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Gene: Slc6a8 (solute carrier family 6 member 8) Rattus norvegicus
Symbol: Slc6a8
Name: solute carrier family 6 member 8
Description: Exhibits choline transmembrane transporter activity and creatine:sodium symporter activity. Involved in creatine transmembrane transport and embryonic brain development. Localizes to glutamatergic synapse and integral component of postsynaptic membrane. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in creatine transporter deficiency and intellectual disability. Orthologous to human SLC6A8 (solute carrier family 6 member 8); PARTICIPATES IN creatine metabolic pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: choline transporter; CHOT1; CHT1; creatine transporter 1; CRT; CT1; sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 (neurotransmitter transporter), member 8; solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Homo sapiens (human) : SLC6A8 (solute carrier family 6 member 8)  HGNC  Alliance
Mus musculus (house mouse) : Slc6a8 (solute carrier family 6 (neurotransmitter transporter, creatine), member 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc6a8 (solute carrier family 6 member 8)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100975352 (sodium- and chloride-dependent creatine transporter 1)
Canis lupus familiaris (dog) : SLC6A8 (solute carrier family 6 member 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc6a8 (solute carrier family 6 member 8)
Sus scrofa (pig) : SLC6A8 (solute carrier family 6 member 8)
Chlorocebus sabaeus (African green monkey) : SLC6A8 (solute carrier family 6 member 8)
Heterocephalus glaber (naked mole-rat) : Slc6a8 (solute carrier family 6 member 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X157,129,987 - 157,139,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,129,987 - 157,139,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,879,305 - 152,888,640 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,570,789 - 159,580,093 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X159,645,625 - 159,654,519 (+)NCBI
Celera1136,495,566 - 136,504,870 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc6a8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619711
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.