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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:practolol
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Accession:CHEBI:258351 term browser browse the term
Definition:N-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias.
Synonyms:exact_synonym: N-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide
 related_synonym: 1-(4-acetamidophenoxy)-3-isopropylamino-2-propanol;   4'-(2-hydroxy-3-(isopropylamino)propoxy)acetanilide;   Formula=C14H22N2O3;   InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17);   InChIKey=DURULFYMVIFBIR-UHFFFAOYSA-N;   N-(4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide;   SMILES=CC(C)NCC(O)COc1ccc(NC(C)=O)cc1;   practololum
 alt_id: CHEBI:101380;   CHEBI:8348
 xref: CAS:6673-35-4;   DrugBank:DB01297;   Drug_Central:3486;   HMDB:HMDB0015411;   KEGG:C11696;   KEGG:D05587;   LINCS:LSM-1531
 xref_mesh: MESH:D011217
 xref: PMID:6827543;   Patent:US3408387;   Wikipedia:Practolol


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practolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [Practolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ren renin decreases activity EXP Practolol results in decreased activity of REN protein CTD PMID:6110712 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pharmaceutical 19319
          drug 19319
            cardiovascular drug 7679
              anti-arrhythmia drug 956
                practolol 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                acetamides 12412
                                                  practolol 4
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