Tsc2 (TSC complex subunit 2) - Rat Genome Database

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Gene: Tsc2 (TSC complex subunit 2) Rattus norvegicus
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Symbol: Tsc2
Name: TSC complex subunit 2
RGD ID: 3908
Description: Enables GTPase activator activity and protein N-terminus binding activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of signal transduction; and regulation of neuron projection development. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in several cellular components, including caveola; glutamatergic synapse; and growth cone. Part of protein-containing complex. Used to study autism spectrum disorder; hepatic angiomyolipoma; and renal cell carcinoma. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2); PARTICIPATES IN mitogen activated protein kinase signaling pathway; mTOR signaling pathway; Wnt signaling, canonical pathway; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Rc; renal carcinoma; tuberin; tuberous sclerosis 2; Tuberous sclerosis 2 (renal carcinoma); tuberous sclerosis 2 homolog protein; tuberous sclerosis 2 protein homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Tsc2_v1   Tsc2_v2   Tsc2Eker  
Genetic Models: LETsc2Eker/Hin
Is Marker For: Strains:   Eker-Tg(Tsc2)5Hin   LETsc2Eker/Hin   Eker-Tg(Tsc2)28Hin  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21013,621,135 - 13,655,773 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1013,621,136 - 13,655,951 (-)Ensembl
Rnor_6.01013,962,006 - 13,996,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,961,947 - 13,996,584 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,778,990 - 13,813,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,848,210 - 13,883,189 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11013,848,241 - 13,882,689NCBI
Celera1013,301,129 - 13,335,713 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
antroquinonol  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylparaben  (EXP)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
DDE  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP,ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enzacamene  (EXP)
epoxiconazole  (EXP)
folpet  (ISO)
GSK690693  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
nickel dichloride  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
quercetin  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sorafenib  (EXP)
sunitinib  (ISO)
Temsirolimus  (ISO)
testosterone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IDA)
anoikis  (IEA,ISO)
cell projection organization  (IGI,IMP)
cellular response to insulin stimulus  (ISO)
establishment of cell polarity  (IMP)
establishment of protein localization  (IMP)
excitatory chemical synaptic transmission  (ISO)
glucose import  (ISO)
heart development  (ISO)
inhibitory chemical synaptic transmission  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
negative regulation of axonogenesis  (IMP)
negative regulation of cell population proliferation  (IMP,ISO)
negative regulation of cell size  (IMP)
negative regulation of epithelial cell proliferation  (IDA)
negative regulation of epithelial to mesenchymal transition  (IMP)
negative regulation of fibroblast proliferation  (IDA)
negative regulation of insulin receptor signaling pathway  (IBA)
negative regulation of macroautophagy  (IMP)
negative regulation of MAP kinase activity  (IMP)
negative regulation of phosphatidylinositol 3-kinase signaling  (ISO)
negative regulation of pinocytosis  (IMP)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein kinase B signaling  (IBA,ISO)
negative regulation of protein phosphorylation  (IMP)
negative regulation of TOR signaling  (IBA,IDA,IEA,ISO)
negative regulation of TORC1 signaling  (ISO)
negative regulation of vascular endothelial cell proliferation  (IMP)
negative regulation of Wnt signaling pathway  (IBA,IDA)
neural tube closure  (ISO)
phosphatidylinositol 3-kinase signaling  (ISO)
positive chemotaxis  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of cell adhesion  (IMP)
positive regulation of dendritic spine development  (IMP)
positive regulation of fibroblast migration  (IMP)
positive regulation of GTPase activity  (IEA)
positive regulation of macroautophagy  (IEA,ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
protein import into nucleus  (ISO)
protein kinase B signaling  (ISO)
protein localization  (ISO)
protein localization to cell surface  (IMP)
protein transport into plasma membrane raft  (ISO)
regulation of cell cycle  (IBA)
regulation of endocytosis  (ISO)
regulation of insulin receptor signaling pathway  (ISO)
regulation of postsynapse organization  (IDA,IMP)
regulation of small GTPase mediated signal transduction  (IEA)
response to hypoxia  (ISO)
signal transduction  (IDA)
social behavior  (IMP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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Additional References at PubMed
PMID:8806680   PMID:9250859   PMID:9580671   PMID:10491404   PMID:10585443   PMID:10807585   PMID:10827137   PMID:11741832   PMID:12097287   PMID:12226091   PMID:12403809   PMID:12468542  
PMID:12582162   PMID:12750296   PMID:14566415   PMID:15039427   PMID:15249583   PMID:15355997   PMID:15579027   PMID:15851513   PMID:16027168   PMID:16027169   PMID:16300636   PMID:16424383  
PMID:16452087   PMID:16636147   PMID:16959574   PMID:17074751   PMID:17114346   PMID:17458623   PMID:17510244   PMID:18094073   PMID:18198340   PMID:18218111   PMID:18511518   PMID:18670866  
PMID:19389623   PMID:19420259   PMID:19897899   PMID:19914239   PMID:20453062   PMID: