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Gene: Tsc2 (TSC complex subunit 2) Rattus norvegicus
Symbol: Tsc2
Name: TSC complex subunit 2
RGD ID: 3908
Description: Exhibits GTPase activator activity and protein N-terminus binding activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of signal transduction; and regulation of neuron projection development. Localizes to several cellular components, including caveola; glutamatergic synapse; and growth cone. Used to study autism spectrum disorder; hepatic angiomyolipoma; and renal cell carcinoma. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2); PARTICIPATES IN mitogen activated protein kinase signaling pathway; mTOR signaling pathway; Wnt signaling, canonical pathway; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
Also known as: Rc; renal carcinoma; tuberin; tuberous sclerosis 2; Tuberous sclerosis 2 (renal carcinoma); tuberous sclerosis 2 homolog protein; tuberous sclerosis 2 protein homolog
Homo sapiens (human) : TSC2 (TSC complex subunit 2)  HGNC  Alliance
Mus musculus (house mouse) : Tsc2 (TSC complex subunit 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tsc2 (TSC complex subunit 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TSC2 (TSC complex subunit 2)
Canis lupus familiaris (dog) : TSC2 (TSC complex subunit 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tsc2 (TSC complex subunit 2)
Sus scrofa (pig) : TSC2 (TSC complex subunit 2)
Chlorocebus sabaeus (African green monkey) : TSC2 (TSC complex subunit 2)
Heterocephalus glaber (naked mole-rat) : Tsc2 (TSC complex subunit 2)
more info ...
Allele / Splice: Tsc2_v1   Tsc2_v2   Tsc2Eker  
Genetic Models: LETsc2Eker/Hin
Is Marker For: Strains:   Eker-Tg(Tsc2)5Hin   LETsc2Eker/Hin   Eker-Tg(Tsc2)28Hin  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01013,962,006 - 13,996,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,961,947 - 13,996,584 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,778,990 - 13,813,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,848,210 - 13,883,189 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11013,848,241 - 13,882,689NCBI
Celera1013,301,129 - 13,335,713 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences