Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111331784145331901Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111331784145331901Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111709108145709243Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111781466145781606Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112370826146371085Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112370826146371085Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112370826146371085Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115370937149371074Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115370937149371074Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116235703150235821Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116464410150464554Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118758772160769245Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118758772160769245Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118758772160769245Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118758772160769245Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122376665142690215Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2123041095157041211Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123390053148858457Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2124095391158095504Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124600000168400000Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126200000135600000Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127822099161822198Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127822099161822198Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129500000163500000Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132182239166182410Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133302991167303138Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133302991167303138Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1299
Count of miRNA genes:722
Interacting mature miRNAs:873
Transcripts:ENSMUST00000070724, ENSMUST00000110116, ENSMUST00000129382, ENSMUST00000130524, ENSMUST00000131552
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001145830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF022801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF498249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF498250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL840635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL935278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY902323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU846788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX323085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U85712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U85713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U85714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000070724   ⟹   ENSMUSP00000064844
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2134,786,530 - 135,399,675 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110116   ⟹   ENSMUSP00000105743
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2134,786,159 - 135,475,258 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129382
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2135,220,718 - 135,262,252 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130524
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2134,786,175 - 134,989,373 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131552   ⟹   ENSMUSP00000118756
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2134,786,067 - 135,475,247 (+)Ensembl
RefSeq Acc Id: ENSMUST00000201485   ⟹   ENSMUSP00000144399
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2135,220,765 - 135,262,257 (+)Ensembl
RefSeq Acc Id: ENSMUST00000201524
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2135,249,173 - 135,255,513 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202531
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2134,786,229 - 135,254,624 (+)Ensembl
RefSeq Acc Id: NM_001145830   ⟹   NP_001139302
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392134,628,084 - 135,317,178 (+)NCBI
GRCm382134,786,164 - 135,475,258 (+)ENTREZGENE
MGSCv372134,611,900 - 135,300,994 (+)RGD
Celera2135,990,426 - 136,678,579 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_019677   ⟹   NP_062651
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392134,628,084 - 135,317,178 (+)NCBI
GRCm382134,786,164 - 135,475,258 (+)ENTREZGENE
MGSCv372134,611,900 - 135,300,994 (+)RGD
Celera2135,990,426 - 136,678,579 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006498930   ⟹   XP_006498993
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392134,679,747 - 135,316,152 (+)NCBI
GRCm382134,837,836 - 135,475,258 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159560   ⟹   XP_036015453
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392134,752,707 - 135,316,152 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_062651   ⟸   NM_019677
- Peptide Label: isoform 2
- UniProtKB: Q9Z1B3 (UniProtKB/Swiss-Prot),   Q3UPW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139302   ⟸   NM_001145830
- Peptide Label: isoform 1
- UniProtKB: Q9Z1B3 (UniProtKB/Swiss-Prot),   Q3UPW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006498993   ⟸   XM_006498930
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000105743   ⟸   ENSMUST00000110116
RefSeq Acc Id: ENSMUSP00000064844   ⟸   ENSMUST00000070724
RefSeq Acc Id: ENSMUSP00000118756   ⟸   ENSMUST00000131552
RefSeq Acc Id: ENSMUSP00000144399   ⟸   ENSMUST00000201485
RefSeq Acc Id: XP_036015453   ⟸   XM_036159560
- Peptide Label: isoform X2
Protein Domains
C2   PH_14   PI-PLC X-box   PI-PLC Y-box   PLCXc

Promoters
RGD ID:6832075
Promoter ID:MM_KWN:31892
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   Brain,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000070724,   ENSMUST00000110116,   NM_019677,   OTTMUST00000037034,   UC008MNW.1,   UC008MNZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362134,611,781 - 134,612,281 (+)MPROMDB
RGD ID:6878882
Promoter ID:EPDNEW_M2892
Type:initiation region
Name:Plcb1_1
Description:Mus musculus phospholipase C, beta 1 , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382134,786,164 - 134,786,224EPDNEW
RGD ID:6832076
Promoter ID:MM_KWN:31896
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000037035
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362135,196,076 - 135,196,576 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97613 AgrOrtholog
Ensembl Genes ENSMUSG00000051177 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000064844 UniProtKB/Swiss-Prot
  ENSMUSP00000105743 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000118756 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000144399 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000070724 UniProtKB/Swiss-Prot
  ENSMUST00000110116 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000131552 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000201485 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1230.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC_EF-hand-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18795 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97613 ENTREZGENE
NCBI Gene 18795 ENTREZGENE
PANTHER PTHR10336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10336:SF12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF1154 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plcb1 PhenoGen
PIRSF PLC-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PIPLC_X_DOMAIN UniProtKB/Swiss-Prot
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PLCXc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCYc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0J9YUY5_MOUSE UniProtKB/TrEMBL
  PLCB1_MOUSE UniProtKB/Swiss-Prot
  Q2M4J2_MOUSE UniProtKB/TrEMBL
  Q3UPW0 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1B3 ENTREZGENE
UniProt Secondary Q62075 UniProtKB/Swiss-Prot
  Q6PDH1 UniProtKB/Swiss-Prot
  Q8K5A5 UniProtKB/Swiss-Prot
  Q8K5A6 UniProtKB/Swiss-Prot
  Q9Z0E5 UniProtKB/Swiss-Prot
  Q9Z2T5 UniProtKB/Swiss-Prot