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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:synephrine
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Accession:CHEBI:29081 term browser browse the term
Definition:A phenethylamine alkaloid that is 4-(2-aminoethyl)phenol substituted by a hydroxy group at position 1 and a methyl group at the amino nitrogen.
Synonyms:related_synonym: 1-(4-Hydroxyphenyl)-2-(methylamino)ethanol;   1-(4-hydroxyphenyl)-2-methylaminoethanol;   4-hydroxy-alpha-[(methylamino)methyl]benzenemethanol;   Formula=C9H13NO2;   InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3;   InChIKey=YRCWQPVGYLYSOX-UHFFFAOYSA-N;   Oxedrine;   SMILES=CNCC(O)c1ccc(O)cc1;   Sympatol;   beta-methylamino-alpha-(4-hydroxyphenyl)ethyl alcohol;   p-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol
 alt_id: CHEBI:11190;   CHEBI:18964;   CHEBI:570
 xref: Beilstein:1103010;   CAS:94-07-5;   Drug_Central:3577;   KEGG:C04548;   KEGG:D07148;   LINCS:LSM-4956
 xref_mesh: MESH:D013578
 xref: PMID:17675045;   PMID:18077120;   PMID:23682231;   Wikipedia:Synephrine
 cyclic_relationship: is_conjugate_base_of CHEBI:58606


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synephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions ISO Synephrine binds to and results in increased activity of ADRA1A protein CTD PMID:20217639 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra2a adrenoceptor alpha 2A affects binding ISO Synephrine binds to ADRA2A protein CTD PMID:20217639 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2c adrenoceptor alpha 2C affects binding ISO Synephrine binds to ADRA2C protein CTD PMID:20217639 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Adrb2 adrenoceptor beta 2 increases activity EXP Synephrine results in increased activity of ADRB2 protein CTD PMID:19363516 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Synephrine results in decreased activity of CA1 protein CTD PMID:28800181 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Synephrine results in decreased activity of CA2 protein CTD PMID:28800181 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]
Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]; Synephrine inhibits the reaction [IL4 protein results in increased expression of CCL11 mRNA]
CTD PMID:25111027 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Synephrine promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein] CTD PMID:24487736 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]
Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]; Synephrine inhibits the reaction [IL4 protein results in increased expression of CCL11 mRNA]; Synephrine inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]
CTD PMID:25111027 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein] CTD PMID:24487736 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of MPO protein] CTD PMID:24487736 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:24487736 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nmur2 neuromedin U receptor 2 increases activity ISO
EXP
Synephrine results in increased activity of NMUR2 protein CTD PMID:24598981 NCBI chr10:41,392,663...41,408,518
Ensembl chr10:41,392,666...41,408,518
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein] CTD PMID:24487736 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine CTD PMID:21140131 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions EXP [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Synephrine CTD PMID:21140131 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Synephrine inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein] CTD PMID:25111027 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein] CTD PMID:24487736 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            alkaloid 5350
              phenethylamine alkaloid 56
                synephrine 18
                  D-synephrine 0
                  L-synephrine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        amino alcohol 882
                                          ethanolamines 769
                                            synephrine 18
                                              D-synephrine 0
                                              L-synephrine 0
paths to the root

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