Slc4a1ap (solute carrier family 4 member 1 adaptor protein) - Rat Genome Database

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Gene: Slc4a1ap (solute carrier family 4 member 1 adaptor protein) Rattus norvegicus
Analyze
Symbol: Slc4a1ap
Name: solute carrier family 4 member 1 adaptor protein
RGD ID: 1307080
Description: Predicted to enable mRNA binding activity. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human SLC4A1AP (solute carrier family 4 member 1 adaptor protein); INTERACTS WITH 17alpha-ethynylestradiol; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kanadaptin; LOC298805; solute carrier family 4 (anion exchanger), member 1, adaptor protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2624,905,941 - 24,933,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl624,905,941 - 24,933,815 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,206,790 - 25,234,455 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0625,522,686 - 25,550,354 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0625,001,891 - 25,029,578 (-)NCBIRnor_WKY
Rnor_6.0626,214,083 - 26,241,337 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,214,335 - 26,241,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,037,605 - 36,064,887 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4624,966,415 - 24,969,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1624,969,374 - 24,996,865 (-)NCBI
Celera624,400,906 - 24,428,310 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Slc4a1ap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2624,905,941 - 24,933,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl624,905,941 - 24,933,815 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,206,790 - 25,234,455 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0625,522,686 - 25,550,354 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0625,001,891 - 25,029,578 (-)NCBIRnor_WKY
Rnor_6.0626,214,083 - 26,241,337 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,214,335 - 26,241,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,037,605 - 36,064,887 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4624,966,415 - 24,969,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1624,969,374 - 24,996,865 (-)NCBI
Celera624,400,906 - 24,428,310 (-)NCBICelera
Cytogenetic Map6q14NCBI
SLC4A1AP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,663,889 - 27,694,969 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl227,663,426 - 27,695,366 (+)EnsemblGRCh38hg38GRCh38
GRCh37227,886,756 - 27,917,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,739,842 - 27,771,351 (+)NCBINCBI36Build 36hg18NCBI36
Build 34227,797,988 - 27,829,482NCBI
Celera227,731,809 - 27,763,317 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,627,294 - 27,659,109 (+)NCBIHuRef
CHM1_1227,817,073 - 27,848,599 (+)NCBICHM1_1
T2T-CHM13v2.0227,706,977 - 27,738,031 (+)NCBIT2T-CHM13v2.0
Slc4a1ap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,684,125 - 31,723,318 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,684,339 - 31,714,276 (+)EnsemblGRCm39 Ensembl
GRCm38531,526,781 - 31,561,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,526,995 - 31,556,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,829,368 - 31,856,411 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,803,602 - 31,830,624 (+)NCBIMGSCv36mm8
Celera529,005,884 - 29,032,691 (+)NCBICelera
Cytogenetic Map5B1NCBI
Slc4a1ap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,617,269 - 9,654,458 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,617,238 - 9,654,972 (+)NCBIChiLan1.0ChiLan1.0
SLC4A1AP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A27,747,433 - 27,778,466 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,747,433 - 27,778,466 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A27,661,396 - 27,692,923 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MRPL33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,784,127 - 21,793,486 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,784,183 - 21,793,484 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,578,371 - 21,587,673 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01722,344,792 - 22,354,153 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,994,788 - 22,354,156 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,646,718 - 21,656,020 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,697,602 - 21,706,910 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,812,532 - 21,821,834 (+)NCBIUU_Cfam_GSD_1.0
Slc4a1ap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,879,944 - 65,907,810 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364934,931,755 - 4,959,628 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC4A1AP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,506,254 - 111,531,625 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,503,994 - 111,532,133 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23118,470,245 - 118,497,762 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC4A1AP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11479,934,049 - 79,965,589 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1479,931,917 - 79,966,493 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604532,184,703 - 32,216,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc4a1ap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247389,684,427 - 9,735,021 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc4a1ap
79 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:116
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000006525
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
RH130046  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2624,905,961 - 24,906,143 (+)MAPPERmRatBN7.2
Rnor_6.0626,214,104 - 26,214,285NCBIRnor6.0
Rnor_5.0636,037,626 - 36,037,807UniSTSRnor5.0
RGSC_v3.4624,966,441 - 24,966,622UniSTSRGSC3.4
Celera624,400,927 - 24,401,108UniSTS
RH 3.4 Map689.0UniSTS
Cytogenetic Map6q13UniSTS
RH135398  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2624,921,061 - 24,921,245 (+)MAPPERmRatBN7.2
Rnor_6.0626,228,796 - 26,228,979NCBIRnor6.0
Rnor_5.0636,052,319 - 36,052,502UniSTSRnor5.0
RGSC_v3.4624,981,233 - 24,981,416UniSTSRGSC3.4
Celera624,415,938 - 24,416,121UniSTS
Cytogenetic Map6q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 35 20 19 20 8 11 74 32 41 11 8
Low 2 22 21 21 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006525   ⟹   ENSRNOP00000006525
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl624,905,941 - 24,933,815 (-)Ensembl
Rnor_6.0 Ensembl626,214,335 - 26,241,337 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114902   ⟹   ENSRNOP00000085405
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl624,905,941 - 24,933,815 (-)Ensembl
RefSeq Acc Id: NM_001106709   ⟹   NP_001100179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2624,905,941 - 24,933,606 (-)NCBI
Rnor_6.0626,214,083 - 26,241,337 (-)NCBI
Rnor_5.0636,037,605 - 36,064,887 (-)NCBI
RGSC_v3.4624,966,415 - 24,969,487 (-)RGD
Celera624,400,906 - 24,428,310 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111909   ⟹   XP_038967837
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2624,905,941 - 24,933,651 (-)NCBI
RefSeq Acc Id: XM_039111910   ⟹   XP_038967838
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2624,905,941 - 24,933,606 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001100179   ⟸   NM_001106709
- Sequence:
RefSeq Acc Id: ENSRNOP00000006525   ⟸   ENSRNOT00000006525
RefSeq Acc Id: XP_038967837   ⟸   XM_039111909
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967838   ⟸   XM_039111910
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000085405   ⟸   ENSRNOT00000114902
Protein Domains
FHA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTF1-F1-model_v2 AlphaFold D3ZTF1 1-712 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694431
Promoter ID:EPDNEW_R4956
Type:single initiation site
Name:Slc4a1ap_1
Description:solute carrier family 4 member 1 adaptor protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,241,351 - 26,241,411EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307080 AgrOrtholog
BioCyc Gene G2FUF-38365 BioCyc
Ensembl Genes ENSRNOG00000004901 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006525 ENTREZGENE
  ENSRNOP00000006525.8 UniProtKB/TrEMBL
  ENSRNOP00000085405 ENTREZGENE
  ENSRNOP00000085405.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006525 ENTREZGENE
  ENSRNOT00000006525.8 UniProtKB/TrEMBL
  ENSRNOT00000114902 ENTREZGENE
  ENSRNOT00000114902.1 UniProtKB/TrEMBL
InterPro FHA_dom UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
NCBI Gene 298805 ENTREZGENE
Pfam FHA UniProtKB/TrEMBL
PhenoGen Slc4a1ap PhenoGen
PROSITE FHA_DOMAIN UniProtKB/TrEMBL
SMART FHA UniProtKB/TrEMBL
Superfamily-SCOP SMAD_FHA UniProtKB/TrEMBL
UniProt A0A8I6A1K0_RAT UniProtKB/TrEMBL
  D3ZTF1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc4a1ap  solute carrier family 4 member 1 adaptor protein  Slc4a1ap  solute carrier family 4 (anion exchanger), member 1, adaptor protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Slc4a1ap  solute carrier family 4 (anion exchanger), member 1, adaptor protein   Slc4a1ap_predicted  solute carrier family 4 (anion exchanger), member 1, adaptor protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc4a1ap_predicted  solute carrier family 4 (anion exchanger), member 1, adaptor protein (predicted)      Symbol and Name status set to approved 70820 APPROVED