CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: synephrine
Accession: CHEBI:29081
browse the term
Definition: A phenethylamine alkaloid that is 4-(2-aminoethyl)phenol substituted by a hydroxy group at position 1 and a methyl group at the amino nitrogen.
Synonyms: related_synonym: 1-(4-Hydroxyphenyl)-2-(methylamino)ethanol; 1-(4-hydroxyphenyl)-2-methylaminoethanol; 4-hydroxy-alpha-[(methylamino)methyl]benzenemethanol; Formula=C9H13NO2; InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3; InChIKey=YRCWQPVGYLYSOX-UHFFFAOYSA-N; Oxedrine; SMILES=CNCC(O)c1ccc(O)cc1; Sympatol; beta-methylamino-alpha-(4-hydroxyphenyl)ethyl alcohol; p-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol
alt_id: CHEBI:11190; CHEBI:18964; CHEBI:570
xref: Beilstein:1103010; CAS:94-07-5; Drug_Central:3577; KEGG:C04548; KEGG:D07148; LINCS:LSM-4956
xref_mesh: MESH:D013578
xref: PMID:17675045; PMID:18077120; PMID:23682231; Wikipedia:Synephrine
cyclic_relationship: is_conjugate_base_of CHEBI:58606
G
Adra1a
adrenoceptor alpha 1A
multiple interactions
ISO
Synephrine binds to and results in increased activity of ADRA1A protein
CTD
PMID:20217639
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
G
Adra2a
adrenoceptor alpha 2A
affects binding
ISO
Synephrine binds to ADRA2A protein
CTD
PMID:20217639
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
G
Adra2c
adrenoceptor alpha 2C
affects binding
ISO
Synephrine binds to ADRA2C protein
CTD
PMID:20217639
NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846
G
Adrb2
adrenoceptor beta 2
increases activity
EXP
Synephrine results in increased activity of ADRB2 protein
CTD
PMID:19363516
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
G
Car1
carbonic anhydrase 1
decreases activity
ISO
Synephrine results in decreased activity of CA1 protein
CTD
PMID:28800181
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
G
Car2
carbonic anhydrase 2
decreases activity
ISO
Synephrine results in decreased activity of CA2 protein
CTD
PMID:28800181
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Ccl11
C-C motif chemokine ligand 11
multiple interactions
ISO
Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein] Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]; Synephrine inhibits the reaction [IL4 protein results in increased expression of CCL11 mRNA]
CTD
PMID:25111027
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
G
Il10
interleukin 10
multiple interactions
ISO
Synephrine promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein]
CTD
PMID:24487736
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il4
interleukin 4
multiple interactions
ISO
Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein] Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]; Synephrine inhibits the reaction [IL4 protein results in increased expression of CCL11 mRNA]; Synephrine inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]
CTD
PMID:25111027
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il6
interleukin 6
multiple interactions
ISO
Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]
CTD
PMID:24487736
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Mpo
myeloperoxidase
multiple interactions
ISO
Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of MPO protein]
CTD
PMID:24487736
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD
PMID:24487736
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nmur2
neuromedin U receptor 2
increases activity
ISO EXP
Synephrine results in increased activity of NMUR2 protein
CTD
PMID:24598981
NCBI chr10:40,166,223...40,182,078
Ensembl chr10:40,166,226...40,182,078
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
CTD
PMID:24487736
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Slc22a1
solute carrier family 22 member 1
multiple interactions
EXP
[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine
CTD
PMID:21140131
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
G
Slc22a3
solute carrier family 22 member 3
multiple interactions
EXP
[Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Synephrine
CTD
PMID:21140131
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
G
Stat6
signal transducer and activator of transcription 6
multiple interactions
ISO
Synephrine inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]
CTD
PMID:25111027
NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
G
Tnf
tumor necrosis factor
multiple interactions
ISO
Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]
CTD
PMID:24487736
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all