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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phosphoethanolamine
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Accession:CHEBI:36711 term browser browse the term
Synonyms:related_synonym: phosphoethanolamines


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9-[2-(phosphonomethoxy)ethyl]guanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases response to substance 		ISO 9-((2-phosphonylmethoxy)ethyl)guanine analog inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine]; Quercetin inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog]
SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine; SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog 		CTD PMID:23856525 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
lysophosphatidylethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of BIRC3 protein] CTD PMID:25125499 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]
lysophosphatidylethanolamine analog inhibits the reaction [Glycochenodeoxycholic Acid results in increased cleavage of CASP3 protein] 		CTD PMID:25125499 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
increases expression 		ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of CFLAR mRNA]
lysophosphatidylethanolamine analog results in increased expression of CFLAR protein
Glycochenodeoxycholic Acid promotes the reaction [lysophosphatidylethanolamine analog results in increased expression of CFLAR protein]; lysophosphatidylethanolamine analog promotes the reaction [Glycochenodeoxycholic Acid results in increased expression of CFLAR protein]
lysophosphatidylethanolamine analog results in increased expression of CFLAR mRNA; lysophosphatidylethanolamine analog results in increased expression of CFLAR protein 		CTD PMID:25125499 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [lysophosphatidylethanolamine analog co-treated with cobaltous chloride] results in increased phosphorylation of GSK3B protein CTD PMID:25125499 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases expression 		ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of and results in increased degradation of MCL1 protein]
lysophosphatidylethanolamine analog results in increased expression of MCL1 protein
lysophosphatidylethanolamine analog inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of and results in increased degradation of MCL1 protein] 		CTD PMID:25125499 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of lysophosphatidylethanolamine; [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of lysophosphatidylethanolamine analog CTD PMID:29515023 NCBI chr13:50,865,253...50,985,107
Ensembl chr13:50,867,920...50,984,938 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in increased activity of PARP1 protein] CTD PMID:25125499 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of lysophosphatidylethanolamine CTD PMID:30258081 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
phosphatidylethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor decreases abundance ISO AHR protein results in decreased abundance of phosphatidylethanolamine CTD PMID:29416063 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO phosphatidylethanolamine results in increased stability of and results in increased activity of CYP1A2 protein CTD PMID:15966743 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Fgf19 fibroblast growth factor 19 increases abundance ISO FGF19 protein results in increased abundance of phosphatidylethanolamine CTD PMID:29416063 NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:209,485,813...209,490,267 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO calpeptin inhibits the reaction [dehydroeburicoic acid promotes the reaction [MAP1LC3B protein binds to phosphatidylethanolamine]]; dehydroeburicoic acid promotes the reaction [MAP1LC3B protein binds to phosphatidylethanolamine] CTD PMID:19848398 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases abundance ISO PPARGC1B results in increased abundance of phosphatidylethanolamine CTD PMID:17932310 NCBI chr18:57,029,264...57,131,466
Ensembl chr18:57,029,275...57,131,466 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
affects binding 		ISO [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to phosphatidylethanolamine] CTD PMID:15313215 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to phosphatidylethanolamine] CTD PMID:15313215 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307 		JBrowse link
rosuvastatin calcium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
multiple interactions 		ISO Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA] 		CTD PMID:18192897 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO
EXP 		Rosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium 		CTD PMID:15901796 PMID:19853032 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
affects secretion
increases expression 		ISO
EXP 		ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the secretion of Rosuvastatin Calcium
[Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
Rosuvastatin Calcium results in increased expression of ABCC2 protein 		CTD PMID:19853032 PMID:23562342 PMID:24909372 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Rosuvastatin Calcium results in increased expression of ABCC3 protein CTD PMID:24909372 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of ABCG1 mRNA CTD PMID:18192897 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity 		EXP
ISO 		[Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
Rosuvastatin Calcium results in increased activity of ABCG2 protein 		CTD PMID:19853032 PMID:30083819 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [Piracetam co-treated with Rosuvastatin Calcium] inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]; Rosuvastatin Calcium inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein] CTD PMID:28441890 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation EXP Rosuvastatin Calcium affects the phosphorylation of AKT1 protein CTD PMID:27815113 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
increases expression 		ISO Niacin promotes the reaction [Rosuvastatin Calcium results in increased expression of APOA1 protein] CTD PMID:12767421 PMID:15539964 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729 		JBrowse link
G Apob apolipoprotein B decreases expression ISO Rosuvastatin Calcium results in decreased expression of APOB protein CTD PMID:15539964 PMID:18702965 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA] CTD PMID:32007421 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Rosuvastatin Calcium results in decreased expression of BCL2 protein CTD PMID:20852871 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G C3 complement C3 decreases expression ISO Rosuvastatin Calcium results in decreased expression of C3 mRNA CTD PMID:32771489 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression 		ISO Rosuvastatin Calcium results in increased activity of CASP3 protein
Rosuvastatin Calcium results in increased expression of CASP3 protein 		CTD PMID:21478229 PMID:32771489 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase increases activity
multiple interactions 		EXP Rosuvastatin Calcium results in increased activity of CAT protein
[Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein] 		CTD PMID:20146376 PMID:32007421 PMID:35130744 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Rosuvastatin Calcium results in decreased expression of CCL2 mRNA CTD PMID:15681303 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Creb5 cAMP responsive element binding protein 5 decreases expression ISO Rosuvastatin Calcium results in decreased expression of CREB5 mRNA CTD PMID:18192897 NCBI chr 4:83,723,587...84,124,786
Ensembl chr 4:83,723,194...84,120,793 		JBrowse link
G Crp C-reactive protein multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3] CTD PMID:21562509 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression 		EXP [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species CTD PMID:21562509 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression 		ISO
EXP 		Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species 		CTD PMID:16633368 PMID:21562509 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of ESR1 protein CTD PMID:32771489 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions 		ISO Rosuvastatin Calcium results in increased expression of GCLC mRNA
[Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA 		CTD PMID:18154958 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gpr183 G protein-coupled receptor 183 multiple interactions
increases expression 		ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GPR183 mRNA] CTD PMID:18192897 NCBI chr15:105,445,129...105,457,192
Ensembl chr15:105,437,561...105,466,977 		JBrowse link
G Gzmk granzyme K multiple interactions
increases expression 		ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GZMK mRNA] CTD PMID:18192897 NCBI chr 2:46,573,997...46,582,015
Ensembl chr 2:46,573,997...46,582,015 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases secretion ISO HNF4A protein results in increased secretion of Rosuvastatin Calcium CTD PMID:27160211 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758 		JBrowse link
G Il18rap interleukin 18 receptor accessory protein decreases expression
multiple interactions 		ISO Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA] 		CTD PMID:18192897 NCBI chr 9:50,263,723...50,296,583
Ensembl chr 9:50,263,733...50,296,583 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Rosuvastatin Calcium results in decreased expression of IL1B mRNA CTD PMID:15681303 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Rosuvastatin Calcium results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 decreases expression ISO Rosuvastatin Calcium results in decreased expression of KCNJ15 mRNA CTD PMID:18192897 NCBI chr11:48,046,953...48,091,285
Ensembl chr11:48,035,655...48,092,457 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] CTD PMID:27097221 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Mb myoglobin affects expression EXP Rosuvastatin Calcium affects the expression of MB protein CTD PMID:27815113 NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:110,640,512...110,647,958 		JBrowse link
G Mstn myostatin increases expression ISO Rosuvastatin Calcium results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:55,944,513...55,950,913
Ensembl chr 9:55,944,513...55,950,913 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA] CTD PMID:32007421 PMID:35130744 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions 		EXP Rosuvastatin Calcium results in increased expression of NOS2 mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA] 		CTD PMID:21443142 PMID:32007421 PMID:35130744 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
affects response to substance
increases expression 		ISO
EXP 		Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]; Rosuvastatin Calcium results in increased phosphorylation of and results in increased activity of NOS3 protein
NOS3 protein affects the susceptibility to Rosuvastatin Calcium
Rosuvastatin Calcium results in increased expression of NOS3 mRNA 		CTD PMID:12354446 PMID:15681303 PMID:18162361 PMID:21562509 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Orm1 orosomucoid 1 multiple interactions
decreases expression 		ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ORM1 mRNA] CTD PMID:18192897 NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:81,788,395...81,791,667 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein] CTD PMID:27097221 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839 		JBrowse link
G Selp selectin P decreases expression EXP Rosuvastatin Calcium results in decreased expression of SELP mRNA CTD PMID:15681303 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987 		JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:27097221 NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:88,573,149...88,637,202 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions
increases uptake
decreases expression
affects transport 		EXP
ISO 		Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium]
diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]
Rosuvastatin Calcium results in decreased expression of SLCO1A4 protein
SLCO1A4 protein affects the transport of Rosuvastatin Calcium 		CTD PMID:19833843 PMID:24909372 PMID:26888941 PMID:28867436 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases uptake 		EXP
ISO 		Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium] 		CTD PMID:26888941 PMID:31299240 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases uptake
multiple interactions 		ISO SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium
Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium] 		CTD PMID:24285294 NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:163,371,410...163,419,279 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression 		EXP [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species CTD PMID:21562509 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of TFF1 mRNA CTD PMID:32771489 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression 		ISO
EXP 		Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
Rosuvastatin Calcium results in decreased expression of TGFB1 mRNA 		CTD PMID:15681303 PMID:27097221 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions 		EXP Rosuvastatin Calcium results in decreased expression of TNF mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein] 		CTD PMID:15681303 PMID:32007421 PMID:35130744 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:32007421 PMID:35130744 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253 		JBrowse link
G Vnn3 vanin 3 decreases expression ISO Rosuvastatin Calcium results in decreased expression of VNN3P mRNA CTD PMID:18192897 NCBI chr 1:23,390,596...23,402,858
Ensembl chr 1:23,390,596...23,402,858 		JBrowse link
G Wt1 WT1 transcription factor increases expression EXP Rosuvastatin Calcium results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:112,021,641...112,068,444 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    role 20801
      application 20602
        NMR chemical shift reference compound 18441
          phosphoric acid 13981
            phosphoric acid derivative 13893
              organic phosphate 13892
                phosphoethanolamine 64
                  1-aminopropan-2-yl phosphate + 0
                  2,3-Dihydroxypropyl 2-(dimethylamino)ethyl hydrogen phosphate 0
                  9-[2-(phosphonomethoxy)ethyl]guanine 1
                  C16 Sphinganine-1-phosphate 0
                  C17 Sphingosine-1-phosphate 0
                  CDP-N,N-dimethylethanolamine 0
                  CDP-N-methylethanolamine 0
                  CDP-ethanolamine + 0
                  L-histidinol phosphate 0
                  N,N-dimethylethanolamine phosphate 0
                  N-(Docosanoyl)-tetradecasphing-4-enine-1-phosphoethanolamine 0
                  N-Gluconyl ethanolamine phosphate 0
                  N-Lactoyl ethanolamine phosphate 0
                  N-methylethanolamine phosphate 0
                  O-phosphoethanolamine + 0
                  PE-Cer(d14:2(4E,6E)/19:0) 0
                  PE-Cer(d15:2(4E,6E)/22:0) 0
                  PE-Cer(d16:2(4E,6E)/16:0) 0
                  PE-Cer(d16:2(4E,6E)/21:0) 0
                  PL2B 0
                  Phospho-anandamide 0
                  R-1 Methanandamide phosphate 0
                  ceramide phosphoethanolamine + 49
                  creatinolfosfate 0
                  glycerophosphatidylethanolamine + 0
                  glycerophosphoethanolamine + 15
                  guanidinoethyl methyl phosphates + 0
                  serine phosphoethanolamine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    p-block element atom 20786
                      chalcogen 20473
                        oxygen atom 20439
                          oxygen molecular entity 20439
                            hydroxides 20211
                              oxoacid 19273
                                pnictogen oxoacid 15102
                                  phosphorus oxoacid 14658
                                    phosphoric acids 13981
                                      phosphoric acid 13981
                                        phosphoric acid derivative 13893
                                          phosphate 13895
                                            organic phosphate 13892
                                              phosphoethanolamine 64
                                                1-aminopropan-2-yl phosphate + 0
                                                2,3-Dihydroxypropyl 2-(dimethylamino)ethyl hydrogen phosphate 0
                                                9-[2-(phosphonomethoxy)ethyl]guanine 1
                                                C16 Sphinganine-1-phosphate 0
                                                C17 Sphingosine-1-phosphate 0
                                                CDP-N,N-dimethylethanolamine 0
                                                CDP-N-methylethanolamine 0
                                                CDP-ethanolamine + 0
                                                L-histidinol phosphate 0
                                                N,N-dimethylethanolamine phosphate 0
                                                N-(Docosanoyl)-tetradecasphing-4-enine-1-phosphoethanolamine 0
                                                N-Gluconyl ethanolamine phosphate 0
                                                N-Lactoyl ethanolamine phosphate 0
                                                N-methylethanolamine phosphate 0
                                                O-phosphoethanolamine + 0
                                                PE-Cer(d14:2(4E,6E)/19:0) 0
                                                PE-Cer(d15:2(4E,6E)/22:0) 0
                                                PE-Cer(d16:2(4E,6E)/16:0) 0
                                                PE-Cer(d16:2(4E,6E)/21:0) 0
                                                PL2B 0
                                                Phospho-anandamide 0
                                                R-1 Methanandamide phosphate 0
                                                ceramide phosphoethanolamine + 49
                                                creatinolfosfate 0
                                                glycerophosphatidylethanolamine + 0
                                                glycerophosphoethanolamine + 15
                                                guanidinoethyl methyl phosphates + 0
                                                serine phosphoethanolamine + 0
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