Slc6a8 (solute carrier family 6 member 8) - Rat Genome Database

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Gene: Slc6a8 (solute carrier family 6 member 8) Rattus norvegicus
Analyze
Symbol: Slc6a8
Name: solute carrier family 6 member 8
RGD ID: 619711
Description: Enables choline transmembrane transporter activity and creatine:sodium symporter activity. Involved in creatine transmembrane transport and embryonic brain development. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in creatine transporter deficiency and intellectual disability. Orthologous to human SLC6A8 (solute carrier family 6 member 8); PARTICIPATES IN creatine metabolic pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: choline transporter; CHOT1; CHT1; creatine transporter 1; CRT; CT1; sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 (neurotransmitter transporter), member 8; solute carrier family 6 (neurotransmitter transporter, creatine), member 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,384,675 - 151,393,979 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX151,384,675 - 151,393,979 (+)Ensembl
Rnor_6.0X157,129,987 - 157,139,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,129,987 - 157,139,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,879,305 - 152,888,640 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,570,789 - 159,580,093 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X159,645,625 - 159,654,519 (+)NCBI
Celera1136,495,566 - 136,504,870 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atenolol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
diflunisal  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
folic acid  (ISO)
folpet  (ISO)
graphite  (EXP)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (EXP)
naphthalenes  (EXP)
orphenadrine  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
resorcinol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium dichromate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1. Braissant O, etal., BMC Dev Biol. 2005 May 26;5:9.
2. Functional and immunocytochemical characterization of the creatine transporter in rat hippocampal neurons. Dodd JR, etal., J Neurochem. 2010 Nov;115(3):684-93. doi: 10.1111/j.1471-4159.2010.06957.x. Epub 2010 Sep 27.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. X-linked mental retardation with seizures and carrier manifestations is caused by a mutation in the creatine-transporter gene (SLC6A8) located in Xq28. Hahn KA, etal., Am J Hum Genet. 2002 May;70(5):1349-56. Epub 2002 Mar 15.
5. Effects of creatine and beta-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models. Kim DW, etal., BMC Neurosci. 2010 Oct 28;11:141. doi: 10.1186/1471-2202-11-141.
6. Age- and sex-dependent effects of ethanol on hippocampal hemicholinium-3 sensitive choline carriers during postnatal development of rats. Kristofikova Z, etal., Neurochem Res 2003 Apr;28(3-4):397-405.
7. Localisation of the high-affinity choline transporter-1 in the rat skeletal motor unit. Lips KS, etal., Cell Tissue Res 2002 Mar;307(3):275-80. Epub 2002 Feb 14.
8. Primary structure and functional expression of a choline transporter expressed in the rat nervous system. Mayser W, etal., FEBS Lett 1992 Jun 22;305(1):31-6.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Human, rat and chicken small intestinal Na+ - Cl- -creatine transporter: functional, molecular characterization and localization. Peral MJ, etal., J Physiol. 2002 Nov 15;545(1):133-44. doi: 10.1113/jphysiol.2002.026377.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. The putative rat choline transporter CHOT1 transports creatine and is highly expressed in neural and muscle-rich tissues. Schloss P, etal., Biochem Biophys Res Commun 1994 Jan 28;198(2):637-45.
17. Determination of Intrinsic Creatine Transporter (Slc6a8) Activity and Creatine Transport Function of Leukocytes in Rats. Taii A, etal., Biol Pharm Bull. 2020;43(3):474-479. doi: 10.1248/bpb.b19-00807.
18. A creatine transporter is operative at the brush border level of the rat jejunal enterocyte. Tosco M, etal., J Membr Biol. 2004 Nov;202(2):85-95. doi: 10.1007/s00232-004-0721-8.
19. Myocellular creatine and creatine transporter serine phosphorylation after starvation. Zhao CR, etal., J Surg Res 2002 Jun 1;105(1):10-6.
Additional References at PubMed
PMID:12477932   PMID:15326124   PMID:15953352   PMID:16167890   PMID:17971421   PMID:18555535   PMID:19580854   PMID:19682207   PMID:19804817   PMID:20462973   PMID:20569423   PMID:22307408  
PMID:23824558   PMID:25861866   PMID:27941337   PMID:33452333  


Genomics

Comparative Map Data
Slc6a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,384,675 - 151,393,979 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX151,384,675 - 151,393,979 (+)Ensembl
Rnor_6.0X157,129,987 - 157,139,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,129,987 - 157,139,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,879,305 - 152,888,640 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,570,789 - 159,580,093 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X159,645,625 - 159,654,519 (+)NCBI
Celera1136,495,566 - 136,504,870 (-)NCBICelera
Cytogenetic MapXq37NCBI
SLC6A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,687,926 - 153,696,593 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX153,687,926 - 153,696,588 (+)EnsemblGRCh38hg38GRCh38
GRCh37X152,953,381 - 152,962,048 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,606,586 - 152,615,234 (+)NCBINCBI36hg18NCBI36
Build 34X152,474,238 - 152,482,887NCBI
CeleraX153,187,436 - 153,195,732 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,612,842 - 141,619,133 (+)NCBIHuRef
CHM1_1X152,828,182 - 152,836,459 (+)NCBICHM1_1
T2T-CHM13v2.0X151,961,591 - 151,970,260 (+)NCBI
Slc6a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,716,739 - 72,726,108 (+)NCBIGRCm39mm39
GRCm39 EnsemblX72,716,756 - 72,726,108 (+)Ensembl
GRCm38X73,673,133 - 73,682,502 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,673,150 - 73,682,502 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X70,918,472 - 70,927,841 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X69,925,870 - 69,935,222 (+)NCBImm8
CeleraX64,926,949 - 64,936,317 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.38NCBI
Slc6a8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955580419,696 - 426,727 (+)NCBIChiLan1.0ChiLan1.0
LOC100975352
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,126,415 - 153,132,917 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,126,415 - 153,133,189 (+)Ensemblpanpan1.1panPan2
SLC6A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,505,117 - 121,511,674 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,505,141 - 121,510,347 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX106,832,742 - 106,841,046 (+)NCBI
ROS_Cfam_1.0X124,644,861 - 124,653,192 (+)NCBI
UMICH_Zoey_3.1X120,414,322 - 120,422,627 (+)NCBI
UNSW_CanFamBas_1.0X122,929,312 - 122,937,588 (+)NCBI
UU_Cfam_GSD_1.0X122,691,440 - 122,699,746 (+)NCBI
Slc6a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X118,833,463 - 118,840,527 (+)NCBI
SpeTri2.0NW_004936809571,234 - 578,298 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,294,856 - 124,452,182 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,435,282 - 124,452,182 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,008,693 - 142,016,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,116,490 - 128,124,899 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,116,944 - 128,124,918 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606565,978,641 - 65,987,221 (+)NCBIVero_WHO_p1.0
Slc6a8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624946389,806 - 396,653 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
DXWox37  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,393,061 - 151,393,404 (-)MAPPERmRatBN7.2
Rnor_6.0X157,130,562 - 157,130,904NCBIRnor6.0
Rnor_5.01152,879,880 - 152,880,222UniSTSRnor5.0
RGSC_v3.4X159,579,176 - 159,579,518UniSTSRGSC3.4
Celera1136,496,141 - 136,496,483UniSTS
Cytogenetic MapXq37UniSTS
D16S3203  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01152,880,577 - 152,880,694NCBIRnor5.0
RGSC_v3.4X159,578,704 - 159,578,820UniSTSRGSC3.4
Cytogenetic MapXq37UniSTS
D19322  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,393,796 - 151,393,956 (-)MAPPERmRatBN7.2
Rnor_6.0X157,130,010 - 157,130,169NCBIRnor6.0
Rnor_5.01152,879,328 - 152,879,487UniSTSRnor5.0
RGSC_v3.4X159,579,911 - 159,580,070UniSTSRGSC3.4
Celera1136,495,589 - 136,495,748UniSTS
Cytogenetic MapXq37UniSTS
Slc6a8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,392,780 - 151,393,840 (-)MAPPERmRatBN7.2
Rnor_6.0X157,130,126 - 157,131,185NCBIRnor6.0
Rnor_5.01152,879,444 - 152,880,503UniSTSRnor5.0
RGSC_v3.4X159,578,895 - 159,579,954UniSTSRGSC3.4
Celera1136,495,705 - 136,496,764UniSTS
Cytogenetic MapXq37UniSTS
UniSTS:479272  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,391,369 - 151,392,516 (-)MAPPERmRatBN7.2
Rnor_6.0X157,131,450 - 157,132,596NCBIRnor6.0
Rnor_5.01152,880,768 - 152,881,914UniSTSRnor5.0
RGSC_v3.4X159,577,484 - 159,578,630UniSTSRGSC3.4
Celera1136,497,029 - 136,498,175UniSTS
Cytogenetic MapXq37UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:387
Count of miRNA genes:219
Interacting mature miRNAs:250
Transcripts:ENSRNOT00000025702
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 12 4 4 3 6 71 35 35 3 3
Low 11 45 37 19 37 5 5 3 6 8 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000092123   ⟹   ENSRNOP00000074536
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,384,675 - 151,393,979 (+)Ensembl
Rnor_6.0 EnsemblX157,129,987 - 157,139,291 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113585   ⟹   ENSRNOP00000081044
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,384,675 - 151,393,979 (+)Ensembl
RefSeq Acc Id: NM_017348   ⟹   NP_059044
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,384,675 - 151,393,979 (+)NCBI
Rnor_6.0X157,129,987 - 157,139,291 (-)NCBI
Rnor_5.01152,879,305 - 152,888,640 (-)NCBI
RGSC_v3.4X159,570,789 - 159,580,093 (+)RGD
Celera1136,495,566 - 136,504,870 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229611   ⟹   XP_006229673
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,385,160 - 151,393,979 (+)NCBI
Rnor_6.0X157,129,987 - 157,139,321 (-)NCBI
Rnor_5.01152,879,305 - 152,888,640 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_059044 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229673 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68238 (Get FASTA)   NCBI Sequence Viewer  
  EDL85036 (Get FASTA)   NCBI Sequence Viewer  
  P28570 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_059044   ⟸   NM_017348
- UniProtKB: P28570 (UniProtKB/Swiss-Prot),   B4F7D9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229673   ⟸   XM_006229611
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000074536   ⟸   ENSRNOT00000092123
RefSeq Acc Id: ENSRNOP00000081044   ⟸   ENSRNOT00000113585

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28570-F1-model_v2 AlphaFold P28570 1-635 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702057
Promoter ID:EPDNEW_R12581
Type:single initiation site
Name:Slc6a8_1
Description:solute carrier family 6 member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X157,139,332 - 157,139,392EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619711 AgrOrtholog
BioCyc Gene G2FUF-668 BioCyc
Ensembl Genes ENSRNOG00000057620 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000074536 ENTREZGENE
  ENSRNOP00000074536.2 UniProtKB/TrEMBL
  ENSRNOP00000081044 ENTREZGENE
  ENSRNOP00000081044.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000092123 ENTREZGENE
  ENSRNOT00000092123.2 UniProtKB/TrEMBL
  ENSRNOT00000113585 ENTREZGENE
  ENSRNOT00000113585.1 UniProtKB/TrEMBL
InterPro Na/ntran_symport UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/ntran_symport_creatine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 50690 ENTREZGENE
PANTHER PTHR11616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc6a8 PhenoGen
PRINTS CRTTRANSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NANEUSMPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF161070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZS61_RAT UniProtKB/TrEMBL
  A0A8L2R9U9_RAT UniProtKB/TrEMBL
  B4F7D9 ENTREZGENE, UniProtKB/TrEMBL
  P28570 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc6a8  solute carrier family 6 member 8  Slc6a8  solute carrier family 6 (neurotransmitter transporter), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc6a8  solute carrier family 6 (neurotransmitter transporter), member 8  Slc6a8  solute carrier family 6 (neurotransmitter transporter, creatine), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc6a8  solute carrier family 6 (neurotransmitter transporter, creatine), member 8    choline transporter  Name updated 1299863 APPROVED
2004-09-10 Slc6a8  choline transporter  CHOT1    Symbol and Name updated 1299863 APPROVED
2002-08-07 CHOT1  choline transporter      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in brain, cerebellum, spinal chord and heart 737698
gene_expression highest levels of mRNA expressed in cerebellum, choroid plexus, medial habenula, pontine nuclei and pyramidal cell layer of the hippocampus 737699
gene_expression expressed in motoneurons and parasympathetic neurons of tongue 1299242
gene_function functions as a creatine uptake transporter with a Km of 46.2 microM 634748
gene_process may play a role in synaptic transmitter synthesis and recycling 1299242
gene_regulation creatine transport is inhibited by creatine uptake inhibitor beta guanidinopropionate 634748