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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:3133 term browser browse the term
Definition:The di-4-toluate ester of (+-)-N-tert-butylnoradrenaline (colterol). A pro-drug for colterol, a beta2-adrenergic receptor agonist, bitolterol is used as its methanesulfonate salt for relief of bronchospasm in conditions such as asthma, chronic bronchitis and emphysema.
Synonyms:exact_synonym: 4-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,2-diyl bis(4-methylbenzoate)
 related_synonym: 4-[2-(tert-butylamino)-1-hydroxyethyl]-o-phenylene di-p-toluate;   Formula=C28H31NO5;   InChI=1S/C28H31NO5/c1-18-6-10-20(11-7-18)26(31)33-24-15-14-22(23(30)17-29-28(3,4)5)16-25(24)34-27(32)21-12-8-19(2)9-13-21/h6-16,23,29-30H,17H2,1-5H3;   InChIKey=FZGVEKPRDOIXJY-UHFFFAOYSA-N;   SMILES=Cc1ccc(cc1)C(=O)Oc1ccc(cc1OC(=O)c1ccc(C)cc1)C(O)CNC(C)(C)C;   bis(4-methylbenzoic acid) 4-[2-(tert-butylamino)-1-hydroxyethyl]-1,2-phenylene ester;   bitolterolum
 xref: Beilstein:2229527;   CAS:30392-40-6;   DrugBank:DB00901;   Drug_Central:384;   KEGG:C06853;   KEGG:D07534
 xref_mesh: MESH:C011685
 xref: PMID:3278878;   PMID:473792;   Patent:DE2015573;   Patent:US4138581;   Reaxys:2229527;   Wikipedia:Bitolterol

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bitolterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 increases activity
multiple interactions
ISO bitolterol results in increased activity of ADRB2 protein
ICI 118551 inhibits the reaction [bitolterol results in increased activity of ADRB2 protein]
CTD PMID:34601065 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      application 19557
        anti-asthmatic agent 9290
          anti-asthmatic drug 8666
            bitolterol 1
              (R)-bitolterol 0
              (S)-bitolterol 0
              bitolterol mesylate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19554
                        hydrogen molecular entity 19546
                          hydrides 19022
                            inorganic hydride 17950
                              pnictogen hydride 17936
                                nitrogen hydride 17835
                                  azane 17621
                                    ammonia 17620
                                      organic amino compound 17620
                                        amino alcohol 1043
                                          ethanolamines 806
                                            bitolterol 1
                                              (R)-bitolterol 0
                                              (S)-bitolterol 0
                                              bitolterol mesylate + 0
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