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Gene: Slc6a8 (solute carrier family 6 member 8) Rattus norvegicus
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Symbol: Slc6a8
Name: solute carrier family 6 member 8
Description: Exhibits choline transmembrane transporter activity and creatine:sodium symporter activity. Involved in creatine transmembrane transport and embryonic brain development. Localizes to the glutamatergic synapse and integral component of postsynaptic membrane. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in creatine transporter deficiency and intellectual disability. Orthologous to human SLC6A8 (solute carrier family 6 member 8); PARTICIPATES IN creatine metabolic pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: choline transporter; CHOT1; CHT1; creatine transporter 1; CRT; CT1; sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 (neurotransmitter transporter), member 8; solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Orthologs:
Homo sapiens (human) : SLC6A8 (solute carrier family 6 member 8)  HGNC  Alliance
Mus musculus (house mouse) : Slc6a8 (solute carrier family 6 (neurotransmitter transporter, creatine), member 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc6a8 (solute carrier family 6 member 8)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC6A8 (solute carrier family 6 member 8)
Canis lupus familiaris (dog) : SLC6A8 (solute carrier family 6 member 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc6a8 (solute carrier family 6 member 8)
Sus scrofa (pig) : SLC6A8 (solute carrier family 6 member 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X157,129,987 - 157,139,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01152,879,305 - 152,888,640 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,570,789 - 159,580,093 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X159,645,625 - 159,654,519 (+)NCBI
Celera1136,495,566 - 136,504,870 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Slc6a8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619711
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.