Gene: Tsc2 (TSC complex subunit 2) Rattus norvegicus
Symbol: Tsc2
Name: TSC complex subunit 2
Description: ENCODES a protein that exhibits GTPase activator activity; protein heterodimerization activity; protein N-terminus binding; INVOLVED IN aging; cell projection organization; establishment of cell polarity; PARTICIPATES IN mitogen activated protein kinase signaling pathway; mTOR signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH embryonic lethality; ASSOCIATED WITH Autism Spectrum Disorder; Carcinoma, Renal Cell; Diabetes Mellitus, Experimental; FOUND IN caveola; cell projection; cytoskeleton; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene
Type: protein-coding
Also known as: Rc; renal carcinoma; tuberin; tuberous sclerosis 2; Tuberous sclerosis 2 (renal carcinoma); tuberous sclerosis 2 homolog protein; tuberous sclerosis 2 protein homolog
Homo sapiens (human) : TSC2 (TSC complex subunit 2)  HGNC  AGR
Mus musculus (house mouse) : Tsc2 (tuberous sclerosis 2)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Tsc2 (TSC complex subunit 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TSC2 (TSC complex subunit 2)
Canis lupus familiaris (dog) : TSC2 (TSC complex subunit 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tsc2 (TSC complex subunit 2)
more info ...
Allele / Splice: Tsc2_v1   Tsc2_v2   Tsc2Eker  
Genetic Models: LETsc2Eker/Hin
Is Marker For: Strains:   Eker-Tg(Tsc2)5Hin   LETsc2Eker/Hin   Eker-Tg(Tsc2)28Hin  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01013,962,006 - 13,996,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01013,778,990 - 13,813,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,848,210 - 13,883,189 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11013,848,241 - 13,882,689NCBI
Celera1013,301,129 - 13,335,713 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tsc2
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3908
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-11-07
Status: ACTIVE