CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: antidyskinesia agent
Accession: CHEBI:66956
browse the term
Definition: Any compound which can be used to treat or alleviate the symptoms of dyskinesia.
Synonyms: related_synonym: antidyskinesia agents; antidyskinesia drug; antidyskinesia drugs; antidyskinetic agent; antidyskinetic agents; antidyskinetic drug; antidyskinetic drugs
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Drd1
dopamine receptor D1
multiple interactions affects localization
ISO
A 77636 binds to and results in increased activity of DRD1 protein; SCH 23390 inhibits the reaction [A 77636 affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [A 77636 results in increased activity of DRD1 protein]
CTD
PMID:15985612
NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
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Bdnf
brain derived neurotrophic factor
multiple interactions
ISO
[Fluoxetine co-treated with Amantadine] results in increased expression of BDNF mRNA
CTD
PMID:19211973
NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
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Ifi27
interferon, alpha-inducible protein 27
increases expression
ISO
Amantadine results in increased expression of IFI27 mRNA
CTD
PMID:16756086
NCBI chr12:103,400,448...103,406,504
Ensembl chr12:103,400,470...103,406,498
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Ifnar1
interferon (alpha and beta) receptor 1
affects expression
ISO
Amantadine affects the expression of IFNAR1 mRNA
CTD
PMID:16756086
NCBI chr16:91,281,016...91,307,411
Ensembl chr16:91,282,126...91,304,329
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Jak1
Janus kinase 1
increases expression
ISO
Amantadine results in increased expression of JAK1 protein
CTD
PMID:16756086
NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479
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Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
Amantadine results in decreased activity of KCNH2 protein
CTD
PMID:21158687
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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Map2
microtubule-associated protein 2
decreases expression
ISO
Amantadine results in decreased expression of MAP2 mRNA
CTD
PMID:34748853
NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742
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Oas2
2'-5' oligoadenylate synthetase 2
increases expression
ISO
Amantadine results in increased expression of OAS2 mRNA
CTD
PMID:16756086
NCBI chr 5:120,868,398...120,887,949
Ensembl chr 5:120,868,398...120,887,918
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Slc47a1
solute carrier family 47, member 1
multiple interactions
ISO
Amantadine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr11:61,234,226...61,269,668
Ensembl chr11:61,234,227...61,269,171
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Slc47a2
solute carrier family 47, member 2
multiple interactions
ISO
Amantadine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr11:61,192,453...61,233,686
Ensembl chr11:61,192,457...61,233,686
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
[Amantadine co-treated with Ursodeoxycholic Acid co-treated with 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester] results in increased activity of STAT1
CTD
PMID:15918519
NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
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Tdp1
tyrosyl-DNA phosphodiesterase 1
decreases activity
ISO
Amantadine analog results in decreased activity of TDP1 protein
CTD
PMID:29248742
NCBI chr12:99,850,767...99,921,482
Ensembl chr12:99,850,776...99,921,478
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Avp
arginine vasopressin
increases expression multiple interactions
ISO
Apomorphine results in increased expression of AVP protein Metoclopramide inhibits the reaction [Apomorphine results in increased expression of AVP protein]
CTD
PMID:16575035
NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474
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Bmp6
bone morphogenetic protein 6
multiple interactions
ISO
Apomorphine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Apomorphine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]
CTD
PMID:25633564
NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278
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Bmpr1a
bone morphogenetic protein receptor, type 1A
decreases expression
ISO
Apomorphine results in decreased expression of BMPR1A mRNA
CTD
PMID:25633564
NCBI chr14:34,133,018...34,225,335
Ensembl chr14:34,132,691...34,225,298
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Cck
cholecystokinin
multiple interactions decreases activity
ISO
Naloxone inhibits the reaction [CCK protein results in decreased activity of Apomorphine]
CTD
PMID:3561887
NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760
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Cckbr
cholecystokinin B receptor
affects response to substance
EXP
CCKBR protein affects the susceptibility to Apomorphine
CTD
PMID:11702094
NCBI chr 7:105,075,201...105,085,546
Ensembl chr 7:105,074,938...105,120,105
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Apomorphine results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
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Drd1
dopamine receptor D1
multiple interactions
ISO EXP
Apomorphine binds to and results in increased activity of DRD1 protein; SCH 23390 inhibits the reaction [Apomorphine results in increased activity of DRD1 protein] [[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]
CTD
PMID:8103921 PMID:15985612
NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
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Drd2
dopamine receptor D2
multiple interactions affects response to substance increases response to substance
EXP ISO
[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein] DRD2 protein affects the susceptibility to Apomorphine DRD2 protein results in increased susceptibility to Apomorphine
CTD
PMID:2571179 PMID:7520908 PMID:8103596 PMID:8103921 PMID:14639100 PMID:19497322 More...
NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
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Drd3
dopamine receptor D3
increases response to substance
EXP
DRD3 protein results in increased susceptibility to Apomorphine
CTD
PMID:19497322
NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
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Fos
FBJ osteosarcoma oncogene
increases expression
ISO
Apomorphine results in increased expression of FOS protein
CTD
PMID:10904129
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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Furin
furin, paired basic amino acid cleaving enzyme
decreases expression
ISO
Apomorphine results in decreased expression of FURIN mRNA
CTD
PMID:25633564
NCBI chr 7:80,038,942...80,055,188
Ensembl chr 7:80,038,333...80,055,184
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Gdnf
glial cell line derived neurotrophic factor
multiple interactions
ISO
GDNF protein affects the susceptibility to [Apomorphine co-treated with Oxidopamine]
CTD
PMID:11771942
NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056
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Gh
growth hormone
increases secretion increases expression
ISO
Apomorphine results in increased secretion of GH1 protein Apomorphine results in increased expression of GH1 protein
CTD
PMID:993808 PMID:8889285
NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691
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Hamp
hepcidin antimicrobial peptide
multiple interactions decreases secretion decreases expression
ISO
Apomorphine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Apomorphine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]; Apomorphine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] Apomorphine results in decreased secretion of HAMP protein modified form Apomorphine results in decreased expression of HAMP mRNA
CTD
PMID:25633564
NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
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Htr1a
5-hydroxytryptamine (serotonin) receptor 1A
multiple interactions
ISO
[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]
CTD
PMID:8539317
NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630
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Htr6
5-hydroxytryptamine (serotonin) receptor 6
increases response to substance multiple interactions
ISO
HTR6 protein results in increased susceptibility to Apomorphine Ro4368554 inhibits the reaction [HTR6 protein results in increased susceptibility to Apomorphine]
CTD
PMID:17920665
NCBI chr 4:138,787,017...138,802,881
Ensembl chr 4:138,788,419...138,802,881
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Il6
interleukin 6
multiple interactions
ISO
Apomorphine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
CTD
PMID:25633564
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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Jun
jun proto-oncogene
multiple interactions
ISO
Apomorphine inhibits the reaction [Oxidopamine results in increased phosphorylation of JUN protein]
CTD
PMID:14599342
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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Odc1
ornithine decarboxylase, structural 1
increases activity
EXP
Apomorphine results in increased activity of ODC1 protein
CTD
PMID:10354516
NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506
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Penk
preproenkephalin
multiple interactions
ISO
Apomorphine inhibits the reaction [Reserpine results in increased expression of PENK mRNA]
CTD
PMID:17719177
NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819
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Prl
prolactin
decreases expression
ISO
Apomorphine results in decreased expression of PRL protein
CTD
PMID:8889285
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
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Pvalb
parvalbumin
affects expression
ISO
Apomorphine affects the expression of PVALB protein
CTD
PMID:15238432
NCBI chr15:78,075,312...78,090,600
Ensembl chr15:78,075,314...78,090,600
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Rgs9
regulator of G-protein signaling 9
affects response to substance
EXP
RGS9 affects the susceptibility to Apomorphine
CTD
PMID:15728856
NCBI chr11:109,116,174...109,189,013
Ensembl chr11:109,116,181...109,188,955
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Shh
sonic hedgehog
multiple interactions
ISO
SHH protein modified form affects the susceptibility to [Apomorphine co-treated with Oxidopamine]
CTD
PMID:11771942
NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Apomorphine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Syt7
synaptotagmin VII
multiple interactions
ISO
[Reserpine co-treated with Apomorphine] results in increased expression of SYT7 mRNA
CTD
PMID:17719177
NCBI chr19:10,366,142...10,430,545
Ensembl chr19:10,366,454...10,430,544
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Tac1
tachykinin 1
multiple interactions
ISO
Apomorphine promotes the reaction [Reserpine results in increased expression of TAC1 mRNA]
CTD
PMID:17719177
NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
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Comt
catechol-O-methyltransferase
increases methylation
ISO
COMT protein results in increased methylation of Benserazide
CTD
PMID:11160877
NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
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Ddc
dopa decarboxylase
multiple interactions
ISO
Benserazide binds to and results in decreased activity of DDC protein
CTD
PMID:35151785
NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144
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Drd1
dopamine receptor D1
multiple interactions
ISO
[Oxidopamine co-treated with levodopa methyl ester] promotes the reaction [Benserazide results in increased expression of DRD1 protein]
CTD
PMID:19399396
NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
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Drd2
dopamine receptor D2
multiple interactions
ISO
[Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein]
CTD
PMID:19399396
NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
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A930009A15Rik
RIKEN cDNA A930009A15 gene
decreases expression
ISO
Benztropine results in decreased expression of DCD protein
CTD
PMID:34122009
NCBI chr10:115,399,555...115,418,359
Ensembl chr10:115,405,891...115,418,353
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Abcb4
ATP-binding cassette, sub-family B member 4
decreases activity
ISO
Benztropine results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
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Acot2
acyl-CoA thioesterase 2
increases expression
ISO
Benztropine results in increased expression of ACOT2 protein
CTD
PMID:34122009
NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647
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Actbl2
actin, beta-like 2
increases expression
ISO
Benztropine results in increased expression of ACTBL2 protein
CTD
PMID:34122009
NCBI chr13:111,391,547...111,394,283
Ensembl chr13:111,391,547...111,394,283
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Actr1a
ARP1 actin-related protein 1A, centractin alpha
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of ACTR1A protein
CTD
PMID:34122009
NCBI chr19:46,365,252...46,384,180
Ensembl chr19:46,365,250...46,384,187
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Actr3
ARP3 actin-related protein 3
decreases expression
ISO
Benztropine results in decreased expression of ACTR3 protein
CTD
PMID:34122009
NCBI chr 1:125,320,642...125,363,464
Ensembl chr 1:125,320,642...125,363,464
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Adsl
adenylosuccinate lyase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of ADSL protein
CTD
PMID:34122009
NCBI chr15:80,832,691...80,855,148
Ensembl chr15:80,832,691...80,855,147
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Agps
alkylglycerone phosphate synthase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of AGPS protein
CTD
PMID:34122009
NCBI chr 2:75,662,477...75,761,694
Ensembl chr 2:75,662,521...75,761,694
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Ak1
adenylate kinase 1
decreases expression
ISO
Benztropine results in decreased expression of AK1 protein
CTD
PMID:34122009
NCBI chr 2:32,511,770...32,525,070
Ensembl chr 2:32,511,770...32,525,070
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Anxa1
annexin A1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of ANXA1 protein
CTD
PMID:34122009
NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308
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Anxa5
annexin A5
decreases expression
ISO
Benztropine results in decreased expression of ANXA5 protein
CTD
PMID:34122009
NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043
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Anxa6
annexin A6
decreases expression
ISO
Benztropine results in decreased expression of ANXA6 protein
CTD
PMID:34122009
NCBI chr11:54,869,779...54,924,297
Ensembl chr11:54,869,934...54,924,271
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Anxa7
annexin A7
increases expression
ISO
Benztropine results in increased expression of ANXA7 protein
CTD
PMID:34122009
NCBI chr14:20,505,344...20,530,009
Ensembl chr14:20,505,328...20,530,201
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Armt1
acidic residue methyltransferase 1
increases expression
ISO
Benztropine results in increased expression of ARMT1 protein
CTD
PMID:34122009
NCBI chr10:4,382,572...4,405,140
Ensembl chr10:4,382,467...4,405,141
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Asns
asparagine synthetase
decreases expression
ISO
Benztropine results in decreased expression of ASNS protein
CTD
PMID:34122009
NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254
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Asph
aspartate-beta-hydroxylase
increases expression
ISO
Benztropine results in increased expression of ASPH protein
CTD
PMID:34122009
NCBI chr 4:9,449,085...9,669,344
Ensembl chr 4:9,448,069...9,669,344
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Atp2a3
ATPase, Ca++ transporting, ubiquitous
increases expression
ISO
Benztropine results in increased expression of ATP2A3 protein
CTD
PMID:34122009
NCBI chr11:72,851,995...72,883,869
Ensembl chr11:72,851,995...72,883,870
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Atp5f1c
ATP synthase F1 subunit gamma
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of ATP5F1C protein
CTD
PMID:34122009
NCBI chr 2:10,060,841...10,085,321
Ensembl chr 2:10,060,827...10,085,321
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Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
decreases expression
ISO
Benztropine results in decreased expression of ATP6V1B2 protein
CTD
PMID:34122009
NCBI chr 8:69,541,388...69,566,370
Ensembl chr 8:69,541,298...69,566,363
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Atxn10
ataxin 10
increases expression
ISO
Benztropine results in increased expression of ATXN10 protein
CTD
PMID:34122009
NCBI chr15:85,220,456...85,348,038
Ensembl chr15:85,220,446...85,347,413
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Baz1b
bromodomain adjacent to zinc finger domain, 1B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of BAZ1B protein
CTD
PMID:34122009
NCBI chr 5:135,214,094...135,274,985
Ensembl chr 5:135,216,118...135,274,983
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Bcar1
breast cancer anti-estrogen resistance 1
decreases expression
ISO
Benztropine results in decreased expression of BCAR1 protein
CTD
PMID:34122009
NCBI chr 8:112,437,106...112,470,481
Ensembl chr 8:112,437,106...112,470,441
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Bltp1
bridge-like lipid transfer protein family member 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of BLTP1 protein
CTD
PMID:34122009
NCBI chr 3:36,917,212...37,107,182
Ensembl chr 3:36,917,253...37,107,182
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Bmp6
bone morphogenetic protein 6
increases expression
ISO
Benztropine results in increased expression of BMP6 mRNA
CTD
PMID:32816093
NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278
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Brd2
bromodomain containing 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of BRD2 protein
CTD
PMID:34122009
NCBI chr17:34,330,993...34,341,581
Ensembl chr17:34,330,997...34,341,608
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Bsg
basigin
decreases expression
ISO
Benztropine results in decreased expression of BSG protein
CTD
PMID:34122009
NCBI chr10:79,540,192...79,547,813
Ensembl chr10:79,540,325...79,547,803
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Cald1
caldesmon 1
multiple interactions decreases expression
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CALD1 protein Benztropine results in decreased expression of CALD1 protein
CTD
PMID:34122009
NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408
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Calu
calumenin
decreases expression
ISO
Benztropine results in decreased expression of CALU protein
CTD
PMID:34122009
NCBI chr 6:29,348,105...29,376,674
Ensembl chr 6:29,348,068...29,377,109
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Camk2d
calcium/calmodulin-dependent protein kinase II, delta
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of CAMK2D protein
CTD
PMID:34122009
NCBI chr 3:126,389,136...126,639,975
Ensembl chr 3:126,389,951...126,639,975
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Caprin1
cell cycle associated protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CAPRIN1 protein
CTD
PMID:34122009
NCBI chr 2:103,593,292...103,627,946
Ensembl chr 2:103,593,286...103,627,994
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Casp8ap2
caspase 8 associated protein 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CASP8AP2 protein
CTD
PMID:34122009
NCBI chr 4:32,615,462...32,653,271
Ensembl chr 4:32,615,451...32,653,265
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Cbx5
chromobox 5
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of CBX5 protein
CTD
PMID:34122009
NCBI chr15:103,099,973...103,148,337
Ensembl chr15:103,099,971...103,148,243
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Ccar1
cell division cycle and apoptosis regulator 1
increases expression
ISO
Benztropine results in increased expression of CCAR1 protein
CTD
PMID:34122009
NCBI chr10:62,579,707...62,628,147
Ensembl chr10:62,579,707...62,628,065
G
Ccdc121
coiled-coil domain containing 121
increases expression
ISO
Benztropine results in increased expression of CCDC121 protein
CTD
PMID:34122009
NCBI chr 5:31,643,205...31,645,820
Ensembl chr 5:31,643,084...31,645,820
G
Cct6a
chaperonin containing TCP1 subunit 6A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CCT6A protein
CTD
PMID:34122009
NCBI chr 5:129,864,420...129,875,284
Ensembl chr 5:129,864,062...129,875,212
G
Cct7
chaperonin containing TCP1 subunit 7
decreases expression
ISO
Benztropine results in decreased expression of CCT7 protein
CTD
PMID:34122009
NCBI chr 6:85,428,487...85,445,459
Ensembl chr 6:85,428,496...85,445,457
G
Cct8
chaperonin containing TCP1 subunit 8
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CCT8 protein
CTD
PMID:34122009
NCBI chr16:87,280,213...87,292,757
Ensembl chr16:87,280,214...87,292,761
G
Cd276
CD276 antigen
decreases expression
ISO
Benztropine results in decreased expression of CD276 protein
CTD
PMID:34122009
NCBI chr 9:58,431,581...58,463,437
Ensembl chr 9:58,431,581...58,462,720
G
Cenpv
centromere protein V
increases expression
ISO
Benztropine results in increased expression of CENPV protein
CTD
PMID:34122009
NCBI chr11:62,415,770...62,430,695
Ensembl chr11:62,415,772...62,430,087
G
Chd4
chromodomain helicase DNA binding protein 4
decreases expression
ISO
Benztropine results in decreased expression of CHD4 protein
CTD
PMID:34122009
NCBI chr 6:125,073,144...125,107,554
Ensembl chr 6:125,072,944...125,107,554
G
Ckb
creatine kinase, brain
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of CKB protein
CTD
PMID:34122009
NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772
G
Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
decreases expression multiple interactions
ISO
Benztropine results in decreased expression of CNP protein [Cuprizone co-treated with Benztropine] results in decreased expression of CNP protein
CTD
PMID:34122009
NCBI chr11:100,465,765...100,472,565
Ensembl chr11:100,465,730...100,482,555
G
Col14a1
collagen, type XIV, alpha 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of COL14A1 protein
CTD
PMID:34122009
NCBI chr15:55,171,040...55,384,199
Ensembl chr15:55,171,146...55,384,199
G
Col5a2
collagen, type V, alpha 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of COL5A2 protein
CTD
PMID:34122009
NCBI chr 1:45,413,491...45,542,442
Ensembl chr 1:45,413,481...45,542,442
G
Cops4
COP9 signalosome subunit 4
decreases expression
ISO
Benztropine results in decreased expression of COPS4 protein
CTD
PMID:34122009
NCBI chr 5:100,666,223...100,695,668
Ensembl chr 5:100,666,175...100,695,669
G
Coro1b
coronin, actin binding protein 1B
decreases expression
ISO
Benztropine results in decreased expression of CORO1B protein
CTD
PMID:34122009
NCBI chr19:4,198,610...4,204,034
Ensembl chr19:4,198,618...4,204,034
G
Coro7
coronin 7
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CORO7 protein
CTD
PMID:34122009
NCBI chr16:4,444,748...4,497,584
Ensembl chr16:4,443,997...4,497,641
G
Cpne3
copine III
decreases expression
ISO
Benztropine results in decreased expression of CPNE3 protein
CTD
PMID:34122009
NCBI chr 4:19,519,252...19,570,108
Ensembl chr 4:19,519,254...19,570,108
G
Cpsf3
cleavage and polyadenylation specificity factor 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CPSF3 protein
CTD
PMID:34122009
NCBI chr12:21,336,298...21,365,057
Ensembl chr12:21,335,392...21,365,057
G
Crtap
cartilage associated protein
increases expression
ISO
Benztropine results in increased expression of CRTAP protein
CTD
PMID:34122009
NCBI chr 9:114,204,204...114,219,743
Ensembl chr 9:114,204,202...114,219,743
G
Cryz
crystallin, zeta
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CRYZ protein
CTD
PMID:34122009
NCBI chr 3:154,302,348...154,328,819
Ensembl chr 3:154,302,348...154,328,819
G
Csde1
cold shock domain containing E1, RNA binding
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CSDE1 protein
CTD
PMID:34122009
NCBI chr 3:102,927,347...102,965,502
Ensembl chr 3:102,927,742...102,965,502
G
Cstf2
cleavage stimulation factor, 3' pre-RNA subunit 2
decreases expression
ISO
Benztropine results in decreased expression of CSTF2 protein
CTD
PMID:34122009
NCBI chr X:132,959,925...132,987,571
Ensembl chr X:132,959,936...132,987,568
G
Ctbp1
C-terminal binding protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CTBP1 protein
CTD
PMID:34122009
NCBI chr 5:33,405,067...33,432,348
Ensembl chr 5:33,405,067...33,432,338
G
Cul2
cullin 2
increases expression
ISO
Benztropine results in increased expression of CUL2 protein
CTD
PMID:34122009
NCBI chr18:3,382,970...3,436,700
Ensembl chr18:3,382,988...3,436,377
G
Cul4b
cullin 4B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CUL4B protein
CTD
PMID:34122009
NCBI chr X:37,620,493...37,665,073
Ensembl chr X:37,622,151...37,665,073
G
Cxcl15
C-X-C motif chemokine ligand 15
increases expression
ISO
Benztropine results in increased expression of CXCL8 mRNA
CTD
PMID:32816093
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
G
Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of DARS2 protein
CTD
PMID:34122009
NCBI chr 1:160,868,171...160,898,236
Ensembl chr 1:160,868,171...160,898,228
G
Dazap1
DAZ associated protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of DAZAP1 protein
CTD
PMID:34122009
NCBI chr10:80,097,168...80,124,242
Ensembl chr10:80,097,320...80,124,242
G
Dctn2
dynactin 2
increases expression
ISO
Benztropine results in increased expression of DCTN2 protein
CTD
PMID:34122009
NCBI chr10:127,102,131...127,117,828
Ensembl chr10:127,102,237...127,117,819
G
Ddx17
DEAD box helicase 17
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of DDX17 protein
CTD
PMID:34122009
NCBI chr15:79,411,897...79,430,976
Ensembl chr15:79,411,937...79,430,942
G
Ddx3x
DEAD box helicase 3, X-linked
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of DDX3X protein
CTD
PMID:34122009
NCBI chr X:13,147,261...13,160,222
Ensembl chr X:13,147,209...13,160,291
G
Dgcr6
DiGeorge syndrome critical region gene 6
decreases expression
ISO
Benztropine results in decreased expression of DGCR6 protein
CTD
PMID:34122009
NCBI chr16:17,870,736...17,889,497
Ensembl chr16:17,870,724...17,889,496
G
Dhcr24
24-dehydrocholesterol reductase
increases expression
ISO
Benztropine results in increased expression of DHCR24 protein
CTD
PMID:34122009
NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310
G
Dhx8
DEAH-box helicase 8
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of DHX8 protein
CTD
PMID:34122009
NCBI chr11:101,623,782...101,658,184
Ensembl chr11:101,623,745...101,658,184
G
Dlat
dihydrolipoamide S-acetyltransferase
increases expression multiple interactions
ISO
Benztropine results in increased expression of DLAT protein [Cuprizone co-treated with Benztropine] results in decreased expression of DLAT protein
CTD
PMID:34122009
NCBI chr 9:50,545,933...50,571,080
Ensembl chr 9:50,545,933...50,571,080
G
Dlg2
discs large MAGUK scaffold protein 2
increases expression
ISO
Benztropine results in increased expression of DLG2 protein
CTD
PMID:34122009
NCBI chr 7:90,125,399...92,098,454
Ensembl chr 7:90,125,880...92,098,455
G
Dnajb11
DnaJ heat shock protein family (Hsp40) member B11
increases expression
ISO
Benztropine results in increased expression of DNAJB11 protein
CTD
PMID:34122009
NCBI chr16:22,676,595...22,698,384
Ensembl chr16:22,676,595...22,698,384
G
Dpp3
dipeptidylpeptidase 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of DPP3 protein
CTD
PMID:34122009
NCBI chr19:4,957,257...4,978,315
Ensembl chr19:4,957,257...4,978,315
G
Dpysl2
dihydropyrimidinase-like 2
decreases expression
ISO
Benztropine results in decreased expression of DPYSL2 protein
CTD
PMID:34122009
NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,106,137
G
Dpysl3
dihydropyrimidinase-like 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of DPYSL3 protein
CTD
PMID:34122009
NCBI chr18:43,454,044...43,571,354
Ensembl chr18:43,454,049...43,571,351
G
Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
decreases expression
ISO
Benztropine results in decreased expression of DYNC1LI1 protein
CTD
PMID:34122009
NCBI chr 9:114,517,899...114,552,856
Ensembl chr 9:114,517,858...114,553,370
G
Ebna1bp2
EBNA1 binding protein 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EBNA1BP2 protein
CTD
PMID:34122009
NCBI chr 4:118,477,996...118,484,973
Ensembl chr 4:118,477,996...118,484,973
G
Eef1g
eukaryotic translation elongation factor 1 gamma
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EEF1G protein
CTD
PMID:34122009
NCBI chr19:8,944,405...8,955,544
Ensembl chr19:8,944,405...8,955,843
G
Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
increases expression
ISO
Benztropine results in increased expression of EIF2S3 protein
CTD
PMID:34122009
NCBI chr X:93,232,315...93,256,257
Ensembl chr X:93,232,313...93,256,468
G
Eif3b
eukaryotic translation initiation factor 3, subunit B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3B protein
CTD
PMID:34122009
NCBI chr 5:140,405,060...140,429,113
Ensembl chr 5:140,405,083...140,429,115
G
Eif3c
eukaryotic translation initiation factor 3, subunit C
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3C protein
CTD
PMID:34122009
NCBI chr 7:126,146,083...126,165,538
Ensembl chr 7:126,145,627...126,165,583
G
Eif3h
eukaryotic translation initiation factor 3, subunit H
decreases expression
ISO
Benztropine results in decreased expression of EIF3H protein
CTD
PMID:34122009
NCBI chr15:51,649,956...51,728,901
Ensembl chr15:51,649,954...51,728,919
G
Eif3l
eukaryotic translation initiation factor 3, subunit L
increases expression multiple interactions
ISO
Benztropine results in increased expression of EIF3L protein [Cuprizone co-treated with Benztropine] results in decreased expression of EIF3L protein
CTD
PMID:34122009
NCBI chr15:78,959,423...78,978,600
Ensembl chr15:78,959,379...78,978,605
G
Eif5
eukaryotic translation initiation factor 5
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EIF5 protein
CTD
PMID:34122009
NCBI chr12:111,504,535...111,513,187
Ensembl chr12:111,504,450...111,513,186
G
Eif5b
eukaryotic translation initiation factor 5B
multiple interactions increases expression
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EIF5B protein Benztropine results in increased expression of EIF5B protein
CTD
PMID:34122009
NCBI chr 1:38,037,091...38,094,660
Ensembl chr 1:38,037,091...38,094,660
G
Eif6
eukaryotic translation initiation factor 6
decreases expression
ISO
Benztropine results in decreased expression of EIF6 protein
CTD
PMID:34122009
NCBI chr 2:155,661,757...155,668,845
Ensembl chr 2:155,661,752...155,668,845
G
Eno1
enolase 1, alpha non-neuron
decreases expression
ISO
Benztropine results in decreased expression of ENO1 protein
CTD
PMID:34122009
NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336
G
Ephb3
Eph receptor B3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EPHB3 protein
CTD
PMID:34122009
NCBI chr16:21,023,530...21,042,054
Ensembl chr16:21,023,505...21,042,055
G
Epn1
epsin 1
decreases expression
ISO
Benztropine results in decreased expression of EPN1 protein
CTD
PMID:34122009
NCBI chr 7:5,083,207...5,101,178
Ensembl chr 7:5,083,234...5,101,177
G
Eps8
epidermal growth factor receptor pathway substrate 8
decreases expression
ISO
Benztropine results in decreased expression of EPS8 protein
CTD
PMID:34122009
NCBI chr 6:137,454,242...137,626,262
Ensembl chr 6:137,454,243...137,631,874
G
Erh
ERH mRNA splicing and mitosis factor
increases expression
ISO
Benztropine results in increased expression of ERH protein
CTD
PMID:34122009
NCBI chr12:80,680,799...80,690,616
Ensembl chr12:80,680,796...80,691,115
G
Erlin2
ER lipid raft associated 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of ERLIN2 protein
CTD
PMID:34122009
NCBI chr 8:27,513,399...27,529,465
Ensembl chr 8:27,513,289...27,530,356
G
Ewsr1
Ewing sarcoma breakpoint region 1
decreases expression
ISO
Benztropine results in decreased expression of EWSR1 protein
CTD
PMID:34122009
NCBI chr11:5,019,687...5,049,314
Ensembl chr11:5,019,689...5,049,266
G
Exosc9
exosome component 9
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EXOSC9 protein
CTD
PMID:34122009
NCBI chr 3:36,606,755...36,619,876
Ensembl chr 3:36,606,755...36,619,876
G
Ezr
ezrin
decreases expression
ISO
Benztropine results in decreased expression of EZR protein
CTD
PMID:34122009
NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183
G
Fabp3
fatty acid binding protein 3, muscle and heart
increases expression
ISO
Benztropine results in increased expression of FABP3 protein
CTD
PMID:34122009
NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256
G
Fdps
farnesyl diphosphate synthetase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of FDPS protein
CTD
PMID:34122009
NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266
G
Flot2
flotillin 2
increases expression
ISO
Benztropine results in increased expression of FLOT2 protein
CTD
PMID:34122009
NCBI chr11:77,928,757...77,951,260
Ensembl chr11:77,928,757...77,951,260
G
Flt1
FMS-like tyrosine kinase 1
decreases expression
ISO
Benztropine results in decreased expression of FLT1 protein
CTD
PMID:34122009
NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821
G
Fyco1
FYVE and coiled-coil domain containing 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of FYCO1 protein
CTD
PMID:34122009
NCBI chr 9:123,618,565...123,681,110
Ensembl chr 9:123,618,565...123,680,964
G
G3bp2
G3BP stress granule assembly factor 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of G3BP2 protein
CTD
PMID:34122009
NCBI chr 5:92,200,004...92,285,584
Ensembl chr 5:92,200,005...92,231,578
G
G6pdx
glucose-6-phosphate dehydrogenase X-linked
decreases expression
ISO
Benztropine results in decreased expression of G6PD protein
CTD
PMID:34122009
NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
G
Galnt2
polypeptide N-acetylgalactosaminyltransferase 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of GALNT2 protein
CTD
PMID:34122009
NCBI chr 8:124,958,133...125,072,461
Ensembl chr 8:124,958,130...125,072,463
G
Gart
phosphoribosylglycinamide formyltransferase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GART protein
CTD
PMID:34122009
NCBI chr16:91,418,283...91,444,505
Ensembl chr16:91,418,074...91,443,840
G
Gatad2b
GATA zinc finger domain containing 2B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GATAD2B protein
CTD
PMID:34122009
NCBI chr 3:90,200,488...90,270,712
Ensembl chr 3:90,200,485...90,270,714
G
Gda
guanine deaminase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of GDA protein
CTD
PMID:34122009
NCBI chr19:21,368,671...21,450,025
Ensembl chr19:21,368,671...21,450,809
G
Gfpt1
glutamine fructose-6-phosphate transaminase 1
decreases expression
ISO
Benztropine results in decreased expression of GFPT1 protein
CTD
PMID:34122009
NCBI chr 6:87,019,828...87,069,189
Ensembl chr 6:87,019,828...87,069,179
G
Ggct
gamma-glutamyl cyclotransferase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GGCT protein
CTD
PMID:34122009
NCBI chr 6:54,962,080...54,969,947
Ensembl chr 6:54,959,565...54,969,935
G
Glrx3
glutaredoxin 3
increases expression
ISO
Benztropine results in increased expression of GLRX3 protein
CTD
PMID:34122009
NCBI chr 7:137,039,302...137,071,360
Ensembl chr 7:137,039,343...137,070,323
G
Gls
glutaminase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GLS protein
CTD
PMID:34122009
NCBI chr 1:52,202,608...52,274,168
Ensembl chr 1:52,202,607...52,272,391
G
Gna12
guanine nucleotide binding protein, alpha 12
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GNA12 protein
CTD
PMID:34122009
NCBI chr 5:140,745,699...140,816,186
Ensembl chr 5:140,744,163...140,816,186
G
Golga4
golgin A4
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of GOLGA4 protein
CTD
PMID:34122009
NCBI chr 9:118,335,280...118,411,587
Ensembl chr 9:118,335,335...118,411,587
G
Golgb1
golgin B1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GOLGB1 protein
CTD
PMID:34122009
NCBI chr16:36,695,455...36,753,447
Ensembl chr16:36,695,502...36,753,447
G
Got2
glutamatic-oxaloacetic transaminase 2, mitochondrial
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of GOT2 protein
CTD
PMID:34122009
NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175
G
Gpi1
glucose-6-phosphate isomerase 1
increases expression
ISO
Benztropine results in increased expression of GPI protein
CTD
PMID:34122009
NCBI chr 7:33,900,752...33,929,761
Ensembl chr 7:33,900,755...33,929,761
G
Gpkow
G patch domain and KOW motifs
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GPKOW protein
CTD
PMID:34122009
NCBI chr X:7,563,373...7,576,500
Ensembl chr X:7,563,370...7,576,501
G
Gtf2e1
general transcription factor II E, polypeptide 1 (alpha subunit)
decreases expression
ISO
Benztropine results in decreased expression of GTF2E1 protein
CTD
PMID:34122009
NCBI chr16:37,330,158...37,360,151
Ensembl chr16:37,330,152...37,360,151
G
Gtf2f1
general transcription factor IIF, polypeptide 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GTF2F1 protein
CTD
PMID:34122009
NCBI chr17:57,310,402...57,318,398
Ensembl chr17:57,310,405...57,318,288
G
Gtpbp4
GTP binding protein 4
increases expression
ISO
Benztropine results in increased expression of GTPBP4 protein
CTD
PMID:34122009
NCBI chr13:9,016,039...9,046,080
Ensembl chr13:9,016,367...9,046,119
G
Gys1
glycogen synthase 1, muscle
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GYS1 protein
CTD
PMID:34122009
NCBI chr 7:45,084,263...45,106,041
Ensembl chr 7:45,084,268...45,106,043
G
H2ac20
H2A clustered histone 20
increases expression
ISO
Benztropine results in increased expression of H2AC20 protein
CTD
PMID:34122009
NCBI chr 3:96,127,728...96,128,209
Ensembl chr 3:96,127,677...96,128,196
G
H2aj
H2J.A histone
increases expression
ISO
Benztropine results in increased expression of H2AJ protein
CTD
PMID:34122009
NCBI chr 6:136,785,246...136,787,072
Ensembl chr 6:136,785,242...136,787,072
G
Hacd3
3-hydroxyacyl-CoA dehydratase 3
increases expression
ISO
Benztropine results in increased expression of HACD3 protein
CTD
PMID:34122009
NCBI chr 9:64,894,265...64,929,014
Ensembl chr 9:64,894,265...64,928,975
G
Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
increases expression
ISO
Benztropine results in increased expression of HADHB protein
CTD
PMID:34122009
NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591
G
Hars1
histidyl-tRNA synthetase 1
increases expression
ISO
Benztropine results in increased expression of HARS1 protein
CTD
PMID:34122009
NCBI chr18:36,899,581...36,916,258
Ensembl chr18:36,899,581...36,916,258
G
Hat1
histone aminotransferase 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of HAT1 protein
CTD
PMID:34122009
NCBI chr 2:71,219,604...71,271,966
Ensembl chr 2:71,219,302...71,271,966
G
Hcfc1
host cell factor C1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of HCFC1 protein
CTD
PMID:34122009
NCBI chr X:72,986,400...73,011,430
Ensembl chr X:72,986,398...73,009,963
G
Hmcn2
hemicentin 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of HMCN2 protein
CTD
PMID:34122009
NCBI chr 2:31,204,273...31,350,751
Ensembl chr 2:31,204,427...31,350,750
G
Hnrnpd
heterogeneous nuclear ribonucleoprotein D
decreases expression
ISO
Benztropine results in decreased expression of HNRNPD protein
CTD
PMID:34122009
NCBI chr 5:100,103,794...100,126,926
Ensembl chr 5:100,103,794...100,126,797
G
Hnrnpk
heterogeneous nuclear ribonucleoprotein K
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of HNRNPK protein
CTD
PMID:34122009
NCBI chr13:58,538,946...58,551,157
Ensembl chr13:58,538,956...58,551,157
G
Hps3
HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of HPS3 protein
CTD
PMID:34122009
NCBI chr 3:20,050,109...20,089,478
Ensembl chr 3:20,050,109...20,089,479
G
Hsd17b12
hydroxysteroid (17-beta) dehydrogenase 12
increases expression
ISO
Benztropine results in increased expression of HSD17B12 protein
CTD
PMID:34122009
NCBI chr 2:93,863,042...93,988,254
Ensembl chr 2:93,863,034...93,988,309
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Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of HSD17B4 protein
CTD
PMID:34122009
NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
G
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of HSP90B1 protein
CTD
PMID:34122009
NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373
G
Idi1
isopentenyl-diphosphate delta isomerase
decreases expression
ISO
Benztropine results in decreased expression of IDI1 protein
CTD
PMID:34122009
NCBI chr13:8,935,642...8,942,432
Ensembl chr13:8,935,537...8,942,487
G
Il1a
interleukin 1 alpha
decreases expression
ISO
Benztropine results in decreased expression of IL1A mRNA
CTD
PMID:32816093
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
G
Il1b
interleukin 1 beta
decreases expression
ISO
Benztropine results in decreased expression of IL1B mRNA
CTD
PMID:32816093
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
G
Il24
interleukin 24
increases expression
ISO
Benztropine results in increased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
G
Jam3
junction adhesion molecule 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of JAM3 protein
CTD
PMID:34122009
NCBI chr 9:27,008,680...27,066,739
Ensembl chr 9:27,008,680...27,066,717
G
Jpt2
Jupiter microtubule associated homolog 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of JPT2 protein
CTD
PMID:34122009
NCBI chr17:25,161,444...25,179,597
Ensembl chr17:25,156,393...25,179,663
G
Kars1
lysyl-tRNA synthetase 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of KARS1 protein
CTD
PMID:34122009
NCBI chr 8:112,720,071...112,737,986
Ensembl chr 8:112,720,075...112,737,955
G
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
Benztropine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
G
Kctd12
potassium channel tetramerisation domain containing 12
decreases expression
ISO
Benztropine results in decreased expression of KCTD12 protein
CTD
PMID:34122009
NCBI chr14:103,214,017...103,220,073
Ensembl chr14:103,214,017...103,220,073
G
Khdrbs1
KH domain containing, RNA binding, signal transduction associated 1
decreases expression
ISO
Benztropine results in decreased expression of KHDRBS1 protein
CTD
PMID:34122009
NCBI chr 4:129,596,143...129,637,402
Ensembl chr 4:129,596,957...129,636,096
G
Kif5c
kinesin family member 5C
decreases expression
ISO
Benztropine results in decreased expression of KIF5C protein
CTD
PMID:34122009
NCBI chr 2:49,509,298...49,664,790
Ensembl chr 2:49,509,310...49,664,790
G
Klhdc2
kelch domain containing 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of KLHDC2 protein
CTD
PMID:34122009
NCBI chr12:69,343,455...69,357,461
Ensembl chr12:69,343,455...69,357,461
G
Klhl41
kelch-like 41
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of KLHL41 protein
CTD
PMID:34122009
NCBI chr 2:69,500,464...69,514,583
Ensembl chr 2:69,500,464...69,514,574
G
Kpna4
karyopherin subunit alpha 4
increases expression
ISO
Benztropine results in increased expression of KPNA4 protein
CTD
PMID:34122009
NCBI chr 3:68,979,554...69,034,425
Ensembl chr 3:68,974,482...69,034,446
G
Ktn1
kinectin 1
decreases expression multiple interactions
ISO
Benztropine results in decreased expression of KTN1 protein [Cuprizone co-treated with Benztropine] results in increased expression of KTN1 protein
CTD
PMID:34122009
NCBI chr14:47,886,551...47,974,021
Ensembl chr14:47,885,905...47,977,351
G
Lactb2
lactamase, beta 2
increases expression
ISO
Benztropine results in increased expression of LACTB2 protein
CTD
PMID:34122009
NCBI chr 1:13,695,069...13,730,749
Ensembl chr 1:13,693,554...13,730,770
G
Lamb1
laminin B1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of LAMB1 protein
CTD
PMID:34122009
NCBI chr12:31,315,230...31,379,643
Ensembl chr12:31,315,233...31,379,643
G
Lamc1
laminin, gamma 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of LAMC1 protein
CTD
PMID:34122009
NCBI chr 1:153,094,668...153,208,532
Ensembl chr 1:153,094,668...153,208,532
G
Lima1
LIM domain and actin binding 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of LIMA1 protein
CTD
PMID:34122009
NCBI chr15:99,676,351...99,773,292
Ensembl chr15:99,676,351...99,773,337
G
Lipa
lysosomal acid lipase A
increases expression
ISO
Benztropine results in increased expression of LIPA protein
CTD
PMID:34122009
NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874
G
Lmod2
leiomodin 2 (cardiac)
increases expression
ISO
Benztropine results in increased expression of LMOD2 protein
CTD
PMID:34122009
NCBI chr 6:24,597,770...24,605,413
Ensembl chr 6:24,597,761...24,605,413
G
Lss
lanosterol synthase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of LSS protein
CTD
PMID:34122009
NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972
G
Lta4h
leukotriene A4 hydrolase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of LTA4H protein
CTD
PMID:34122009
NCBI chr10:93,289,258...93,320,758
Ensembl chr10:93,289,273...93,320,737
G
Luc7l
Luc7-like
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of LUC7L protein
CTD
PMID:34122009
NCBI chr17:26,471,874...26,504,484
Ensembl chr17:26,471,870...26,504,478
G
Magea1
MAGE family member A1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of MAGEA9B protein
CTD
PMID:34122009
NCBI chr X:153,871,515...153,872,786
Ensembl chr X:153,871,682...153,872,789
G
Magea9
MAGE family member A9
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of MAGEA9 protein
CTD
PMID:34122009
NCBI chr X:63,217,154...63,222,385
Ensembl chr X:63,217,154...63,222,384
G
Maged2
MAGE family member D2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of MAGED2 protein
CTD
PMID:34122009
NCBI chr X:149,589,417...149,597,358
Ensembl chr X:149,589,366...149,597,341
G
Map1s
microtubule-associated protein 1S
increases expression
ISO
Benztropine results in increased expression of MAP1S protein
CTD
PMID:34122009
NCBI chr 8:71,358,618...71,370,173
Ensembl chr 8:71,358,576...71,370,173
G
Map4
microtubule-associated protein 4
decreases expression
ISO
Benztropine results in decreased expression of MAP4 protein
CTD
PMID:34122009
NCBI chr 9:109,758,909...109,913,018
Ensembl chr 9:109,760,528...109,913,023
G
Mapre1
microtubule-associated protein, RP/EB family, member 1
decreases expression
ISO
Benztropine results in decreased expression of MAPRE1 protein
CTD
PMID:34122009
NCBI chr 2:153,583,131...153,615,237
Ensembl chr 2:153,583,194...153,615,230
G
Marcksl1
MARCKS-like 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of MARCKSL1 protein
CTD
PMID:34122009
NCBI chr 4:129,407,374...129,409,774
Ensembl chr 4:129,407,374...129,409,778
G
Mat2b
methionine adenosyltransferase 2 non-catalytic beta subunit methionine
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of MAT2B protein
CTD
PMID:34122009
NCBI chr11:40,570,141...40,586,030
Ensembl chr11:40,570,141...40,586,030
G
Mboat7
membrane bound O-acyltransferase domain containing 7
decreases expression
ISO
Benztropine results in decreased expression of MBOAT7 protein
CTD
PMID:34122009
NCBI chr 7:3,680,788...3,696,188
Ensembl chr 7:3,680,788...3,696,522
G
Mdh1
malate dehydrogenase 1, NAD (soluble)
decreases expression
ISO
Benztropine results in decreased expression of MDH1 protein
CTD
PMID:34122009
NCBI chr11:21,506,692...21,521,934
Ensembl chr11:21,506,692...21,522,367
G
Met
met proto-oncogene
increases expression
ISO
Benztropine results in increased expression of MET mRNA
CTD
PMID:32816093
NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
G
Metap2
methionine aminopeptidase 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of METAP2 protein
CTD
PMID:34122009
NCBI chr10:93,694,351...93,732,952
Ensembl chr10:93,694,351...93,732,955
G
Mif
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
increases expression
ISO
Benztropine results in increased expression of MIF protein
CTD
PMID:34122009
NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074
G
Mtdh
metadherin
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of MTDH protein
CTD
PMID:34122009
NCBI chr15:34,082,613...34,143,683
Ensembl chr15:34,082,840...34,145,770
G
Mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of MTHFD1L protein
CTD
PMID:34122009
NCBI chr10:3,918,282...4,117,081
Ensembl chr10:3,923,118...4,117,081
G
Myh3
myosin, heavy polypeptide 3, skeletal muscle, embryonic
increases expression
ISO
Benztropine results in increased expression of MYH3 protein
CTD
PMID:34122009
NCBI chr11:66,969,101...66,993,117
Ensembl chr11:66,969,126...66,993,112
G
Nat10
N-acetyltransferase 10
decreases expression
ISO
Benztropine results in decreased expression of NAT10 protein
CTD
PMID:34122009
NCBI chr 2:103,551,603...103,593,292
Ensembl chr 2:103,551,601...103,591,615
G
Ncbp1
nuclear cap binding protein subunit 1
decreases expression
ISO
Benztropine results in decreased expression of NCBP1 protein
CTD
PMID:34122009
NCBI chr 4:46,138,732...46,172,403
Ensembl chr 4:46,138,613...46,172,403
G
Nectin2
nectin cell adhesion molecule 2
decreases expression
ISO
Benztropine results in decreased expression of NECTIN2 protein
CTD
PMID:34122009
NCBI chr 7:19,450,569...19,483,498
Ensembl chr 7:19,450,569...19,484,408
G
Nnmt
nicotinamide N-methyltransferase
increases expression
ISO
Benztropine results in increased expression of NNMT protein
CTD
PMID:34122009
NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453
G
Noc2l
NOC2 like nucleolar associated transcriptional repressor
increases expression
ISO
Benztropine results in increased expression of NOC2L protein
CTD
PMID:34122009
NCBI chr 4:156,319,112...156,332,078
Ensembl chr 4:156,320,376...156,332,073
G
Nsf
N-ethylmaleimide sensitive fusion protein
decreases expression
ISO
Benztropine results in decreased expression of NSF protein
CTD
PMID:34122009
NCBI chr11:103,712,608...103,844,882
Ensembl chr11:103,712,608...103,844,882
G
Nsfl1c
NSFL1 (p97) cofactor (p47)
decreases expression
ISO
Benztropine results in decreased expression of NSFL1C protein
CTD
PMID:34122009
NCBI chr 2:151,336,102...151,353,230
Ensembl chr 2:151,336,102...151,353,334
G
Numa1
nuclear mitotic apparatus protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of NUMA1 protein
CTD
PMID:34122009
NCBI chr 7:101,583,169...101,664,166
Ensembl chr 7:101,583,318...101,664,171
G
Nup153
nucleoporin 153
increases expression
ISO
Benztropine results in increased expression of NUP153 protein
CTD
PMID:34122009
NCBI chr13:46,833,369...46,890,682
Ensembl chr13:46,833,381...46,881,416
G
Nup50
nucleoporin 50
increases expression
ISO
Benztropine results in increased expression of NUP50 protein
CTD
PMID:34122009
NCBI chr15:84,800,100...84,827,164
Ensembl chr15:84,807,612...84,827,164
G
Nup54
nucleoporin 54
decreases expression
ISO
Benztropine results in decreased expression of NUP54 protein
CTD
PMID:34122009
NCBI chr 5:92,563,399...92,583,117
Ensembl chr 5:92,563,399...92,583,078
G
Nup93
nucleoporin 93
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of NUP93 protein
CTD
PMID:34122009
NCBI chr 8:94,941,203...95,043,858
Ensembl chr 8:94,941,192...95,043,855
G
Nxf1
nuclear RNA export factor 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of NXF1 protein
CTD
PMID:34122009
NCBI chr19:8,734,467...8,748,274
Ensembl chr19:8,734,437...8,748,286
G
Oat
ornithine aminotransferase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of OAT protein
CTD
PMID:34122009
NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127
G
Ogdh
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
decreases expression
ISO
Benztropine results in decreased expression of OGDH protein
CTD
PMID:34122009
NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642
G
Ola1
Obg-like ATPase 1
increases expression
ISO
Benztropine results in increased expression of OLA1 protein
CTD
PMID:34122009
NCBI chr 2:72,923,145...73,044,791
Ensembl chr 2:72,923,145...73,049,268
G
P4hb
prolyl 4-hydroxylase, beta polypeptide
decreases expression
ISO
Benztropine results in decreased expression of P4HB protein
CTD
PMID:34122009
NCBI chr11:120,451,124...120,464,079
Ensembl chr11:120,451,124...120,464,079
G
Pa2g4
proliferation-associated 2G4
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PA2G4 protein
CTD
PMID:34122009
NCBI chr10:128,393,635...128,401,803
Ensembl chr10:128,393,635...128,401,856
G
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PAFAH1B1 protein
CTD
PMID:34122009
NCBI chr11:74,564,775...74,615,210
Ensembl chr11:74,564,775...74,615,496
G
Pag1
phosphoprotein associated with glycosphingolipid microdomains 1
decreases expression
ISO
Benztropine results in decreased expression of PAG1 protein
CTD
PMID:34122009
NCBI chr 3:9,752,539...9,898,744
Ensembl chr 3:9,752,539...9,898,739
G
Parp1
poly (ADP-ribose) polymerase family, member 1
multiple interactions decreases expression
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of PARP1 protein Benztropine results in decreased expression of PARP1 protein
CTD
PMID:34122009
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
G
Pcbp1
poly(rC) binding protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PCBP1 protein
CTD
PMID:34122009
NCBI chr 6:86,501,462...86,503,171
Ensembl chr 6:86,501,474...86,503,303
G
Pcbp2
poly(rC) binding protein 2
decreases expression
ISO
Benztropine results in decreased expression of PCBP2 protein
CTD
PMID:34122009
NCBI chr15:102,378,974...102,408,503
Ensembl chr15:102,378,974...102,408,496
G
Pcdhga2
protocadherin gamma subfamily A, 2
decreases expression
ISO
Benztropine results in decreased expression of PCDHGA2 protein
CTD
PMID:34122009
NCBI chr18:37,801,980...37,974,923
Ensembl chr18:37,802,006...37,974,923
G
Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
decreases expression
ISO
Benztropine results in decreased expression of PCMT1 protein
CTD
PMID:34122009
NCBI chr10:7,503,608...7,556,922
Ensembl chr10:7,505,137...7,556,900
G
Pcnp
PEST proteolytic signal containing nuclear protein
increases expression
ISO
Benztropine results in increased expression of PCNP protein
CTD
PMID:34122009
NCBI chr16:55,835,870...55,851,590
Ensembl chr16:55,827,608...55,850,102
G
Pcx
pyruvate carboxylase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of PC protein
CTD
PMID:34122009
NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780
G
Pdcl3
phosducin-like 3
decreases expression
ISO
Benztropine results in decreased expression of PDCL3 protein
CTD
PMID:34122009
NCBI chr 1:39,026,895...39,036,317
Ensembl chr 1:39,024,689...39,036,319
G
Pdia3
protein disulfide isomerase associated 3
decreases expression
ISO
Benztropine results in decreased expression of PDIA3 protein
CTD
PMID:34122009
NCBI chr 2:121,244,383...121,269,168
Ensembl chr 2:121,244,256...121,269,168
G
Pdia6
protein disulfide isomerase associated 6
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PDIA6 protein
CTD
PMID:34122009
NCBI chr12:17,316,590...17,334,786
Ensembl chr12:17,316,546...17,334,771
G
Pdlim5
PDZ and LIM domain 5
decreases expression
ISO
Benztropine results in decreased expression of PDLIM5 protein
CTD
PMID:34122009
NCBI chr 3:141,945,346...142,101,480
Ensembl chr 3:141,945,351...142,101,454
G
Pebp1
phosphatidylethanolamine binding protein 1
decreases expression
ISO
Benztropine results in decreased expression of PEBP1 protein
CTD
PMID:34122009
NCBI chr 5:117,420,716...117,425,629
Ensembl chr 5:117,420,719...117,425,690
G
Pfn1
profilin 1
increases expression
ISO
Benztropine results in increased expression of PFN1 protein
CTD
PMID:34122009
NCBI chr11:70,542,670...70,547,625
Ensembl chr11:70,542,676...70,545,470
G
Pgk1
phosphoglycerate kinase 1
decreases expression
ISO
Benztropine results in decreased expression of PGK1 protein
CTD
PMID:34122009
NCBI chr X:105,230,706...105,247,305
Ensembl chr X:105,230,706...105,247,305
G
Pgm3
phosphoglucomutase 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PGM3 protein
CTD
PMID:34122009
NCBI chr 9:86,423,997...86,453,927
Ensembl chr 9:86,436,430...86,453,895
G
Phf14
PHD finger protein 14
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PHF14 protein
CTD
PMID:34122009
NCBI chr 6:11,907,728...12,100,155
Ensembl chr 6:11,907,808...12,081,204
G
Phgdh
3-phosphoglycerate dehydrogenase
decreases expression
ISO
Benztropine results in decreased expression of PHGDH protein
CTD
PMID:34122009
NCBI chr 3:98,220,487...98,247,285
Ensembl chr 3:98,220,486...98,247,306
G
Pid1
phosphotyrosine interaction domain containing 1
increases expression
ISO
Benztropine results in increased expression of PID1 mRNA
CTD
PMID:32816093
NCBI chr 1:84,014,014...84,317,550
Ensembl chr 1:84,014,017...84,341,901
G
Pin1
peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PIN1 protein
CTD
PMID:34122009
NCBI chr 9:20,563,335...20,575,008
Ensembl chr 9:20,563,391...20,577,880
G
Pmpca
peptidase (mitochondrial processing) alpha
increases expression
ISO
Benztropine results in increased expression of PMPCA protein
CTD
PMID:34122009
NCBI chr 2:26,275,554...26,287,134
Ensembl chr 2:26,279,351...26,287,134
G
Pnma1
paraneoplastic antigen MA1
increases expression
ISO
Benztropine results in increased expression of PNMA1 protein
CTD
PMID:34122009
NCBI chr12:84,192,905...84,195,263
Ensembl chr12:84,192,905...84,195,263
G
Pnma8a
PNMA family member 8A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PNMA8A protein
CTD
PMID:34122009
NCBI chr 7:16,683,325...16,698,532
Ensembl chr 7:16,693,604...16,698,532
G
Pon3
paraoxonase 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PON3 protein
CTD
PMID:34122009
NCBI chr 6:5,216,253...5,256,236
Ensembl chr 6:5,220,852...5,256,286
G
Ppa1
pyrophosphatase (inorganic) 1
increases expression multiple interactions
ISO
Benztropine results in increased expression of PPA1 protein [Cuprizone co-treated with Benztropine] results in decreased expression of PPA1 protein
CTD
PMID:34122009
NCBI chr10:61,484,400...61,509,944
Ensembl chr10:61,484,331...61,509,947
G
Ppm1f
protein phosphatase 1F (PP2C domain containing)
decreases expression
ISO
Benztropine results in decreased expression of PPM1F protein
CTD
PMID:34122009
NCBI chr16:16,714,314...16,745,239
Ensembl chr16:16,714,333...16,745,228
G
Ppp1r12a
protein phosphatase 1, regulatory subunit 12A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of PPP1R12A protein
CTD
PMID:34122009
NCBI chr10:107,997,913...108,115,846
Ensembl chr10:107,998,054...108,120,336
G
Ppp1r14b
protein phosphatase 1, regulatory inhibitor subunit 14B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PPP1R14B protein
CTD
PMID:34122009
NCBI chr19:6,952,416...6,954,692
Ensembl chr19:6,952,336...6,954,692
G
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
increases expression
ISO
Benztropine results in increased expression of PPP3CA protein
CTD
PMID:34122009
NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488
G
Prkar2a
protein kinase, cAMP dependent regulatory, type II alpha
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PRKAR2A protein
CTD
PMID:34122009
NCBI chr 9:108,569,342...108,627,643
Ensembl chr 9:108,566,513...108,627,635
G
Prkcsh
protein kinase C substrate 80K-H
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of PRKCSH protein
CTD
PMID:34122009
NCBI chr 9:21,914,314...21,925,521
Ensembl chr 9:21,914,102...21,925,518
G
Prmt1
protein arginine N-methyltransferase 1
decreases expression
ISO
Benztropine results in decreased expression of PRMT1 protein
CTD
PMID:34122009
NCBI chr 7:44,626,179...44,635,844
Ensembl chr 7:44,625,413...44,635,992
G
Prpf6
pre-mRNA splicing factor 6
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PRPF6 protein
CTD
PMID:34122009
NCBI chr 2:181,243,112...181,297,454
Ensembl chr 2:181,233,661...181,297,453
G
Psma1
proteasome subunit alpha 1
decreases expression
ISO
Benztropine results in decreased expression of PSMA1 protein
CTD
PMID:34122009
NCBI chr 7:113,863,785...113,875,351
Ensembl chr 7:113,863,841...113,875,353
G
Psmb7
proteasome (prosome, macropain) subunit, beta type 7
decreases expression
ISO
Benztropine results in decreased expression of PSMB7 protein
CTD
PMID:34122009
NCBI chr 2:38,478,058...38,533,964
Ensembl chr 2:38,478,048...38,534,099
G
Psmc1
protease (prosome, macropain) 26S subunit, ATPase 1
decreases expression
ISO
Benztropine results in decreased expression of PSMC1 protein
CTD
PMID:34122009
NCBI chr12:100,076,461...100,089,623
Ensembl chr12:100,076,413...100,089,664
G
Psmc3
proteasome (prosome, macropain) 26S subunit, ATPase 3
increases expression
ISO
Benztropine results in increased expression of PSMC3 protein
CTD
PMID:34122009
NCBI chr 2:90,884,361...90,889,783
Ensembl chr 2:90,884,354...90,896,714
G
Psmd7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
increases expression
ISO
Benztropine results in increased expression of PSMD7 protein
CTD
PMID:34122009
NCBI chr 8:108,307,012...108,315,114
Ensembl chr 8:108,307,013...108,315,096
G
Ptcd3
pentatricopeptide repeat domain 3
increases expression multiple interactions
ISO
Benztropine results in increased expression of PTCD3 protein [Cuprizone co-treated with Benztropine] results in decreased expression of PTCD3 protein
CTD
PMID:34122009
NCBI chr 6:71,857,622...71,886,080
Ensembl chr 6:71,857,622...71,885,734
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
Benztropine results in decreased expression of PTGS2 mRNA
CTD
PMID:32816093
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
G
Ptk7
PTK7 protein tyrosine kinase 7
decreases expression
ISO
Benztropine results in decreased expression of PTK7 protein
CTD
PMID:34122009
NCBI chr17:46,875,377...46,940,975
Ensembl chr17:46,875,397...46,940,430
G
Puf60
poly-U binding splicing factor 60
decreases expression
ISO
Benztropine results in decreased expression of PUF60 protein
CTD
PMID:34122009
NCBI chr15:75,942,031...75,954,386
Ensembl chr15:75,942,031...75,952,773
G
Pwp2
PWP2 periodic tryptophan protein homolog (yeast)
increases expression
ISO
Benztropine results in increased expression of PWP2 protein
CTD
PMID:34122009
NCBI chr10:78,006,743...78,021,005
Ensembl chr10:78,006,743...78,020,983
G
Pycr1
pyrroline-5-carboxylate reductase 1
increases expression
ISO
Benztropine results in increased expression of PYCR1 protein
CTD
PMID:34122009
NCBI chr11:120,527,591...120,534,602
Ensembl chr11:120,526,538...120,534,595
G
Qdpr
quinoid dihydropteridine reductase
decreases expression
ISO
Benztropine results in decreased expression of QDPR protein
CTD
PMID:34122009
NCBI chr 5:45,591,374...45,607,571
Ensembl chr 5:45,591,363...45,607,578
G
Rack1
receptor for activated C kinase 1
decreases expression
ISO
Benztropine results in decreased expression of RACK1 protein
CTD
PMID:34122009
NCBI chr11:48,691,187...48,697,068
Ensembl chr11:48,691,159...48,697,261
G
Rbm15
RNA binding motif protein 15
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of RBM15 protein
CTD
PMID:34122009
NCBI chr 3:107,212,827...107,244,102
Ensembl chr 3:107,232,737...107,240,989
G
Ric8a
RIC8 guanine nucleotide exchange factor A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of RIC8A protein
CTD
PMID:34122009
NCBI chr 7:140,437,310...140,443,644
Ensembl chr 7:140,436,870...140,444,285
G
Rpl10a
ribosomal protein L10A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of RPL10A protein
CTD
PMID:34122009
NCBI chr17:28,547,557...28,550,007
Ensembl chr17:28,547,445...28,550,007
G
Rpl19
ribosomal protein L19
increases expression
ISO
Benztropine results in increased expression of RPL19 protein
CTD
PMID:34122009
NCBI chr11:97,912,829...97,921,319
Ensembl chr11:97,917,536...97,921,318
G
Rpl24
ribosomal protein L24
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of RPL24 protein
CTD
PMID:34122009
NCBI chr16:55,786,638...55,791,800
Ensembl chr16:55,786,638...55,791,798
G
Rpl30
ribosomal protein L30
increases expression
ISO
Benztropine results in increased expression of RPL30 protein
CTD
PMID:34122009
NCBI chr15:34,440,649...34,443,405
Ensembl chr15:34,440,651...34,443,786
G
Rpl7a
ribosomal protein L7A
decreases expression
ISO
Benztropine results in decreased expression of RPL7A protein
CTD
PMID:34122009
NCBI chr 2:26,800,697...26,803,330
Ensembl chr 2:26,800,776...26,803,330
G
Rplp1
ribosomal protein lateral stalk subunit P1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of RPLP1 protein
CTD
PMID:34122009
NCBI chr 9:61,820,565...61,821,792
Ensembl chr 9:61,820,566...61,821,824
G
Rps12
ribosomal protein S12
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of RPS12 protein
CTD
PMID:34122009
NCBI chr10:23,661,042...23,664,297
Ensembl chr10:23,661,081...23,663,173
G
Rps18
ribosomal protein S18
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of RPS18 protein
CTD
PMID:34122009
NCBI chr17:34,170,972...34,174,639
Ensembl chr17:34,170,973...34,174,975
G
Rps27
ribosomal protein S27
increases expression
ISO
Benztropine results in increased expression of RPS27 protein
CTD
PMID:34122009
NCBI chr 3:90,119,974...90,120,955
Ensembl chr 3:90,119,829...90,120,958
G
Rps27a
ribosomal protein S27A
increases expression
ISO
Benztropine results in increased expression of RPS27A protein
CTD
PMID:34122009
NCBI chr11:29,495,842...29,498,040
Ensembl chr11:29,495,846...29,498,109
G
Rps3
ribosomal protein S3
decreases expression
ISO
Benztropine results in decreased expression of RPS3 protein
CTD
PMID:34122009
NCBI chr 7:99,127,103...99,132,916
Ensembl chr 7:99,127,103...99,132,945
G
Ruvbl2
RuvB-like AAA ATPase 2
increases expression
ISO
Benztropine results in increased expression of RUVBL2 protein
CTD
PMID:34122009
NCBI chr 7:45,071,320...45,084,817
Ensembl chr 7:45,071,184...45,087,520
G
Sae1
SUMO1 activating enzyme subunit 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SAE1 protein
CTD
PMID:34122009
NCBI chr 7:16,054,161...16,121,821
Ensembl chr 7:16,054,159...16,121,731
G
Sars1
seryl-tRNA synthetase 1
decreases expression
ISO
Benztropine results in decreased expression of SARS1 protein
CTD
PMID:34122009
NCBI chr 3:108,332,180...108,352,575
Ensembl chr 3:108,332,181...108,352,525
G
Satb2
special AT-rich sequence binding protein 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of SATB2 protein
CTD
PMID:34122009
NCBI chr 1:56,833,145...57,019,350
Ensembl chr 1:56,833,140...57,017,809
G
Sccpdh
saccharopine dehydrogenase (putative)
decreases expression
ISO
Benztropine results in decreased expression of SCCPDH protein
CTD
PMID:34122009
NCBI chr 1:179,495,796...179,514,754
Ensembl chr 1:179,495,775...179,514,754
G
Sdcbp
syndecan binding protein
decreases expression
ISO
Benztropine results in decreased expression of SDCBP protein
CTD
PMID:34122009
NCBI chr 4:6,365,713...6,396,120
Ensembl chr 4:6,365,650...6,408,423
G
Sec23a
SEC23 homolog A, COPII coat complex component
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of SEC23A protein
CTD
PMID:34122009
NCBI chr12:59,005,170...59,058,803
Ensembl chr12:59,005,169...59,058,803
G
Sec61b
SEC61 translocon subunit beta
increases expression
ISO
Benztropine results in increased expression of SEC61B protein
CTD
PMID:34122009
NCBI chr 4:47,474,661...47,483,233
Ensembl chr 4:47,474,658...47,483,242
G
Sec63
SEC63 homolog, protein translocation regulator
increases expression
ISO
Benztropine results in increased expression of SEC63 protein
CTD
PMID:34122009
NCBI chr10:42,637,492...42,708,510
Ensembl chr10:42,637,492...42,708,510
G
Serbp1
serpine1 mRNA binding protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SERBP1 protein
CTD
PMID:34122009
NCBI chr 6:67,243,963...67,266,286
Ensembl chr 6:67,215,160...67,274,720
G
Serpinb3a
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
increases expression
ISO
Benztropine results in increased expression of SERPINB4 protein
CTD
PMID:34122009
NCBI chr 1:106,973,317...106,980,033
Ensembl chr 1:106,973,317...106,980,033
G
Sf1
splicing factor 1
decreases expression
ISO
Benztropine results in decreased expression of SF1 protein
CTD
PMID:34122009
NCBI chr19:6,413,952...6,428,060
Ensembl chr19:6,413,720...6,428,060
G
Sf3b3
splicing factor 3b, subunit 3
decreases expression
ISO
Benztropine results in decreased expression of SF3B3 protein
CTD
PMID:34122009
NCBI chr 8:111,537,123...111,573,578
Ensembl chr 8:111,536,871...111,573,419
G
Sgca
sarcoglycan, alpha (dystrophin-associated glycoprotein)
decreases expression
ISO
Benztropine results in decreased expression of SGCA protein
CTD
PMID:34122009
NCBI chr11:94,853,603...94,867,153
Ensembl chr11:94,853,617...94,867,153
G
Sh3pxd2b
SH3 and PX domains 2B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SH3PXD2B protein
CTD
PMID:34122009
NCBI chr11:32,297,777...32,378,189
Ensembl chr11:32,297,820...32,378,173
G
Shmt1
serine hydroxymethyltransferase 1 (soluble)
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SHMT1 protein
CTD
PMID:34122009
NCBI chr11:60,679,723...60,702,062
Ensembl chr11:60,678,930...60,702,544
G
Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Benztropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
G
Slc2a1
solute carrier family 2 (facilitated glucose transporter), member 1
decreases expression
ISO
Benztropine results in decreased expression of SLC2A1 protein
CTD
PMID:34122009
NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180
G
Slc38a2
solute carrier family 38, member 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of SLC38A2 protein
CTD
PMID:34122009
NCBI chr15:96,585,267...96,597,609
Ensembl chr15:96,585,273...96,597,611
G
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of SLC3A2 protein
CTD
PMID:34122009
NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733
G
Slc6a3
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
multiple interactions
ISO
Benztropine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
CTD
PMID:17250655
NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
G
Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
Benztropine results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
G
Smarcb1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
decreases expression
ISO
Benztropine results in decreased expression of SMARCB1 protein
CTD
PMID:34122009
NCBI chr10:75,732,603...75,757,448
Ensembl chr10:75,732,603...75,757,451
G
Smc3
structural maintenance of chromosomes 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SMC3 protein
CTD
PMID:34122009
NCBI chr19:53,588,827...53,634,262
Ensembl chr19:53,588,829...53,634,264
G
Smu1
smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SMU1 protein
CTD
PMID:34122009
NCBI chr 4:40,735,649...40,757,885
Ensembl chr 4:40,736,542...40,757,923
G
Snrnp200
small nuclear ribonucleoprotein 200 (U5)
increases expression multiple interactions
ISO
Benztropine results in increased expression of SNRNP200 protein [Cuprizone co-treated with Benztropine] results in decreased expression of SNRNP200 protein
CTD
PMID:34122009
NCBI chr 2:127,050,306...127,082,373
Ensembl chr 2:127,050,306...127,082,371
G
Snrpa
small nuclear ribonucleoprotein polypeptide A
increases expression
ISO
Benztropine results in increased expression of SNRPA protein
CTD
PMID:34122009
NCBI chr 7:26,886,431...26,895,696
Ensembl chr 7:26,886,430...26,895,696
G
Snrpd2
small nuclear ribonucleoprotein D2
increases expression
ISO
Benztropine results in increased expression of SNRPD2 protein
CTD
PMID:34122009
NCBI chr 7:18,883,370...18,886,659
Ensembl chr 7:18,883,647...18,887,467
G
Srek1
splicing regulatory glutamine/lysine-rich protein 1
decreases expression
ISO
Benztropine results in decreased expression of SREK1 protein
CTD
PMID:34122009
NCBI chr13:103,873,291...103,911,379
Ensembl chr13:103,875,856...103,911,116
G
Srsf5
serine and arginine-rich splicing factor 5
increases expression
ISO
Benztropine results in increased expression of SRSF5 protein
CTD
PMID:34122009
NCBI chr12:80,992,308...80,997,277
Ensembl chr12:80,992,278...80,997,281
G
Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of STAT3 protein
CTD
PMID:34122009
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
G
Stim1
stromal interaction molecule 1
decreases expression
ISO
Benztropine results in decreased expression of STIM1 protein
CTD
PMID:34122009
NCBI chr 7:101,909,279...102,086,525
Ensembl chr 7:101,917,013...102,086,526
G
Stip1
stress-induced phosphoprotein 1
decreases expression
ISO
Benztropine results in decreased expression of STIP1 protein
CTD
PMID:34122009
NCBI chr19:6,998,064...7,017,394
Ensembl chr19:6,998,070...7,017,335
G
Strap
serine/threonine kinase receptor associated protein
decreases expression
ISO
Benztropine results in decreased expression of STRAP protein
CTD
PMID:34122009
NCBI chr 6:137,712,080...137,728,928
Ensembl chr 6:137,712,076...137,728,930
G
Stub1
STIP1 homology and U-Box containing protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of STUB1 protein
CTD
PMID:34122009
NCBI chr17:26,049,608...26,051,893
Ensembl chr17:26,049,479...26,052,378
G
Suclg1
succinate-CoA ligase, GDP-forming, alpha subunit
decreases expression
ISO
Benztropine results in decreased expression of SUCLG1 protein
CTD
PMID:34122009
NCBI chr 6:73,225,488...73,253,890
Ensembl chr 6:73,225,365...73,253,894
G
Sumo2
small ubiquitin-like modifier 2
decreases expression
ISO
Benztropine results in decreased expression of SUMO2 protein
CTD
PMID:34122009
NCBI chr11:115,413,935...115,427,056
Ensembl chr11:115,413,928...115,427,102
G
Sun1
Sad1 and UNC84 domain containing 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SUN1 protein
CTD
PMID:34122009
NCBI chr 5:139,186,313...139,235,594
Ensembl chr 5:139,186,392...139,235,595
G
Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
decreases expression
ISO
Benztropine results in decreased expression of SYNCRIP protein
CTD
PMID:34122009
NCBI chr 9:88,331,417...88,364,645
Ensembl chr 9:88,329,062...88,364,627
G
Tagln2
transgelin 2
decreases expression
ISO
Benztropine results in decreased expression of TAGLN2 protein
CTD
PMID:34122009
NCBI chr 1:172,327,813...172,334,942
Ensembl chr 1:172,327,614...172,334,947
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Tbcb
tubulin folding cofactor B
decreases expression
ISO
Benztropine results in decreased expression of TBCB protein
CTD
PMID:34122009
NCBI chr 7:29,923,554...29,931,622
Ensembl chr 7:29,923,556...29,931,697
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Tcaf1
TRPM8 channel-associated factor 1
multiple interactions decreases expression
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of TCAF1 protein Benztropine results in decreased expression of TCAF1 protein
CTD
PMID:34122009
NCBI chr 6:42,644,933...42,687,065
Ensembl chr 6:42,644,936...42,687,022
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Tgoln1
trans-golgi network protein
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of TGOLN2 protein
CTD
PMID:34122009
NCBI chr 6:72,585,403...72,593,983
Ensembl chr 6:72,585,415...72,593,983
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Tln2
talin 2
decreases expression
ISO
Benztropine results in decreased expression of TLN2 protein
CTD
PMID:34122009
NCBI chr 9:67,124,371...67,541,357
Ensembl chr 9:67,124,369...67,466,985
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Tmpo
thymopoietin
decreases expression
ISO
Benztropine results in decreased expression of TMPO protein
CTD
PMID:34122009
NCBI chr10:90,983,433...91,017,614
Ensembl chr10:90,983,433...91,017,177
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Tnks1bp1
tankyrase 1 binding protein 1
decreases expression multiple interactions
ISO
Benztropine results in decreased expression of TNKS1BP1 protein [Cuprizone co-treated with Benztropine] results in decreased expression of TNKS1BP1 protein
CTD
PMID:34122009
NCBI chr 2:84,878,356...84,903,392
Ensembl chr 2:84,878,366...84,903,392
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Tomm34
translocase of outer mitochondrial membrane 34
decreases expression multiple interactions
ISO
Benztropine results in decreased expression of TOMM34 protein [Cuprizone co-treated with Benztropine] results in increased expression of TOMM34 protein
CTD
PMID:34122009
NCBI chr 2:163,895,458...163,913,168
Ensembl chr 2:163,895,460...163,913,089
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Top1mt
DNA topoisomerase 1, mitochondrial
increases expression
ISO
Benztropine results in increased expression of TOP1MT protein
CTD
PMID:34122009
NCBI chr15:75,528,878...75,551,184
Ensembl chr15:75,528,884...75,550,649
G
Tpm2
tropomyosin 2, beta
decreases expression
ISO
Benztropine results in decreased expression of TPM2 protein
CTD
PMID:34122009
NCBI chr 4:43,513,726...43,523,583
Ensembl chr 4:43,514,711...43,523,765
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Tpm3
tropomyosin 3, gamma
decreases expression
ISO
Benztropine results in decreased expression of TPM3 protein
CTD
PMID:34122009
NCBI chr 3:89,979,958...90,008,209
Ensembl chr 3:89,979,956...90,008,209
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Tpr
translocated promoter region, nuclear basket protein
decreases expression
ISO
Benztropine results in decreased expression of TPR protein
CTD
PMID:34122009
NCBI chr 1:150,268,544...150,325,686
Ensembl chr 1:150,268,589...150,325,686
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Trim28
tripartite motif-containing 28
multiple interactions decreases expression
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of TRIM28 protein Benztropine results in decreased expression of TRIM28 protein
CTD
PMID:34122009
NCBI chr 7:12,758,079...12,764,959
Ensembl chr 7:12,733,041...12,764,962
G
Tspan3
tetraspanin 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of TSPAN3 protein
CTD
PMID:34122009
NCBI chr 9:56,043,168...56,068,354
Ensembl chr 9:56,039,009...56,072,761
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Ttc21a
tetratricopeptide repeat domain 21A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of TTC21A protein
CTD
PMID:34122009
NCBI chr 9:119,766,656...119,798,496
Ensembl chr 9:119,766,672...119,796,859
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Ttyh2
tweety family member 2
increases expression
ISO
Benztropine results in increased expression of TTYH2 protein
CTD
PMID:34122009
NCBI chr11:114,566,294...114,611,810
Ensembl chr11:114,566,257...114,611,803
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Ttyh3
tweety family member 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of TTYH3 protein
CTD
PMID:34122009
NCBI chr 5:140,606,332...140,634,826
Ensembl chr 5:140,606,333...140,634,786
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Tubb5
tubulin, beta 5 class I
increases expression
ISO
Benztropine results in increased expression of TUBB protein
CTD
PMID:34122009
NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198
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Twf2
twinfilin actin binding protein 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of TWF2 protein
CTD
PMID:34122009
NCBI chr 9:106,080,307...106,092,586
Ensembl chr 9:106,080,307...106,092,588
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Txlna
taxilin alpha
decreases expression
ISO
Benztropine results in decreased expression of TXLNA protein
CTD
PMID:34122009
NCBI chr 4:129,519,870...129,534,867
Ensembl chr 4:129,519,871...129,534,858
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Tyms
thymidylate synthase
increases expression
ISO
Benztropine results in increased expression of TYMS protein
CTD
PMID:34122009
NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615
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U2af2
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
decreases expression
ISO
Benztropine results in decreased expression of U2AF2 protein
CTD
PMID:34122009
NCBI chr 7:5,063,884...5,082,937
Ensembl chr 7:5,065,142...5,082,937
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Uba2
ubiquitin-like modifier activating enzyme 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of UBA2 protein
CTD
PMID:34122009
NCBI chr 7:33,840,121...33,868,014
Ensembl chr 7:33,840,113...33,869,024
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Ubap2l
ubiquitin-associated protein 2-like
decreases expression
ISO
Benztropine results in decreased expression of UBAP2L protein
CTD
PMID:34122009
NCBI chr 3:89,906,896...89,959,867
Ensembl chr 3:89,907,447...89,959,935
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Ubc
ubiquitin C
increases expression
ISO
Benztropine results in increased expression of UBC protein
CTD
PMID:34122009
NCBI chr 5:125,463,029...125,467,081
Ensembl chr 5:125,463,029...125,467,266
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Ubqln2
ubiquilin 2
decreases expression
ISO
Benztropine results in decreased expression of UBQLN2 protein
CTD
PMID:34122009
NCBI chr X:152,281,228...152,284,558
Ensembl chr X:152,281,223...152,284,566
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Uchl1
ubiquitin carboxy-terminal hydrolase L1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of UCHL1 protein
CTD
PMID:34122009
NCBI chr 5:66,833,464...66,844,577
Ensembl chr 5:66,833,434...66,844,577
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Uchl3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
decreases expression
ISO
Benztropine results in decreased expression of UCHL3 protein
CTD
PMID:34122009
NCBI chr14:101,891,387...101,933,561
Ensembl chr14:101,891,403...101,933,561
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Ugdh
UDP-glucose dehydrogenase
decreases expression
ISO
Benztropine results in decreased expression of UGDH protein
CTD
PMID:34122009
NCBI chr 5:65,570,550...65,593,185
Ensembl chr 5:65,570,564...65,593,292
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Unc45b
unc-45 myosin chaperone B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of UNC45B protein
CTD
PMID:34122009
NCBI chr11:82,802,112...82,834,284
Ensembl chr11:82,801,376...82,834,229
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Uqcrc2
ubiquinol cytochrome c reductase core protein 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of UQCRC2 protein
CTD
PMID:34122009
NCBI chr 7:120,234,412...120,258,746
Ensembl chr 7:120,234,399...120,258,747
G
Uso1
USO1 vesicle docking factor
decreases expression
ISO
Benztropine results in decreased expression of USO1 protein
CTD
PMID:34122009
NCBI chr 5:92,285,770...92,350,659
Ensembl chr 5:92,285,797...92,350,657
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Usp10
ubiquitin specific peptidase 10
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of USP10 protein
CTD
PMID:34122009
NCBI chr 8:120,637,099...120,684,299
Ensembl chr 8:120,637,099...120,684,299
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Usp14
ubiquitin specific peptidase 14
increases expression
ISO
Benztropine results in increased expression of USP14 protein
CTD
PMID:34122009
NCBI chr18:9,993,615...10,030,149
Ensembl chr18:9,993,066...10,045,119
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Utp18
UTP18 small subunit processome component
increases expression
ISO
Benztropine results in increased expression of UTP18 protein
CTD
PMID:34122009
NCBI chr11:93,750,069...93,776,592
Ensembl chr11:93,750,069...93,776,592
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Vasp
vasodilator-stimulated phosphoprotein
decreases expression
ISO
Benztropine results in decreased expression of VASP protein
CTD
PMID:34122009
NCBI chr 7:18,990,854...19,005,779
Ensembl chr 7:18,990,854...19,005,742
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Wars1
tryptophanyl-tRNA synthetase1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of WARS1 protein
CTD
PMID:34122009
NCBI chr12:108,825,956...108,860,095
Ensembl chr12:108,825,956...108,860,100
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Wdr12
WD repeat domain 12
decreases expression
ISO
Benztropine results in decreased expression of WDR12 protein
CTD
PMID:34122009
NCBI chr 1:60,110,520...60,137,659
Ensembl chr 1:60,108,944...60,137,804
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Xirp2
xin actin-binding repeat containing 2
decreases expression
ISO
Benztropine results in decreased expression of XIRP2 protein
CTD
PMID:34122009
NCBI chr 2:67,276,343...67,356,964
Ensembl chr 2:67,004,178...67,356,959
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Xpo7
exportin 7
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of XPO7 protein
CTD
PMID:34122009
NCBI chr14:70,899,566...71,004,075
Ensembl chr14:70,891,686...71,004,068
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Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
increases expression
ISO
Benztropine results in increased expression of YWHAQ protein
CTD
PMID:34122009
NCBI chr12:21,440,330...21,467,437
Ensembl chr12:21,440,072...21,467,638
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Zbtb42
zinc finger and BTB domain containing 42
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of ZBTB42 protein
CTD
PMID:34122009
NCBI chr12:112,645,042...112,649,181
Ensembl chr12:112,645,262...112,649,181
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Zfr
zinc finger RNA binding protein
decreases expression
ISO
Benztropine results in decreased expression of ZFR protein
CTD
PMID:34122009
NCBI chr15:12,117,649...12,185,535
Ensembl chr15:12,117,917...12,185,769
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Zkscan7
zinc finger with KRAB and SCAN domains 7
decreases expression
ISO
Benztropine results in decreased expression of ZKSCAN7 protein
CTD
PMID:34122009
NCBI chr 9:122,715,883...122,727,684
Ensembl chr 9:122,714,750...122,727,683
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Abcb4
ATP-binding cassette, sub-family B member 4
decreases activity
ISO
Biperiden results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
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Bmp6
bone morphogenetic protein 6
increases expression
ISO
Biperiden results in increased expression of BMP6 mRNA
CTD
PMID:32816093
NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278
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Chrm1
cholinergic receptor, muscarinic 1, CNS
multiple interactions
ISO
Biperiden binds to and results in decreased activity of CHRM1 protein
CTD
PMID:21336581
NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951
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Cxcl15
C-X-C motif chemokine ligand 15
increases expression
ISO
Biperiden results in increased expression of CXCL8 mRNA
CTD
PMID:32816093
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Ereg
epiregulin
increases expression
ISO
Biperiden results in increased expression of EREG mRNA
CTD
PMID:32816093
NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
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Il1a
interleukin 1 alpha
increases expression
ISO
Biperiden results in increased expression of IL1A mRNA
CTD
PMID:32816093
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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Il1b
interleukin 1 beta
increases expression
ISO
Biperiden results in increased expression of IL1B mRNA
CTD
PMID:32816093
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Il24
interleukin 24
increases expression
ISO
Biperiden results in increased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
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Met
met proto-oncogene
increases expression
ISO
Biperiden results in increased expression of MET mRNA
CTD
PMID:32816093
NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
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Pid1
phosphotyrosine interaction domain containing 1
increases expression
ISO
Biperiden results in increased expression of PID1 mRNA
CTD
PMID:32816093
NCBI chr 1:84,014,014...84,317,550
Ensembl chr 1:84,014,017...84,341,901
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Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
increases expression
ISO
Biperiden results in increased expression of SLC7A11 mRNA
CTD
PMID:32816093
NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
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Abcb1a
ATP-binding cassette, sub-family B member 1A
increases expression multiple interactions
ISO
Bromocriptine results in increased expression of ABCB1 protein Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Spiperone inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]
CTD
PMID:9111066
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
G
Abcb1b
ATP-binding cassette, sub-family B member 1B
increases activity increases expression multiple interactions
ISO
Bromocriptine results in increased activity of ABCB1B promoter Bromocriptine results in increased expression of ABCB1B mRNA Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; eticlopride inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Pertussis Toxin inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Spiperone inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]
CTD
PMID:9111066
NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315
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Akr1c18
aldo-keto reductase family 1, member C18
increases expression multiple interactions
ISO
Bromocriptine results in increased expression of AKR1C3 mRNA methyl cellosolve inhibits the reaction [Bromocriptine results in increased expression of AKR1C3 mRNA]
CTD
PMID:21427058
NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
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Atf3
activating transcription factor 3
increases expression
ISO
Bromocriptine results in increased expression of ATF3 mRNA; Bromocriptine results in increased expression of ATF3 protein
CTD
PMID:21867702
NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
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Bax
BCL2-associated X protein
increases expression multiple interactions
ISO
Bromocriptine results in increased expression of BAX protein [Bromocriptine co-treated with Octreotide] results in increased expression of BAX protein
CTD
PMID:15046398
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Bdnf
brain derived neurotrophic factor
decreases secretion
EXP
Bromocriptine results in decreased secretion of BDNF protein
CTD
PMID:12770616
NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
G
Ctnnb1
catenin beta 1
multiple interactions
EXP
[Bromocriptine co-treated with Estradiol] results in decreased expression of CTNNB1 protein
CTD
PMID:11786374
NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
multiple interactions decreases expression
ISO
Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of CYP11A1 mRNA] Bromocriptine results in decreased expression of CYP11A1 protein
CTD
PMID:12742521 PMID:21427058
NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
Bromocriptine results in decreased activity of CYP1A1 protein
CTD
PMID:33814510
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Bromocriptine results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
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Dbh
dopamine beta hydroxylase
decreases activity
ISO
Bromocriptine results in decreased activity of DBH protein
CTD
PMID:501350
NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212
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Drd2
dopamine receptor D2
affects expression affects response to substance multiple interactions decreases expression increases expression increases response to substance
ISO EXP
Bromocriptine affects the expression of DRD2 mRNA DRD2 protein affects the susceptibility to Bromocriptine Bromocriptine binds to and results in increased activity of DRD2 mRNA; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA] Bromocriptine results in decreased expression of DRD2 mRNA [Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA Bromocriptine results in increased expression of DRD2 mRNA DRD2 polymorphism results in increased susceptibility to Bromocriptine
CTD
PMID:1534540 PMID:8103596 PMID:15781964 PMID:16901644 PMID:20063113
NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
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Drd3
dopamine receptor D3
multiple interactions decreases expression
ISO
[1-Methyl-4-phenylpyridinium co-treated with Bromocriptine] results in decreased expression of DRD3 mRNA Bromocriptine results in decreased expression of DRD3 mRNA
CTD
PMID:17000468
NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
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Esr1
estrogen receptor 1 (alpha)
multiple interactions
EXP
[Bromocriptine co-treated with Estradiol] results in increased expression of ESR1 protein
CTD
PMID:11786374
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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Fshb
follicle stimulating hormone beta
increases expression
ISO
Bromocriptine results in increased expression of FSHB protein
CTD
PMID:86031
NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
G
Gdnf
glial cell line derived neurotrophic factor
decreases expression decreases secretion
EXP
Bromocriptine results in decreased expression of GDNF mRNA Bromocriptine results in decreased secretion of GDNF protein
CTD
PMID:12770616
NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056
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Gh
growth hormone
increases expression decreases expression
ISO
Bromocriptine results in increased expression of GH1 protein Bromocriptine results in decreased expression of GH1 protein
CTD
PMID:772175 PMID:3226523 PMID:3745407 PMID:7293648 PMID:19420816
NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691
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Hmox1
heme oxygenase 1
increases expression
ISO
Bromocriptine results in increased expression of HMOX1 mRNA; Bromocriptine results in increased expression of HMOX1 protein
CTD
PMID:21867702
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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Htr7
5-hydroxytryptamine (serotonin) receptor 7
multiple interactions
ISO
[Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Bromocriptine binds to and results in decreased activity of HTR7 protein
CTD
PMID:18996971 PMID:19509219
NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907
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Ins2
insulin II
decreases expression
ISO
Bromocriptine results in decreased expression of INS protein
CTD
PMID:16803851
NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
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Lhb
luteinizing hormone beta
increases expression
ISO
Bromocriptine results in increased expression of LHB protein
CTD
PMID:86031
NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
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Mapk1
mitogen-activated protein kinase 1
multiple interactions
ISO
Bromocriptine promotes the reaction [Estrogens results in increased phosphorylation of and affects the localization of MAPK1 protein]
CTD
PMID:19595700
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
G
Mapk3
mitogen-activated protein kinase 3
multiple interactions
ISO
Bromocriptine promotes the reaction [Estrogens results in increased phosphorylation of and affects the localization of MAPK3 protein]
CTD
PMID:19595700
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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Nfe2l2
nuclear factor, erythroid derived 2, like 2
increases localization
ISO
Bromocriptine results in increased localization of NFE2L2 protein
CTD
PMID:21867702
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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Ngf
nerve growth factor
increases secretion
EXP
Bromocriptine results in increased secretion of NGF protein
CTD
PMID:12770616
NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
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Nos2
nitric oxide synthase 2, inducible
multiple interactions
EXP
Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of NOS2 protein]
CTD
PMID:21867702
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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Nr5a2
nuclear receptor subfamily 5, group A, member 2
multiple interactions
ISO
Bromocriptine affects the reaction [methyl cellosolve results in increased expression of NR5A2 mRNA]
CTD
PMID:21427058
NCBI chr 1:136,770,300...136,888,186
Ensembl chr 1:136,770,309...136,888,186
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Pcna
proliferating cell nuclear antigen
multiple interactions
ISO
[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of PCNA protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PCNA protein]
CTD
PMID:15677882
NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
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Pomc
pro-opiomelanocortin-alpha
decreases expression increases expression multiple interactions
ISO
Bromocriptine results in decreased expression of POMC protein alternative form Bromocriptine results in increased expression of POMC mRNA; Bromocriptine results in increased expression of POMC protein modified form Bromocriptine inhibits the reaction [POMC protein results in decreased secretion of Corticosterone]
CTD
PMID:1325994 PMID:6274577 PMID:12742521
NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642
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Prkcd
protein kinase C, delta
multiple interactions affects localization
ISO
Bromocriptine promotes the reaction [Estrogens results in increased expression of and results in increased cleavage of PRKCD protein] Bromocriptine affects the localization of PRKCD protein
CTD
PMID:19595700
NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
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Prl
prolactin
multiple interactions decreases secretion decreases expression
ISO EXP
Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Nalorphine results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein] Bromocriptine results in decreased secretion of PRL protein Bromocriptine results in decreased expression of PRL protein Bromocriptine inhibits the reaction [Amisulpride results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Estradiol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of PRL protein]; Estradiol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Ethanol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]
CTD
PMID:86031 PMID:86795 PMID:90217 PMID:1407345 PMID:1874184 PMID:2042694 PMID:2887062 PMID:3019639 PMID:3208992 PMID:3625096 PMID:3660204 PMID:3745407 PMID:3776530 PMID:4072572 PMID:6441721 PMID:6477585 PMID:6507109 PMID:6669217 PMID:6693536 PMID:6986893 PMID:7106173 PMID:7168914 PMID:7243090 PMID:7670571 PMID:8914150 PMID:11685661 PMID:11786374 PMID:12106810 PMID:12161478 PMID:12742521 PMID:12824819 PMID:15046398 PMID:15677882 PMID:21427058 More...
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
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Scarb1
scavenger receptor class B, member 1
multiple interactions
ISO
Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of SCARB1 mRNA]
CTD
PMID:21427058
NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
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Sod1
superoxide dismutase 1, soluble
multiple interactions
EXP
Bromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of NOS2 protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein]
CTD
PMID:21867702
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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Star
steroidogenic acute regulatory protein
decreases expression
ISO
Bromocriptine results in decreased expression of STAR protein
CTD
PMID:12742521
NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
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Stat5a
signal transducer and activator of transcription 5A
affects localization
EXP
Bromocriptine affects the localization of STAT5A protein
CTD
PMID:17884938
NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
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Tgfa
transforming growth factor alpha
multiple interactions
ISO
Bromocriptine inhibits the reaction [Estradiol results in increased expression of TGFA mRNA]
CTD
PMID:1534540
NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of TGFB1 protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of TGFB1 protein]
CTD
PMID:15677882
NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
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Tnf
tumor necrosis factor
multiple interactions
EXP ISO
Bromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein] Bromocriptine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:11752888 PMID:21867702
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VEGFA protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of VEGFA protein]
CTD
PMID:15677882
NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
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Vip
vasoactive intestinal polypeptide
multiple interactions
ISO
Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein] [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]
CTD
PMID:6441721 PMID:15677882
NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617
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Bdnf
brain derived neurotrophic factor
increases expression
ISO
Cabergoline results in increased expression of BDNF protein
CTD
PMID:35104500
NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
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Creb1
cAMP responsive element binding protein 1
increases expression
ISO
Cabergoline results in increased expression of CREB1 protein modified form
CTD
PMID:35104500
NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
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Drd2
dopamine receptor D2
multiple interactions
ISO
Cabergoline binds to and results in increased activity of DRD2 protein
CTD
PMID:35104500
NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
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Gdnf
glial cell line derived neurotrophic factor
increases expression increases secretion
EXP
cabergoline results in increased expression of GDNF mRNA cabergoline results in increased secretion of GDNF protein
CTD
PMID:12770616
NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056
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Ngf
nerve growth factor
increases expression increases secretion
EXP
cabergoline results in increased expression of NGF mRNA cabergoline results in increased secretion of NGF protein
CTD
PMID:12770616
NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
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Prl
prolactin
decreases expression multiple interactions decreases secretion
ISO
cabergoline results in decreased expression of PRL protein Haloperidol inhibits the reaction [cabergoline results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [cabergoline results in decreased secretion of PRL protein]
CTD
PMID:2570719 PMID:3745407 PMID:7670571 PMID:15377706
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
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Bax
BCL2-associated X protein
multiple interactions
ISO EXP
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Carbidopa inhibits the reaction [Cisplatin results in increased expression of BAX protein] Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Bcl2
B cell leukemia/lymphoma 2
multiple interactions
EXP ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD
PMID:34560070 PMID:35202708
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Casp3
caspase 3
multiple interactions
EXP ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
CTD
PMID:34560070 PMID:35202708
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Casp9
caspase 9
multiple interactions
ISO EXP
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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Comt
catechol-O-methyltransferase
increases methylation
ISO
COMT protein results in increased methylation of Carbidopa
CTD
PMID:11160877
NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
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Ddc
dopa decarboxylase
multiple interactions
EXP ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA] Carbidopa binds to and results in decreased activity of DDC protein
CTD
PMID:35151785 PMID:35202708
NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144
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Dnm1l
dynamin 1-like
multiple interactions
EXP
Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]
CTD
PMID:35202708
NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823
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Fis1
fission, mitochondrial 1
multiple interactions
EXP
Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]
CTD
PMID:35202708
NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088
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Gpt
glutamic pyruvic transaminase, soluble
multiple interactions
EXP
Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]
CTD
PMID:35202708
NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
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Il1b
interleukin 1 beta
multiple interactions
ISO EXP
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]; Carbidopa inhibits the reaction [Cisplatin results in increased secretion of IL1B protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD
PMID:34560070
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Maoa
monoamine oxidase A
multiple interactions
EXP ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]; Carbidopa inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr X:16,485,937...16,554,051
Ensembl chr X:16,485,937...16,554,057
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Mfn1
mitofusin 1
multiple interactions
EXP
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]
CTD
PMID:35202708
NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388
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mt-Atp6
ATP synthase 6, mitochondrial
multiple interactions
EXP
Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]
CTD
PMID:35202708
NCBI chr MT:7,927...8,607
Ensembl chr MT:7,927...8,607
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mt-Cytb
cytochrome b, mitochondrial
multiple interactions
EXP
Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]
CTD
PMID:35202708
NCBI chr MT:14,145...15,288
Ensembl chr MT:14,145...15,288
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mt-Nd1
NADH dehydrogenase 1, mitochondrial
multiple interactions
EXP
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]
CTD
PMID:35202708
NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707
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Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
EXP ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]; Carbidopa inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
CTD
PMID:34560070
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO EXP
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]
CTD
PMID:34560070
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
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Tnf
tumor necrosis factor
multiple interactions
EXP ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of TNF protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of TNF protein]; Carbidopa inhibits the reaction [Cisplatin results in increased secretion of TNF protein]
CTD
PMID:34560070
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Tph1
tryptophan hydroxylase 1
multiple interactions
EXP
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]
CTD
PMID:35202708
NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961
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Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
carbinoxamine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
carbinoxamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Bche
butyrylcholinesterase
decreases activity
ISO
Dimenhydrinate results in decreased activity of BCHE protein
CTD
PMID:236606
NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Dimenhydrinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Atg5
autophagy related 5
affects response to substance
EXP
ATG5 protein affects the susceptibility to Diphenhydramine
CTD
PMID:22310178
NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287
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Bche
butyrylcholinesterase
multiple interactions decreases activity
ISO
Protons affects the reaction [Diphenhydramine results in decreased activity of BCHE protein]
CTD
PMID:236606
NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
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Bmp6
bone morphogenetic protein 6
decreases expression
ISO
Diphenhydramine results in decreased expression of BMP6 mRNA
CTD
PMID:32816093
NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278
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Cxcl15
C-X-C motif chemokine ligand 15
multiple interactions decreases expression decreases response to substance
ISO
Diphenhydramine inhibits the reaction [Histamine results in increased expression of CXCL8 mRNA]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of CXCL8 protein]; HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein] Diphenhydramine results in decreased expression of CXCL8 mRNA
CTD
PMID:7522859 PMID:9609743 PMID:11336536 PMID:32816093
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Ereg
epiregulin
decreases expression
ISO
Diphenhydramine results in decreased expression of EREG mRNA
CTD
PMID:32816093
NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
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F3
coagulation factor III
multiple interactions
ISO
Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3]
CTD
PMID:16009787
NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
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Gnai1
G protein subunit alpha i1
increases response to substance
EXP
GNAI1 results in increased susceptibility to Diphenhydramine
CTD
PMID:14614911
NCBI chr 5:18,470,133...18,565,411
Ensembl chr 5:18,470,133...18,565,353
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Gnai2
G protein subunit alpha i2
increases response to substance
EXP
GNAI2 results in increased susceptibility to Diphenhydramine
CTD
PMID:14614911
NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566
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Hrh1
histamine receptor H1
multiple interactions
ISO
Diphenhydramine binds to and results in decreased activity of HRH1 protein; Diphenhydramine binds to and results in increased activity of HRH1 protein; Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein] [Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin
CTD
PMID:1912125 PMID:2419744 PMID:2461127 PMID:7522859 PMID:9609743 PMID:12856827 More...
NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257
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Il1b
interleukin 1 beta
increases expression decreases expression
ISO
Diphenhydramine results in increased expression of IL1B mRNA Diphenhydramine results in decreased expression of IL1B mRNA
CTD
PMID:28138970 PMID:32816093
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Il24
interleukin 24
decreases expression
ISO
Diphenhydramine results in decreased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
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Il6
interleukin 6
multiple interactions
ISO
Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein]
CTD
PMID:11336536
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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Mapk8
mitogen-activated protein kinase 8
increases activity
ISO
Diphenhydramine results in increased activity of MAPK8
CTD
PMID:17390763
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions
ISO
[Diphenhydramine co-treated with PK 11195] binds to and results in increased activity of NR1I3 protein alternative form
CTD
PMID:20869355
NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
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Pla2g4a
phospholipase A2, group IVA (cytosolic, calcium-dependent)
multiple interactions
ISO
Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]
CTD
PMID:9609743
NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
Diphenhydramine results in decreased expression of PTGS2 mRNA
CTD
PMID:32816093
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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Slc22a1
solute carrier family 22 (organic cation transporter), member 1
multiple interactions
ISO
Diphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD
PMID:16263091
NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:16263091 PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Slc22a3
solute carrier family 22 (organic cation transporter), member 3
multiple interactions
ISO
Diphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD
PMID:16263091
NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591
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Slc22a5
solute carrier family 22 (organic cation transporter), member 5
multiple interactions
EXP
Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]
CTD
PMID:19821448
NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486
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Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
decreases expression
ISO
Diphenhydramine results in decreased expression of SLC7A11 mRNA
CTD
PMID:32816093
NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
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Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
Diphenhydramine results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
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Acox3
acyl-Coenzyme A oxidase 3, pristanoyl
affects binding
ISO
entacapone binds to ACOX3 protein
CTD
PMID:19783845
NCBI chr 5:35,740,293...35,772,397
Ensembl chr 5:35,740,384...35,772,696
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Acsl1
acyl-CoA synthetase long-chain family member 1
affects binding
ISO
entacapone binds to ACSL1 protein
CTD
PMID:19783845
NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088
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Adprhl1
ADP-ribosylhydrolase like 1
affects binding
ISO
entacapone binds to ADPRHL1 protein
CTD
PMID:19783845
NCBI chr 8:13,268,449...13,304,079
Ensembl chr 8:13,271,663...13,304,162
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Auh
AU RNA binding protein/enoyl-coenzyme A hydratase
affects binding
ISO
entacapone binds to AUH protein
CTD
PMID:19783845
NCBI chr13:52,989,155...53,083,742
Ensembl chr13:52,989,155...53,083,717
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Cltc
clathrin heavy chain
affects binding
ISO
entacapone binds to CLTC protein
CTD
PMID:19783845
NCBI chr11:86,585,178...86,648,637
Ensembl chr11:86,585,177...86,648,391
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Comt
catechol-O-methyltransferase
decreases activity affects binding multiple interactions
ISO EXP
entacapone results in decreased activity of COMT protein entacapone binds to COMT protein [entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; entacapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]
CTD
PMID:12898346 PMID:15566291 PMID:19783845 PMID:20334432 PMID:23206800 PMID:29688484 More...
NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
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Cxcl15
C-X-C motif chemokine ligand 15
increases expression
ISO
entacapone results in increased expression of CXCL8 mRNA
CTD
PMID:32816093
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Echs1
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
affects binding
ISO
entacapone binds to ECHS1 protein
CTD
PMID:19783845
NCBI chr 7:139,685,623...139,696,334
Ensembl chr 7:139,685,623...139,696,389
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Ereg
epiregulin
increases expression
ISO
entacapone results in increased expression of EREG mRNA
CTD
PMID:32816093
NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
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Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
decreases expression
ISO
entacapone results in decreased expression of GPAM protein
CTD
PMID:29688484
NCBI chr19:55,056,067...55,115,666
Ensembl chr19:55,055,700...55,115,670
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Hbb-b1
hemoglobin, beta adult major chain
affects binding
ISO
entacapone binds to HBB protein
CTD
PMID:19783845
G
Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
affects binding
ISO
entacapone binds to HSD17B13 protein
CTD
PMID:19783845
NCBI chr 5:104,103,308...104,125,254
Ensembl chr 5:104,103,306...104,125,276
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Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
affects binding
ISO
entacapone binds to HSD17B4 protein
CTD
PMID:19783845
NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
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Il1a
interleukin 1 alpha
increases expression
ISO
entacapone results in increased expression of IL1A mRNA
CTD
PMID:32816093
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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Il1b
interleukin 1 beta
increases expression
ISO
entacapone results in increased expression of IL1B mRNA
CTD
PMID:32816093
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Met
met proto-oncogene
increases expression
ISO
entacapone results in increased expression of MET mRNA
CTD
PMID:32816093
NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
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Pcx
pyruvate carboxylase
affects binding
ISO
entacapone binds to PC protein
CTD
PMID:19783845
NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780
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Pid1
phosphotyrosine interaction domain containing 1
decreases expression
ISO
entacapone results in decreased expression of PID1 mRNA
CTD
PMID:32816093
NCBI chr 1:84,014,014...84,317,550
Ensembl chr 1:84,014,017...84,341,901
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
entacapone results in increased expression of PTGS2 mRNA
CTD
PMID:32816093
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
decreases expression
ISO
entacapone results in decreased expression of SLC7A11 mRNA
CTD
PMID:32816093
NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
G
Slpi
secretory leukocyte peptidase inhibitor
decreases expression
ISO
entacapone results in decreased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
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Snca
synuclein, alpha
multiple interactions
ISO
entacapone inhibits the reaction [SNCA protein binds to SNCA protein]
CTD
PMID:20150427
NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
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Sult2a1
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
affects binding
ISO
entacapone binds to SULT2A1 protein
CTD
PMID:19783845
NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334
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Tnfaip6
tumor necrosis factor alpha induced protein 6
decreases expression
ISO
entacapone results in decreased expression of TNFAIP6 mRNA
CTD
PMID:32816093
NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698
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Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
increases glucuronidation
ISO
UGT1A1 protein results in increased glucuronidation of entacapone
CTD
PMID:15802387
NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
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Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
increases glucuronidation
ISO
UGT1A10 protein results in increased glucuronidation of entacapone
CTD
PMID:15802387
NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726
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Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
increases glucuronidation
ISO
UGT1A3 protein results in increased glucuronidation of entacapone
CTD
PMID:15802387
NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719
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Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
increases glucuronidation decreases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of entacapone UGT1A9 protein mutant form results in decreased glucuronidation of entacapone
CTD
PMID:15044611 PMID:15802387 PMID:16344532
NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719
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Abcb1a
ATP-binding cassette, sub-family B member 1A
multiple interactions decreases activity decreases expression
ISO
Haloperidol inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin] Haloperidol results in decreased activity of ABCB1 protein Haloperidol results in decreased expression of ABCB1 mRNA
CTD
PMID:15946544 PMID:16810505
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Abcc1
ATP-binding cassette, sub-family C member 1
multiple interactions decreases expression
ISO
Haloperidol inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin] Haloperidol results in decreased expression of ABCC1 mRNA
CTD
PMID:15946544
NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
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Abcg2
ATP binding cassette subfamily G member 2 (Junior blood group)
multiple interactions
ISO
Haloperidol inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]
CTD
PMID:18834354
NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
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Acadvl
acyl-Coenzyme A dehydrogenase, very long chain
decreases expression
ISO
Haloperidol results in decreased expression of ACADVL protein
CTD
PMID:34122009
NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237
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Acat1
acetyl-Coenzyme A acetyltransferase 1
decreases expression
ISO
Haloperidol results in decreased expression of ACAT1 protein
CTD
PMID:34122009
NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
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Ache
acetylcholinesterase
multiple interactions
ISO
Haloperidol inhibits the reaction [potassium bromate results in increased activity of ACHE protein]
CTD
PMID:37865952
NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
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Acsl3
acyl-CoA synthetase long-chain family member 3
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of ACSL3 protein
CTD
PMID:34122009
NCBI chr 1:78,635,600...78,685,462
Ensembl chr 1:78,635,542...78,685,460
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Ada
adenosine deaminase
multiple interactions
ISO
Haloperidol inhibits the reaction [potassium bromate results in increased activity of ADA protein]
CTD
PMID:37865952
NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159
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Adam1a
a disintegrin and metallopeptidase domain 1a
decreases expression
ISO
Haloperidol results in decreased expression of ADAM1A mRNA
CTD
PMID:16715494
NCBI chr 5:121,656,667...121,659,758
Ensembl chr 5:121,656,639...121,660,134
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Adcy5
adenylate cyclase 5
affects response to substance multiple interactions
EXP
ADCY5 protein affects the susceptibility to Haloperidol SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Haloperidol]
CTD
PMID:12223546
NCBI chr16:34,974,933...35,126,108
Ensembl chr16:34,975,247...35,126,108
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Adcyap1r1
adenylate cyclase activating polypeptide 1 receptor 1
affects expression
ISO
Haloperidol affects the expression of ADCYAP1R1 mRNA
CTD
PMID:27900577
NCBI chr 6:55,428,486...55,478,440
Ensembl chr 6:55,428,963...55,478,436
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Adora2a
adenosine A2a receptor
affects response to substance
EXP
ADORA2A protein affects the susceptibility to Haloperidol
CTD
PMID:11172060
NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618
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Adsl
adenylosuccinate lyase
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of ADSL protein
CTD
PMID:34122009
NCBI chr15:80,832,691...80,855,148
Ensembl chr15:80,832,691...80,855,147
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Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1
decreases expression
EXP
Haloperidol results in decreased expression of AGPAT1 mRNA
CTD
PMID:14647396
NCBI chr17:34,823,164...34,832,392
Ensembl chr17:34,823,236...34,832,423
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Agps
alkylglycerone phosphate synthase
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of AGPS protein
CTD
PMID:34122009
NCBI chr 2:75,662,477...75,761,694
Ensembl chr 2:75,662,521...75,761,694
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Ak4
adenylate kinase 4
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of AK4 protein
CTD
PMID:34122009
NCBI chr 4:101,273,675...101,324,968
Ensembl chr 4:101,276,474...101,324,192
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Akt1
thymoma viral proto-oncogene 1
decreases expression
ISO
Haloperidol results in decreased expression of AKT1 mRNA
CTD
PMID:15860345
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
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Akt2
thymoma viral proto-oncogene 2
increases expression
ISO
Haloperidol results in increased expression of AKT2 mRNA
CTD
PMID:15860345
NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251
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Aldh18a1
aldehyde dehydrogenase 18 family, member A1
decreases expression
ISO
Haloperidol results in decreased expression of ALDH18A1 protein
CTD
PMID:34122009
NCBI chr19:40,538,701...40,576,907
Ensembl chr19:40,538,701...40,576,907
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Aldoc
aldolase C, fructose-bisphosphate
increases expression
ISO
Haloperidol results in increased expression of ALDOC mRNA
CTD
PMID:15860345
NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607
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Ankhd1
ankyrin repeat and KH domain containing 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of ANKHD1 protein
CTD
PMID:34122009
NCBI chr18:36,693,656...36,791,961
Ensembl chr18:36,693,040...36,791,966
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Ap2a2
adaptor-related protein complex 2, alpha 2 subunit
decreases expression
ISO
Haloperidol results in decreased expression of AP2A2 mRNA
CTD
PMID:15860345
NCBI chr 7:141,142,093...141,212,924
Ensembl chr 7:141,142,086...141,212,924
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Ap2b1
adaptor-related protein complex 2, beta 1 subunit
affects expression
ISO
Haloperidol affects the expression of AP2B1 mRNA
CTD
PMID:15860345
NCBI chr11:83,189,545...83,295,861
Ensembl chr11:83,189,850...83,295,861
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Ap2m1
adaptor-related protein complex 2, mu 1 subunit
increases expression
ISO
Haloperidol results in increased expression of AP2M1 protein
CTD
PMID:34122009
NCBI chr16:20,354,230...20,363,659
Ensembl chr16:20,354,228...20,363,659
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Ap3b1
adaptor-related protein complex 3, beta 1 subunit
increases expression
ISO
Haloperidol results in increased expression of AP3B1 protein
CTD
PMID:34122009
NCBI chr13:94,492,332...94,702,838
Ensembl chr13:94,495,468...94,702,825
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Apod
apolipoprotein D
increases expression
EXP
Haloperidol results in increased expression of APOD mRNA
CTD
PMID:14647396
NCBI chr16:31,115,010...31,133,626
Ensembl chr16:31,115,010...31,133,626
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Appl1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of APPL1 protein
CTD
PMID:34122009
NCBI chr14:26,640,943...26,692,567
Ensembl chr14:26,640,945...26,693,189
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Arc
activity regulated cytoskeletal-associated protein
increases expression multiple interactions
ISO
Haloperidol results in increased expression of ARC mRNA 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of ARC mRNA]
CTD
PMID:18208916 PMID:19695244
NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419
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Arf1
ADP-ribosylation factor 1
decreases expression
ISO
Haloperidol results in decreased expression of ARF1 mRNA
CTD
PMID:15860345
NCBI chr11:59,102,237...59,119,042
Ensembl chr11:59,102,238...59,119,096
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Arf3
ADP-ribosylation factor 3
decreases expression
ISO
Haloperidol results in decreased expression of ARF3 mRNA
CTD
PMID:15860345
NCBI chr15:98,635,505...98,660,999
Ensembl chr15:98,634,515...98,661,095
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Arl3
ADP-ribosylation factor-like 3
decreases expression
ISO
Haloperidol results in decreased expression of ARL3 mRNA
CTD
PMID:15860345
NCBI chr19:46,519,548...46,561,621
Ensembl chr19:46,519,535...46,561,637
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Arl5a
ADP-ribosylation factor-like 5A
decreases expression
ISO
Haloperidol results in decreased expression of ARL5A mRNA
CTD
PMID:15860345
NCBI chr 2:52,287,961...52,314,886
Ensembl chr 2:52,287,963...52,314,913
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Arpc4
actin related protein 2/3 complex, subunit 4
increases expression
EXP
Haloperidol results in increased expression of ARPC4 mRNA
CTD
PMID:14647396
NCBI chr 6:113,355,074...113,367,408
Ensembl chr 6:113,355,076...113,367,409
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Asns
asparagine synthetase
decreases expression
ISO
Haloperidol results in decreased expression of ASNS mRNA
CTD
PMID:17175557
NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254
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Asph
aspartate-beta-hydroxylase
increases expression
ISO
Haloperidol results in increased expression of ASPH protein
CTD
PMID:34122009
NCBI chr 4:9,449,085...9,669,344
Ensembl chr 4:9,448,069...9,669,344
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Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
decreases expression
ISO
Haloperidol results in decreased expression of ATP1A1 mRNA
CTD
PMID:15860345
NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000
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Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
decreases expression
ISO
Haloperidol results in decreased expression of ATP1A3 mRNA
CTD
PMID:15860345
NCBI chr 7:24,677,592...24,705,338
Ensembl chr 7:24,677,592...24,705,383
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Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
increases expression
ISO
Haloperidol results in increased expression of ATP1B1 mRNA
CTD
PMID:15860345
NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924
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Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
decreases expression
ISO
Haloperidol results in decreased expression of ATP1B2 mRNA
CTD
PMID:15860345
NCBI chr11:69,490,554...69,496,786
Ensembl chr11:69,490,562...69,496,768
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Atp1b3
ATPase, Na+/K+ transporting, beta 3 polypeptide
increases expression
ISO
Haloperidol results in increased expression of ATP1B3 mRNA
CTD
PMID:15860345
NCBI chr 9:96,214,708...96,246,368
Ensembl chr 9:96,214,708...96,246,495
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Atp2a3
ATPase, Ca++ transporting, ubiquitous
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of ATP2A3 protein
CTD
PMID:34122009
NCBI chr11:72,851,995...72,883,869
Ensembl chr11:72,851,995...72,883,870
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Atp6v1b1
ATPase, H+ transporting, lysosomal V1 subunit B1
decreases expression
ISO
Haloperidol results in decreased expression of ATP6V1B1 protein
CTD
PMID:34122009
NCBI chr 6:83,719,999...83,735,837
Ensembl chr 6:83,719,972...83,735,837
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Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
decreases expression
EXP
Haloperidol results in decreased expression of ATP6V1B2 mRNA
CTD
PMID:16465460
NCBI chr 8:69,541,388...69,566,370
Ensembl chr 8:69,541,298...69,566,363
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Axin2
axin 2
decreases expression
ISO
Haloperidol results in decreased expression of AXIN2 mRNA
CTD
PMID:16715494
NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609
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Bax
BCL2-associated X protein
decreases expression increases expression
ISO
Haloperidol results in decreased expression of BAX protein Haloperidol results in increased expression of BAX mRNA; Haloperidol results in increased expression of BAX protein
CTD
PMID:16462815 PMID:17069804
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Bcat2
branched chain aminotransferase 2, mitochondrial
decreases expression
ISO
Haloperidol results in decreased expression of BCAT2 protein
CTD
PMID:34122009
NCBI chr 7:45,219,773...45,239,134
Ensembl chr 7:45,219,577...45,239,135
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Bcl2
B cell leukemia/lymphoma 2
increases expression
ISO
Haloperidol results in increased expression of BCL2 protein
CTD
PMID:17069804
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Bcl2l1
BCL2-like 1
multiple interactions increases expression decreases expression
ISO
EPO protein inhibits the reaction [Haloperidol results in decreased expression of BCL2L1 protein] Haloperidol results in increased expression of BCL2L1 protein
CTD
PMID:16462815 PMID:17805306
NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
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Bdnf
brain derived neurotrophic factor
multiple interactions increases expression decreases expression
ISO EXP
BDNF protein inhibits the reaction [Haloperidol results in increased activity of CASP3 protein]; EPO protein inhibits the reaction [Haloperidol results in decreased expression of BDNF protein]; Haloperidol inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA] Haloperidol results in increased expression of BDNF mRNA Haloperidol results in increased expression of BDNF protein Haloperidol inhibits the reaction [Cocaine results in decreased expression of BDNF protein] Haloperidol results in decreased expression of BDNF mRNA; Haloperidol results in decreased expression of BDNF protein
CTD
PMID:11488957 PMID:12393228 PMID:12478621 PMID:15168214 PMID:17442543 PMID:17805306 PMID:18208916 PMID:20554863 PMID:29182611 More...
NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
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Bet1l
Bet1 golgi vesicular membrane trafficking protein like
affects expression
ISO
Haloperidol affects the expression of BET1L mRNA
CTD
PMID:15860345
NCBI chr 7:140,433,297...140,437,306
Ensembl chr 7:140,433,307...140,437,490
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Bop1
block of proliferation 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of BOP1 protein
CTD
PMID:34122009
NCBI chr15:76,337,188...76,361,449
Ensembl chr15:76,337,189...76,361,477
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Bptf
bromodomain PHD finger transcription factor
decreases expression
EXP
Haloperidol results in decreased expression of BPTF mRNA
CTD
PMID:14647396
NCBI chr11:106,923,907...107,022,982
Ensembl chr11:106,923,907...107,022,953
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Cacna1a
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
decreases expression
ISO EXP
Haloperidol results in decreased expression of CACNA1A mRNA
CTD
PMID:14647396 PMID:16715494
NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875
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Calca
calcitonin/calcitonin-related polypeptide, alpha
affects activity
ISO
Haloperidol affects the activity of CALCA protein
CTD
PMID:10075105
NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
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Calm2
calmodulin 2
increases expression
ISO
Haloperidol results in increased expression of CALM2 mRNA
CTD
PMID:19289156
NCBI chr17:87,740,829...87,754,363
Ensembl chr17:87,740,840...87,754,363
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
multiple interactions increases expression decreases expression
ISO
Haloperidol results in decreased expression of and results in decreased phosphorylation of CAMK2A protein Haloperidol results in increased expression of CAMK2A mRNA Haloperidol results in decreased expression of CAMK2A protein
CTD
PMID:15860345 PMID:18061412 PMID:19289156
NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224
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Camk2b
calcium/calmodulin-dependent protein kinase II, beta
decreases expression
ISO
Haloperidol results in decreased expression of CAMK2B mRNA
CTD
PMID:15860345
NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362
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Camk2d
calcium/calmodulin-dependent protein kinase II, delta
decreases expression
ISO
Haloperidol results in decreased expression of CAMK2D mRNA
CTD
PMID:15860345
NCBI chr 3:126,389,136...126,639,975
Ensembl chr 3:126,389,951...126,639,975
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Camk4
calcium/calmodulin-dependent protein kinase IV
decreases expression increases expression
ISO
Haloperidol results in decreased expression of CAMK4 protein Haloperidol results in increased expression of CAMK4 mRNA
CTD
PMID:15860345 PMID:19289156
NCBI chr18:33,067,995...33,328,820
Ensembl chr18:33,067,984...33,324,281
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Camkk1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
decreases expression
ISO
Haloperidol results in decreased expression of CAMKK1 protein
CTD
PMID:19289156
NCBI chr11:72,906,869...72,932,899
Ensembl chr11:72,909,834...72,932,899
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Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
decreases expression
ISO
Haloperidol results in decreased expression of CAMKK2 protein
CTD
PMID:19289156
NCBI chr 5:122,856,064...122,918,295
Ensembl chr 5:122,869,233...122,917,472
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Cap1
cyclase associated actin cytoskeleton regulatory protein 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of CAP1 protein
CTD
PMID:34122009
NCBI chr 4:122,752,841...122,779,869
Ensembl chr 4:122,752,840...122,779,849
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Casp3
caspase 3
multiple interactions increases expression increases activity
ISO
BDNF protein inhibits the reaction [Haloperidol results in increased activity of CASP3 protein]; EPO protein inhibits the reaction [Haloperidol results in increased expression of CASP3 protein]
CTD
PMID:15168214 PMID:17805306 PMID:18590723
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Cat
catalase
multiple interactions decreases activity decreases expression
ISO EXP
Carvedilol inhibits the reaction [Haloperidol results in decreased expression of CAT protein]; Haloperidol results in decreased activity of and results in decreased expression of CAT protein; Zolpidem inhibits the reaction [Haloperidol results in decreased activity of CAT] Cannabidiol inhibits the reaction [Haloperidol results in decreased activity of CAT protein]
CTD
PMID:12010767 PMID:12482469 PMID:16564057 PMID:17513028 PMID:30217539
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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Cbx5
chromobox 5
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of CBX5 protein
CTD
PMID:34122009
NCBI chr15:103,099,973...103,148,337
Ensembl chr15:103,099,971...103,148,243
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Ccdc121
coiled-coil domain containing 121
increases expression
ISO
Haloperidol results in increased expression of CCDC121 protein
CTD
PMID:34122009
NCBI chr 5:31,643,205...31,645,820
Ensembl chr 5:31,643,084...31,645,820
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Cck
cholecystokinin
increases expression
ISO
Haloperidol results in increased expression of CCK mRNA
CTD
PMID:10974607
NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760
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Ccnd1
cyclin D1
decreases expression
ISO
Haloperidol results in decreased expression of CCND1 mRNA
CTD
PMID:15860345
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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Ccnd3
cyclin D3
increases expression
ISO
Haloperidol results in increased expression of CCND3 mRNA
CTD
PMID:15860345
NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616
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Ccnl1
cyclin L1
increases expression
ISO
Haloperidol results in increased expression of CCNL1 mRNA
CTD
PMID:15860345
NCBI chr 3:65,853,333...65,869,451
Ensembl chr 3:65,853,572...65,865,670
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Cct8
chaperonin containing TCP1 subunit 8
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of CCT8 protein
CTD
PMID:34122009
NCBI chr16:87,280,213...87,292,757
Ensembl chr16:87,280,214...87,292,761
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Cdc42
cell division cycle 42
increases expression
ISO
Haloperidol results in increased expression of CDC42 mRNA
CTD
PMID:15860345
NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031
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Cdk4
cyclin dependent kinase 4
increases expression
ISO
Haloperidol results in increased expression of CDK4 mRNA
CTD
PMID:15860345
NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
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Cdk5
cyclin dependent kinase 5
increases expression
ISO
Haloperidol results in increased expression of CDK5 mRNA
CTD
PMID:15860345
NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528
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Cfap161
cilia and flagella associated protein 161
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of CFAP161 protein
CTD
PMID:34122009
NCBI chr 7:83,424,820...83,447,528
Ensembl chr 7:83,423,309...83,444,088
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Cfdp1
craniofacial development protein 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of CFDP1 protein
CTD
PMID:34122009
NCBI chr 8:112,493,314...112,580,969
Ensembl chr 8:112,495,123...112,580,923
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Cfl1
cofilin 1, non-muscle
increases expression
ISO
Haloperidol results in increased expression of CFL1 protein
CTD
PMID:34122009
NCBI chr19:5,540,483...5,544,059
Ensembl chr19:5,540,483...5,545,229
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Chl1
cell adhesion molecule L1-like
decreases expression
EXP
Haloperidol results in decreased expression of CHL1 mRNA
CTD
PMID:14647396
NCBI chr 6:103,487,372...103,709,999
Ensembl chr 6:103,487,547...103,727,172
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Chn1
chimerin 1
decreases expression
EXP
Haloperidol results in decreased expression of CHN1 mRNA
CTD
PMID:14647396
NCBI chr 2:73,441,004...73,605,723
Ensembl chr 2:73,441,004...73,605,690
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Chordc1
cysteine and histidine rich domain containing 1
increases expression
ISO
Haloperidol results in increased expression of CHORDC1 protein
CTD
PMID:34122009
NCBI chr 9:18,203,563...18,225,296
Ensembl chr 9:18,203,421...18,228,738
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Chrm4
cholinergic receptor, muscarinic 4
affects response to substance
EXP
CHRM4 affects the susceptibility to Haloperidol
CTD
PMID:21269601
NCBI chr 2:91,752,531...91,760,180
Ensembl chr 2:91,757,594...91,759,033
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Cldn11
claudin 11
decreases expression
EXP
Haloperidol results in decreased expression of CLDN11 mRNA
CTD
PMID:17177202
NCBI chr 3:31,204,069...31,218,475
Ensembl chr 3:31,204,069...31,218,473
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Clta
clathrin light chain A
affects expression
ISO
Haloperidol affects the expression of CLTA mRNA
CTD
PMID:15860345
NCBI chr 4:44,003,816...44,032,846
Ensembl chr 4:44,004,452...44,032,846
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Cltb
clathrin light chain B
decreases expression
ISO
Haloperidol results in decreased expression of CLTB mRNA
CTD
PMID:15860345
NCBI chr13:54,740,199...54,759,186
Ensembl chr13:54,740,214...54,759,157
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Cmya5
cardiomyopathy associated 5
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of CMYA5 protein
CTD
PMID:34122009
NCBI chr13:93,177,221...93,281,278
Ensembl chr13:93,177,221...93,281,232
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Cnot3
CCR4-NOT transcription complex, subunit 3
decreases expression
ISO
Haloperidol results in decreased expression of CNOT3 protein
CTD
PMID:34122009
NCBI chr 7:3,646,717...3,664,108
Ensembl chr 7:3,648,267...3,664,108
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Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
decreases expression
EXP
Haloperidol results in decreased expression of CNP mRNA
CTD
PMID:17177202
NCBI chr11:100,465,765...100,472,565
Ensembl chr11:100,465,730...100,482,555
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Cnr1
cannabinoid receptor 1
multiple interactions increases methylation
EXP ISO
CNR1 protein affects the reaction [[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]]; CNR1 protein affects the reaction [[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]] Haloperidol results in increased methylation of CNR1 promoter Haloperidol inhibits the reaction [Methylazoxymethanol Acetate results in decreased methylation of CNR1 promoter]
CTD
PMID:28017790 PMID:30496751
NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
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Coil
coilin
increases expression
ISO
Haloperidol results in increased expression of COIL mRNA
CTD
PMID:16715494
NCBI chr11:88,864,761...88,882,439
Ensembl chr11:88,861,078...88,882,439
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Cops3
COP9 signalosome subunit 3
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of COPS3 protein
CTD
PMID:34122009
NCBI chr11:59,708,621...59,739,080
Ensembl chr11:59,708,621...59,730,664
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Cops4
COP9 signalosome subunit 4
decreases expression
ISO
Haloperidol results in decreased expression of COPS4 protein
CTD
PMID:34122009
NCBI chr 5:100,666,223...100,695,668
Ensembl chr 5:100,666,175...100,695,669
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Cpn1
carboxypeptidase N, polypeptide 1
increases expression
ISO
Haloperidol results in increased expression of CPN1 mRNA
CTD
PMID:16715494
NCBI chr19:43,944,746...43,974,990
Ensembl chr19:43,944,746...43,974,995
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Cpne3
copine III
decreases expression
ISO
Haloperidol results in decreased expression of CPNE3 protein
CTD
PMID:34122009
NCBI chr 4:19,519,252...19,570,108
Ensembl chr 4:19,519,254...19,570,108
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Creb1
cAMP responsive element binding protein 1
multiple interactions increases expression increases activity increases phosphorylation
EXP ISO
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein] Haloperidol results in increased expression of CREB1 mRNA; Haloperidol results in increased expression of CREB1 protein Amphetamine affects the reaction [Haloperidol results in increased activity of CREB1 protein modified form]
CTD
PMID:12125044 PMID:12871586 PMID:26894264
NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
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Crh
corticotropin releasing hormone
decreases expression
ISO
Haloperidol results in decreased expression of CRH mRNA
CTD
PMID:16205782
NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560
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Crhbp
corticotropin releasing hormone binding protein
decreases expression
ISO
Haloperidol results in decreased expression of CRHBP mRNA
CTD
PMID:16715494
NCBI chr13:95,567,884...95,581,339
Ensembl chr13:95,567,879...95,581,432
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Cry1
cryptochrome circadian regulator 1
decreases expression
ISO
Haloperidol results in decreased expression of CRY1 mRNA
CTD
PMID:27746588
NCBI chr10:84,967,564...85,020,918
Ensembl chr10:84,967,564...85,020,928
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Csnk2a1
casein kinase 2, alpha 1 polypeptide
decreases expression
ISO
Haloperidol results in decreased expression of CSNK2A1 mRNA
CTD
PMID:16715494
NCBI chr 2:152,068,468...152,123,772
Ensembl chr 2:152,068,759...152,123,772
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Cst3
cystatin C
increases expression
EXP
Haloperidol results in increased expression of CST3 mRNA
CTD
PMID:14647396
NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612
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Ctnna1
catenin alpha 1
decreases expression
ISO
Haloperidol results in decreased expression of CTNNA1 protein
CTD
PMID:34122009
NCBI chr18:35,251,955...35,387,829
Ensembl chr18:35,251,912...35,387,832
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Ctnnb1
catenin beta 1
decreases expression increases expression multiple interactions
EXP ISO
Haloperidol results in decreased expression of CTNNB1 mRNA Haloperidol results in increased expression of CTNNB1 protein DRD2 protein affects the reaction [Haloperidol results in increased expression of CTNNB1 protein]
CTD
PMID:16144542 PMID:18797397
NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
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Ctrl
chymotrypsin-like
increases expression
ISO
Haloperidol results in increased expression of CTRL mRNA
CTD
PMID:16715494
NCBI chr 8:106,658,626...106,660,494
Ensembl chr 8:106,658,635...106,660,494
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Ctsk
cathepsin K
increases expression
ISO
Haloperidol results in increased expression of CTSK mRNA
CTD
PMID:16715494
NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673
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Cyb5r1
cytochrome b5 reductase 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of CYB5R1 protein
CTD
PMID:34122009
NCBI chr 1:134,333,519...134,339,476
Ensembl chr 1:134,333,297...134,339,478
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Cyp2d22
cytochrome P450, family 2, subfamily d, polypeptide 22
affects response to substance
ISO
CYP2D6 protein polymorphism affects the susceptibility to Haloperidol
CTD
PMID:15538130
NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
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Cyp3a13
cytochrome P450, family 3, subfamily a, polypeptide 13
multiple interactions
ISO
CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol; Fluoxetine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]; Fluvoxamine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]; nefazodone inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]; norfluoxetine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]; Trazodone inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]
CTD
PMID:12584149
NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
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Dcaf6
DDB1 and CUL4 associated factor 6
decreases expression
EXP
Haloperidol results in decreased expression of DCAF6 mRNA
CTD
PMID:14647396
NCBI chr 1:165,157,069...165,288,475
Ensembl chr 1:165,156,267...165,288,044
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Dclk1
doublecortin-like kinase 1
increases expression
EXP ISO
Haloperidol results in increased expression of DCLK1 mRNA
CTD
PMID:15860345 PMID:18797397
NCBI chr 3:55,149,724...55,446,489
Ensembl chr 3:55,149,785...55,446,489
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Ddx27
DEAD box helicase 27
increases expression
ISO
Haloperidol results in increased expression of DDX27 protein
CTD
PMID:34122009
NCBI chr 2:166,857,233...166,876,865
Ensembl chr 2:166,857,113...166,876,867
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Ddx46
DEAD box helicase 46
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of DDX46 protein
CTD
PMID:34122009
NCBI chr13:55,782,790...55,829,080
Ensembl chr13:55,782,841...55,829,069
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Ddx5
DEAD box helicase 5
decreases expression
ISO
Haloperidol results in decreased expression of DDX5 protein
CTD
PMID:34122009
NCBI chr11:106,671,181...106,680,011
Ensembl chr11:106,671,181...106,680,011
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Dennd10
DENN domain containing 10
increases expression
ISO
Haloperidol results in increased expression of DENND10 mRNA
CTD
PMID:16715494
NCBI chr19:60,800,029...60,824,673
Ensembl chr19:60,800,023...60,824,665
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Depp1
DEPP1 autophagy regulator
increases expression
ISO
Haloperidol results in increased expression of DEPP1 mRNA
CTD
PMID:17175557
NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755
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Dgka
diacylglycerol kinase, alpha
decreases expression
ISO
Haloperidol results in decreased expression of DGKA mRNA
CTD
PMID:15860345
NCBI chr10:128,556,000...128,581,002
Ensembl chr10:128,556,003...128,580,724
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Dhx36
DEAH-box helicase 36
decreases expression
ISO
Haloperidol results in decreased expression of DHX36 protein
CTD
PMID:34122009
NCBI chr 3:62,375,436...62,414,464
Ensembl chr 3:62,375,434...62,414,425
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Dhx38
DEAH-box helicase 38
decreases expression
ISO
Haloperidol results in decreased expression of DHX38 protein
CTD
PMID:34122009
NCBI chr 8:110,274,631...110,292,493
Ensembl chr 8:110,274,643...110,292,493
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Dlat
dihydrolipoamide S-acetyltransferase
decreases expression
ISO
Haloperidol results in decreased expression of DLAT mRNA
CTD
PMID:15860345
NCBI chr 9:50,545,933...50,571,080
Ensembl chr 9:50,545,933...50,571,080
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Dlg2
discs large MAGUK scaffold protein 2
increases expression
ISO
Haloperidol results in increased expression of DLG2 protein
CTD
PMID:34122009
NCBI chr 7:90,125,399...92,098,454
Ensembl chr 7:90,125,880...92,098,455
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Dnah1
dynein, axonemal, heavy chain 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of DNAH1 protein
CTD
PMID:34122009
NCBI chr14:30,982,332...31,045,926
Ensembl chr14:30,982,332...31,045,853
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Dnah3
dynein, axonemal, heavy chain 3
increases expression
ISO
Haloperidol results in increased expression of DNAH3 protein
CTD
PMID:34122009
NCBI chr 7:119,520,555...119,694,520
Ensembl chr 7:119,521,894...119,694,503
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Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of DNAJB1 protein
CTD
PMID:34122009
NCBI chr 8:84,334,804...84,339,282
Ensembl chr 8:84,334,822...84,339,282
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Dnajb11
DnaJ heat shock protein family (Hsp40) member B11
increases expression multiple interactions
ISO
Haloperidol results in increased expression of DNAJB11 protein [Cuprizone co-treated with Haloperidol] results in increased expression of DNAJB11 protein
CTD
PMID:34122009
NCBI chr16:22,676,595...22,698,384
Ensembl chr16:22,676,595...22,698,384
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Dpf1
double PHD fingers 1
increases expression
EXP
Haloperidol results in increased expression of DPF1 mRNA
CTD
PMID:14647396
NCBI chr 7:29,003,366...29,017,017
Ensembl chr 7:29,003,376...29,017,668
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Dr1
down-regulator of transcription 1
decreases expression
ISO
Haloperidol results in decreased expression of DR1 protein
CTD
PMID:34122009
NCBI chr 5:108,416,763...108,428,387
Ensembl chr 5:108,416,763...108,428,392
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Drd1
dopamine receptor D1
affects binding increases expression decreases expression affects activity
ISO EXP
Haloperidol binds to DRD1 protein Haloperidol results in increased expression of DRD1 protein Haloperidol results in decreased expression of DRD1 mRNA Haloperidol affects the activity of DRD1 protein
CTD
PMID:8750706 PMID:8794996 PMID:12887421 PMID:16983399 PMID:23611293
NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
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Drd2
dopamine receptor D2
affects binding affects activity multiple interactions increases expression affects response to substance
ISO EXP
DRD2 protein binds to Haloperidol; DRD2 protein binds to Haloperidol analog; Haloperidol binds to DRD2 protein Haloperidol affects the activity of DRD2 protein [Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; cyclo(leucylglycine) inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein]; felbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein]; Haloperidol binds to and results in decreased activity of DRD2 protein; Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Haloperidol inhibits the reaction [iodosulpride binds to DRD2 protein]; Haloperidol inhibits the reaction [Spiperone binds to DRD2 protein]; Haloperidol promotes the reaction [Dopamine binds to DRD2 protein]; zinc chloride inhibits the reaction [Haloperidol binds to DRD2 protein] Haloperidol results in increased expression of DRD2; Haloperidol results in increased expression of DRD2 mRNA; Haloperidol results in increased expression of DRD2 protein Haloperidol binds to DRD2; Haloperidol binds to DRD2 protein; Haloperidol binds to DRD2 protein alternative form [Haloperidol binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Ethanol; [Haloperidol results in increased expression of DRD2 protein] which results in decreased susceptibility to Pentobarbital; Haloperidol binds to and results in decreased activity of DRD2 protein DRD2 affects the susceptibility to Haloperidol; DRD2 protein affects the susceptibility to Haloperidol Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]
CTD
PMID:1351265 PMID:1361536 PMID:1380082 PMID:2945998 PMID:7845605 PMID:7878047 PMID:8115415 PMID:8200438 PMID:8794996 PMID:9109525 PMID:9808703 PMID:10720636 PMID:10936494 PMID:11172060 PMID:11927170 PMID:11997696 PMID:12191584 PMID:12476322 PMID:14552778 PMID:15716360 PMID:16033416 PMID:16144542 PMID:18295747 PMID:19120057 PMID:20361897 PMID:20730801 PMID:23611293 More...
NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
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Drd3
dopamine receptor D3
affects binding multiple interactions
ISO
DRD3 protein binds to Haloperidol analog Haloperidol affects the reaction [Methylazoxymethanol Acetate results in increased expression of DRD3 mRNA]
CTD
PMID:14552778 PMID:32360362
NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
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Drd4
dopamine receptor D4
affects activity affects binding
ISO
Haloperidol affects the activity of DRD4 protein Haloperidol binds to Drd4 protein
CTD RGD
PMID:23611293 PMID:8078498
RGD:7248459
NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377
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Drp2
dystrophin related protein 2
increases expression
ISO
Haloperidol results in increased expression of DRP2 mRNA alternative form
CTD
PMID:16715494
NCBI chr X:133,304,868...133,357,323
Ensembl chr X:133,305,300...133,357,322
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Dtnbp1
dystrobrevin binding protein 1
increases response to substance affects response to substance
ISO
DTNBP1 gene polymorphism results in increased susceptibility to Haloperidol DTNBP1 protein affects the susceptibility to Haloperidol
CTD
PMID:19369910
NCBI chr13:45,075,552...45,155,614
Ensembl chr13:45,075,551...45,155,623
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Dusp1
dual specificity phosphatase 1
decreases expression
ISO
Haloperidol results in decreased expression of DUSP1 mRNA
CTD
PMID:15860345
NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102
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Dusp6
dual specificity phosphatase 6
decreases expression
ISO
Haloperidol results in decreased expression of DUSP6 mRNA
CTD
PMID:15860345
NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351
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Dvl3
dishevelled segment polarity protein 3
multiple interactions increases expression
ISO
DRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]
CTD
PMID:16144542
NCBI chr16:20,335,694...20,352,763
Ensembl chr16:20,335,732...20,352,760
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Eef1g
eukaryotic translation elongation factor 1 gamma
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of EEF1G protein
CTD
PMID:34122009
NCBI chr19:8,944,405...8,955,544
Ensembl chr19:8,944,405...8,955,843
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Egr1
early growth response 1
affects expression multiple interactions increases expression
ISO EXP
Haloperidol affects the expression of EGR1 protein Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]; OPRM1 protein inhibits the reaction [Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]] Haloperidol results in increased expression of EGR1 mRNA; Haloperidol results in increased expression of EGR1 protein
CTD
PMID:12243769 PMID:16452686 PMID:17028028 PMID:17913375 PMID:18208916 PMID:19695244 PMID:20184921 More...
NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
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Egr2
early growth response 2
affects expression increases expression decreases expression
EXP ISO
Haloperidol affects the expression of EGR2 mRNA Haloperidol results in increased expression of EGR2 mRNA Haloperidol results in decreased expression of EGR2 protein
CTD
PMID:17028028 PMID:18208916 PMID:19401217
NCBI chr10:67,370,334...67,383,354
Ensembl chr10:67,371,305...67,378,018
G
Eif2b5
eukaryotic translation initiation factor 2B, subunit 5 epsilon
increases expression
ISO
Haloperidol results in increased expression of EIF2B5 protein
CTD
PMID:34122009
NCBI chr16:20,317,544...20,328,073
Ensembl chr16:20,317,567...20,328,073
G
Eif5a
eukaryotic translation initiation factor 5A
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of EIF5A protein
CTD
PMID:34122009
NCBI chr11:69,807,538...69,812,784
Ensembl chr11:69,807,540...69,812,784
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Elk1
ELK1, member of ETS oncogene family
increases phosphorylation multiple interactions
EXP ISO
Haloperidol results in increased phosphorylation of ELK1 protein Nifedipine affects the reaction [Haloperidol results in increased phosphorylation of ELK1 protein] SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of ELK1 protein]
CTD
PMID:12871586 PMID:17913375
NCBI chr X:20,799,634...20,816,847
Ensembl chr X:20,799,634...20,816,847
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Eno1
enolase 1, alpha non-neuron
increases expression
ISO
Haloperidol results in increased expression of ENO1 mRNA
CTD
PMID:15860345
NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336
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Epo
erythropoietin
multiple interactions
ISO
EPO protein inhibits the reaction [Haloperidol results in decreased expression of BCL2L1 protein]; EPO protein inhibits the reaction [Haloperidol results in decreased expression of BDNF protein]; EPO protein inhibits the reaction [Haloperidol results in increased expression of CASP3 protein]
CTD
PMID:17805306
NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504
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Erap1
endoplasmic reticulum aminopeptidase 1
decreases expression
ISO
Haloperidol results in decreased expression of ERAP1 protein
CTD
PMID:34122009
NCBI chr13:74,787,692...74,841,321
Ensembl chr13:74,787,687...74,841,320
G
Erbb2
erb-b2 receptor tyrosine kinase 2
multiple interactions
ISO
Haloperidol results in increased expression of and results in increased phosphorylation of ERBB2 protein
CTD
PMID:26961615
NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542
G
Erbb4
erb-b2 receptor tyrosine kinase 4
increases expression multiple interactions
ISO
Haloperidol results in increased expression of ERBB4 protein Haloperidol results in increased expression of and results in increased phosphorylation of ERBB4 protein
CTD
PMID:18184445 PMID:26961615
NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218
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Ergic1
endoplasmic reticulum-golgi intermediate compartment 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of ERGIC1 protein
CTD
PMID:34122009
NCBI chr17:26,779,736...26,875,908
Ensembl chr17:26,780,463...26,875,908
G
Ezr
ezrin
decreases expression
ISO
Haloperidol results in decreased expression of EZR protein
CTD
PMID:34122009
NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183
G
Fabp3
fatty acid binding protein 3, muscle and heart
affects response to substance increases expression
EXP ISO
FABP3 affects the susceptibility to Haloperidol Haloperidol results in increased expression of FABP3 protein
CTD
PMID:20181611 PMID:34122009
NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256
G
Fasn
fatty acid synthase
increases expression
ISO
Haloperidol results in increased expression of FASN mRNA
CTD
PMID:16027736
NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
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Flt1
FMS-like tyrosine kinase 1
decreases expression
ISO
Haloperidol results in decreased expression of FLT1 protein
CTD
PMID:34122009
NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821
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Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Haloperidol results in increased expression of FNDC4 mRNA
CTD
PMID:17175557
NCBI chr 5:31,449,589...31,453,279
Ensembl chr 5:31,449,586...31,453,424
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Fos
FBJ osteosarcoma oncogene
multiple interactions increases expression decreases expression
EXP ISO
8-Hydroxy-2-(di-n-propylamino)tetralin affects the reaction [Haloperidol results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Haloperidol results in increased expression of FOS protein]; ifenprodil inhibits the reaction [Haloperidol results in increased expression of FOS protein]; tandospirone inhibits the reaction [Haloperidol results in increased expression of FOS protein]; traxoprodil mesylate inhibits the reaction [Haloperidol results in increased expression of FOS protein]; WAY 100135 inhibits the reaction [tandospirone inhibits the reaction [Haloperidol results in increased expression of FOS protein]] Haloperidol results in increased expression of FOS mRNA; Haloperidol results in increased expression of FOS protein Haloperidol results in decreased expression of FOS mRNA; Haloperidol results in decreased expression of FOS protein 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Dronabinol promotes the reaction [Haloperidol results in increased expression of FOS protein]; Nifedipine affects the reaction [Haloperidol results in increased expression of FOS protein]; Nimodipine affects the reaction [Haloperidol results in increased expression of FOS protein]; Propranolol inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Theophylline inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]
CTD
PMID:1393566 PMID:9571656 PMID:9748542 PMID:10199625 PMID:10435392 PMID:11166331 PMID:11409749 PMID:11440804 PMID:11516571 PMID:11602683 PMID:11997696 PMID:12093589 PMID:12125044 PMID:12243769 PMID:12464447 PMID:15120589 PMID:15140647 PMID:17028028 PMID:17913375 PMID:18208916 PMID:18295747 PMID:18521575 PMID:18585397 PMID:18789920 PMID:19352073 PMID:19695244 More...
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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Fosb
FBJ osteosarcoma oncogene B
increases expression multiple interactions
EXP ISO
Haloperidol results in increased expression of FOSB protein alternative form Haloperidol results in increased expression of FOSB modified form; Haloperidol results in increased expression of FOSB mRNA; Haloperidol results in increased expression of FOSB protein 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOSB mRNA]
CTD
PMID:8714707 PMID:11180499 PMID:12243769 PMID:15579174 PMID:19695244 PMID:24067299 More...
NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976
G
Fosl1
fos-like antigen 1
multiple interactions increases expression
ISO
Amphetamine affects the reaction [Haloperidol results in increased expression of FOSL1 protein] Haloperidol results in increased expression of FOSL1 mRNA; Haloperidol results in increased expression of FOSL1 protein
CTD
PMID:12125044 PMID:18208916
NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974
G
Fosl2
fos-like antigen 2
increases expression
ISO
Haloperidol results in increased expression of FOSL2 mRNA
CTD
PMID:12243769
NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186
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Fyn
Fyn proto-oncogene
multiple interactions increases phosphorylation affects response to substance
EXP
FYN gene mutant form inhibits the reaction [Haloperidol results in increased phosphorylation of GRIN2B protein] Haloperidol results in increased phosphorylation of FYN protein FYN protein affects the susceptibility to Haloperidol
CTD
PMID:16407246
NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377
G
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
decreases expression
EXP
Haloperidol results in decreased expression of GABRA1 mRNA
CTD
PMID:18797397
NCBI chr11:42,021,766...42,073,893
Ensembl chr11:42,021,766...42,073,757
G
Gabrb1
gamma-aminobutyric acid type A receptor subunit beta 1
increases expression
ISO
Haloperidol results in increased expression of GABRB1 mRNA; Haloperidol results in increased expression of GABRB1 protein
CTD
PMID:26894264
NCBI chr 5:71,815,264...72,306,915
Ensembl chr 5:71,815,456...72,306,380
G
Gabrb3
GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3
increases expression
ISO
Haloperidol results in increased expression of GABRB3 mRNA
CTD
PMID:18923069
NCBI chr 7:57,240,266...57,478,550
Ensembl chr 7:57,069,440...57,478,550
G
Gad1
glutamate decarboxylase 1
multiple interactions increases expression decreases expression
ISO
[Haloperidol co-treated with Fluvoxamine] affects the expression of GAD1 protein Haloperidol results in increased expression of GAD1 mRNA Haloperidol results in decreased expression of GAD1 mRNA; Haloperidol results in decreased expression of GAD1 protein
CTD
PMID:12887421 PMID:14519413 PMID:15061247 PMID:15967061 PMID:18923069 PMID:19359144 More...
NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
G
Gad2
glutamic acid decarboxylase 2
decreases expression increases expression
ISO
Haloperidol results in decreased expression of GAD2 mRNA; Haloperidol results in decreased expression of GAD2 protein Haloperidol results in increased expression of GAD2 mRNA
CTD
PMID:18923069 PMID:19359144
NCBI chr 2:22,512,262...22,583,889
Ensembl chr 2:22,512,217...22,583,886
G
Galnt2
polypeptide N-acetylgalactosaminyltransferase 2
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of GALNT2 protein
CTD
PMID:34122009
NCBI chr 8:124,958,133...125,072,461
Ensembl chr 8:124,958,130...125,072,463
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Gapdh
glyceraldehyde-3-phosphate dehydrogenase
increases expression
ISO
Haloperidol results in increased expression of GAPDH mRNA
CTD
PMID:15860345
NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
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Gda
guanine deaminase
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of GDA protein
CTD
PMID:34122009
NCBI chr19:21,368,671...21,450,025
Ensembl chr19:21,368,671...21,450,809
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Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
increases expression
ISO
Haloperidol results in increased expression of GDPD3 mRNA
CTD
PMID:17175557
NCBI chr 7:126,365,586...126,374,817
Ensembl chr 7:126,365,506...126,374,821
G
Gfap
glial fibrillary acidic protein
decreases expression
ISO
Haloperidol results in decreased expression of GFAP protein
CTD
PMID:34122009
NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
G
Gimap5
GTPase, IMAP family member 5
decreases expression
ISO
Haloperidol results in decreased expression of GIMAP5 mRNA
CTD
PMID:16715494
NCBI chr 6:48,723,131...48,731,134
Ensembl chr 6:48,723,131...48,731,144
G
Gja1
gap junction protein, alpha 1
decreases expression
ISO
Haloperidol results in decreased expression of GJA1 protein
CTD
PMID:18585900
NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
G
Glo1
glyoxalase 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of GLO1 protein
CTD
PMID:34122009
NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845
G
Glul
glutamate-ammonia ligase
decreases expression
ISO
Haloperidol results in decreased expression of GLUL mRNA
CTD
PMID:15860345
NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469
G
Gna12
guanine nucleotide binding protein, alpha 12
decreases expression
ISO
Haloperidol results in decreased expression of GNA12 mRNA
CTD
PMID:15860345
NCBI chr 5:140,745,699...140,816,186
Ensembl chr 5:140,744,163...140,816,186
G
Gnai1
G protein subunit alpha i1
decreases expression
ISO
Haloperidol results in decreased expression of GNAI1 mRNA
CTD
PMID:15860345
NCBI chr 5:18,470,133...18,565,411
Ensembl chr 5:18,470,133...18,565,353
G
Gnai2
G protein subunit alpha i2
decreases expression
ISO
Haloperidol results in decreased expression of GNAI2 mRNA
CTD
PMID:15860345
NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566
G
Gnai3
G protein subunit alpha i3
decreases expression
ISO
Haloperidol results in decreased expression of GNAI3 mRNA
CTD
PMID:15860345
NCBI chr 3:108,014,591...108,053,468
Ensembl chr 3:108,014,596...108,053,462
G
Gnao1
guanine nucleotide binding protein, alpha O
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of GNAO1 protein
CTD
PMID:34122009
NCBI chr 8:94,537,213...94,696,016
Ensembl chr 8:94,536,594...94,696,016
G
Gnas
GNAS complex locus
decreases expression
ISO
Haloperidol results in decreased expression of GNAS mRNA
CTD
PMID:15860345
NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537
G
Gnrh1
gonadotropin releasing hormone 1
multiple interactions
ISO
Haloperidol inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]
CTD
PMID:18603625
NCBI chr14:67,982,717...67,986,889
Ensembl chr14:67,982,630...67,986,888
G
Got2
glutamatic-oxaloacetic transaminase 2, mitochondrial
affects expression multiple interactions
ISO
Haloperidol affects the expression of GOT2 mRNA [Cuprizone co-treated with Haloperidol] results in increased expression of GOT2 protein
CTD
PMID:15860345 PMID:34122009
NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175
G
Gpx1
glutathione peroxidase 1
increases expression
EXP
Haloperidol results in increased expression of GPX1 mRNA
CTD
PMID:14647396
NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
G
Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
decreases expression
ISO
Haloperidol results in decreased expression of GRIA1 mRNA
CTD
PMID:15860345
NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070
G
Grik2
glutamate receptor, ionotropic, kainate 2 (beta 2)
increases expression
ISO
Haloperidol results in increased expression of GRIK2 mRNA
CTD
PMID:18923069
NCBI chr10:48,969,776...49,666,523
Ensembl chr10:48,970,929...49,664,862
G
Grik4
glutamate receptor, ionotropic, kainate 4
increases expression
ISO
Haloperidol results in increased expression of GRIK4 mRNA
CTD
PMID:15860345
NCBI chr 9:42,431,708...42,856,296
Ensembl chr 9:42,429,431...42,855,789
G
Grik5
glutamate receptor, ionotropic, kainate 5 (gamma 2)
increases expression
EXP ISO
Haloperidol results in increased expression of GRIK5 mRNA
CTD
PMID:14647396 PMID:15860345
NCBI chr 7:24,709,274...24,775,421
Ensembl chr 7:24,709,274...24,771,771
G
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
decreases expression increases expression
ISO
Haloperidol results in decreased expression of GRIN1 mRNA Haloperidol results in increased expression of GRIN1 mRNA
CTD
PMID:12020038
NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
G
Grin2a
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
decreases expression
ISO
Haloperidol results in decreased expression of GRIN2A mRNA; Haloperidol results in decreased expression of GRIN2A protein
CTD
PMID:12608697 PMID:15860345 PMID:18061412
NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424
G
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
multiple interactions increases phosphorylation
EXP
FYN gene mutant form inhibits the reaction [Haloperidol results in increased phosphorylation of GRIN2B protein]
CTD
PMID:16407246
NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
G
Grin2c
glutamate receptor, ionotropic, NMDA2C (epsilon 3)
increases expression
ISO
Haloperidol results in increased expression of GRIN2C mRNA
CTD
PMID:15860345
NCBI chr11:115,139,995...115,158,123
Ensembl chr11:115,139,995...115,158,069
G
Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
decreases expression
ISO
Haloperidol results in decreased expression of GRIN2D mRNA
CTD
PMID:18923069
NCBI chr 7:45,481,307...45,520,708
Ensembl chr 7:45,481,307...45,527,802
G
Grin3b
glutamate receptor, ionotropic, NMDA3B
increases expression
ISO
Haloperidol results in increased expression of GRIN3B mRNA
CTD
PMID:15860345
NCBI chr10:79,806,227...79,813,024
Ensembl chr10:79,806,549...79,813,024
G
Grk6
G protein-coupled receptor kinase 6
decreases expression
ISO
Haloperidol results in decreased expression of GRK6 mRNA
CTD
PMID:16715494
NCBI chr13:55,592,865...55,608,740
Ensembl chr13:55,592,885...55,608,740
G
Grm1
glutamate receptor, metabotropic 1
increases expression
ISO
Haloperidol results in increased expression of GRM1 mRNA
CTD
PMID:15860345
NCBI chr10:10,561,803...10,958,126
Ensembl chr10:10,561,803...10,958,100
G
Grm2
glutamate receptor, metabotropic 2
increases expression
ISO
Haloperidol results in increased expression of GRM2 mRNA
CTD
PMID:18923069
NCBI chr 9:106,521,733...106,533,308
Ensembl chr 9:106,520,294...106,533,281
G
Gsk3a
glycogen synthase kinase 3 alpha
increases expression multiple interactions
ISO
Haloperidol results in increased expression of GSK3A protein DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3A protein]
CTD
PMID:16144542
NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276
G
Gsk3b
glycogen synthase kinase 3 beta
multiple interactions increases expression
ISO
DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein] Haloperidol results in increased expression of GSK3B mRNA; Haloperidol results in increased expression of GSK3B protein
CTD
PMID:16144542 PMID:19359144
NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
G
Gstm1
glutathione S-transferase, mu 1
increases expression
ISO
Haloperidol results in increased expression of GSTM1 mRNA
CTD
PMID:15860345
NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
G
Gstm2
glutathione S-transferase, mu 2
decreases expression
ISO
Haloperidol results in decreased expression of GSTM2 mRNA
CTD
PMID:15860345
NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769
G
Gstp1
glutathione S-transferase, pi 1
multiple interactions decreases expression
ISO
Haloperidol inhibits the reaction [GSTP1 protein results in decreased susceptibility to Doxorubicin] Haloperidol results in decreased expression of GSTP1 mRNA
CTD
PMID:15946544
NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
G
Gtf2e1
general transcription factor II E, polypeptide 1 (alpha subunit)
decreases expression
ISO
Haloperidol results in decreased expression of GTF2E1 protein
CTD
PMID:34122009
NCBI chr16:37,330,158...37,360,151
Ensembl chr16:37,330,152...37,360,151
G
H2ac18
H2A clustered histone 18
increases expression
EXP
Haloperidol results in increased expression of H2AC18 mRNA
CTD
PMID:14647396
NCBI chr 3:96,152,853...96,153,439
Ensembl chr 3:96,152,813...96,153,398
G
H2ac20
H2A clustered histone 20
increases expression
ISO
Haloperidol results in increased expression of H2AC20 protein
CTD
PMID:34122009
NCBI chr 3:96,127,728...96,128,209
Ensembl chr 3:96,127,677...96,128,196
G
H2aj
H2J.A histone
increases expression
ISO
Haloperidol results in increased expression of H2AJ protein
CTD
PMID:34122009
NCBI chr 6:136,785,246...136,787,072
Ensembl chr 6:136,785,242...136,787,072
G
Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of HADHB protein
CTD
PMID:34122009
NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591
G
Hars1
histidyl-tRNA synthetase 1
increases expression
ISO
Haloperidol results in increased expression of HARS1 protein
CTD
PMID:34122009
NCBI chr18:36,899,581...36,916,258
Ensembl chr18:36,899,581...36,916,258
G
Hcfc1
host cell factor C1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of HCFC1 protein
CTD
PMID:34122009
NCBI chr X:72,986,400...73,011,430
Ensembl chr X:72,986,398...73,009,963
G
Higd1a
HIG1 domain family, member 1A
increases expression
EXP
Haloperidol results in increased expression of HIGD1A mRNA
CTD
PMID:14647396
NCBI chr 9:121,677,623...121,686,862
Ensembl chr 9:121,677,629...121,687,428
G
Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
increases activity increases expression multiple interactions
ISO
Haloperidol results in increased activity of HMGCR protein Haloperidol results in increased expression of HMGCR mRNA [Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides
CTD
PMID:16027736 PMID:17052361
NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
G
Hmgcs1
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
increases expression
ISO
Haloperidol results in increased expression of HMGCS1 mRNA
CTD
PMID:16027736 PMID:17052361
NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796
G
Hnrnpc
heterogeneous nuclear ribonucleoprotein C
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of HNRNPC protein
CTD
PMID:34122009
NCBI chr14:52,310,834...52,341,462
Ensembl chr14:52,310,834...52,341,485
G
Hnrnpk
heterogeneous nuclear ribonucleoprotein K
decreases expression
ISO
Haloperidol results in decreased expression of HNRNPK protein
CTD
PMID:34122009
NCBI chr13:58,538,946...58,551,157
Ensembl chr13:58,538,956...58,551,157
G
Homer1
homer scaffolding protein 1
multiple interactions increases expression
ISO
Cycloserine inhibits the reaction [Haloperidol results in increased expression of HOMER1 mRNA]
CTD
PMID:12464447 PMID:15860345 PMID:20147574
NCBI chr13:93,440,265...93,549,471
Ensembl chr13:93,436,143...93,541,637
G
Hpcal4
hippocalcin-like 4
decreases expression
ISO
Haloperidol results in decreased expression of HPCAL4 mRNA
CTD
PMID:12437575
NCBI chr 4:123,077,297...123,088,492
Ensembl chr 4:123,077,020...123,088,494
G
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
decreases expression
ISO
Haloperidol results in decreased expression of HSD17B4 protein
CTD
PMID:34122009
NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
G
Hspg2
perlecan (heparan sulfate proteoglycan 2)
decreases expression multiple interactions
EXP
Haloperidol results in decreased expression of HSPG2 mRNA HSPG2 gene results in increased susceptibility to [Haloperidol co-treated with Reserpine]
CTD
PMID:20072119
NCBI chr 4:137,196,062...137,297,941
Ensembl chr 4:137,196,080...137,297,941
G
Hsph1
heat shock 105kDa/110kDa protein 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of HSPH1 protein
CTD
PMID:34122009
NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841
G
Htr1d
5-hydroxytryptamine (serotonin) receptor 1D
decreases expression
ISO
Haloperidol results in decreased expression of HTR1D mRNA
CTD
PMID:16715494
NCBI chr 4:136,150,835...136,171,716
Ensembl chr 4:136,150,835...136,171,709
G
Htr2a
5-hydroxytryptamine (serotonin) receptor 2A
affects binding multiple interactions
ISO
Haloperidol binds to HTR2A protein [Phencyclidine co-treated with Haloperidol] affects the activity of HTR2A protein
CTD
PMID:7520908 PMID:12191584 PMID:15380371
NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934
G
Htr2c
5-hydroxytryptamine (serotonin) receptor 2C
decreases expression
ISO
Haloperidol results in decreased expression of HTR2C mRNA
CTD
PMID:17868938
NCBI chr X:145,745,509...145,980,273
Ensembl chr X:145,745,509...145,980,273
G
Id2
inhibitor of DNA binding 2
decreases expression increases expression
ISO
Haloperidol results in decreased expression of ID2 mRNA Haloperidol results in increased expression of ID2 mRNA
CTD
PMID:12437575
NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139
G
Ikbip
IKBKB interacting protein
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of IKBIP protein
CTD
PMID:34122009
NCBI chr10:90,918,667...90,938,475
Ensembl chr10:90,918,802...90,938,469
G
Il10
interleukin 10
multiple interactions
EXP
[Cannabidiol co-treated with Haloperidol] results in increased expression of IL10 protein
CTD
PMID:30217539
NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
G
Il1b
interleukin 1 beta
increases expression multiple interactions
EXP
Haloperidol results in increased expression of IL1B protein Cannabidiol inhibits the reaction [Haloperidol results in increased expression of IL1B protein]
CTD
PMID:30217539
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
G
Il6
interleukin 6
multiple interactions increases expression
EXP
Cannabidiol inhibits the reaction [Haloperidol results in increased expression of IL6 mRNA]
CTD
PMID:30217539
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
G
Ilkap
integrin-linked kinase-associated serine/threonine phosphatase 2C
decreases expression
ISO
Haloperidol results in decreased expression of ILKAP mRNA
CTD
PMID:15860345
NCBI chr 1:91,301,568...91,326,566
Ensembl chr 1:91,301,583...91,326,537
G
Impdh1
inosine monophosphate dehydrogenase 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of IMPDH1 protein
CTD
PMID:34122009
NCBI chr 6:29,200,435...29,216,363
Ensembl chr 6:29,200,433...29,216,363
G
Inha
inhibin alpha
decreases expression
ISO
Haloperidol results in decreased expression of INHA mRNA
CTD
PMID:16715494
NCBI chr 1:75,483,872...75,487,010
Ensembl chr 1:75,483,721...75,487,010
G
Inhbe
inhibin beta-E
increases expression
ISO
Haloperidol results in increased expression of INHBE mRNA
CTD
PMID:17175557
NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280
G
Jun
jun proto-oncogene
increases expression decreases expression
ISO
Haloperidol results in increased expression of JUN mRNA; Haloperidol results in increased expression of JUN protein Haloperidol results in decreased expression of JUN mRNA
CTD
PMID:12093589 PMID:12125044 PMID:15860345 PMID:18208916
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
G
Junb
jun B proto-oncogene
multiple interactions increases expression decreases expression
ISO
8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of JUNB mRNA] Haloperidol results in decreased expression of JUNB mRNA
CTD
PMID:12093589 PMID:19695244
NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347
G
Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
increases expression
EXP
Haloperidol results in increased expression of KCNA1 mRNA; Haloperidol results in increased expression of KCNA1 protein
CTD
PMID:18797397
NCBI chr 6:126,613,426...126,622,764
Ensembl chr 6:126,617,360...126,623,347
G
Kcnab1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
decreases expression
EXP
Haloperidol results in decreased expression of KCNAB1 mRNA
CTD
PMID:18797397
NCBI chr 3:64,856,636...65,285,643
Ensembl chr 3:64,856,617...65,285,644
G
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
multiple interactions decreases activity
ISO
Haloperidol inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Haloperidol results in decreased activity of KCNH2 protein
CTD
PMID:15671647 PMID:16278312 PMID:16494862 PMID:19583963 PMID:21158687
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
G
Kcnip3
Kv channel interacting protein 3, calsenilin
decreases expression
EXP
Haloperidol results in decreased expression of KCNIP3 mRNA; Haloperidol results in decreased expression of KCNIP3 protein
CTD
PMID:18797397
NCBI chr 2:127,298,418...127,364,014
Ensembl chr 2:127,298,418...127,364,014
G
Kdm1a
lysine (K)-specific demethylase 1A
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of KDM1A protein
CTD
PMID:34122009
NCBI chr 4:136,277,844...136,330,127
Ensembl chr 4:136,277,851...136,330,034
G
Kdr
kinase insert domain protein receptor
increases expression
ISO
Haloperidol results in increased expression of KDR protein
CTD
PMID:34122009
NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
G
Kif5c
kinesin family member 5C
decreases expression
ISO
Haloperidol results in decreased expression of KIF5C protein
CTD
PMID:34122009
NCBI chr 2:49,509,298...49,664,790
Ensembl chr 2:49,509,310...49,664,790
G
Kiz
kizuna centrosomal protein
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of KIZ protein
CTD
PMID:34122009
NCBI chr 2:146,697,743...146,812,018
Ensembl chr 2:146,697,784...146,812,017
G
Klc1
kinesin light chain 1
decreases expression
EXP
Haloperidol results in decreased expression of KLC1 mRNA
CTD
PMID:18797397
NCBI chr12:111,724,869...111,774,278
Ensembl chr12:111,725,283...111,774,278
G
Klc4
kinesin light chain 4
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of KLC4 protein
CTD
PMID:34122009
NCBI chr17:46,941,550...46,957,115
Ensembl chr17:46,941,550...46,956,948
G
Klhdc2
kelch domain containing 2
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of KLHDC2 protein
CTD
PMID:34122009
NCBI chr12:69,343,455...69,357,461
Ensembl chr12:69,343,455...69,357,461
G
Kmt2a
lysine (K)-specific methyltransferase 2A
decreases expression
EXP
Haloperidol results in decreased expression of KMT2A mRNA
CTD
PMID:14647396
NCBI chr 9:44,714,652...44,793,492
Ensembl chr 9:44,714,652...44,792,594
G
Kpna4
karyopherin subunit alpha 4
increases expression
ISO
Haloperidol results in increased expression of KPNA4 protein
CTD
PMID:34122009
NCBI chr 3:68,979,554...69,034,425
Ensembl chr 3:68,974,482...69,034,446
G
Kras
Kirsten rat sarcoma viral oncogene homolog
increases expression
ISO
Haloperidol results in increased expression of KRAS mRNA
CTD
PMID:15860345
NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965
G
Kremen1
kringle containing transmembrane protein 1
multiple interactions increases expression
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of KREMEN1 protein Haloperidol results in increased expression of KREMEN1 protein
CTD
PMID:34122009
NCBI chr11:5,141,551...5,212,220
Ensembl chr11:5,141,552...5,211,558
G
Lamtor3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
increases expression
EXP
Haloperidol results in increased expression of LAMTOR3 mRNA
CTD
PMID:14647396
NCBI chr 3:137,624,316...137,634,523
Ensembl chr 3:137,624,267...137,634,661
G
Ldhb
lactate dehydrogenase B
decreases expression increases expression
EXP ISO
Haloperidol results in decreased expression of LDHB mRNA Haloperidol results in increased expression of LDHB mRNA
CTD
PMID:15860345 PMID:16465460
NCBI chr 6:142,435,975...142,453,683
Ensembl chr 6:142,435,975...142,453,683
G
Ldlr
low density lipoprotein receptor
increases expression
ISO
Haloperidol results in increased expression of LDLR mRNA
CTD
PMID:17052361
NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
G
Lgals1
lectin, galactose binding, soluble 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of LGALS1 protein
CTD
PMID:34122009
NCBI chr15:78,810,925...78,814,665
Ensembl chr15:78,810,925...78,814,665
G
Lipa
lysosomal acid lipase A
increases expression
ISO
Haloperidol results in increased expression of LIPA protein
CTD
PMID:34122009
NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874
G
Mag
myelin-associated glycoprotein
decreases expression
EXP
Haloperidol results in decreased expression of MAG mRNA
CTD
PMID:17177202
NCBI chr 7:30,598,600...30,614,347
Ensembl chr 7:30,598,601...30,614,298
G
Map1a
microtubule-associated protein 1 A
increases expression decreases expression
ISO
Haloperidol results in increased expression of MAP1A mRNA Haloperidol results in decreased expression of MAP1A protein
CTD
PMID:15860345 PMID:34122009
NCBI chr 2:121,119,608...121,141,313
Ensembl chr 2:121,120,081...121,141,313
G
Map2
microtubule-associated protein 2
increases expression
ISO
Haloperidol results in increased expression of MAP2 mRNA
CTD
PMID:15079866
NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742
G
Map2k1
mitogen-activated protein kinase kinase 1
decreases expression
ISO
Haloperidol results in decreased expression of MAP2K1 mRNA
CTD
PMID:15860345
NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
G
Map2k2
mitogen-activated protein kinase kinase 2
decreases expression increases expression
ISO EXP
Haloperidol results in decreased expression of MAP2K2 mRNA Haloperidol results in increased expression of MAP2K2 mRNA
CTD
PMID:14647396 PMID:15860345
NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809
G
Map2k5
mitogen-activated protein kinase kinase 5
decreases expression
ISO
Haloperidol results in decreased expression of MAP2K5 mRNA
CTD
PMID:15860345
NCBI chr 9:63,071,050...63,288,964
Ensembl chr 9:63,071,050...63,285,184
G
Map3k1
mitogen-activated protein kinase kinase kinase 1
increases expression
ISO
Haloperidol results in increased expression of MAP3K1 mRNA
CTD
PMID:15860345
NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527
G
Map3k12
mitogen-activated protein kinase kinase kinase 12
increases expression
ISO
Haloperidol results in increased expression of MAP3K12 mRNA
CTD
PMID:15860345
NCBI chr15:102,406,079...102,425,311
Ensembl chr15:102,406,081...102,425,499
G
Mapk1
mitogen-activated protein kinase 1
increases phosphorylation decreases expression multiple interactions
EXP ISO
Haloperidol results in increased phosphorylation of MAPK1 protein Haloperidol results in decreased expression of MAPK1 mRNA [potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]; Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]; CNR1 protein affects the reaction [[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]
CTD
PMID:12871586 PMID:15860345 PMID:28017790
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
G
Mapk14
mitogen-activated protein kinase 14
affects expression
ISO
Haloperidol affects the expression of MAPK14 mRNA
CTD
PMID:15860345
NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
G
Mapk3
mitogen-activated protein kinase 3
increases phosphorylation multiple interactions
EXP
Haloperidol results in increased phosphorylation of MAPK3 protein [potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]; Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]; CNR1 protein affects the reaction [[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]
CTD
PMID:12871586 PMID:28017790
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
G
Mapk6
mitogen-activated protein kinase 6
affects expression
ISO
Haloperidol affects the expression of MAPK6 mRNA
CTD
PMID:15860345
NCBI chr 9:75,294,064...75,317,303
Ensembl chr 9:75,276,344...75,317,287
G
Mapk8
mitogen-activated protein kinase 8
increases phosphorylation
ISO
Haloperidol results in increased phosphorylation of MAPK8 protein
CTD
PMID:17092607
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
G
Mapk9
mitogen-activated protein kinase 9
affects expression
ISO
Haloperidol affects the expression of MAPK9 mRNA
CTD
PMID:15860345
NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
G
Mapre1
microtubule-associated protein, RP/EB family, member 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of MAPRE1 protein
CTD
PMID:34122009
NCBI chr 2:153,583,131...153,615,237
Ensembl chr 2:153,583,194...153,615,230
G
Mas1
MAS1 oncogene
decreases expression
ISO
Haloperidol results in decreased expression of MAS1 mRNA
CTD
PMID:16715494
NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030
G
Mbp
myelin basic protein
decreases expression
EXP
Haloperidol results in decreased expression of MBP mRNA
CTD
PMID:17177202
NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
G
Mcam
melanoma cell adhesion molecule
increases expression
ISO
Haloperidol results in increased expression of MCAM protein
CTD
PMID:34122009
NCBI chr 9:44,045,958...44,054,024
Ensembl chr 9:44,045,766...44,054,024
G
Mchr1
melanin-concentrating hormone receptor 1
affects binding
ISO
Haloperidol binds to MCHR1 protein
CTD
PMID:16983399
NCBI chr15:81,119,700...81,123,165
Ensembl chr15:81,119,700...81,123,165
G
Mmp10
matrix metallopeptidase 10
decreases expression
ISO
Haloperidol results in decreased expression of MMP10 protein
CTD
PMID:34122009
NCBI chr 9:7,502,343...7,510,243
Ensembl chr 9:7,502,353...7,510,241
G
Mog
myelin oligodendrocyte glycoprotein
decreases expression
EXP
Haloperidol results in decreased expression of MOG mRNA
CTD
PMID:17177202
NCBI chr17:37,321,632...37,334,290
Ensembl chr17:37,321,635...37,334,290
G
Mrps31
mitochondrial ribosomal protein S31
increases expression
ISO
Haloperidol results in increased expression of MRPS31 protein
CTD
PMID:34122009
NCBI chr 8:22,901,356...22,919,685
Ensembl chr 8:22,901,377...22,919,681
G
Myadm
myeloid-associated differentiation marker
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of MYADM protein
CTD
PMID:34122009
NCBI chr 7:3,337,563...3,347,871
Ensembl chr 7:3,337,605...3,348,958
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Myo5b
myosin VB
decreases expression
ISO
Haloperidol results in decreased expression of MYO5B protein
CTD
PMID:34122009
NCBI chr18:74,575,435...74,905,769
Ensembl chr18:74,574,007...74,904,564
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Nap1l3
nucleosome assembly protein 1-like 3
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of NAP1L3 protein
CTD
PMID:34122009
NCBI chr X:121,304,257...121,307,082
Ensembl chr X:121,304,262...121,307,098
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Ncan
neurocan
decreases expression
EXP
Haloperidol results in decreased expression of NCAN mRNA
CTD
PMID:18797397
NCBI chr 8:70,545,735...70,573,494
Ensembl chr 8:70,545,735...70,573,523
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Ncaph
non-SMC condensin I complex, subunit H
decreases expression
ISO
Haloperidol results in decreased expression of NCAPH protein
CTD
PMID:34122009
NCBI chr 2:126,945,729...126,975,857
Ensembl chr 2:126,945,729...126,975,874
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Ncl
nucleolin
increases expression
EXP
Haloperidol results in increased expression of NCL mRNA
CTD
PMID:14647396
NCBI chr 1:86,272,441...86,287,177
Ensembl chr 1:86,272,441...86,287,122
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Ndufv1
NADH:ubiquinone oxidoreductase core subunit V1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of NDUFV1 protein
CTD
PMID:34122009
NCBI chr19:4,057,499...4,062,755
Ensembl chr19:4,057,384...4,062,806
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Nedd4
neural precursor cell expressed, developmentally down-regulated 4
decreases expression
EXP
Haloperidol results in decreased expression of NEDD4 mRNA
CTD
PMID:18797397
NCBI chr 9:72,569,613...72,657,133
Ensembl chr 9:72,569,628...72,657,134
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Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
decreases expression
ISO
Haloperidol results in decreased expression of NFKB1 protein
CTD
PMID:16500086
NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
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Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
decreases expression
ISO
Haloperidol results in decreased expression of NGFR mRNA
CTD
PMID:16513140
NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561
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Nifk
nucleolar protein interacting with the FHA domain of MKI67
decreases expression
ISO
Haloperidol results in decreased expression of NIFK protein
CTD
PMID:34122009
NCBI chr 1:118,249,573...118,261,561
Ensembl chr 1:118,249,569...118,261,552
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Nop14
NOP14 nucleolar protein
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of NOP14 protein
CTD
PMID:34122009
NCBI chr 5:34,795,880...34,817,566
Ensembl chr 5:34,795,880...34,817,492
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Nop53
NOP53 ribosome biogenesis factor
increases expression
EXP
Haloperidol results in increased expression of NOP53 mRNA
CTD
PMID:14647396
NCBI chr 7:15,671,760...15,680,033
Ensembl chr 7:15,670,108...15,679,999
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Nos2
nitric oxide synthase 2, inducible
multiple interactions increases expression
EXP
Cannabidiol inhibits the reaction [Haloperidol results in increased expression of NOS2 mRNA]
CTD
PMID:30217539
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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Nppa
natriuretic peptide type A
affects activity
ISO
Haloperidol affects the activity of NPPA protein modified form
CTD
PMID:1363893
NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536
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Nptx2
neuronal pentraxin 2
decreases expression
ISO
Haloperidol results in decreased expression of NPTX2 mRNA
CTD
PMID:18208916
NCBI chr 5:144,482,697...144,494,288
Ensembl chr 5:144,482,712...144,494,288
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Npy
neuropeptide Y
multiple interactions increases expression decreases expression
ISO
Haloperidol promotes the reaction [Amphetamine results in decreased expression of NPY protein] Haloperidol results in increased expression of NPY protein Haloperidol results in decreased expression of NPY mRNA
CTD
PMID:7644023 PMID:15985714 PMID:16516965
NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487
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Nqo1
NAD(P)H dehydrogenase, quinone 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of NQO1 protein
CTD
PMID:34122009
NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Haloperidol results in increased expression of NR0B2 mRNA
CTD
PMID:17175557
NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
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Nr1d1
nuclear receptor subfamily 1, group D, member 1
increases expression
ISO
Haloperidol results in increased expression of NR1D1 mRNA
CTD
PMID:11564422
NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
affects response to substance multiple interactions increases expression decreases expression
EXP ISO
NR4A1 affects the susceptibility to Haloperidol 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of NR4A1 mRNA] Haloperidol results in decreased expression of NR4A1 mRNA
CTD
PMID:10987852 PMID:11564422 PMID:14603264 PMID:19695244
NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676
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Nr4a3
nuclear receptor subfamily 4, group A, member 3
increases expression
ISO
Haloperidol results in increased expression of NR4A3 mRNA
CTD
PMID:19695244
NCBI chr 4:48,045,098...48,086,446
Ensembl chr 4:48,045,153...48,086,447
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Nrg1
neuregulin 1
increases expression
ISO
Haloperidol results in increased expression of NRG1 protein
CTD
PMID:18184445 PMID:26961615
NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825 Ensembl chr 8:32,304,579...33,374,825
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Nsf
N-ethylmaleimide sensitive fusion protein
decreases expression
ISO
Haloperidol results in decreased expression of NSF mRNA Haloperidol results in decreased expression of NSF protein
CTD
PMID:15860345 PMID:34122009
NCBI chr11:103,712,608...103,844,882
Ensembl chr11:103,712,608...103,844,882
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Nts
neurotensin
multiple interactions increases expression
EXP ISO
SLC6A3 protein promotes the reaction [Haloperidol results in increased expression of NTS mRNA] Haloperidol results in increased expression of NTS mRNA; Haloperidol results in increased expression of NTS protein 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]; Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]
CTD
PMID:10199625 PMID:11120399 PMID:11602683 PMID:12887421 PMID:14603264 PMID:14698760 More...
NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347
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Numbl
numb-like
decreases expression
EXP
Haloperidol results in decreased expression of NUMBL mRNA
CTD
PMID:18797397
NCBI chr 7:26,957,884...26,981,570
Ensembl chr 7:26,957,858...26,981,569
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Nup54
nucleoporin 54
decreases expression
ISO
Haloperidol results in decreased expression of NUP54 protein
CTD
PMID:34122009
NCBI chr 5:92,563,399...92,583,117
Ensembl chr 5:92,563,399...92,583,078
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Nupr1
nuclear protein transcription regulator 1
increases expression
ISO
Haloperidol results in increased expression of NUPR1 mRNA
CTD
PMID:17175557
NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033
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Oat
ornithine aminotransferase
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of OAT protein
CTD
PMID:34122009
NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127
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Oprl1
opioid receptor-like 1
affects response to substance
EXP
OPRL1 affects the susceptibility to Haloperidol
CTD
PMID:16237164
NCBI chr 2:181,356,585...181,362,778
Ensembl chr 2:181,356,809...181,362,778
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Oprm1
opioid receptor, mu 1
multiple interactions
EXP
OPRM1 protein inhibits the reaction [Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]]
CTD
PMID:20184921
NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198
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Osbpl8
oxysterol binding protein-like 8
increases expression
EXP
Haloperidol results in increased expression of OSBPL8 mRNA
CTD
PMID:14647396
NCBI chr10:111,000,663...111,133,110
Ensembl chr10:111,000,613...111,133,110
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Park7
Parkinson disease (autosomal recessive, early onset) 7
increases expression
EXP
Haloperidol results in increased expression of PARK7 mRNA
CTD
PMID:14647396
NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894
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Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
decreases expression
ISO
Haloperidol results in decreased expression of PCMT1 protein
CTD
PMID:34122009
NCBI chr10:7,503,608...7,556,922
Ensembl chr10:7,505,137...7,556,900
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Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
increases expression
EXP
Haloperidol results in increased expression of PCSK1N mRNA
CTD
PMID:14647396
NCBI chr X:7,786,061...7,790,649
Ensembl chr X:7,786,061...7,790,649
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Pde10a
phosphodiesterase 10A
increases expression
ISO
Haloperidol results in increased expression of PDE10A mRNA; Haloperidol results in increased expression of PDE10A protein
CTD
PMID:18222493
NCBI chr17:8,742,719...9,205,480
Ensembl chr17:8,744,204...9,205,480
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Pde1b
phosphodiesterase 1B, Ca2+-calmodulin dependent
increases expression
ISO EXP
Haloperidol results in increased expression of PDE1B mRNA; Haloperidol results in increased expression of PDE1B protein
CTD
PMID:14647396 PMID:18222493
NCBI chr15:103,411,461...103,438,483
Ensembl chr15:103,411,461...103,438,479
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Pde4a
phosphodiesterase 4A, cAMP specific
decreases expression
ISO
Haloperidol results in decreased expression of PDE4A protein
CTD
PMID:20222156
NCBI chr 9:21,076,998...21,124,544
Ensembl chr 9:21,077,010...21,124,544
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Pde5a
phosphodiesterase 5A, cGMP-specific
multiple interactions
ISO
Haloperidol inhibits the reaction [potassium bromate results in increased activity of PDE5A protein]
CTD
PMID:37865952
NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023
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Pdlim5
PDZ and LIM domain 5
decreases expression
ISO
Haloperidol results in decreased expression of PDLIM5 protein
CTD
PMID:34122009
NCBI chr 3:141,945,346...142,101,480
Ensembl chr 3:141,945,351...142,101,454
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Pdyn
prodynorphin
multiple interactions
ISO
[1-aminocyclopentane-1,2,4-tricarboxylic acid co-treated with Haloperidol] results in increased expression of PDYN mRNA
CTD
PMID:17224239
NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764
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Pdzrn3
PDZ domain containing RING finger 3
decreases expression
ISO
Haloperidol results in decreased expression of PDZRN3 protein
CTD
PMID:34122009
NCBI chr 6:101,126,568...101,354,858
Ensembl chr 6:101,126,570...101,354,858
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Penk
preproenkephalin
multiple interactions increases expression
EXP ISO
3,4-dicarboxyphenylglycine promotes the reaction [Haloperidol results in increased expression of PENK mRNA]; Docosahexaenoic Acids inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; Tretinoin inhibits the reaction [Haloperidol results in increased expression of PENK mRNA] Haloperidol results in increased expression of PENK mRNA; Haloperidol results in increased expression of PENK protein 1-aminocyclopentane-1,2,4-tricarboxylic acid inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; 1-aminoindan-1,5-dicarboxylic acid inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; 2-(2,3-dicarboxycyclopropyl)glycine promotes the reaction [Haloperidol results in increased expression of PENK mRNA]; 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; Memantine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]
CTD
PMID:3838946 PMID:7637876 PMID:12373537 PMID:12727308 PMID:12834887 PMID:12887421 PMID:14603264 PMID:14642644 PMID:15215559 PMID:17224239 More...
NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819
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Per1
period circadian clock 1
increases expression
ISO
Haloperidol results in increased expression of PER1 mRNA
CTD
PMID:27746588
NCBI chr11:68,985,934...69,000,791
Ensembl chr11:68,986,043...69,000,786
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Pfdn5
prefoldin 5
increases expression
EXP
Haloperidol results in increased expression of PFDN5 mRNA
CTD
PMID:14647396
NCBI chr15:102,234,551...102,239,925
Ensembl chr15:102,234,551...102,240,308
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Pfkp
phosphofructokinase, platelet
increases expression multiple interactions
ISO
Haloperidol results in increased expression of PFKP mRNA [Cuprizone co-treated with Haloperidol] results in increased expression of PFKP protein
CTD
PMID:15860345 PMID:34122009
NCBI chr13:6,629,910...6,699,096
Ensembl chr13:6,629,804...6,698,813
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Pfn1
profilin 1
increases expression
ISO
Haloperidol results in increased expression of PFN1 protein
CTD
PMID:34122009
NCBI chr11:70,542,670...70,547,625
Ensembl chr11:70,542,676...70,545,470
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Pgk1
phosphoglycerate kinase 1
increases expression
ISO
Haloperidol results in increased expression of PGK1 mRNA
CTD
PMID:15860345
NCBI chr X:105,230,706...105,247,305
Ensembl chr X:105,230,706...105,247,305
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Phactr1
phosphatase and actin regulator 1
increases expression
EXP
Haloperidol results in increased expression of PHACTR1 mRNA
CTD
PMID:14647396
NCBI chr13:42,833,909...43,292,002
Ensembl chr13:42,834,099...43,292,002
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Picalm
phosphatidylinositol binding clathrin assembly protein
decreases expression
ISO
Haloperidol results in decreased expression of PICALM mRNA
CTD
PMID:15860345
NCBI chr 7:89,778,711...89,858,655
Ensembl chr 7:89,779,421...89,862,673
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Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
decreases expression
ISO
Haloperidol results in decreased expression of PIK3R3 mRNA
CTD
PMID:16715494
NCBI chr 4:116,078,593...116,160,253
Ensembl chr 4:116,078,815...116,160,253 Ensembl chr 4:116,078,815...116,160,253
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Pkib
protein kinase inhibitor beta, cAMP dependent, testis specific
decreases expression
ISO
Haloperidol results in decreased expression of PKIB mRNA
CTD
PMID:15860345
NCBI chr10:57,508,077...57,617,208
Ensembl chr10:57,508,077...57,617,208
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Pkm
pyruvate kinase, muscle
increases expression
ISO
Haloperidol results in increased expression of PKM mRNA
CTD
PMID:15860345
NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658
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Plp1
proteolipid protein (myelin) 1
decreases expression
EXP
Haloperidol results in decreased expression of PLP1 mRNA
CTD
PMID:17177202 PMID:18797397
NCBI chr X:135,720,897...135,739,331
Ensembl chr X:135,723,420...135,740,482
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Plpbp
pyridoxal phosphate binding protein
increases expression
ISO
Haloperidol results in increased expression of PLPBP protein
CTD
PMID:34122009
NCBI chr 8:27,530,801...27,546,160
Ensembl chr 8:27,532,583...27,546,160
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Pls3
plastin 3 (T-isoform)
decreases expression
ISO
Haloperidol results in decreased expression of PLS3 protein
CTD
PMID:34122009
NCBI chr X:74,829,259...74,918,788
Ensembl chr X:74,829,260...74,918,788
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Pmpca
peptidase (mitochondrial processing) alpha
increases expression
ISO
Haloperidol results in increased expression of PMPCA protein
CTD
PMID:34122009
NCBI chr 2:26,275,554...26,287,134
Ensembl chr 2:26,279,351...26,287,134
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Ppa1
pyrophosphatase (inorganic) 1
increases expression
ISO
Haloperidol results in increased expression of PPA1 protein
CTD
PMID:34122009
NCBI chr10:61,484,400...61,509,944
Ensembl chr10:61,484,331...61,509,947
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Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
multiple interactions
EXP
[Cannabidiol co-treated with Haloperidol] results in increased expression of PPARGC1A protein
CTD
PMID:30217539
NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
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Ppm1a
protein phosphatase 1A, magnesium dependent, alpha isoform
decreases expression
ISO
Haloperidol results in decreased expression of PPM1A mRNA
CTD
PMID:15860345
NCBI chr12:72,804,231...72,846,593
Ensembl chr12:72,804,229...72,846,593
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Ppm1b
protein phosphatase 1B, magnesium dependent, beta isoform
decreases expression
ISO
Haloperidol results in decreased expression of PPM1B mRNA
CTD
PMID:15860345
NCBI chr17:85,264,169...85,331,420
Ensembl chr17:85,264,169...85,331,419
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Ppm1f
protein phosphatase 1F (PP2C domain containing)
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of PPM1F protein
CTD
PMID:34122009
NCBI chr16:16,714,314...16,745,239
Ensembl chr16:16,714,333...16,745,228
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Ppp1cb
protein phosphatase 1 catalytic subunit beta
decreases expression
ISO
Haloperidol results in decreased expression of PPP1CB mRNA
CTD
PMID:15860345
NCBI chr 5:32,616,192...32,651,057
Ensembl chr 5:32,616,187...32,674,777
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Ppp1cc
protein phosphatase 1 catalytic subunit gamma
decreases expression
ISO
Haloperidol results in decreased expression of PPP1CC mRNA
CTD
PMID:15860345
NCBI chr 5:122,296,338...122,313,336
Ensembl chr 5:122,296,341...122,313,336
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Ppp1r14b
protein phosphatase 1, regulatory inhibitor subunit 14B
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of PPP1R14B protein
CTD
PMID:34122009
NCBI chr19:6,952,416...6,954,692
Ensembl chr19:6,952,336...6,954,692
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Ppp1r1a
protein phosphatase 1, regulatory inhibitor subunit 1A
decreases expression
ISO
Haloperidol results in decreased expression of PPP1R1A mRNA
CTD
PMID:15860345
NCBI chr15:103,438,706...103,446,465
Ensembl chr15:103,438,706...103,446,430
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Ppp1r1b
protein phosphatase 1, regulatory inhibitor subunit 1B
increases phosphorylation
EXP
Haloperidol results in increased phosphorylation of PPP1R1B protein
CTD
PMID:12871586
NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622
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Ppp1r2
protein phosphatase 1, regulatory inhibitor subunit 2
decreases expression
ISO
Haloperidol results in decreased expression of PPP1R2 mRNA
CTD
PMID:15860345
NCBI chr16:31,070,359...31,094,095
Ensembl chr16:31,070,355...31,094,095
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Ppp1r9b
protein phosphatase 1, regulatory subunit 9B
decreases expression
ISO
Haloperidol results in decreased expression of PPP1R9B protein
CTD
PMID:16844384
NCBI chr11:94,882,038...94,897,724
Ensembl chr11:94,881,861...94,897,725
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Ppp2ca
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
decreases expression
ISO
Haloperidol results in decreased expression of PPP2CA mRNA
CTD
PMID:15860345
NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605
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Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
decreases expression
ISO
Haloperidol results in decreased expression of PPP2CB mRNA
CTD
PMID:15860345
NCBI chr 8:34,089,672...34,109,831
Ensembl chr 8:34,089,653...34,109,469
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Ppp2r1a
protein phosphatase 2, regulatory subunit A, alpha
increases expression
ISO
Haloperidol results in increased expression of PPP2R1A mRNA
CTD
PMID:15860345
NCBI chr17:21,165,716...21,186,167
Ensembl chr17:21,165,573...21,186,178
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Ppp2r2a
protein phosphatase 2, regulatory subunit B, alpha
decreases expression
ISO
Haloperidol results in decreased expression of PPP2R2A mRNA
CTD
PMID:15860345
NCBI chr14:67,251,505...67,309,920
Ensembl chr14:67,251,505...67,309,893
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Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
multiple interactions decreases expression
ISO
[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein Haloperidol results in decreased expression of PPP3CA mRNA; Haloperidol results in decreased expression of PPP3CA protein
CTD
PMID:16033416
NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488
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Ppp5c
protein phosphatase 5, catalytic subunit
decreases expression multiple interactions
EXP ISO
Haloperidol results in decreased expression of PPP5C mRNA [Cuprizone co-treated with Haloperidol] results in decreased expression of PPP5C protein
CTD
PMID:14647396 PMID:34122009
NCBI chr 7:16,738,575...16,761,812
Ensembl chr 7:16,738,565...16,761,849
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Prkaca
protein kinase, cAMP dependent, catalytic, alpha
increases expression
ISO
Haloperidol results in increased expression of PRKACA mRNA; Haloperidol results in increased expression of PRKACA protein
CTD
PMID:15860345 PMID:26894264
NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072
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Prkacb
protein kinase, cAMP dependent, catalytic, beta
increases expression
ISO
Haloperidol results in increased expression of PRKACB mRNA
CTD
PMID:15860345
NCBI chr 3:146,435,334...146,518,691
Ensembl chr 3:146,435,329...146,518,745
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Prkar2a
protein kinase, cAMP dependent regulatory, type II alpha
multiple interactions increases expression
ISO
Haloperidol promotes the reaction [Cyclic AMP binds to PRKAR2A protein] [Cuprizone co-treated with Haloperidol] results in decreased expression of PRKAR2A protein Haloperidol results in increased expression of PRKAR2A mRNA; Haloperidol results in increased expression of PRKAR2A protein
CTD
PMID:11907174 PMID:34122009
NCBI chr 9:108,569,342...108,627,643
Ensembl chr 9:108,566,513...108,627,635
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Prkar2b
protein kinase, cAMP dependent regulatory, type II beta
multiple interactions increases expression decreases expression
ISO
Haloperidol promotes the reaction [Cyclic AMP binds to PRKAR2B protein] Haloperidol results in increased expression of PRKAR2B mRNA; Haloperidol results in increased expression of PRKAR2B protein Haloperidol results in decreased expression of PRKAR2B mRNA
CTD
PMID:11907174 PMID:15860345
NCBI chr12:32,008,468...32,111,639
Ensembl chr12:32,008,475...32,111,295
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Prkcb
protein kinase C, beta
multiple interactions increases expression
ISO
[Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB protein Haloperidol results in increased expression of PRKCB mRNA
CTD
PMID:15860345 PMID:15967061
NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625
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Prkce
protein kinase C, epsilon
increases expression
ISO
Haloperidol results in increased expression of PRKCE mRNA
CTD
PMID:15860345
NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347
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Prkcsh
protein kinase C substrate 80K-H
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of PRKCSH protein
CTD
PMID:34122009
NCBI chr 9:21,914,314...21,925,521
Ensembl chr 9:21,914,102...21,925,518
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Prkcz
protein kinase C, zeta
increases expression
ISO
Haloperidol results in increased expression of PRKCZ mRNA
CTD
PMID:15860345
NCBI chr 4:155,344,579...155,445,856
Ensembl chr 4:155,344,586...155,445,818
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Prl
prolactin
affects expression increases secretion multiple interactions increases expression
ISO
Haloperidol affects the expression of PRL protein Haloperidol results in increased secretion of PRL protein Haloperidol inhibits the reaction [Aripiprazole results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [cabergoline results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Dopamine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [talipexole results in decreased secretion of PRL protein]; LHRH, N-acetyl-(4-chlorophenylalanyl)(1)-(4-chlorophenylalanyl)(2)-tryptophyl(3)-arginyl(6)-alanine(10)- inhibits the reaction [Haloperidol results in increased expression of PRL protein]; Triptorelin Pamoate inhibits the reaction [Haloperidol results in increased expression of PRL protein]
CTD
PMID:1304992 PMID:1380082 PMID:2136057 PMID:3019639 PMID:3158510 PMID:3883215 PMID:3906589 PMID:7018927 PMID:7214106 PMID:7348089 PMID:7670571 PMID:8613910 PMID:8915564 PMID:9090331 PMID:9128918 PMID:9265911 PMID:9265916 PMID:9376336 PMID:9572212 PMID:10661492 PMID:11048906 PMID:11071396 PMID:11997696 PMID:15289996 PMID:15638391 PMID:16282852 PMID:18521575 More...
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
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Prpf19
pre-mRNA processing factor 19
increases expression
ISO
Haloperidol results in increased expression of PRPF19 protein
CTD
PMID:34122009
NCBI chr19:10,872,595...10,886,923
Ensembl chr19:10,872,595...10,886,923
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Prpf38b
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
decreases expression
EXP
Haloperidol results in decreased expression of PRPF38B mRNA
CTD
PMID:14647396
NCBI chr 3:108,810,121...108,819,055
Ensembl chr 3:108,810,121...108,819,043
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Prrc2a
proline-rich coiled-coil 2A
decreases expression
EXP
Haloperidol results in decreased expression of PRRC2A mRNA
CTD
PMID:18797397
NCBI chr17:35,368,052...35,384,877
Ensembl chr17:35,368,052...35,383,873
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Prxl2a
peroxiredoxin like 2A
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of PRXL2A protein
CTD
PMID:34122009
NCBI chr14:40,715,692...40,735,790
Ensembl chr14:40,715,697...40,735,745
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Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
decreases expression
ISO
Haloperidol results in decreased expression of PSMB9 mRNA
CTD
PMID:16452686
NCBI chr17:34,401,006...34,406,347
Ensembl chr17:34,400,961...34,406,738
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Psmd12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of PSMD12 protein
CTD
PMID:34122009
NCBI chr11:107,370,354...107,388,862
Ensembl chr11:107,370,310...107,395,188
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
EXP
Haloperidol results in increased expression of PTGS2 mRNA
CTD
PMID:30217539
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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Ptma
prothymosin alpha
increases expression
ISO
Haloperidol results in increased expression of PTMA protein
CTD
PMID:34122009
NCBI chr 1:86,454,442...86,458,434
Ensembl chr 1:86,454,448...86,458,434
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Ptms
parathymosin
increases expression
EXP
Haloperidol results in increased expression of PTMS mRNA
CTD
PMID:14647396
NCBI chr 6:124,890,638...124,894,909
Ensembl chr 6:124,890,644...124,897,066
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Pura
purine rich element binding protein A
increases expression
ISO
Haloperidol results in increased expression of PURA protein
CTD
PMID:34122009
NCBI chr18:36,413,614...36,434,575
Ensembl chr18:36,414,150...36,425,588
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Purb
purine rich element binding protein B
decreases expression
ISO
Haloperidol results in decreased expression of PURB protein
CTD
PMID:34122009
NCBI chr11:6,417,599...6,426,076
Ensembl chr11:6,417,599...6,425,917
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Pvalb
parvalbumin
multiple interactions
ISO
Haloperidol inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA]
CTD
PMID:12589379
NCBI chr15:78,075,312...78,090,600
Ensembl chr15:78,075,314...78,090,600
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Pycr1
pyrroline-5-carboxylate reductase 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of PYCR1 protein
CTD
PMID:34122009
NCBI chr11:120,527,591...120,534,602
Ensembl chr11:120,526,538...120,534,595
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Pygm
muscle glycogen phosphorylase
decreases expression
ISO
Haloperidol results in decreased expression of PYGM protein
CTD
PMID:34122009
NCBI chr19:6,434,438...6,448,494
Ensembl chr19:6,434,429...6,448,489
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Qki
quaking, KH domain containing RNA binding
increases expression
ISO
Haloperidol results in increased expression of QKI mRNA alternative form
CTD
PMID:19335891
NCBI chr17:10,425,480...10,538,706
Ensembl chr17:10,421,530...10,538,783
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Rab10
RAB10, member RAS oncogene family
increases expression
ISO
Haloperidol results in increased expression of RAB10 mRNA
CTD
PMID:15860345
NCBI chr12:3,297,428...3,359,969
Ensembl chr12:3,297,428...3,359,969
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Rab11a
RAB11A, member RAS oncogene family
increases expression
ISO
Haloperidol results in increased expression of RAB11A mRNA
CTD
PMID:15860345
NCBI chr 9:64,622,582...64,645,038
Ensembl chr 9:64,622,581...64,645,040
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Rab12
RAB12, member RAS oncogene family
increases expression
ISO
Haloperidol results in increased expression of RAB12 mRNA
CTD
PMID:12437575
NCBI chr17:66,801,507...66,826,712
Ensembl chr17:66,801,507...66,826,724
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Rab28
RAB28, member RAS oncogene family
increases expression
ISO
Haloperidol results in increased expression of RAB28 mRNA
CTD
PMID:15860345
NCBI chr 5:41,782,316...41,865,535
Ensembl chr 5:41,782,319...41,865,500
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Rab4a
RAB4A, member RAS oncogene family
decreases expression
ISO
Haloperidol results in decreased expression of RAB4A mRNA
CTD
PMID:15860345
NCBI chr 8:124,532,748...124,562,030
Ensembl chr 8:124,532,724...124,562,026
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Rab5a
RAB5A, member RAS oncogene family
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RAB5A protein
CTD
PMID:34122009
NCBI chr17:53,786,262...53,814,706
Ensembl chr17:53,786,262...53,814,708
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Rab6a
RAB6A, member RAS oncogene family
increases expression
ISO
Haloperidol results in increased expression of RAB6A mRNA
CTD
PMID:15860345
NCBI chr 7:100,256,778...100,290,475
Ensembl chr 7:100,256,617...100,290,475
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Rab7
RAB7, member RAS oncogene family
decreases expression
ISO
Haloperidol results in decreased expression of RAB7A mRNA
CTD
PMID:15860345
NCBI chr 6:87,976,088...88,022,252
Ensembl chr 6:87,976,088...88,022,252
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Rab8a
RAB8A, member RAS oncogene family
decreases expression
ISO
Haloperidol results in decreased expression of RAB8A mRNA
CTD
PMID:15860345
NCBI chr 8:72,915,044...72,935,210
Ensembl chr 8:72,915,044...72,937,748
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Rac1
Rac family small GTPase 1
increases expression
ISO
Haloperidol results in increased expression of RAC1 mRNA
CTD
PMID:15860345
NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791
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Rala
v-ral simian leukemia viral oncogene A (ras related)
increases expression
ISO
Haloperidol results in increased expression of RALA mRNA
CTD
PMID:15860345
NCBI chr13:18,055,160...18,118,802
Ensembl chr13:18,055,156...18,118,824
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Ralb
v-ral simian leukemia viral oncogene B
increases expression
ISO
Haloperidol results in increased expression of RALB mRNA
CTD
PMID:15860345
NCBI chr 1:119,398,035...119,432,512
Ensembl chr 1:119,398,035...119,432,524
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Ranbp3
RAN binding protein 3
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of RANBP3 protein
CTD
PMID:34122009
NCBI chr17:56,980,225...57,018,769
Ensembl chr17:56,980,294...57,018,764
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Rap1b
RAS related protein 1b
increases expression
ISO
Haloperidol results in increased expression of RAP1B mRNA
CTD
PMID:15860345
NCBI chr10:117,650,502...117,681,879
Ensembl chr10:117,649,776...117,681,940
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Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
decreases expression
EXP
Haloperidol results in decreased expression of RAPGEF4 mRNA
CTD
PMID:18797397
NCBI chr 2:71,811,559...72,087,818
Ensembl chr 2:71,811,584...72,087,818
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Rarb
retinoic acid receptor, beta
increases expression
ISO
Haloperidol results in increased expression of RARB mRNA alternative form
CTD
PMID:11564422
NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924
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Rasgrf1
RAS protein-specific guanine nucleotide-releasing factor 1
affects localization
ISO
Haloperidol affects the localization of RASGRF1 protein
CTD
PMID:17092607
NCBI chr 9:89,791,565...89,909,032
Ensembl chr 9:89,791,961...89,909,030
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Rasgrp1
RAS guanyl releasing protein 1
decreases expression
ISO
Haloperidol results in decreased expression of RASGRP1 mRNA
CTD
PMID:15860345
NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482
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Rcn1
reticulocalbin 1
multiple interactions decreases expression
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RCN1 protein Haloperidol results in decreased expression of RCN1 protein
CTD
PMID:34122009
NCBI chr 2:105,216,293...105,229,664
Ensembl chr 2:105,216,636...105,229,664
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Rdh11
retinol dehydrogenase 11
decreases expression
ISO
Haloperidol results in decreased expression of RDH11 protein
CTD
PMID:34122009
NCBI chr12:79,221,007...79,238,629
Ensembl chr12:79,221,111...79,239,067
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Rdx
radixin
decreases expression
ISO
Haloperidol results in decreased expression of RDX protein
CTD
PMID:34122009
NCBI chr 9:51,958,450...52,000,038
Ensembl chr 9:51,958,473...52,011,763
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Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
increases expression
ISO
Haloperidol results in increased expression of RELA protein
CTD
PMID:18554768 PMID:18590723
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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Reln
reelin
decreases expression
ISO
Haloperidol results in decreased expression of RELN mRNA; Haloperidol results in decreased expression of RELN protein
CTD
PMID:19359144
NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700
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Rgs2
regulator of G-protein signaling 2
increases expression
ISO
Haloperidol results in increased expression of RGS2 mRNA
CTD
PMID:11409749 PMID:11516571
NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899
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Rgs4
regulator of G-protein signaling 4
increases expression
ISO
Haloperidol results in increased expression of RGS4 mRNA
CTD
PMID:15860345
NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211
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Rgs8
regulator of G-protein signaling 8
increases expression
ISO
Haloperidol results in increased expression of RGS8 mRNA
CTD
PMID:15860345
NCBI chr 1:153,528,612...153,573,415
Ensembl chr 1:153,528,771...153,576,069
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Rgs9
regulator of G-protein signaling 9
affects response to substance
EXP
RGS9 affects the susceptibility to Haloperidol
CTD
PMID:15728856
NCBI chr11:109,116,174...109,189,013
Ensembl chr11:109,116,181...109,188,955
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Rhoa
ras homolog family member A
decreases expression
ISO
Haloperidol results in decreased expression of RHOA mRNA
CTD
PMID:15860345
NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
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Rims1
regulating synaptic membrane exocytosis 1
decreases expression
ISO
Haloperidol results in decreased expression of RIMS1 mRNA
CTD
PMID:15860345
NCBI chr 1:22,356,196...22,845,239
Ensembl chr 1:22,356,475...22,845,203
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Rorb
RAR-related orphan receptor beta
decreases expression
ISO
Haloperidol results in decreased expression of RORB mRNA
CTD
PMID:11564422
NCBI chr19:18,907,966...19,088,560
Ensembl chr19:18,907,969...19,088,560
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Rpl13
ribosomal protein L13
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RPL13 protein
CTD
PMID:34122009
NCBI chr 8:123,829,089...123,831,983
Ensembl chr 8:123,829,089...123,831,983
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Rpl18a
ribosomal protein L18A
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RPL18A protein
CTD
PMID:34122009
NCBI chr 8:71,347,366...71,350,087
Ensembl chr 8:71,347,366...71,350,056
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Rpl19
ribosomal protein L19
decreases expression multiple interactions
ISO
Haloperidol results in decreased expression of RPL19 protein [Cuprizone co-treated with Haloperidol] results in increased expression of RPL19 protein
CTD
PMID:34122009
NCBI chr11:97,912,829...97,921,319
Ensembl chr11:97,917,536...97,921,318
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Rpl30
ribosomal protein L30
increases expression
ISO
Haloperidol results in increased expression of RPL30 protein
CTD
PMID:34122009
NCBI chr15:34,440,649...34,443,405
Ensembl chr15:34,440,651...34,443,786
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Rpl6
ribosomal protein L6
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RPL6 protein
CTD
PMID:34122009
NCBI chr 5:121,342,564...121,347,304
Ensembl chr 5:121,342,544...121,347,304
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Rpl8
ribosomal protein L8
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RPL8 protein
CTD
PMID:34122009
NCBI chr15:76,788,271...76,790,518
Ensembl chr15:76,788,278...76,790,514
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Rplp2
ribosomal protein lateral stalk subunit P2
increases expression
EXP
Haloperidol results in increased expression of RPLP2 mRNA
CTD
PMID:14647396
NCBI chr 7:141,027,564...141,031,272
Ensembl chr 7:141,027,283...141,031,498
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Rps10
ribosomal protein S10
increases expression
EXP
Haloperidol results in increased expression of RPS10 mRNA
CTD
PMID:14647396
NCBI chr17:27,849,389...27,854,218
Ensembl chr17:27,849,392...27,855,643
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Rps16
ribosomal protein S16
decreases expression
ISO
Haloperidol results in decreased expression of RPS16 protein
CTD
PMID:34122009
NCBI chr 7:28,050,114...28,052,123
Ensembl chr 7:28,050,077...28,052,580
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Rps27
ribosomal protein S27
increases expression
ISO
Haloperidol results in increased expression of RPS27 protein
CTD
PMID:34122009
NCBI chr 3:90,119,974...90,120,955
Ensembl chr 3:90,119,829...90,120,958
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Rps27a
ribosomal protein S27A
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RPS27A protein
CTD
PMID:34122009
NCBI chr11:29,495,842...29,498,040
Ensembl chr11:29,495,846...29,498,109
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Rps9
ribosomal protein S9
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RPS9 protein
CTD
PMID:34122009
NCBI chr 7:3,707,035...3,709,896
Ensembl chr 7:3,706,992...3,709,896
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Rrad
Ras-related associated with diabetes
increases expression
ISO
Haloperidol results in increased expression of RRAD mRNA
CTD
PMID:15860345
NCBI chr 8:105,354,702...105,357,921
Ensembl chr 8:105,354,702...105,357,959
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Rrbp1
ribosome binding protein 1
decreases expression
ISO
Haloperidol results in decreased expression of RRBP1 protein
CTD
PMID:34122009
NCBI chr 2:143,789,315...143,853,216
Ensembl chr 2:143,789,315...143,853,183
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Rsf1
remodeling and spacing factor 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of RSF1 protein
CTD
PMID:34122009
NCBI chr 7:97,229,103...97,341,989
Ensembl chr 7:97,229,096...97,341,985
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Rtn4
reticulon 4
decreases expression
EXP
Haloperidol results in decreased expression of RTN4 mRNA
CTD
PMID:18797397
NCBI chr11:29,642,898...29,694,414
Ensembl chr11:29,642,947...29,694,331
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Rxrg
retinoid X receptor gamma
affects response to substance increases expression
EXP ISO
RXRG protein affects the susceptibility to Haloperidol Haloperidol results in increased expression of RXRG mRNA alternative form
CTD
PMID:10336693 PMID:11564422
NCBI chr 1:167,425,902...167,467,191
Ensembl chr 1:167,425,953...167,467,192
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S100a9
S100 calcium binding protein A9 (calgranulin B)
decreases expression
EXP
Haloperidol results in decreased expression of S100A9 mRNA
CTD
PMID:18797397
NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
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Sae1
SUMO1 activating enzyme subunit 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SAE1 protein
CTD
PMID:34122009
NCBI chr 7:16,054,161...16,121,821
Ensembl chr 7:16,054,159...16,121,731
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Sars1
seryl-tRNA synthetase 1
decreases expression
ISO
Haloperidol results in decreased expression of SARS1 protein
CTD
PMID:34122009
NCBI chr 3:108,332,180...108,352,575
Ensembl chr 3:108,332,181...108,352,525
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Satb2
special AT-rich sequence binding protein 2
decreases expression
ISO
Haloperidol results in decreased expression of SATB2 protein
CTD
PMID:34122009
NCBI chr 1:56,833,145...57,019,350
Ensembl chr 1:56,833,140...57,017,809
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Sbds
SBDS ribosome maturation factor
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of SBDS protein
CTD
PMID:34122009
NCBI chr 5:130,274,573...130,284,371
Ensembl chr 5:130,274,572...130,284,371
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Sc5d
sterol-C5-desaturase
increases expression
ISO
Haloperidol results in increased expression of SC5D mRNA
CTD
PMID:17052361
NCBI chr 9:42,162,888...42,175,607
Ensembl chr 9:42,162,891...42,175,552
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Scd2
stearoyl-Coenzyme A desaturase 2
increases expression
ISO
Haloperidol results in increased expression of SCD mRNA
CTD
PMID:16027736
NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303
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Sec61a1
SEC61 translocon subunit alpha 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SEC61A1 protein
CTD
PMID:34122009
NCBI chr 6:88,480,589...88,495,782
Ensembl chr 6:88,480,561...88,495,887
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Sec63
SEC63 homolog, protein translocation regulator
increases expression
ISO
Haloperidol results in increased expression of SEC63 protein
CTD
PMID:34122009
NCBI chr10:42,637,492...42,708,510
Ensembl chr10:42,637,492...42,708,510
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Serpina3b
serine (or cysteine) peptidase inhibitor, clade A, member 3B
increases expression
ISO
Haloperidol results in increased expression of SERPINA3 mRNA; Haloperidol results in increased expression of SERPINA3 protein
CTD
PMID:17175557 PMID:34122009
NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804
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Serpini1
serine (or cysteine) peptidase inhibitor, clade I, member 1
decreases expression
EXP
Haloperidol results in decreased expression of SERPINI1 mRNA
CTD
PMID:18797397
NCBI chr 3:75,464,800...75,549,830
Ensembl chr 3:75,464,854...75,550,802
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Sf3b4
splicing factor 3b, subunit 4
decreases expression
ISO
Haloperidol results in decreased expression of SF3B4 protein
CTD
PMID:34122009
NCBI chr 3:96,079,822...96,084,880
Ensembl chr 3:96,079,648...96,084,880
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Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SGCD protein
CTD
PMID:34122009
NCBI chr11:46,861,904...47,880,309
Ensembl chr11:46,787,080...47,879,796
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Sgk1
serum/glucocorticoid regulated kinase 1
increases expression
ISO
Haloperidol results in increased expression of SGK1 mRNA
CTD
PMID:16452686
NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802
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Sh3kbp1
SH3-domain kinase binding protein 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SH3KBP1 protein
CTD
PMID:34122009
NCBI chr X:158,409,888...158,758,916
Ensembl chr X:158,410,268...158,761,065
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Sh3pxd2b
SH3 and PX domains 2B
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of SH3PXD2B protein
CTD
PMID:34122009
NCBI chr11:32,297,777...32,378,189
Ensembl chr11:32,297,820...32,378,173
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Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
increases expression
EXP
Haloperidol results in increased expression of SLC17A6 mRNA; Haloperidol results in increased expression of SLC17A6 protein
CTD
PMID:18155072
NCBI chr 7:51,271,578...51,320,874
Ensembl chr 7:51,271,754...51,320,867
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Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
affects response to substance
EXP
SLC17A8 protein affects the susceptibility to Haloperidol
CTD
PMID:18278042
NCBI chr10:89,409,882...89,457,111
Ensembl chr10:89,409,882...89,457,115
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Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
affects binding
ISO
Haloperidol binds to SLC18A2 protein
CTD
PMID:7912402
NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444
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Slc1a1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
decreases expression
ISO
Haloperidol results in decreased expression of SLC1A1 mRNA
CTD
PMID:12873733
NCBI chr19:28,812,535...28,891,360
Ensembl chr19:28,812,449...28,891,360
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Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
decreases expression
ISO
Haloperidol results in decreased expression of SLC1A2 mRNA
CTD
PMID:12873733
NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129
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Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
decreases expression
ISO
Haloperidol results in decreased expression of SLC1A3 mRNA
CTD
PMID:15860345
NCBI chr15:8,663,608...8,742,648
Ensembl chr15:8,663,608...8,740,248
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Haloperidol inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
CTD
PMID:23770354
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Slc25a3
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SLC25A3 protein
CTD
PMID:34122009
NCBI chr10:90,952,436...90,959,902
Ensembl chr10:90,952,436...90,959,921
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Slc2a4
solute carrier family 2 (facilitated glucose transporter), member 4
increases expression
ISO
Haloperidol results in increased expression of SLC2A4 mRNA
CTD
PMID:16002093
NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
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Slc39a7
solute carrier family 39 (zinc transporter), member 7
increases expression
EXP
Haloperidol results in increased expression of SLC39A7 mRNA
CTD
PMID:14647396
NCBI chr17:34,247,240...34,250,664
Ensembl chr17:34,247,243...34,250,656
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Slc6a3
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
multiple interactions increases expression
EXP ISO
SLC6A3 protein promotes the reaction [Haloperidol results in increased expression of NTS mRNA] Haloperidol results in increased expression of SLC6A3 protein
CTD
PMID:14698760 PMID:17069804
NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
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Slc6a4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
increases expression
ISO
Haloperidol results in increased expression of SLC6A4
CTD
PMID:12007678
NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166
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Snap25
synaptosomal-associated protein 25
affects response to substance affects expression
ISO
SNAP25 gene SNP affects the susceptibility to Haloperidol Haloperidol affects the expression of SNAP25 mRNA
CTD
PMID:15823421 PMID:15860345
NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348
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Snrpd2
small nuclear ribonucleoprotein D2
increases expression
EXP
Haloperidol results in increased expression of SNRPD2 mRNA
CTD
PMID:14647396
NCBI chr 7:18,883,370...18,886,659
Ensembl chr 7:18,883,647...18,887,467
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Sod1
superoxide dismutase 1, soluble
increases expression decreases expression multiple interactions
ISO
Haloperidol results in increased expression of SOD1 mRNA Haloperidol results in decreased expression of SOD1 protein Clozapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]; Haloperidol results in decreased activity of and results in decreased expression of SOD1 protein; olanzapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]; Risperidone inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]
CTD
PMID:12482469 PMID:12752374 PMID:16564057
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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Sod2
superoxide dismutase 2, mitochondrial
decreases expression multiple interactions
ISO
Haloperidol results in decreased expression of SOD2 mRNA; Haloperidol results in decreased expression of SOD2 protein Haloperidol results in decreased activity of and results in decreased expression of SOD2 protein
CTD
PMID:12482469 PMID:15860345 PMID:16564057
NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
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Sod3
superoxide dismutase 3, extracellular
increases expression
ISO
Haloperidol results in increased expression of SOD3 mRNA
CTD
PMID:15860345
NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760
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Speg
SPEG complex locus
increases expression
ISO
Haloperidol results in increased expression of SPEG protein
CTD
PMID:34122009
NCBI chr 1:75,351,931...75,408,964
Ensembl chr 1:75,351,941...75,408,964
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Srebf2
sterol regulatory element binding factor 2
multiple interactions
ISO
Haloperidol results in increased cleavage of and results in increased activity of SREBF2 protein
CTD
PMID:17052361
NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580
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Srpra
signal recognition particle receptor alpha
decreases expression
ISO
Haloperidol results in decreased expression of SRPRA protein
CTD
PMID:34122009
NCBI chr 9:35,122,499...35,128,299
Ensembl chr 9:35,111,471...35,159,269
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Srsf2
serine and arginine-rich splicing factor 2
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SRSF2 protein
CTD
PMID:34122009
NCBI chr11:116,740,723...116,744,511
Ensembl chr11:116,740,727...116,743,920
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Srsf5
serine and arginine-rich splicing factor 5
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SRSF5 protein
CTD
PMID:34122009
NCBI chr12:80,992,308...80,997,277
Ensembl chr12:80,992,278...80,997,281
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Stip1
stress-induced phosphoprotein 1
decreases expression
ISO
Haloperidol results in decreased expression of STIP1 protein
CTD
PMID:34122009
NCBI chr19:6,998,064...7,017,394
Ensembl chr19:6,998,070...7,017,335
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Strn4
striatin, calmodulin binding protein 4
increases expression
EXP
Haloperidol results in increased expression of STRN4 mRNA
CTD
PMID:14647396
NCBI chr 7:16,549,814...16,574,856
Ensembl chr 7:16,549,814...16,574,856
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Stt3a
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of STT3A protein
CTD
PMID:34122009
NCBI chr 9:36,640,640...36,678,918
Ensembl chr 9:36,640,640...36,678,975
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Stx1a
syntaxin 1A (brain)
increases expression
ISO
Haloperidol results in increased expression of STX1A mRNA
CTD
PMID:15860345
NCBI chr 5:135,051,473...135,079,954
Ensembl chr 5:135,052,336...135,079,954
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Stx1b
syntaxin 1B
affects expression
ISO
Haloperidol affects the expression of STX1B mRNA
CTD
PMID:15860345
NCBI chr 7:127,403,072...127,423,703
Ensembl chr 7:127,403,072...127,423,721
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Stx4a
syntaxin 4A (placental)
increases expression
ISO
Haloperidol results in increased expression of STX4 mRNA
CTD
PMID:15860345
NCBI chr 7:127,439,832...127,450,160
Ensembl chr 7:127,423,466...127,448,191
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Stx5a
syntaxin 5A
decreases expression
ISO
Haloperidol results in decreased expression of STX5 mRNA
CTD
PMID:15860345
NCBI chr19:8,718,788...8,733,006
Ensembl chr19:8,718,777...8,733,433
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Stx7
syntaxin 7
decreases expression
ISO
Haloperidol results in decreased expression of STX7 mRNA
CTD
PMID:15860345
NCBI chr10:24,025,182...24,064,859
Ensembl chr10:24,025,200...24,066,120
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Stx8
syntaxin 8
affects expression
ISO
Haloperidol affects the expression of STX8 mRNA
CTD
PMID:15860345
NCBI chr11:67,857,237...68,097,974
Ensembl chr11:67,857,019...68,097,974
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Supt3
SPT3, SAGA and STAGA complex component
increases expression
ISO
Haloperidol results in increased expression of SUPT3H mRNA
CTD
PMID:16715494
NCBI chr17:45,088,005...45,430,181
Ensembl chr17:45,088,039...45,430,177
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Syn2
synapsin II
increases expression
ISO
Haloperidol results in increased expression of SYN2 mRNA
CTD
PMID:15860345
NCBI chr 6:115,111,863...115,259,587
Ensembl chr 6:115,111,863...115,258,967
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Sypl1
synaptophysin like 1
decreases expression
EXP
Haloperidol results in decreased expression of SYPL1 mRNA
CTD
PMID:18797397
NCBI chr12:33,003,874...33,029,503
Ensembl chr12:33,003,890...33,029,859
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Syt11
synaptotagmin XI
increases expression
ISO
Haloperidol results in increased expression of SYT11 mRNA
CTD
PMID:15860345
NCBI chr 3:88,652,006...88,682,466
Ensembl chr 3:88,652,007...88,682,471
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Syt3
synaptotagmin III
decreases expression
ISO
Haloperidol results in decreased expression of SYT3 mRNA
CTD
PMID:15860345
NCBI chr 7:44,032,197...44,049,454
Ensembl chr 7:44,033,526...44,049,611
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Syt4
synaptotagmin IV
affects expression
ISO
Haloperidol affects the expression of SYT4 mRNA
CTD
PMID:15860345
NCBI chr18:31,570,861...31,580,468
Ensembl chr18:31,570,861...31,580,459
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Tac1
tachykinin 1
increases expression
ISO
Haloperidol results in increased expression of TAC1 mRNA
CTD
PMID:10974607
NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
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Tagln
transgelin
decreases expression
ISO
Haloperidol results in decreased expression of TAGLN mRNA
CTD
PMID:17175557
NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356
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Tagln2
transgelin 2
decreases expression
ISO
Haloperidol results in decreased expression of TAGLN2 protein
CTD
PMID:34122009
NCBI chr 1:172,327,813...172,334,942
Ensembl chr 1:172,327,614...172,334,947
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Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
decreases expression
ISO
Haloperidol results in decreased expression of TAP1 mRNA
CTD
PMID:16452686
NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199
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Tatdn1
TatD DNase domain containing 1
increases expression
EXP
Haloperidol results in increased expression of TATDN1 mRNA
CTD
PMID:14647396
NCBI chr15:58,762,002...58,805,605
Ensembl chr15:58,762,004...58,805,587
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Tcaf1
TRPM8 channel-associated factor 1
decreases expression
ISO
Haloperidol results in decreased expression of TCAF1 protein
CTD
PMID:34122009
NCBI chr 6:42,644,933...42,687,065
Ensembl chr 6:42,644,936...42,687,022
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Tcerg1
transcription elongation regulator 1 (CA150)
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of TCERG1 protein
CTD
PMID:34122009
NCBI chr18:42,644,369...42,708,850
Ensembl chr18:42,644,552...42,708,858
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Tgoln1
trans-golgi network protein
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of TGOLN2 protein
CTD
PMID:34122009
NCBI chr 6:72,585,403...72,593,983
Ensembl chr 6:72,585,415...72,593,983
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Th
tyrosine hydroxylase
increases expression
ISO
Haloperidol results in increased expression of TH protein
CTD
PMID:17028028
NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
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Thra
thyroid hormone receptor alpha
increases expression decreases expression
ISO
Haloperidol results in increased expression of THRA mRNA alternative form Haloperidol results in decreased expression of THRA mRNA alternative form
CTD
PMID:11564422
NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832
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Tln2
talin 2
decreases expression
ISO
Haloperidol results in decreased expression of TLN2 protein
CTD
PMID:34122009
NCBI chr 9:67,124,371...67,541,357
Ensembl chr 9:67,124,369...67,466,985
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Tm9sf2
transmembrane 9 superfamily member 2
decreases expression
ISO
Haloperidol results in decreased expression of TM9SF2 protein
CTD
PMID:34122009
NCBI chr14:122,342,290...122,397,015
Ensembl chr14:122,344,450...122,397,016
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Tmem109
transmembrane protein 109
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of TMEM109 protein
CTD
PMID:34122009
NCBI chr19:10,848,021...10,859,107
Ensembl chr19:10,848,024...10,859,365
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Tmod3
tropomodulin 3
decreases expression
ISO
Haloperidol results in decreased expression of TMOD3 protein
CTD
PMID:34122009
NCBI chr 9:75,405,066...75,466,939
Ensembl chr 9:75,404,989...75,466,939
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Tmprss2
transmembrane protease, serine 2
increases expression
ISO
Haloperidol results in increased expression of TMPRSS2 mRNA
CTD
PMID:32808185
NCBI chr16:97,365,882...97,460,741
Ensembl chr16:97,365,882...97,412,395
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Tnf
tumor necrosis factor
multiple interactions increases expression
ISO EXP
Haloperidol affects the reaction [Phencyclidine affects the expression of TNF mRNA] Cannabidiol inhibits the reaction [Haloperidol results in increased expression of TNF mRNA] Haloperidol results in increased expression of TNF protein
CTD
PMID:16478754 PMID:18554768 PMID:18590723 PMID:30217539
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Tnik
TRAF2 and NCK interacting kinase
decreases expression
EXP
Haloperidol results in decreased expression of TNIK mRNA
CTD
PMID:14647396
NCBI chr 3:28,317,362...28,724,734
Ensembl chr 3:28,317,363...28,730,007
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Tor1a
torsin family 1, member A (torsin A)
affects response to substance
EXP
TOR1A gene mutant form affects the susceptibility to Haloperidol
CTD
PMID:20227500
NCBI chr 2:30,850,573...30,857,930
Ensembl chr 2:30,850,639...30,857,945
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Tpi1
triosephosphate isomerase 1
increases expression
ISO
Haloperidol results in increased expression of TPI1 mRNA
CTD
PMID:15860345
NCBI chr 6:124,787,549...124,791,121
Ensembl chr 6:124,787,549...124,791,259
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Trf
transferrin
decreases expression
EXP
Haloperidol results in decreased expression of TRF mRNA
CTD
PMID:17177202
NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
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Trim2
tripartite motif-containing 2
decreases expression
EXP
Haloperidol results in decreased expression of TRIM2 mRNA
CTD
PMID:14647396
NCBI chr 3:84,067,746...84,215,659
Ensembl chr 3:84,067,746...84,214,184
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Trim23
tripartite motif-containing 23
decreases expression
ISO
Haloperidol results in decreased expression of TRIM23 mRNA
CTD
PMID:15860345
NCBI chr13:104,315,187...104,339,983
Ensembl chr13:104,315,305...104,339,880
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Trim28
tripartite motif-containing 28
decreases expression
ISO
Haloperidol results in decreased expression of TRIM28 protein
CTD
PMID:34122009
NCBI chr 7:12,758,079...12,764,959
Ensembl chr 7:12,733,041...12,764,962
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Trmt13
tRNA methyltransferase 13
decreases expression
ISO
Haloperidol results in decreased expression of TRMT13 protein
CTD
PMID:34122009
NCBI chr 3:116,365,706...116,408,236
Ensembl chr 3:116,374,742...116,408,236
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Trp53
transformation related protein 53
increases expression
ISO
Haloperidol results in increased expression of TP53 mRNA; Haloperidol results in increased expression of TP53 protein
CTD
PMID:16462815
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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Trpv5
transient receptor potential cation channel, subfamily V, member 5
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of TRPV5 protein
CTD
PMID:34122009
NCBI chr 6:41,628,595...41,658,158
Ensembl chr 6:41,629,107...41,657,703
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Ttbk1
tau tubulin kinase 1
increases expression
ISO
Haloperidol results in increased expression of TTBK1 protein
CTD
PMID:34122009
NCBI chr17:46,751,577...46,798,596
Ensembl chr17:46,753,374...46,798,601
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Tubb4b
tubulin, beta 4B class IVB
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of TUBB4B protein
CTD
PMID:34122009
NCBI chr 2:25,112,170...25,114,714
Ensembl chr 2:25,112,172...25,114,714
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Txlna
taxilin alpha
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of TXLNA protein
CTD
PMID:34122009
NCBI chr 4:129,519,870...129,534,867
Ensembl chr 4:129,519,871...129,534,858
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Uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
increases expression
EXP
Haloperidol results in increased expression of UBA52 mRNA
CTD
PMID:14647396
NCBI chr 8:70,960,913...70,963,067
Ensembl chr 8:70,960,913...70,963,451
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Ubc
ubiquitin C
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of UBC protein
CTD
PMID:34122009
NCBI chr 5:125,463,029...125,467,081
Ensembl chr 5:125,463,029...125,467,266
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Ube2r2
ubiquitin-conjugating enzyme E2R 2
increases expression
EXP
Haloperidol results in increased expression of UBE2R2 mRNA
CTD
PMID:14647396
NCBI chr 4:41,136,021...41,193,370
Ensembl chr 4:41,135,743...41,193,380
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Ubqln4
ubiquilin 4
decreases expression
ISO
Haloperidol results in decreased expression of UBQLN4 protein
CTD
PMID:34122009
NCBI chr 3:88,460,984...88,477,032
Ensembl chr 3:88,461,065...88,477,032
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Ubtf
upstream binding transcription factor, RNA polymerase I
decreases expression
ISO
Haloperidol results in decreased expression of UBTF protein
CTD
PMID:34122009
NCBI chr11:102,195,393...102,214,738
Ensembl chr11:102,195,386...102,210,568
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Ugp2
UDP-glucose pyrophosphorylase 2
increases expression
ISO
Haloperidol results in increased expression of UGP2 protein
CTD
PMID:34122009
NCBI chr11:21,271,126...21,321,267
Ensembl chr11:21,271,138...21,321,201
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Ugt8a
UDP galactosyltransferase 8A
decreases expression
EXP
Haloperidol results in decreased expression of UGT8A mRNA
CTD
PMID:17177202
NCBI chr 3:125,655,071...125,732,301
Ensembl chr 3:125,658,920...125,732,268
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Unc13a
unc-13 homolog A
decreases expression
ISO
Haloperidol results in decreased expression of UNC13A mRNA
CTD
PMID:15860345
NCBI chr 8:72,079,356...72,124,418
Ensembl chr 8:72,077,061...72,124,401
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Uqcr11
ubiquinol-cytochrome c reductase, complex III subunit XI
increases expression
EXP
Haloperidol results in increased expression of UQCR11 mRNA
CTD
PMID:14647396
NCBI chr10:80,238,831...80,242,655
Ensembl chr10:80,238,831...80,242,664
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Uso1
USO1 vesicle docking factor
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of USO1 protein
CTD
PMID:34122009
NCBI chr 5:92,285,770...92,350,659
Ensembl chr 5:92,285,797...92,350,657
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Usp5
ubiquitin specific peptidase 5 (isopeptidase T)
increases expression multiple interactions
ISO
Haloperidol results in increased expression of USP5 protein [Cuprizone co-treated with Haloperidol] results in increased expression of USP5 protein
CTD
PMID:34122009
NCBI chr 6:124,791,982...124,806,404
Ensembl chr 6:124,791,982...124,806,447
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Usp7
ubiquitin specific peptidase 7
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of USP7 protein
CTD
PMID:34122009
NCBI chr16:8,506,586...8,574,931
Ensembl chr16:8,507,459...8,610,172
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Vamp1
vesicle-associated membrane protein 1
decreases expression increases expression
ISO
Haloperidol results in decreased expression of VAMP1 mRNA Haloperidol results in increased expression of VAMP1 mRNA
CTD
PMID:15860345
NCBI chr 6:125,192,544...125,199,269
Ensembl chr 6:125,192,514...125,222,927
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Vamp2
vesicle-associated membrane protein 2
decreases expression increases expression
ISO
Haloperidol results in decreased expression of VAMP2 mRNA Haloperidol results in increased expression of VAMP2 mRNA
CTD
PMID:15860345
NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210
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Vipr2
vasoactive intestinal peptide receptor 2
decreases expression
ISO
Haloperidol results in decreased expression of VIPR2 mRNA
CTD
PMID:27900577
NCBI chr12:116,041,040...116,117,842
Ensembl chr12:116,041,346...116,109,881
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Vldlr
very low density lipoprotein receptor
increases expression
ISO
Haloperidol results in increased expression of VLDLR protein
CTD
PMID:19359144
NCBI chr19:27,190,070...27,231,631
Ensembl chr19:27,193,884...27,231,631
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Vsnl1
visinin-like 1
decreases expression
ISO
Haloperidol results in decreased expression of VSNL1 mRNA
CTD
PMID:12437575
NCBI chr12:11,375,258...11,486,579
Ensembl chr12:11,375,243...11,486,614
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Wars1
tryptophanyl-tRNA synthetase1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of WARS1 protein
CTD
PMID:34122009
NCBI chr12:108,825,956...108,860,095
Ensembl chr12:108,825,956...108,860,100
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Wbp1l
WW domain binding protein 1 like
decreases expression
EXP
Haloperidol results in decreased expression of WBP1L mRNA
CTD
PMID:14647396
NCBI chr19:46,587,545...46,645,828
Ensembl chr19:46,587,523...46,645,828
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Wdr12
WD repeat domain 12
decreases expression
ISO
Haloperidol results in decreased expression of WDR12 protein
CTD
PMID:34122009
NCBI chr 1:60,110,520...60,137,659
Ensembl chr 1:60,108,944...60,137,804
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Haloperidol results in increased expression of WIPI1 mRNA
CTD
PMID:17175557
NCBI chr11:109,464,347...109,502,215
Ensembl chr11:109,464,157...109,502,793
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Xirp2
xin actin-binding repeat containing 2
decreases expression
ISO
Haloperidol results in decreased expression of XIRP2 protein
CTD
PMID:34122009
NCBI chr 2:67,276,343...67,356,964
Ensembl chr 2:67,004,178...67,356,959
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Xpnpep1
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
increases expression
ISO
Haloperidol results in increased expression of XPNPEP1 protein
CTD
PMID:34122009
NCBI chr19:52,919,710...53,027,093
Ensembl chr19:52,920,357...53,028,645
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Zfr
zinc finger RNA binding protein
decreases expression
ISO
Haloperidol results in decreased expression of ZFR protein
CTD
PMID:34122009
NCBI chr15:12,117,649...12,185,535
Ensembl chr15:12,117,917...12,185,769
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Adra1a
adrenergic receptor, alpha 1a
multiple interactions
ISO
Lisuride binds to and results in decreased activity of ADRA1A protein; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]
CTD
PMID:16545797
NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617
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Htr7
5-hydroxytryptamine (serotonin) receptor 7
multiple interactions
ISO
[Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Lisuride binds to and results in decreased activity of HTR7 protein
CTD
PMID:18996971 PMID:19509219
NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907
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Ifng
interferon gamma
increases expression
ISO
Lisuride results in increased expression of IFNG
CTD
PMID:7948314
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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Prl
prolactin
multiple interactions decreases secretion
ISO
Lisuride inhibits the reaction [Metoclopramide results in increased secretion of PRL protein]; Lisuride results in decreased expression of and results in decreased secretion of PRL protein Lisuride analog results in decreased secretion of PRL protein; Lisuride results in decreased secretion of PRL protein
CTD
PMID:386688 PMID:6492995
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Lisuride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Ache
acetylcholinesterase
multiple interactions decreases activity
ISO
asoxime chloride inhibits the reaction [Memantine inhibits the reaction [Soman results in decreased activity of ACHE protein]]; Memantine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Memantine inhibits the reaction [Soman results in decreased activity of ACHE protein] Memantine results in decreased activity of ACHE protein
CTD
PMID:2241428 PMID:30588862 PMID:30682440
NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
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App
amyloid beta precursor protein
multiple interactions
ISO
Memantine inhibits the reaction [Streptozocin results in increased expression of APP protein modified form]
CTD
PMID:21290839
NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
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Arc
activity regulated cytoskeletal-associated protein
multiple interactions
EXP
Memantine inhibits the reaction [Lipopolysaccharides results in decreased expression of ARC protein]
CTD
PMID:34474083
NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419
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Bax
BCL2-associated X protein
affects expression
ISO
Memantine affects the expression of BAX protein
CTD
PMID:29226720
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Bcl2
B cell leukemia/lymphoma 2
multiple interactions decreases expression
ISO
Memantine analog inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; Memantine inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein] Memantine results in decreased expression of BCL2 protein
CTD
PMID:29226720 PMID:32092300
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
Memantine results in decreased expression of BIRC5 protein
CTD
PMID:29226720
NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
multiple interactions
ISO
Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]; Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein]
CTD
PMID:24333387
NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224
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Capn1
calpain 1
multiple interactions
EXP
Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of CAPN1 protein]
CTD
PMID:34474083
NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927
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Casp1
caspase 1
multiple interactions
EXP
Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein]
CTD
PMID:34474083
NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
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Casp3
caspase 3
multiple interactions increases expression
ISO EXP
Memantine inhibits the reaction [benzo(e)pyrene results in increased activity of CASP3 protein]; Memantine inhibits the reaction [catechol results in increased activity of CASP3 protein]; Memantine inhibits the reaction [salsolinol results in increased activity of CASP3 protein]; Memantine inhibits the reaction [Staurosporine results in increased activity of CASP3 protein] Memantine results in increased expression of CASP3 protein Memantine inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CASP3 protein] Memantine inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Memantine inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]
CTD
PMID:17996985 PMID:19959636 PMID:20347921 PMID:24333387 PMID:29226720 PMID:29800586 More...
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Casp7
caspase 7
multiple interactions
ISO
Memantine inhibits the reaction [benzo(e)pyrene results in increased activity of CASP7 protein]; Memantine inhibits the reaction [catechol results in increased activity of CASP7 protein]
CTD
PMID:19959636 PMID:20347921
NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
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Casp9
caspase 9
increases expression
ISO
Memantine results in increased expression of CASP9 protein
CTD
PMID:29226720
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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Ccnd1
cyclin D1
decreases expression
ISO
Memantine results in decreased expression of CCND1 protein
CTD
PMID:29226720
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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Cdk4
cyclin dependent kinase 4
increases expression
ISO
Memantine results in increased expression of CDK4 protein
CTD
PMID:29226720
NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
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Creb1
cAMP responsive element binding protein 1
multiple interactions
ISO
Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of CREB1 protein]
CTD
PMID:23562514
NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
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Dlg4
discs large MAGUK scaffold protein 4
multiple interactions
ISO EXP
Memantine inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein] Memantine inhibits the reaction [Lipopolysaccharides results in decreased expression of DLG4 protein]
CTD
PMID:24333387 PMID:34474083
NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348
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Dlgap2
DLG associated protein 2
multiple interactions
ISO
Memantine inhibits the reaction [Streptozocin results in decreased expression of DLGAP2 mRNA]
CTD
PMID:24333387
NCBI chr 8:14,145,793...14,903,426
Ensembl chr 8:14,145,865...14,897,680
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Gfap
glial fibrillary acidic protein
multiple interactions
ISO EXP
Memantine inhibits the reaction [Streptozocin results in increased expression of GFAP mRNA]; Memantine inhibits the reaction [Streptozocin results in increased expression of GFAP protein] Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein]
CTD
PMID:24333387 PMID:34474083
NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
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Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
multiple interactions
EXP
Memantine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of GRIN2B protein]
CTD
PMID:34474083
NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
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Gsk3b
glycogen synthase kinase 3 beta
multiple interactions
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Memantine analog inhibits the reaction [Glutamic Acid results in decreased phosphorylation of and results in increased activity of GSK3B protein]]; Memantine analog inhibits the reaction [Glutamic Acid results in decreased phosphorylation of and results in increased activity of GSK3B protein]
CTD
PMID:32092300
NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
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Il1b
interleukin 1 beta
multiple interactions
EXP
Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD
PMID:34474083
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Itgam
integrin alpha M
multiple interactions
ISO
Memantine inhibits the reaction [Streptozocin results in increased expression of ITGAM mRNA]; Memantine inhibits the reaction [Streptozocin results in increased expression of ITGAM protein]
CTD
PMID:24333387
NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
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Mapk1
mitogen-activated protein kinase 1
multiple interactions
ISO
Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein]
CTD
PMID:23562514
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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Mapk3
mitogen-activated protein kinase 3
multiple interactions
ISO
Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK3 protein]
CTD
PMID:23562514
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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Myc
myelocytomatosis oncogene
decreases expression
ISO
Memantine results in decreased expression of MYC protein
CTD
PMID:29226720
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
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Nefl
neurofilament, light polypeptide
multiple interactions
ISO
Memantine inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Memantine inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA]
CTD
PMID:31969611
NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
EXP
Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]
CTD
PMID:34474083
NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
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Penk
preproenkephalin
multiple interactions
ISO
Memantine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]
CTD
PMID:14642644
NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819
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Ppp2ca
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
multiple interactions
EXP
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Okadaic Acid co-treated with Fingolimod Hydrochloride co-treated with Memantine] results in increased expression of PPP2CA mRNA; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Okadaic Acid co-treated with Fingolimod Hydrochloride co-treated with Memantine] results in increased expression of PPP2CA protein
CTD
PMID:33069748
NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605
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Prkcg
protein kinase C, gamma
increases expression
ISO
Memantine results in increased expression of PRKCG mRNA
CTD
PMID:11169168
NCBI chr 7:3,352,038...3,379,615
Ensembl chr 7:3,337,704...3,379,615
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Tnf
tumor necrosis factor
multiple interactions
ISO EXP
Memantine inhibits the reaction [Streptozocin results in increased expression of TNF protein] Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:24333387 PMID:34474083
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
G
Htr2b
5-hydroxytryptamine (serotonin) receptor 2B
affects binding multiple interactions
EXP
mesulergine binds to HTR2B protein Fluoxetine promotes the reaction [mesulergine binds to HTR2B protein]
CTD
PMID:11930908
NCBI chr 1:86,025,268...86,043,960
Ensembl chr 1:86,026,748...86,039,692
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Htr2c
5-hydroxytryptamine (serotonin) receptor 2C
affects binding multiple interactions
ISO
mesulergine binds to HTR2C protein N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [mesulergine binds to HTR2C protein] Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]; Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]
CTD
PMID:18083778 PMID:19439326 PMID:19700373 PMID:29458138
NCBI chr X:145,745,509...145,980,273
Ensembl chr X:145,745,509...145,980,273
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Htr7
5-hydroxytryptamine (serotonin) receptor 7
affects binding multiple interactions
ISO
mesulergine binds to HTR7 protein [mesulergine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; mesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD
PMID:14578406 PMID:20827463
NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907
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Prl
prolactin
multiple interactions
ISO
mesulergine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]
CTD
PMID:1421203
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
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Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
methixene results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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1700017B05Rik
RIKEN cDNA 1700017B05 gene
affects expression
ISO
Orphenadrine affects the expression of C8H15ORF39 mRNA
CTD
PMID:23665939
NCBI chr 9:57,159,605...57,169,882
Ensembl chr 9:57,160,400...57,169,895
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1810055G02Rik
RIKEN cDNA 1810055G02 gene
affects expression
ISO
Orphenadrine affects the expression of C1H11ORF24 mRNA
CTD
PMID:23665939
NCBI chr19:3,758,343...3,767,882
Ensembl chr19:3,758,293...3,767,881
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A2m
alpha-2-macroglobulin
affects expression
ISO
Orphenadrine affects the expression of A2M mRNA
CTD
PMID:23665939
NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186
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Abcb1b
ATP-binding cassette, sub-family B member 1B
affects expression
ISO
Orphenadrine affects the expression of ABCB1B mRNA
CTD
PMID:23665939
NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315
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Abcc2
ATP-binding cassette, sub-family member 2
multiple interactions
ISO
[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of ABCC2 mRNA
CTD
PMID:23665939
NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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Abcc3
ATP-binding cassette, sub-family C member 3
affects expression
ISO
Orphenadrine affects the expression of ABCC3 mRNA
CTD
PMID:23665939
NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
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Abcd2
ATP-binding cassette, sub-family D member 2
affects expression
ISO
Orphenadrine affects the expression of ABCD2 mRNA
CTD
PMID:23665939
NCBI chr15:91,029,874...91,076,013
Ensembl chr15:91,030,074...91,076,002
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Ablim3
actin binding LIM protein family, member 3
affects expression
ISO
Orphenadrine affects the expression of ABLIM3 mRNA
CTD
PMID:23665939
NCBI chr18:61,932,463...62,044,956
Ensembl chr18:61,932,463...62,044,895
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Ace2
angiotensin converting enzyme 2
affects expression
ISO
Orphenadrine affects the expression of ACE2 mRNA
CTD
PMID:23665939
NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416
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Acer3
alkaline ceramidase 3
affects expression
ISO
Orphenadrine affects the expression of ACER3 mRNA
CTD
PMID:23665939
NCBI chr 7:97,863,015...97,970,415
Ensembl chr 7:97,855,596...97,970,415
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Acsl5
acyl-CoA synthetase long-chain family member 5
affects expression
ISO
Orphenadrine affects the expression of ACSL5 mRNA
CTD
PMID:23665939
NCBI chr19:55,240,298...55,285,060
Ensembl chr19:55,240,370...55,286,152
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Acsm3
acyl-CoA synthetase medium-chain family member 3
affects expression
ISO
Orphenadrine affects the expression of ACSM3 mRNA
CTD
PMID:23665939
NCBI chr 7:119,360,106...119,384,119
Ensembl chr 7:119,360,146...119,386,736
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Adgrg2
adhesion G protein-coupled receptor G2
affects expression
ISO
Orphenadrine affects the expression of ADGRG2 mRNA
CTD
PMID:23665939
NCBI chr X:159,173,315...159,281,072
Ensembl chr X:159,173,686...159,281,066
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Adgrv1
adhesion G protein-coupled receptor V1
affects expression
ISO
Orphenadrine affects the expression of ADGRV1 mRNA
CTD
PMID:23665939
NCBI chr13:81,243,187...81,781,504
Ensembl chr13:81,243,187...81,781,273
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Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
affects expression
ISO
Orphenadrine affects the expression of ADH4 mRNA
CTD
PMID:23665939
NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653
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Adora1
adenosine A1 receptor
affects expression
ISO
Orphenadrine affects the expression of ADORA1 mRNA
CTD
PMID:23665939
NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169
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Adora2a
adenosine A2a receptor
affects expression
ISO
Orphenadrine affects the expression of ADORA2A mRNA
CTD
PMID:23665939
NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618
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Adrb2
adrenergic receptor, beta 2
affects expression
ISO
Orphenadrine affects the expression of ADRB2 mRNA
CTD
PMID:23665939
NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030
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Ajuba
ajuba LIM protein
affects expression
ISO
Orphenadrine affects the expression of JUB mRNA
CTD
PMID:23665939
NCBI chr14:54,804,926...54,815,118
Ensembl chr14:54,804,929...54,815,015
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Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
affects expression
ISO
Orphenadrine affects the expression of ALDH1A1 mRNA
CTD
PMID:23665939
NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
G
Alpl
alkaline phosphatase, liver/bone/kidney
affects expression
ISO
Orphenadrine affects the expression of ALPL mRNA
CTD
PMID:23665939
NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
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Als2cl
ALS2 C-terminal like
affects expression
ISO
Orphenadrine affects the expression of ALS2CL mRNA
CTD
PMID:23665939
NCBI chr 9:110,709,203...110,729,598
Ensembl chr 9:110,708,938...110,729,598
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Amigo3
adhesion molecule with Ig like domain 3
affects expression
ISO
Orphenadrine affects the expression of AMIGO3 mRNA
CTD
PMID:23665939
NCBI chr 9:107,930,358...107,932,900
Ensembl chr 9:107,930,358...107,932,900
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Amotl2
angiomotin-like 2
affects expression
ISO
Orphenadrine affects the expression of AMOTL2 mRNA
CTD
PMID:23665939
NCBI chr 9:102,594,290...102,610,616
Ensembl chr 9:102,593,871...102,610,617
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Angptl4
angiopoietin-like 4
affects expression
ISO
Orphenadrine affects the expression of ANGPTL4 mRNA
CTD
PMID:23665939
NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804
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Angptl6
angiopoietin-like 6
affects expression
ISO
Orphenadrine affects the expression of ANGPTL6 mRNA
CTD
PMID:23665939
NCBI chr 9:20,785,104...20,791,116
Ensembl chr 9:20,785,104...20,791,023
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Ankrd9
ankyrin repeat domain 9
affects expression
ISO
Orphenadrine affects the expression of ANKRD9 mRNA
CTD
PMID:23665939
NCBI chr12:110,942,854...110,945,516
Ensembl chr12:110,941,787...110,945,474
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Ano1
anoctamin 1, calcium activated chloride channel
affects expression
ISO
Orphenadrine affects the expression of ANO1 mRNA
CTD
PMID:23665939
NCBI chr 7:144,142,286...144,305,762
Ensembl chr 7:144,142,286...144,305,711
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Anxa5
annexin A5
affects expression
ISO
Orphenadrine affects the expression of ANXA5 mRNA
CTD
PMID:23665939
NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043
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App
amyloid beta precursor protein
affects expression
ISO
Orphenadrine affects the expression of APP mRNA
CTD
PMID:23665939
NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
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Aqp9
aquaporin 9
affects expression
ISO
Orphenadrine affects the expression of AQP9 mRNA
CTD
PMID:23665939
NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964
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Arhgap10
Rho GTPase activating protein 10
affects expression
ISO
Orphenadrine affects the expression of ARHGAP10 mRNA
CTD
PMID:23665939
NCBI chr 8:77,976,995...78,244,628
Ensembl chr 8:77,976,995...78,244,582
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Arhgap22
Rho GTPase activating protein 22
affects expression
ISO
Orphenadrine affects the expression of ARHGAP22 mRNA
CTD
PMID:23665939
NCBI chr14:32,935,952...33,091,893
Ensembl chr14:32,935,983...33,091,891
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Arhgef10
Rho guanine nucleotide exchange factor 10
affects expression
ISO
Orphenadrine affects the expression of ARHGEF10 mRNA
CTD
PMID:23665939
NCBI chr 8:14,956,405...15,051,085
Ensembl chr 8:14,961,663...15,051,085
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Arhgef15
Rho guanine nucleotide exchange factor 15
affects expression
ISO
Orphenadrine affects the expression of ARHGEF15 mRNA
CTD
PMID:23665939
NCBI chr11:68,819,726...68,847,760
Ensembl chr11:68,833,981...68,848,306
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Armcx1
armadillo repeat containing, X-linked 1
affects expression
ISO
Orphenadrine affects the expression of ARMCX1 mRNA
CTD
PMID:23665939
NCBI chr X:133,618,615...133,623,487
Ensembl chr X:133,618,712...133,622,666
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Arrdc2
arrestin domain containing 2
affects expression
ISO
Orphenadrine affects the expression of ARRDC2 mRNA
CTD
PMID:23665939
NCBI chr 8:71,287,773...71,293,173
Ensembl chr 8:71,287,773...71,292,364
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Atf3
activating transcription factor 3
affects expression
ISO
Orphenadrine affects the expression of ATF3 mRNA
CTD
PMID:23665939
NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
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Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
affects expression
ISO
Orphenadrine affects the expression of ATP2B2 mRNA
CTD
PMID:23665939
NCBI chr 6:113,720,803...114,019,574
Ensembl chr 6:113,720,792...114,019,574
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Atrnl1
attractin like 1
affects expression
ISO
Orphenadrine affects the expression of ATRNL1 mRNA
CTD
PMID:23665939
NCBI chr19:57,599,248...58,121,775
Ensembl chr19:57,599,466...58,121,775
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Azin2
antizyme inhibitor 2
affects expression
ISO
Orphenadrine affects the expression of AZIN2 mRNA
CTD
PMID:23665939
NCBI chr 4:128,824,026...128,856,250
Ensembl chr 4:128,824,026...128,856,235
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B3gnt9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
affects expression
ISO
Orphenadrine affects the expression of B3GNT9 mRNA
CTD
PMID:23665939
NCBI chr 8:105,979,270...105,981,895
Ensembl chr 8:105,979,270...105,981,785
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B4galt6
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
affects expression
ISO
Orphenadrine affects the expression of B4GALT6 mRNA
CTD
PMID:23665939
NCBI chr18:20,817,656...20,879,461
Ensembl chr18:20,817,656...20,879,461
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Bambi
BMP and activin membrane-bound inhibitor
affects expression
ISO
Orphenadrine affects the expression of BAMBI mRNA
CTD
PMID:23665939
NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404
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Bbc3
BCL2 binding component 3
affects expression
ISO
Orphenadrine affects the expression of BBC3 mRNA
CTD
PMID:23665939
NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130
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Bcl6
B cell leukemia/lymphoma 6
affects expression
ISO
Orphenadrine affects the expression of BCL6 mRNA
CTD
PMID:23665939
NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602
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Bco2
beta-carotene oxygenase 2
affects expression
ISO
Orphenadrine affects the expression of BCO2 mRNA
CTD
PMID:23665939
NCBI chr 9:50,444,387...50,466,513
Ensembl chr 9:50,444,387...50,466,481
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Bhlha15
basic helix-loop-helix family, member a15
affects expression
ISO
Orphenadrine affects the expression of BHLHA15 mRNA
CTD
PMID:23665939
NCBI chr 5:144,127,104...144,131,259
Ensembl chr 5:144,127,104...144,131,259
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Bicc1
BicC family RNA binding protein 1
affects expression
ISO
Orphenadrine affects the expression of BICC1 mRNA
CTD
PMID:23665939
NCBI chr10:70,758,660...70,995,581
Ensembl chr10:70,758,662...70,995,530
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Bmp4
bone morphogenetic protein 4
affects expression
ISO
Orphenadrine affects the expression of BMP4 mRNA
CTD
PMID:23665939
NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126
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Btbd7
BTB domain containing 7
affects expression
ISO
Orphenadrine affects the expression of BTBD7 mRNA
CTD
PMID:23665939
NCBI chr12:102,747,056...102,844,733
Ensembl chr12:102,747,056...102,844,730
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C1qtnf2
C1q and tumor necrosis factor related protein 2
affects expression
ISO
Orphenadrine affects the expression of C1QTNF2 mRNA
CTD
PMID:23665939
NCBI chr11:43,364,984...43,382,485
Ensembl chr11:43,365,103...43,382,352
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Calcrl
calcitonin receptor-like
affects expression
ISO
Orphenadrine affects the expression of CALCRL mRNA
CTD
PMID:23665939
NCBI chr 2:84,160,970...84,255,786
Ensembl chr 2:84,160,970...84,255,755
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Car1
carbonic anhydrase 1
affects expression
ISO
Orphenadrine affects the expression of CA1 mRNA
CTD
PMID:23665939
NCBI chr 3:14,831,274...14,873,425
Ensembl chr 3:14,831,276...14,873,428
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Car2
carbonic anhydrase 2
affects expression
ISO
Orphenadrine affects the expression of CA2 mRNA
CTD
PMID:23665939
NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830
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Car3
carbonic anhydrase 3
affects expression
ISO
Orphenadrine affects the expression of CA3 mRNA
CTD
PMID:23665939
NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583
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Card19
caspase recruitment domain family, member 19
affects expression
ISO
Orphenadrine affects the expression of CARD19 mRNA
CTD
PMID:23665939
NCBI chr13:49,356,426...49,369,471
Ensembl chr13:49,356,426...49,369,513
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Casp2
caspase 2
affects expression
ISO
Orphenadrine affects the expression of CASP2 mRNA
CTD
PMID:23665939
NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442
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Cblc
Casitas B-lineage lymphoma c
affects expression
ISO
Orphenadrine affects the expression of CBLC mRNA
CTD
PMID:23665939
NCBI chr 7:19,513,643...19,530,734
Ensembl chr 7:19,512,806...19,530,734
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Cbx4
chromobox 4
affects expression
ISO
Orphenadrine affects the expression of CBX4 mRNA
CTD
PMID:23665939
NCBI chr11:118,968,399...118,977,067
Ensembl chr11:118,968,399...118,977,047
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Ccdc68
coiled-coil domain containing 68
affects expression
ISO
Orphenadrine affects the expression of CCDC68 mRNA
CTD
PMID:23665939
NCBI chr18:70,057,929...70,102,559
Ensembl chr18:70,058,497...70,102,555
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Ccn1
cellular communication network factor 1
affects expression
ISO
Orphenadrine affects the expression of CCN1 mRNA
CTD
PMID:23665939
NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736
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Ccnd1
cyclin D1
multiple interactions
ISO
Orphenadrine promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]
CTD
PMID:23665939
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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Ccnd2
cyclin D2
affects expression
ISO
Orphenadrine affects the expression of CCND2 mRNA
CTD
PMID:23665939
NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
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Cd24a
CD24a antigen
affects expression
ISO
Orphenadrine affects the expression of CD24 mRNA
CTD
PMID:23665939
NCBI chr10:43,454,433...43,460,261
Ensembl chr10:43,454,280...43,460,261
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Cd276
CD276 antigen
affects expression
ISO
Orphenadrine affects the expression of CD276 mRNA
CTD
PMID:23665939
NCBI chr 9:58,431,581...58,463,437
Ensembl chr 9:58,431,581...58,462,720
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Cd36
CD36 molecule
affects expression
ISO
Orphenadrine affects the expression of CD36 mRNA
CTD
PMID:23665939
NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
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Cdc42ep1
CDC42 effector protein 1
affects expression
ISO
Orphenadrine affects the expression of CDC42EP1 mRNA
CTD
PMID:23665939
NCBI chr15:78,726,847...78,735,102
Ensembl chr15:78,726,824...78,735,097
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Cdh3
cadherin 3
affects expression
ISO
Orphenadrine affects the expression of CDH3 mRNA
CTD
PMID:23665939
NCBI chr 8:107,237,484...107,283,543
Ensembl chr 8:107,237,523...107,283,929
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Cdr2
cerebellar degeneration-related 2
affects expression
ISO
Orphenadrine affects the expression of CDR2 mRNA
CTD
PMID:23665939
NCBI chr 7:120,556,259...120,581,535
Ensembl chr 7:120,556,259...120,581,535
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Ces2h
carboxylesterase 2H
affects expression
ISO
Orphenadrine affects the expression of CES2 mRNA
CTD
PMID:23665939
NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810
G
Cfap68
cilia and flagella associated protein 68
affects expression
ISO
Orphenadrine affects the expression of CFAP68 mRNA
CTD
PMID:23665939
NCBI chr 9:50,672,674...50,679,536
Ensembl chr 9:50,674,128...50,686,820
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Cgref1
cell growth regulator with EF hand domain 1
affects expression
ISO
Orphenadrine affects the expression of CGREF1 mRNA
CTD
PMID:23665939
NCBI chr 5:31,090,487...31,102,771
Ensembl chr 5:31,090,487...31,102,935
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Chmp4c
charged multivesicular body protein 4C
affects expression
ISO
Orphenadrine affects the expression of CHMP4C mRNA
CTD
PMID:23665939
NCBI chr 3:10,432,033...10,456,065
Ensembl chr 3:10,431,967...10,493,916
G
Cidea
cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
affects expression
ISO
Orphenadrine affects the expression of CIDEA mRNA
CTD
PMID:23665939
NCBI chr18:67,476,634...67,500,864
Ensembl chr18:67,476,674...67,500,855
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Cish
cytokine inducible SH2-containing protein
affects expression
ISO
Orphenadrine affects the expression of CISH mRNA
CTD
PMID:23665939
NCBI chr 9:107,173,858...107,179,983
Ensembl chr 9:107,173,225...107,179,983
G
Clcf1
cardiotrophin-like cytokine factor 1
affects expression
ISO
Orphenadrine affects the expression of CLCF1 mRNA
CTD
PMID:23665939
NCBI chr19:4,264,479...4,273,548
Ensembl chr19:4,264,292...4,273,544
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Cldn23
claudin 23
affects expression
ISO
Orphenadrine affects the expression of CLDN23 mRNA
CTD
PMID:23665939
NCBI chr 8:36,291,863...36,293,713
Ensembl chr 8:36,291,866...36,293,713
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Cndp1
carnosine dipeptidase 1
affects expression
ISO
Orphenadrine affects the expression of CNDP1 mRNA
CTD
PMID:23665939
NCBI chr18:84,628,509...84,668,359
Ensembl chr18:84,628,634...84,668,220
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Col4a3
collagen, type IV, alpha 3
affects expression
ISO
Orphenadrine affects the expression of COL4A3 mRNA
CTD
PMID:23665939
NCBI chr 1:82,564,647...82,699,778
Ensembl chr 1:82,564,642...82,699,780
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Cpt1b
carnitine palmitoyltransferase 1b, muscle
affects expression
ISO
Orphenadrine affects the expression of CPT1B mRNA
CTD
PMID:23665939
NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066
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Crat
carnitine acetyltransferase
affects expression
ISO
Orphenadrine affects the expression of CRAT mRNA
CTD
PMID:23665939
NCBI chr 2:30,290,483...30,305,602
Ensembl chr 2:30,290,483...30,305,825
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Crlf2
cytokine receptor-like factor 2
affects expression
ISO
Orphenadrine affects the expression of CRLF2 mRNA
CTD
PMID:23665939
NCBI chr 5:109,702,575...109,707,301
Ensembl chr 5:109,702,575...109,706,859
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Cryab
crystallin, alpha B
affects expression
ISO
Orphenadrine affects the expression of CRYAB mRNA
CTD
PMID:23665939
NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936
G
Cryl1
crystallin, lambda 1
affects expression
ISO
Orphenadrine affects the expression of CRYL1 mRNA
CTD
PMID:23665939
NCBI chr14:57,512,491...57,635,940
Ensembl chr14:57,512,450...57,635,986
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Csmd1
CUB and Sushi multiple domains 1
affects expression
ISO
Orphenadrine affects the expression of CSMD1 mRNA
CTD
PMID:23665939
NCBI chr 8:15,942,538...17,586,908
Ensembl chr 8:15,942,537...17,585,602
G
Csrnp1
cysteine-serine-rich nuclear protein 1
affects expression
ISO
Orphenadrine affects the expression of CSRNP1 mRNA
CTD
PMID:23665939
NCBI chr 9:119,800,229...119,813,808
Ensembl chr 9:119,800,229...119,813,724
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Cst9
cystatin 9
affects expression
ISO
Orphenadrine affects the expression of CST9L mRNA
CTD
PMID:23665939
NCBI chr 2:148,677,067...148,680,657
Ensembl chr 2:148,677,067...148,680,658
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Ctps1
cytidine 5'-triphosphate synthase 1
affects expression
ISO
Orphenadrine affects the expression of CTPS1 mRNA
CTD
PMID:23665939
NCBI chr 4:120,397,065...120,427,473
Ensembl chr 4:120,397,065...120,427,473
G
Ctrb1
chymotrypsinogen B1
affects expression
ISO
Orphenadrine affects the expression of CTRB mRNA
CTD
PMID:23665939
NCBI chr 8:112,413,142...112,417,642
Ensembl chr 8:112,413,151...112,417,642
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions affects expression
ISO
[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA Orphenadrine affects the expression of CYP1A1 mRNA
CTD
PMID:23665939 PMID:23665940
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions decreases activity
ISO
Orphenadrine inhibits the reaction [CYP1A2 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin] Orphenadrine results in decreased activity of CYP1A2 protein Orphenadrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CTD
PMID:9241656 PMID:18493746
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
multiple interactions decreases activity
ISO
Orphenadrine inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin] Orphenadrine results in decreased activity of CYP2B6 protein
CTD
PMID:9241656 PMID:12464242 PMID:15306208
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
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Cyp2b13
cytochrome P450, family 2, subfamily b, polypeptide 13
affects expression multiple interactions
ISO
Orphenadrine affects the expression of CYP2B2 mRNA [Orphenadrine co-treated with Phenobarbital] affects the expression of CYP2B2 mRNA
CTD
PMID:23665939 PMID:23665940
NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622
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Cyp2c55
cytochrome P450, family 2, subfamily c, polypeptide 55
affects expression
ISO
Orphenadrine affects the expression of CYP2C24 mRNA
CTD
PMID:23665939
NCBI chr19:38,995,384...39,031,134
Ensembl chr19:38,995,463...39,031,137
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions decreases activity
ISO
Orphenadrine inhibits the reaction [CYP2E1 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin] Orphenadrine results in decreased activity of CYP2E1 protein
CTD
PMID:9241656
NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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Cyp4a12b
cytochrome P450, family 4, subfamily a, polypeptide 12B
affects expression
ISO
Orphenadrine affects the expression of CYP4A1 mRNA
CTD
PMID:23665939
NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231
G
Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
affects expression
ISO
Orphenadrine affects the expression of CYP4B1 mRNA
CTD
PMID:23665939
NCBI chr 4:115,481,895...115,504,918
Ensembl chr 4:115,481,922...115,504,920
G
Cyp7a1
cytochrome P450, family 7, subfamily a, polypeptide 1
affects expression
ISO
Orphenadrine affects the expression of CYP7A1 mRNA
CTD
PMID:23665939
NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
G
Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
affects expression
ISO
Orphenadrine affects the expression of CYP8B1 mRNA
CTD
PMID:23665939
NCBI chr 9:121,743,422...121,745,371
Ensembl chr 9:121,743,422...121,745,371
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Cystm1
cysteine-rich transmembrane module containing 1
affects expression
ISO
Orphenadrine affects the expression of CYSTM1 mRNA
CTD
PMID:23665939
NCBI chr18:36,481,677...36,536,032
Ensembl chr18:36,475,573...36,536,150
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Cyyr1
cysteine and tyrosine-rich protein 1
affects expression
ISO
Orphenadrine affects the expression of CYYR1 mRNA
CTD
PMID:23665939
NCBI chr16:85,247,245...85,347,793
Ensembl chr16:85,218,421...85,350,285
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Dact2
dishevelled-binding antagonist of beta-catenin 2
affects expression
ISO
Orphenadrine affects the expression of DACT2 mRNA
CTD
PMID:23665939
NCBI chr17:14,415,492...14,424,595
Ensembl chr17:14,415,314...14,424,566
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Defb36
defensin beta 36
affects expression
ISO
Orphenadrine affects the expression of DEFB36 mRNA
CTD
PMID:23665939
NCBI chr 2:152,446,247...152,454,649
Ensembl chr 2:152,446,247...152,454,649
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Dip2a
disco interacting protein 2 homolog A
affects expression
ISO
Orphenadrine affects the expression of DIP2A mRNA
CTD
PMID:23665939
NCBI chr10:76,098,581...76,181,194
Ensembl chr10:76,095,263...76,181,125
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Dll1
delta like canonical Notch ligand 1
affects expression
ISO
Orphenadrine affects the expression of DLL1 mRNA
CTD
PMID:23665939
NCBI chr17:15,587,616...15,597,275
Ensembl chr17:15,587,616...15,597,134
G
Dnhd1
dynein heavy chain domain 1
affects expression
ISO
Orphenadrine affects the expression of DNHD1 mRNA
CTD
PMID:23665939
NCBI chr 7:105,299,983...105,371,007
Ensembl chr 7:105,300,034...105,371,006
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Dpp6
dipeptidylpeptidase 6
affects expression
ISO
Orphenadrine affects the expression of DPP6 mRNA
CTD
PMID:23665939
NCBI chr 5:27,022,355...27,932,498
Ensembl chr 5:27,022,201...27,932,503
G
Dram1
DNA-damage regulated autophagy modulator 1
affects expression
ISO
Orphenadrine affects the expression of DRAM1 mRNA
CTD
PMID:23665939
NCBI chr10:88,158,663...88,200,218
Ensembl chr10:88,158,666...88,214,942
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Dusp1
dual specificity phosphatase 1
affects expression
ISO
Orphenadrine affects the expression of DUSP1 mRNA
CTD
PMID:23665939
NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102
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Dusp10
dual specificity phosphatase 10
affects expression
ISO
Orphenadrine affects the expression of DUSP10 mRNA
CTD
PMID:23665939
NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833
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Dusp13b
dual specificity phosphatase 13B
affects expression
ISO
Orphenadrine affects the expression of DUSP13B mRNA
CTD
PMID:23665939
NCBI chr14:21,783,463...21,792,947
Ensembl chr14:21,783,462...21,792,947
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Dusp16
dual specificity phosphatase 16
affects expression
ISO
Orphenadrine affects the expression of DUSP16 mRNA
CTD
PMID:23665939
NCBI chr 6:134,692,431...134,769,687
Ensembl chr 6:134,692,431...134,769,588
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Dusp8
dual specificity phosphatase 8
affects expression
ISO
Orphenadrine affects the expression of DUSP8 mRNA
CTD
PMID:23665939
NCBI chr 7:141,633,224...141,649,799
Ensembl chr 7:141,633,227...141,649,580
G
Eeig1
estrogen-induced osteoclastogenesis regulator 1
affects expression
ISO
Orphenadrine affects the expression of EEIG1 mRNA
CTD
PMID:23665939
NCBI chr 2:32,425,344...32,459,763
Ensembl chr 2:32,425,344...32,459,768
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Eeig2
EEIG family member 2
affects expression
ISO
Orphenadrine affects the expression of EEIG2 mRNA
CTD
PMID:23665939
NCBI chr 3:108,878,313...108,935,588
Ensembl chr 3:108,878,313...108,934,923
G
Efemp1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
affects expression
ISO
Orphenadrine affects the expression of EFEMP1 mRNA
CTD
PMID:23665939
NCBI chr11:28,803,154...28,876,743
Ensembl chr11:28,803,204...28,876,743
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Egln3
egl-9 family hypoxia-inducible factor 3
affects expression
ISO
Orphenadrine affects the expression of EGLN3 mRNA
CTD
PMID:23665939
NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646
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Egr1
early growth response 1
affects expression
ISO
Orphenadrine affects the expression of EGR1 mRNA
CTD
PMID:23665939
NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
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Emilin1
elastin microfibril interfacer 1
affects expression
ISO
Orphenadrine affects the expression of EMILIN1 mRNA
CTD
PMID:23665939
NCBI chr 5:31,070,729...31,078,623
Ensembl chr 5:31,070,746...31,078,621
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Epha2
Eph receptor A2
affects expression
ISO
Orphenadrine affects the expression of EPHA2 mRNA
CTD
PMID:23665939
NCBI chr 4:141,028,532...141,056,695
Ensembl chr 4:141,028,551...141,056,695
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Ephb4
Eph receptor B4
affects expression
ISO
Orphenadrine affects the expression of EPHB4 mRNA
CTD
PMID:23665939
NCBI chr 5:137,348,371...137,372,784
Ensembl chr 5:137,348,371...137,376,931
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Eri2
exoribonuclease 2
affects expression
ISO
Orphenadrine affects the expression of ERI2 mRNA
CTD
PMID:23665939
NCBI chr 7:119,383,049...119,393,283
Ensembl chr 7:119,367,902...119,393,281
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F8
coagulation factor VIII
affects expression
ISO
Orphenadrine affects the expression of F8 mRNA
CTD
PMID:23665939
NCBI chr X:74,213,950...74,426,342
Ensembl chr X:74,216,321...74,426,221
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Fam89a
family with sequence similarity 89, member A
affects expression
ISO
Orphenadrine affects the expression of FAM89A mRNA
CTD
PMID:23665939
NCBI chr 8:125,466,996...125,478,605
Ensembl chr 8:125,466,996...125,478,571
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Fbxo27
F-box protein 27
affects expression
ISO
Orphenadrine affects the expression of FBXO27 mRNA
CTD
PMID:23665939
NCBI chr 7:28,392,205...28,398,763
Ensembl chr 7:28,392,274...28,398,763
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Fer1l5
fer-1 like family member 5
affects expression
ISO
Orphenadrine affects the expression of FER1L5 mRNA
CTD
PMID:23665939
NCBI chr 1:36,411,264...36,461,191
Ensembl chr 1:36,411,372...36,461,191
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Fgd5
FYVE, RhoGEF and PH domain containing 5
affects expression
ISO
Orphenadrine affects the expression of FGD5 mRNA
CTD
PMID:23665939
NCBI chr 6:91,955,809...92,052,986
Ensembl chr 6:91,955,859...92,052,985
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Flt1
FMS-like tyrosine kinase 1
affects expression
ISO
Orphenadrine affects the expression of FLT1 mRNA
CTD
PMID:23665939
NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821
G
Flt4
FMS-like tyrosine kinase 4
affects expression
ISO
Orphenadrine affects the expression of FLT4 mRNA
CTD
PMID:23665939
NCBI chr11:49,500,506...49,543,566
Ensembl chr11:49,500,090...49,543,566
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Fmo1
flavin containing monooxygenase 1
affects expression
ISO
Orphenadrine affects the expression of FMO1 mRNA
CTD
PMID:23665939
NCBI chr 1:162,657,130...162,694,170
Ensembl chr 1:162,657,130...162,694,179
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Fndc5
fibronectin type III domain containing 5
affects expression
ISO
Orphenadrine affects the expression of FNDC5 mRNA
CTD
PMID:23665939
NCBI chr 4:129,030,672...129,038,386
Ensembl chr 4:129,030,477...129,038,386
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Fst
follistatin
affects expression
ISO
Orphenadrine affects the expression of FST mRNA
CTD
PMID:23665939
NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487
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Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
affects expression
ISO
Orphenadrine affects the expression of GADD45G mRNA
CTD
PMID:23665939
NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504
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Gdf11
growth differentiation factor 11
affects expression
ISO
Orphenadrine affects the expression of GDF11 mRNA
CTD
PMID:23665939
NCBI chr10:128,716,393...128,727,587
Ensembl chr10:128,718,164...128,727,587
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Ggt1
gamma-glutamyltransferase 1
affects expression
ISO
Orphenadrine affects the expression of GGT1 mRNA
CTD
PMID:23665939
NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034
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Gimd1
GIMAP family P-loop NTPase domain containing 1
affects expression
ISO
Orphenadrine affects the expression of GIMD1 mRNA
CTD
PMID:23665939
NCBI chr 3:132,335,607...132,353,543
Ensembl chr 3:132,335,581...132,351,112
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Gipc2
GIPC PDZ domain containing family, member 2
affects expression
ISO
Orphenadrine affects the expression of GIPC2 mRNA
CTD
PMID:23665939
NCBI chr 3:151,799,476...151,871,537
Ensembl chr 3:151,799,170...151,871,867
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Gmip
Gem-interacting protein
affects expression
ISO
Orphenadrine affects the expression of GMIP mRNA
CTD
PMID:23665939
NCBI chr 8:70,260,912...70,274,520
Ensembl chr 8:70,261,329...70,274,520
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Gna14
guanine nucleotide binding protein, alpha 14
affects expression
ISO
Orphenadrine affects the expression of GNA14 mRNA
CTD
PMID:23665939
NCBI chr19:16,413,031...16,590,706
Ensembl chr19:16,413,126...16,588,184
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Gnai1
G protein subunit alpha i1
affects expression
ISO
Orphenadrine affects the expression of GNAI1 mRNA
CTD
PMID:23665939
NCBI chr 5:18,470,133...18,565,411
Ensembl chr 5:18,470,133...18,565,353
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Gpat3
glycerol-3-phosphate acyltransferase 3
affects expression
ISO
Orphenadrine affects the expression of GPAT3 mRNA
CTD
PMID:23665939
NCBI chr 5:100,994,095...101,046,968
Ensembl chr 5:100,993,579...101,046,968
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Gpr17
G protein-coupled receptor 17
affects expression
ISO
Orphenadrine affects the expression of GPR17 mRNA
CTD
PMID:23665939
NCBI chr18:32,076,052...32,082,925
Ensembl chr18:32,076,050...32,082,689
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Gpx2
glutathione peroxidase 2
affects expression multiple interactions
ISO
Orphenadrine affects the expression of GPX2 mRNA [Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA; [Phenobarbital co-treated with Orphenadrine] affects the expression of GPX2 mRNA
CTD
PMID:23665939 PMID:23665940
NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273
G
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
affects expression
ISO
Orphenadrine affects the expression of GRIA3 mRNA
CTD
PMID:23665939
NCBI chr X:40,489,351...40,767,478
Ensembl chr X:40,489,731...40,767,478
G
Grik5
glutamate receptor, ionotropic, kainate 5 (gamma 2)
affects expression
ISO
Orphenadrine affects the expression of GRIK5 mRNA
CTD
PMID:23665939
NCBI chr 7:24,709,274...24,775,421
Ensembl chr 7:24,709,274...24,771,771
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Gse1
genetic suppressor element 1, coiled-coil protein
affects expression
ISO
Orphenadrine affects the expression of GSE1 mRNA
CTD
PMID:23665939
NCBI chr 8:120,955,233...121,308,122
Ensembl chr 8:120,955,195...121,308,129
G
Gstm4
glutathione S-transferase, mu 4
affects expression
ISO
Orphenadrine affects the expression of GSTM4 mRNA
CTD
PMID:23665939
NCBI chr 3:107,937,887...107,952,495
Ensembl chr 3:107,947,724...107,952,210
G
Gstm5
glutathione S-transferase, mu 5
multiple interactions affects expression
ISO
[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA; [Phenobarbital co-treated with Orphenadrine] affects the expression of GSTM3 mRNA Orphenadrine affects the expression of GSTM3 mRNA
CTD
PMID:23665939 PMID:23665940
NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002
G
Gstp1
glutathione S-transferase, pi 1
affects expression
ISO
Orphenadrine affects the expression of GSTP1 mRNA
CTD
PMID:23665939
NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
G
Hal
histidine ammonia lyase
affects expression
ISO
Orphenadrine affects the expression of HAL mRNA
CTD
PMID:23665939
NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166
G
Hebp2
heme binding protein 2
affects expression
ISO
Orphenadrine affects the expression of HEBP2 mRNA
CTD
PMID:23665939
NCBI chr10:18,415,871...18,421,824
Ensembl chr10:18,415,246...18,421,824
G
Hes1
hes family bHLH transcription factor 1
affects expression
ISO
Orphenadrine affects the expression of HES1 mRNA
CTD
PMID:23665939
NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614
G
Hgf
hepatocyte growth factor
affects expression
ISO
Orphenadrine affects the expression of HGF mRNA
CTD
PMID:23665939
NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150
G
Hid1
HID1 domain containing
affects expression
ISO
Orphenadrine affects the expression of HID1 mRNA
CTD
PMID:23665939
NCBI chr11:115,238,531...115,261,087
Ensembl chr11:115,238,533...115,258,582
G
Hspa1a
heat shock protein 1A
affects expression
ISO
Orphenadrine affects the expression of HSPA1A mRNA
CTD
PMID:23665939
NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
G
Hspa1b
heat shock protein 1B
affects expression
ISO
Orphenadrine affects the expression of HSPA1B mRNA
CTD
PMID:23665939
NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
G
Hycc1
hyccin PI4KA lipid kinase complex subunit 1
affects expression
ISO
Orphenadrine affects the expression of HYCC1 mRNA
CTD
PMID:23665939
NCBI chr 5:24,120,274...24,235,694
Ensembl chr 5:24,120,274...24,235,688
G
Id1
inhibitor of DNA binding 1, HLH protein
affects expression
ISO
Orphenadrine affects the expression of ID1 mRNA
CTD
PMID:23665939
NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330
G
Id3
inhibitor of DNA binding 3
affects expression
ISO
Orphenadrine affects the expression of ID3 mRNA
CTD
PMID:23665939
NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066
G
Ido2
indoleamine 2,3-dioxygenase 2
affects expression
ISO
Orphenadrine affects the expression of IDO2 mRNA
CTD
PMID:23665939
NCBI chr 8:25,021,908...25,066,430
Ensembl chr 8:25,021,908...25,066,349
G
Ier5
immediate early response 5
affects expression
ISO
Orphenadrine affects the expression of IER5 mRNA
CTD
PMID:23665939
NCBI chr 1:154,972,113...154,975,382
Ensembl chr 1:154,972,107...154,975,382
G
Igfbp1
insulin-like growth factor binding protein 1
affects expression
ISO
Orphenadrine affects the expression of IGFBP1 mRNA
CTD
PMID:23665939
NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546
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Ihh
Indian hedgehog
affects expression
ISO
Orphenadrine affects the expression of IHH mRNA
CTD
PMID:23665939
NCBI chr 1:74,984,474...74,990,831
Ensembl chr 1:74,984,474...74,990,831
G
Ikbkg
inhibitor of kappaB kinase gamma
affects expression
ISO
Orphenadrine affects the expression of IKBKG mRNA
CTD
PMID:23665939
NCBI chr X:73,436,883...73,498,013
Ensembl chr X:73,436,896...73,497,460
G
Il17rb
interleukin 17 receptor B
affects expression
ISO
Orphenadrine affects the expression of IL17RB mRNA
CTD
PMID:23665939
NCBI chr14:29,718,125...29,730,853
Ensembl chr14:29,718,092...29,730,853
G
Il33
interleukin 33
affects expression
ISO
Orphenadrine affects the expression of IL33 mRNA
CTD
PMID:23665939
NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
G
Inf2
inverted formin, FH2 and WH2 domain containing
affects expression
ISO
Orphenadrine affects the expression of INF2 mRNA
CTD
PMID:23665939
NCBI chr12:112,555,121...112,581,991
Ensembl chr12:112,555,218...112,581,991
G
Ip6k2
inositol hexaphosphate kinase 2
affects expression
ISO
Orphenadrine affects the expression of IP6K2 mRNA
CTD
PMID:23665939
NCBI chr 9:108,660,928...108,683,532
Ensembl chr 9:108,660,995...108,683,536
G
Irf7
interferon regulatory factor 7
affects expression
ISO
Orphenadrine affects the expression of IRF7 mRNA
CTD
PMID:23665939
NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394
G
Irx1
Iroquois homeobox 1
affects expression
ISO
Orphenadrine affects the expression of IRX1 mRNA
CTD
PMID:23665939
NCBI chr13:72,106,351...72,111,842
Ensembl chr13:72,106,040...72,111,842
G
Isg15
ISG15 ubiquitin-like modifier
affects expression
ISO
Orphenadrine affects the expression of ISG15 mRNA
CTD
PMID:23665939
NCBI chr 4:156,283,881...156,285,275
Ensembl chr 4:156,283,912...156,285,253
G
Itgb3
integrin beta 3
affects expression
ISO
Orphenadrine affects the expression of ITGB3 mRNA
CTD
PMID:23665939
NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302
G
Jun
jun proto-oncogene
affects expression
ISO
Orphenadrine affects the expression of JUN mRNA
CTD
PMID:23665939
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
G
Junb
jun B proto-oncogene
affects expression
ISO
Orphenadrine affects the expression of JUNB mRNA
CTD
PMID:23665939
NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347
G
Kank2
KN motif and ankyrin repeat domains 2
affects expression
ISO
Orphenadrine affects the expression of KANK2 mRNA
CTD
PMID:23665939
NCBI chr 9:21,678,069...21,709,842
Ensembl chr 9:21,678,080...21,710,040
G
Kcnj15
potassium inwardly-rectifying channel, subfamily J, member 15
affects expression
ISO
Orphenadrine affects the expression of KCNJ15 mRNA
CTD
PMID:23665939
NCBI chr16:95,058,417...95,101,119
Ensembl chr16:95,058,417...95,101,119
G
Kcnk5
potassium channel, subfamily K, member 5
affects expression
ISO
Orphenadrine affects the expression of KCNK5 mRNA
CTD
PMID:23665939
NCBI chr14:20,190,125...20,231,850
Ensembl chr14:20,190,125...20,231,877
G
Klf10
Kruppel-like transcription factor 10
affects expression
ISO
Orphenadrine affects the expression of KLF10 mRNA
CTD
PMID:23665939
NCBI chr15:38,291,702...38,300,950
Ensembl chr15:38,291,707...38,300,950
G
Klhl21
kelch-like 21
affects expression
ISO
Orphenadrine affects the expression of KLHL21 mRNA
CTD
PMID:23665939
NCBI chr 4:152,093,348...152,102,134
Ensembl chr 4:152,093,260...152,102,137
G
Kmo
kynurenine 3-monooxygenase
affects expression
ISO
Orphenadrine affects the expression of KMO mRNA
CTD
PMID:23665939
NCBI chr 1:175,459,759...175,488,419
Ensembl chr 1:175,447,947...175,489,682
G
Krt10
keratin 10
affects expression
ISO
Orphenadrine affects the expression of KRT10 mRNA
CTD
PMID:23665939
NCBI chr11:99,276,080...99,288,631
Ensembl chr11:99,276,080...99,280,190
G
Krt8
keratin 8
affects expression
ISO
Orphenadrine affects the expression of KRT8 mRNA
CTD
PMID:23665939
NCBI chr15:101,905,146...101,912,777
Ensembl chr15:101,905,133...101,912,917
G
Lag3
lymphocyte-activation gene 3
affects expression
ISO
Orphenadrine affects the expression of LAG3 mRNA
CTD
PMID:23665939
NCBI chr 6:124,881,322...124,888,668
Ensembl chr 6:124,881,324...124,888,668
G
Lekr1
leucine, glutamate and lysine rich 1
affects expression
ISO
Orphenadrine affects the expression of LEKR1 mRNA
CTD
PMID:23665939
NCBI chr 3:65,566,960...65,743,948
Ensembl chr 3:65,573,649...65,738,776
G
Lgals2
lectin, galactose-binding, soluble 2
affects expression
ISO
Orphenadrine affects the expression of LGALS2 mRNA
CTD
PMID:23665939
NCBI chr15:78,735,060...78,739,729
Ensembl chr15:78,735,060...78,739,729
G
Lhx8
LIM homeobox protein 8
affects expression
ISO
Orphenadrine affects the expression of LHX8 mRNA
CTD
PMID:23665939
NCBI chr 3:154,011,925...154,036,190
Ensembl chr 3:154,011,931...154,036,296
G
Lilrb4b
leukocyte immunoglobulin-like receptor, subfamily B, member 4B
affects expression
ISO
Orphenadrine affects the expression of LILRB4 mRNA
CTD
PMID:23665939
NCBI chr10:51,356,757...51,362,417
Ensembl chr10:51,356,728...51,362,799
G
Lin7a
lin-7 homolog A, crumbs cell polarity complex component
affects expression
ISO
Orphenadrine affects the expression of LIN7A mRNA
CTD
PMID:23665939
NCBI chr10:107,107,410...107,261,007
Ensembl chr10:107,107,547...107,257,335
G
Lmod2
leiomodin 2 (cardiac)
affects expression
ISO
Orphenadrine affects the expression of LMOD2 mRNA
CTD
PMID:23665939
NCBI chr 6:24,597,770...24,605,413
Ensembl chr 6:24,597,761...24,605,413
G
Loxl4
lysyl oxidase-like 4
affects expression
ISO
Orphenadrine affects the expression of LOXL4 mRNA
CTD
PMID:23665939
NCBI chr19:42,580,718...42,601,326
Ensembl chr19:42,582,421...42,601,252
G
Lpcat4
lysophosphatidylcholine acyltransferase 4
affects expression
ISO
Orphenadrine affects the expression of LPCAT4 mRNA
CTD
PMID:23665939
NCBI chr 2:112,070,186...112,077,456
Ensembl chr 2:112,069,813...112,077,456
G
Lpin2
lipin 2
affects expression
ISO
Orphenadrine affects the expression of LPIN2 mRNA
CTD
PMID:23665939
NCBI chr17:71,490,527...71,556,813
Ensembl chr17:71,489,555...71,556,812
G
Lpl
lipoprotein lipase
affects expression
ISO
Orphenadrine affects the expression of LPL mRNA
CTD
PMID:23665939
NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100
G
Lrrn4
leucine rich repeat neuronal 4
affects expression
ISO
Orphenadrine affects the expression of LRRN4 mRNA
CTD
PMID:23665939
NCBI chr 2:132,710,436...132,735,930
Ensembl chr 2:132,710,225...132,722,811
G
Ltc4s
leukotriene C4 synthase
affects expression
ISO
Orphenadrine affects the expression of LTC4S mRNA
CTD
PMID:23665939
NCBI chr11:50,127,288...50,129,378
Ensembl chr11:50,127,288...50,129,443
G
Mafb
MAF bZIP transcription factor B
affects expression
ISO
Orphenadrine affects the expression of MAFB mRNA
CTD
PMID:23665939
NCBI chr 2:160,205,597...160,208,985
Ensembl chr 2:160,205,623...160,208,985
G
Magee1
MAGE family member E1
affects expression
ISO
Orphenadrine affects the expression of MAGEE1 mRNA
CTD
PMID:23665939
NCBI chr X:104,163,984...104,167,567
Ensembl chr X:104,163,984...104,167,533
G
Map1s
microtubule-associated protein 1S
affects expression
ISO
Orphenadrine affects the expression of MAP1S mRNA
CTD
PMID:23665939
NCBI chr 8:71,358,618...71,370,173
Ensembl chr 8:71,358,576...71,370,173
G
Map4k2
mitogen-activated protein kinase kinase kinase kinase 2
affects expression
ISO
Orphenadrine affects the expression of MAP4K2 mRNA
CTD
PMID:23665939
NCBI chr19:6,391,023...6,405,649
Ensembl chr19:6,391,165...6,405,645
G
Map4k4
mitogen-activated protein kinase kinase kinase kinase 4
affects expression
ISO
Orphenadrine affects the expression of MAP4K4 mRNA
CTD
PMID:23665939
NCBI chr 1:39,939,806...40,065,470
Ensembl chr 1:39,940,073...40,065,470
G
Mapk12
mitogen-activated protein kinase 12
affects expression
ISO
Orphenadrine affects the expression of MAPK12 mRNA
CTD
PMID:23665939
NCBI chr15:89,014,787...89,025,270
Ensembl chr15:89,014,787...89,024,906
G
Matn4
matrilin 4
affects expression
ISO
Orphenadrine affects the expression of MATN4 mRNA
CTD
PMID:23665939
NCBI chr 2:164,231,313...164,247,080
Ensembl chr 2:164,231,313...164,247,080
G
Mcam
melanoma cell adhesion molecule
affects expression
ISO
Orphenadrine affects the expression of MCAM mRNA
CTD
PMID:23665939
NCBI chr 9:44,045,958...44,054,024
Ensembl chr 9:44,045,766...44,054,024
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Metap1d
methionyl aminopeptidase type 1D (mitochondrial)
affects expression
ISO
Orphenadrine affects the expression of METAP1D mRNA
CTD
PMID:23665939
NCBI chr 2:71,283,625...71,355,538
Ensembl chr 2:71,283,620...71,355,538
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Mex3b
mex3 RNA binding family member B
affects expression
ISO
Orphenadrine affects the expression of MEX3B mRNA
CTD
PMID:23665939
NCBI chr 7:82,516,541...82,520,784
Ensembl chr 7:82,516,541...82,520,723
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Mex3d
mex3 RNA binding family member D
affects expression
ISO
Orphenadrine affects the expression of MEX3D mRNA
CTD
PMID:23665939
NCBI chr10:80,216,189...80,223,485
Ensembl chr10:80,216,189...80,223,493
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Mfge8
milk fat globule EGF and factor V/VIII domain containing
affects expression
ISO
Orphenadrine affects the expression of MFGE8 mRNA
CTD
PMID:23665939
NCBI chr 7:78,783,516...78,798,808
Ensembl chr 7:78,783,516...78,798,808
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Mid1
midline 1
affects expression
ISO
Orphenadrine affects the expression of MID1 mRNA
CTD
PMID:23665939
NCBI chr X:168,468,178...168,773,692
Ensembl chr X:168,468,195...168,773,794
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Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
affects expression
ISO
Orphenadrine affects the expression of MID1IP1 mRNA
CTD
PMID:23665939
NCBI chr X:10,583,604...10,585,941
Ensembl chr X:10,581,252...10,585,929
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Midn
midnolin
affects expression
ISO
Orphenadrine affects the expression of MIDN mRNA
CTD
PMID:23665939
NCBI chr10:79,984,106...79,994,202
Ensembl chr10:79,984,106...79,994,202
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Mknk2
MAP kinase-interacting serine/threonine kinase 2
affects expression
ISO
Orphenadrine affects the expression of MKNK2 mRNA
CTD
PMID:23665939
NCBI chr10:80,501,152...80,512,264
Ensembl chr10:80,501,161...80,513,946
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Mlxip
MLX interacting protein
affects expression
ISO
Orphenadrine affects the expression of MLXIP mRNA
CTD
PMID:23665939
NCBI chr 5:123,532,438...123,595,998
Ensembl chr 5:123,532,861...123,595,995
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Mmd
monocyte to macrophage differentiation-associated
affects expression
ISO
Orphenadrine affects the expression of MMD mRNA
CTD
PMID:23665939
NCBI chr11:90,078,513...90,169,399
Ensembl chr11:90,140,282...90,169,415
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Mmp12
matrix metallopeptidase 12
affects expression
ISO
Orphenadrine affects the expression of MMP12 mRNA
CTD
PMID:23665939
NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
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Mmp15
matrix metallopeptidase 15
affects expression
ISO
Orphenadrine affects the expression of MMP15 mRNA
CTD
PMID:23665939
NCBI chr 8:96,078,924...96,100,921
Ensembl chr 8:96,078,896...96,101,708
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Mras
muscle and microspikes RAS
affects expression
ISO
Orphenadrine affects the expression of MRAS mRNA
CTD
PMID:23665939
NCBI chr 9:99,267,473...99,319,505
Ensembl chr 9:99,267,473...99,319,434
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Mroh2a
maestro heat-like repeat family member 2A
affects expression
ISO
Orphenadrine affects the expression of MROH2A mRNA
CTD
PMID:23665939
NCBI chr 1:88,154,713...88,190,011
Ensembl chr 1:88,154,708...88,190,011
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Mst1r
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
affects expression
ISO
Orphenadrine affects the expression of MST1R mRNA
CTD
PMID:23665939
NCBI chr 9:107,784,057...107,797,582
Ensembl chr 9:107,784,072...107,797,582
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Mtmr7
myotubularin related protein 7
affects expression
ISO
Orphenadrine affects the expression of MTMR7 mRNA
CTD
PMID:23665939
NCBI chr 8:41,003,184...41,088,210
Ensembl chr 8:41,004,136...41,087,840
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Mtss2
MTSS I-BAR domain containing 2
affects expression
ISO
Orphenadrine affects the expression of MTSS2 mRNA
CTD
PMID:23665939
NCBI chr 8:111,447,718...111,468,032
Ensembl chr 8:111,448,108...111,468,032
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Mybph
myosin binding protein H
affects expression
ISO
Orphenadrine affects the expression of MYBPH mRNA
CTD
PMID:23665939
NCBI chr 1:134,121,159...134,128,975
Ensembl chr 1:134,121,186...134,128,970
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Mypop
Myb-related transcription factor, partner of profilin
affects expression
ISO
Orphenadrine affects the expression of MYPOP mRNA
CTD
PMID:23665939
NCBI chr 7:18,725,230...18,735,691
Ensembl chr 7:18,725,170...18,735,691
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Myrf
myelin regulatory factor
affects expression
ISO
Orphenadrine affects the expression of MYRF mRNA
CTD
PMID:23665939
NCBI chr19:10,185,635...10,218,134
Ensembl chr19:10,185,636...10,218,112
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Nat8f2
N-acetyltransferase 8 (GCN5-related) family member 2
affects expression
ISO
Orphenadrine affects the expression of NAT8F2 mRNA
CTD
PMID:23665939
NCBI chr 6:85,842,404...85,846,119
Ensembl chr 6:85,842,404...85,846,140
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Ncaph
non-SMC condensin I complex, subunit H
affects expression
ISO
Orphenadrine affects the expression of NCAPH mRNA
CTD
PMID:23665939
NCBI chr 2:126,945,729...126,975,857
Ensembl chr 2:126,945,729...126,975,874
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Ncoa7
nuclear receptor coactivator 7
affects expression
ISO
Orphenadrine affects the expression of NCOA7 mRNA
CTD
PMID:23665939
NCBI chr10:30,521,578...30,683,401
Ensembl chr10:30,504,995...30,679,322
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Nefh
neurofilament, heavy polypeptide
affects expression
ISO
Orphenadrine affects the expression of NEFH mRNA
CTD
PMID:22954530
NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064
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Neurl3
neuralized E3 ubiquitin protein ligase 3
affects expression
ISO
Orphenadrine affects the expression of NEURL3 mRNA
CTD
PMID:23665939
NCBI chr 1:36,303,683...36,313,755
Ensembl chr 1:36,303,678...36,313,760
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Nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
affects expression
ISO
Orphenadrine affects the expression of NFKBIZ mRNA
CTD
PMID:23665939
NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262
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Nhsl3
NHS like 3
affects expression
ISO
Orphenadrine affects the expression of NHSL3 mRNA
CTD
PMID:23665939
NCBI chr 4:129,113,371...129,155,194
Ensembl chr 4:129,113,371...129,155,197
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Ninj2
ninjurin 2
affects expression
ISO
Orphenadrine affects the expression of NINJ2 mRNA
CTD
PMID:23665939
NCBI chr 6:120,070,315...120,177,300
Ensembl chr 6:120,070,311...120,177,300
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Nipal2
NIPA-like domain containing 2
affects expression
ISO
Orphenadrine affects the expression of NIPAL2 mRNA
CTD
PMID:23665939
NCBI chr15:34,572,942...34,679,739
Ensembl chr15:34,572,945...34,679,358
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Nlrc4
NLR family, CARD domain containing 4
affects expression
ISO
Orphenadrine affects the expression of NLRC4 mRNA
CTD
PMID:23665939
NCBI chr17:74,733,254...74,766,140
Ensembl chr17:74,732,433...74,766,137
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Noct
nocturnin
affects expression
ISO
Orphenadrine affects the expression of NOCT mRNA
CTD
PMID:23665939
NCBI chr 3:51,131,868...51,159,075
Ensembl chr 3:51,131,868...51,159,065
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Nos1ap
nitric oxide synthase 1 (neuronal) adaptor protein
affects expression
ISO
Orphenadrine affects the expression of NOS1AP mRNA
CTD
PMID:23665939
NCBI chr 1:170,143,039...170,417,371
Ensembl chr 1:170,130,237...170,417,430
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Nos3
nitric oxide synthase 3, endothelial cell
affects expression
ISO
Orphenadrine affects the expression of NOS3 mRNA
CTD
PMID:23665939
NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
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Npy
neuropeptide Y
affects expression
ISO
Orphenadrine affects the expression of NPY mRNA
CTD
PMID:23665939
NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487
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Nr1d1
nuclear receptor subfamily 1, group D, member 1
affects expression
ISO
Orphenadrine affects the expression of NR1D1 mRNA
CTD
PMID:23665939
NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159
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Nrep
neuronal regeneration related protein
affects expression
ISO
Orphenadrine affects the expression of NREP mRNA
CTD
PMID:23665939
NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082
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Nrg1
neuregulin 1
affects expression
ISO
Orphenadrine affects the expression of NRG1 mRNA
CTD
PMID:23665939
NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825 Ensembl chr 8:32,304,579...33,374,825
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Nrxn1
neurexin I
affects expression
ISO
Orphenadrine affects the expression of NRXN1 mRNA
CTD
PMID:23665939
NCBI chr17:90,341,072...91,400,587
Ensembl chr17:90,341,059...91,400,499
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Nupr1
nuclear protein transcription regulator 1
affects expression
ISO
Orphenadrine affects the expression of NUPR1 mRNA
CTD
PMID:23665939
NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033
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Oat
ornithine aminotransferase
affects expression
ISO
Orphenadrine affects the expression of OAT mRNA
CTD
PMID:23665939
NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127
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Ogn
osteoglycin
affects expression
ISO
Orphenadrine affects the expression of OGN mRNA
CTD
PMID:23665939
NCBI chr13:49,761,491...49,777,977
Ensembl chr13:49,761,522...49,777,977
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Omd
osteomodulin
affects expression
ISO
Orphenadrine affects the expression of OMD mRNA
CTD
PMID:23665939
NCBI chr13:49,735,938...49,746,088
Ensembl chr13:49,735,938...49,746,298
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Or2y1
olfactory receptor family 2 subfamily Y member 1
affects expression
ISO
Orphenadrine affects the expression of OR2Y1I mRNA
CTD
PMID:23665939
NCBI chr11:49,385,362...49,386,291
Ensembl chr11:49,379,897...49,388,323
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Osgin1
oxidative stress induced growth inhibitor 1
affects expression
ISO
Orphenadrine affects the expression of OSGIN1 mRNA
CTD
PMID:23665939
NCBI chr 8:120,160,874...120,172,996
Ensembl chr 8:120,160,863...120,172,995
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P3h2
prolyl 3-hydroxylase 2
affects expression
ISO
Orphenadrine affects the expression of P3H2 mRNA
CTD
PMID:23665939
NCBI chr16:25,778,034...25,924,563
Ensembl chr16:25,778,038...25,924,534
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P3h4
prolyl 3-hydroxylase family member 4 (non-enzymatic)
affects expression
ISO
Orphenadrine affects the expression of P3H4 mRNA
CTD
PMID:23665939
NCBI chr11:100,299,293...100,305,542
Ensembl chr11:100,299,282...100,305,662
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Panx2
pannexin 2
affects expression
ISO
Orphenadrine affects the expression of PANX2 mRNA
CTD
PMID:23665939
NCBI chr15:88,941,797...88,957,769
Ensembl chr15:88,943,937...88,957,770
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Pcdh12
protocadherin 12
affects expression
ISO
Orphenadrine affects the expression of PCDH12 mRNA
CTD
PMID:23665939
NCBI chr18:38,400,145...38,417,454
Ensembl chr18:38,400,142...38,417,455
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Pcp4l1
Purkinje cell protein 4-like 1
affects expression
ISO
Orphenadrine affects the expression of PCP4L1 mRNA
CTD
PMID:23665939
NCBI chr 1:171,000,833...171,023,837
Ensembl chr 1:171,000,831...171,023,837
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Pcsk9
proprotein convertase subtilisin/kexin type 9
affects expression
ISO
Orphenadrine affects the expression of PCSK9 mRNA
CTD
PMID:23665939
NCBI chr 4:106,299,531...106,321,522
Ensembl chr 4:106,299,526...106,321,526
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Pde5a
phosphodiesterase 5A, cGMP-specific
affects expression
ISO
Orphenadrine affects the expression of PDE5A mRNA
CTD
PMID:23665939
NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023
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Pdk4
pyruvate dehydrogenase kinase, isoenzyme 4
affects expression
ISO
Orphenadrine affects the expression of PDK4 mRNA
CTD
PMID:23665939
NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
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Pdpn
podoplanin
affects expression
ISO
Orphenadrine affects the expression of PDPN mRNA
CTD
PMID:23665939
NCBI chr 4:142,993,979...143,026,134
Ensembl chr 4:142,994,001...143,026,134
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Per2
period circadian clock 2
affects expression
ISO
Orphenadrine affects the expression of PER2 mRNA
CTD
PMID:23665939
NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046
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Pfkm
phosphofructokinase, muscle
affects expression
ISO
Orphenadrine affects the expression of PFKM mRNA
CTD
PMID:23665939
NCBI chr15:97,990,470...98,030,328
Ensembl chr15:97,990,470...98,030,332
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Phlda2
pleckstrin homology like domain, family A, member 2
affects expression
ISO
Orphenadrine affects the expression of PHLDA2 mRNA
CTD
PMID:23665939
NCBI chr 7:143,055,282...143,056,882
Ensembl chr 7:143,055,282...143,056,887
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Phlda3
pleckstrin homology like domain, family A, member 3
affects expression
ISO
Orphenadrine affects the expression of PHLDA3 mRNA
CTD
PMID:23665939
NCBI chr 1:135,693,823...135,696,872
Ensembl chr 1:135,693,857...135,696,874
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Phldb3
pleckstrin homology like domain, family B, member 3
affects expression
ISO
Orphenadrine affects the expression of PHLDB3 mRNA
CTD
PMID:23665939
NCBI chr 7:24,309,731...24,328,722
Ensembl chr 7:24,310,188...24,328,722
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Phospho1
phosphatase, orphan 1
affects expression
ISO
Orphenadrine affects the expression of PHOSPHO1 mRNA
CTD
PMID:23665939
NCBI chr11:95,715,326...95,722,966
Ensembl chr11:95,715,325...95,722,966
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Pip5k1c
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
affects expression
ISO
Orphenadrine affects the expression of PIP5K1C mRNA
CTD
PMID:23665939
NCBI chr10:81,128,669...81,155,808
Ensembl chr10:81,128,797...81,155,807
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Plekhf2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
affects expression
ISO
Orphenadrine affects the expression of PLEKHF2 mRNA
CTD
PMID:23665939
NCBI chr 4:10,988,662...11,007,619
Ensembl chr 4:10,988,662...11,007,927
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Plekhh1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
affects expression
ISO
Orphenadrine affects the expression of PLEKHH1 mRNA
CTD
PMID:23665939
NCBI chr12:79,075,937...79,128,429
Ensembl chr12:79,075,937...79,128,429
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Plin3
perilipin 3
affects expression
ISO
Orphenadrine affects the expression of PLIN3 mRNA
CTD
PMID:23665939
NCBI chr17:56,585,962...56,597,511
Ensembl chr17:56,584,476...56,599,873
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Pmepa1
prostate transmembrane protein, androgen induced 1
affects expression
ISO
Orphenadrine affects the expression of PMEPA1 mRNA
CTD
PMID:23665939
NCBI chr 2:173,066,251...173,118,329
Ensembl chr 2:173,066,251...173,118,326
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Pmp22
peripheral myelin protein 22
affects expression
ISO
Orphenadrine affects the expression of PMP22 mRNA
CTD
PMID:23665939
NCBI chr11:63,019,808...63,050,373
Ensembl chr11:63,019,808...63,050,373
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Polg2
polymerase (DNA directed), gamma 2, accessory subunit
affects expression
ISO
Orphenadrine affects the expression of POLG2 mRNA
CTD
PMID:23665939
NCBI chr11:106,659,030...106,670,363
Ensembl chr11:106,659,079...106,670,363
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Ppm1j
protein phosphatase 1J
affects expression
ISO
Orphenadrine affects the expression of PPM1J mRNA
CTD
PMID:23665939
NCBI chr 3:104,688,322...104,693,334
Ensembl chr 3:104,688,372...104,693,334
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Ppm1k
protein phosphatase 1K (PP2C domain containing)
affects expression
ISO
Orphenadrine affects the expression of PPM1K mRNA
CTD
PMID:23665939
NCBI chr 6:57,483,487...57,512,537
Ensembl chr 6:57,483,487...57,512,453
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Ppp1r1a
protein phosphatase 1, regulatory inhibitor subunit 1A
affects expression
ISO
Orphenadrine affects the expression of PPP1R1A mRNA
CTD
PMID:23665939
NCBI chr15:103,438,706...103,446,465
Ensembl chr15:103,438,706...103,446,430
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Prelid2
PRELI domain containing 2
affects expression
ISO
Orphenadrine affects the expression of PRELID2 mRNA
CTD
PMID:23665939
NCBI chr18:42,008,761...42,084,259
Ensembl chr18:42,008,665...42,084,307
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Prkch
protein kinase C, eta
affects expression
ISO
Orphenadrine affects the expression of PRKCH mRNA
CTD
PMID:23665939
NCBI chr12:73,631,570...73,824,959
Ensembl chr12:73,631,570...73,824,959
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Prlr
prolactin receptor
affects expression
ISO
Orphenadrine affects the expression of PRLR mRNA
CTD
PMID:23665939
NCBI chr15:10,177,324...10,349,276
Ensembl chr15:10,177,324...10,349,266
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Prp2
proline rich protein 2
affects expression
ISO
Orphenadrine affects the expression of PRP2 mRNA
CTD
PMID:23665939
NCBI chr 6:132,572,874...132,577,665
Ensembl chr 6:132,572,876...132,578,199
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Prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
affects expression
ISO
Orphenadrine affects the expression of PRRG4 mRNA
CTD
PMID:23665939
NCBI chr 2:104,657,374...104,680,216
Ensembl chr 2:104,661,086...104,680,221
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Prss53
serine protease 53
affects expression
ISO
Orphenadrine affects the expression of PRSS53 mRNA
CTD
PMID:23665939
NCBI chr 7:127,484,616...127,490,594
Ensembl chr 7:127,485,013...127,490,142
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Ptprn
protein tyrosine phosphatase receptor type N
affects expression
ISO
Orphenadrine affects the expression of PTPRN mRNA
CTD
PMID:23665939
NCBI chr 1:75,223,679...75,241,437
Ensembl chr 1:75,223,671...75,241,146
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Pvr
poliovirus receptor
affects expression
ISO
Orphenadrine affects the expression of PVR mRNA
CTD
PMID:23665939
NCBI chr 7:19,637,503...19,655,068
Ensembl chr 7:19,637,503...19,655,085
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Pwwp2b
PWWP domain containing 2B
affects expression
ISO
Orphenadrine affects the expression of PWWP2B mRNA
CTD
PMID:23665939
NCBI chr 7:138,828,398...138,847,172
Ensembl chr 7:138,828,398...138,849,819
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Rab11fip5
RAB11 family interacting protein 5 (class I)
affects expression
ISO
Orphenadrine affects the expression of RAB11FIP5 mRNA
CTD
PMID:23665939
NCBI chr 6:85,311,944...85,351,663
Ensembl chr 6:85,311,944...85,351,616
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Rab23
RAB23, member RAS oncogene family
affects expression
ISO
Orphenadrine affects the expression of RAB23 mRNA
CTD
PMID:23665939
NCBI chr 1:33,758,991...33,781,642
Ensembl chr 1:33,758,968...33,781,645
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Rab3d
RAB3D, member RAS oncogene family
affects expression
ISO
Orphenadrine affects the expression of RAB3D mRNA
CTD
PMID:23665939
NCBI chr 9:21,818,787...21,829,623
Ensembl chr 9:21,818,787...21,829,488
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Rarg
retinoic acid receptor, gamma
affects expression
ISO
Orphenadrine affects the expression of RARG mRNA
CTD
PMID:23665939
NCBI chr15:102,143,373...102,165,891
Ensembl chr15:102,143,373...102,165,952
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Rassf1
Ras association (RalGDS/AF-6) domain family member 1
affects expression
ISO
Orphenadrine affects the expression of RASSF1 mRNA
CTD
PMID:23665939
NCBI chr 9:107,428,752...107,439,460
Ensembl chr 9:107,428,754...107,439,466
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Rell1
RELT-like 1
affects expression
ISO
Orphenadrine affects the expression of RELL1 mRNA
CTD
PMID:23665939
NCBI chr 5:64,047,296...64,126,165
Ensembl chr 5:64,066,240...64,126,240
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Renbp
renin binding protein
affects expression
ISO
Orphenadrine affects the expression of RENBP mRNA
CTD
PMID:23665939
NCBI chr X:72,965,727...72,974,408
Ensembl chr X:72,965,727...72,974,456
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Repin1
replication initiator 1
affects expression
ISO
Orphenadrine affects the expression of REPIN1 mRNA
CTD
PMID:23665939
NCBI chr 6:48,570,817...48,576,016
Ensembl chr 6:48,570,817...48,576,016
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Resp18
regulated endocrine-specific protein 18
affects expression
ISO
Orphenadrine affects the expression of RESP18 mRNA
CTD
PMID:23665939
NCBI chr 1:75,248,841...75,255,059
Ensembl chr 1:75,248,843...75,255,059
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Rgs16
regulator of G-protein signaling 16
affects expression
ISO
Orphenadrine affects the expression of RGS16 mRNA
CTD
PMID:23665939
NCBI chr 1:153,616,099...153,621,212
Ensembl chr 1:153,616,095...153,621,214
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Rhbdf2
rhomboid 5 homolog 2
affects expression
ISO
Orphenadrine affects the expression of RHBDF2 mRNA
CTD
PMID:23665939
NCBI chr11:116,488,991...116,517,786
Ensembl chr11:116,488,991...116,517,845
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Rhoc
ras homolog family member C
affects expression
ISO
Orphenadrine affects the expression of RHOC mRNA
CTD
PMID:23665939
NCBI chr 3:104,696,350...104,701,775
Ensembl chr 3:104,695,691...104,701,775
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Rhof
ras homolog family member F (in filopodia)
affects expression
ISO
Orphenadrine affects the expression of RHOF mRNA
CTD
PMID:23665939
NCBI chr 5:123,256,243...123,270,692
Ensembl chr 5:123,241,107...123,270,755
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Rmdn2
regulator of microtubule dynamics 2
affects expression
ISO
Orphenadrine affects the expression of RMDN2 mRNA
CTD
PMID:23665939
NCBI chr17:79,886,025...80,000,630
Ensembl chr17:79,919,292...80,000,621
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Rnd1
Rho family GTPase 1
affects expression
ISO
Orphenadrine affects the expression of RND1 mRNA
CTD
PMID:23665939
NCBI chr15:98,567,086...98,575,342
Ensembl chr15:98,561,302...98,575,342
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Sbspon
somatomedin B and thrombospondin, type 1 domain containing
affects expression
ISO
Orphenadrine affects the expression of SBSPON mRNA
CTD
PMID:23665939
NCBI chr 1:15,924,086...15,962,946
Ensembl chr 1:15,924,086...15,962,946
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Scd1
stearoyl-Coenzyme A desaturase 1
affects expression
ISO
Orphenadrine affects the expression of SCD1 mRNA
CTD
PMID:23665939
NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
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Scnn1a
sodium channel, nonvoltage-gated 1 alpha
affects expression
ISO
Orphenadrine affects the expression of SCNN1A mRNA
CTD
PMID:23665939
NCBI chr 6:125,286,657...125,321,906
Ensembl chr 6:125,297,622...125,321,906
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Sdc3
syndecan 3
affects expression
ISO
Orphenadrine affects the expression of SDC3 mRNA
CTD
PMID:23665939
NCBI chr 4:130,519,855...130,553,629
Ensembl chr 4:130,519,848...130,553,630
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Sebox
SEBOX homeobox
affects expression
ISO
Orphenadrine affects the expression of SEBOX mRNA
CTD
PMID:23665939
NCBI chr11:78,394,328...78,395,907
Ensembl chr11:78,394,273...78,395,907
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Serinc2
serine incorporator 2
affects expression
ISO
Orphenadrine affects the expression of SERINC2 mRNA
CTD
PMID:23665939
NCBI chr 4:130,147,289...130,172,993
Ensembl chr 4:130,147,288...130,172,998
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Serpina7
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
affects expression
ISO
Orphenadrine affects the expression of SERPINA7 mRNA
CTD
PMID:23665939
NCBI chr X:137,979,998...137,985,985
Ensembl chr X:137,980,006...137,985,985
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Sertad1
SERTA domain containing 1
affects expression
ISO
Orphenadrine affects the expression of SERTAD1 mRNA
CTD
PMID:23665939
NCBI chr 7:27,186,378...27,189,741
Ensembl chr 7:27,186,335...27,189,741
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Setd7
SET domain containing (lysine methyltransferase) 7
affects expression
ISO
Orphenadrine affects the expression of SETD7 mRNA
CTD
PMID:23665939
NCBI chr 3:51,422,740...51,468,519
Ensembl chr 3:51,422,740...51,468,300
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Sgk1
serum/glucocorticoid regulated kinase 1
affects expression
ISO
Orphenadrine affects the expression of SGK1 mRNA
CTD
PMID:23665939
NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802
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Sh3pxd2b
SH3 and PX domains 2B
affects expression
ISO
Orphenadrine affects the expression of SH3PXD2B mRNA
CTD
PMID:23665939
NCBI chr11:32,297,777...32,378,189
Ensembl chr11:32,297,820...32,378,173
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Shank3
SH3 and multiple ankyrin repeat domains 3
affects expression
ISO
Orphenadrine affects the expression of SHANK3 mRNA
CTD
PMID:23665939
NCBI chr15:89,376,929...89,444,464
Ensembl chr15:89,383,826...89,444,464
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Shisa4
shisa family member 4
affects expression
ISO
Orphenadrine affects the expression of SHISA4 mRNA
CTD
PMID:23665939
NCBI chr 1:135,298,578...135,302,812
Ensembl chr 1:135,298,795...135,302,975
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Shroom3
shroom family member 3
affects expression
ISO
Orphenadrine affects the expression of SHROOM3 mRNA
CTD
PMID:23665939
NCBI chr 5:92,831,294...93,113,618
Ensembl chr 5:92,831,294...93,113,177
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Sidt1
SID1 transmembrane family, member 1
affects expression
ISO
Orphenadrine affects the expression of SIDT1 mRNA
CTD
PMID:23665939
NCBI chr16:44,060,540...44,153,575
Ensembl chr16:44,060,543...44,153,559
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Sinhcaf
SIN3-HDAC complex associated factor
affects expression
ISO
Orphenadrine affects the expression of SINHCAF mRNA
CTD
PMID:23665939
NCBI chr 6:148,822,538...148,847,968
Ensembl chr 6:148,822,533...148,847,965
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Sipa1
signal-induced proliferation associated gene 1
affects expression
ISO
Orphenadrine affects the expression of SIPA1 mRNA
CTD
PMID:23665939
NCBI chr19:5,701,211...5,713,758
Ensembl chr19:5,701,213...5,713,735
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Skil
SKI-like
affects expression
ISO
Orphenadrine affects the expression of SKIL mRNA
CTD
PMID:23665939
NCBI chr 3:31,149,259...31,176,741
Ensembl chr 3:31,149,207...31,176,726
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Slc12a4
solute carrier family 12, member 4
affects expression
ISO
Orphenadrine affects the expression of SLC12A4 mRNA
CTD
PMID:23665939
NCBI chr 8:106,670,222...106,692,781
Ensembl chr 8:106,670,222...106,692,729
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Slc16a10
solute carrier family 16 (monocarboxylic acid transporters), member 10
affects expression
ISO
Orphenadrine affects the expression of SLC16A10 mRNA
CTD
PMID:23665939
NCBI chr10:39,909,528...40,018,262
Ensembl chr10:39,909,528...40,018,254
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Slc16a11
solute carrier family 16 (monocarboxylic acid transporters), member 11
affects expression
ISO
Orphenadrine affects the expression of SLC16A11 mRNA
CTD
PMID:23665939
NCBI chr11:70,104,717...70,107,239
Ensembl chr11:70,103,578...70,107,243
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Slc16a14
solute carrier family 16 (monocarboxylic acid transporters), member 14
affects expression
ISO
Orphenadrine affects the expression of SLC16A14 mRNA
CTD
PMID:23665939
NCBI chr 1:84,881,344...84,912,927
Ensembl chr 1:84,883,619...84,912,855
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Slc16a5
solute carrier family 16 (monocarboxylic acid transporters), member 5
affects expression
ISO
Orphenadrine affects the expression of SLC16A5 mRNA
CTD
PMID:23665939
NCBI chr11:115,353,231...115,365,224
Ensembl chr11:115,353,300...115,365,224
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Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
affects expression
ISO
Orphenadrine affects the expression of SLC16A6 mRNA
CTD
PMID:23665939
NCBI chr11:109,341,681...109,366,428
Ensembl chr11:109,341,681...109,364,424
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Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
affects expression
ISO
Orphenadrine affects the expression of SLC1A4 mRNA
CTD
PMID:23665939
NCBI chr11:20,252,180...20,282,713
Ensembl chr11:20,252,180...20,282,713
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Orphenadrine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Orphenadrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Slc30a2
solute carrier family 30 (zinc transporter), member 2
affects expression
ISO
Orphenadrine affects the expression of SLC30A2 mRNA
CTD
PMID:23665939
NCBI chr 4:134,070,357...134,081,795
Ensembl chr 4:134,070,492...134,081,795
G
Slc35f2
solute carrier family 35, member F2
affects expression
ISO
Orphenadrine affects the expression of SLC35F2 mRNA
CTD
PMID:23665939
NCBI chr 9:53,678,733...53,725,445
Ensembl chr 9:53,678,822...53,725,438
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Slc41a1
solute carrier family 41, member 1
affects expression
ISO
Orphenadrine affects the expression of SLC41A1 mRNA
CTD
PMID:23665939
NCBI chr 1:131,755,236...131,776,601
Ensembl chr 1:131,755,231...131,776,603
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Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
affects expression
ISO
Orphenadrine affects the expression of SLC6A8 mRNA
CTD
PMID:23665939
NCBI chr X:72,716,739...72,726,108
Ensembl chr X:72,716,756...72,726,108
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Slc7a4
solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
affects expression
ISO
Orphenadrine affects the expression of SLC7A4 mRNA
CTD
PMID:23665939
NCBI chr16:17,389,882...17,394,619
Ensembl chr16:17,389,882...17,401,078
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Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
affects expression
ISO
Orphenadrine affects the expression of SLC9A7 mRNA
CTD
PMID:23665939
NCBI chr X:19,965,090...20,158,274
Ensembl chr X:19,971,993...20,158,046
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Smad6
SMAD family member 6
affects expression
ISO
Orphenadrine affects the expression of SMAD6 mRNA
CTD
PMID:23665939
NCBI chr 9:63,860,358...63,929,374
Ensembl chr 9:63,860,358...63,929,341
G
Smtnl2
smoothelin-like 2
affects expression
ISO
Orphenadrine affects the expression of SMTNL2 mRNA
CTD
PMID:23665939
NCBI chr11:72,279,989...72,302,539
Ensembl chr11:72,279,990...72,302,539
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Snx10
sorting nexin 10
affects expression
ISO
Orphenadrine affects the expression of SNX10 mRNA
CTD
PMID:23665939
NCBI chr 6:51,500,882...51,567,659
Ensembl chr 6:51,500,881...51,567,659
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Sort1
sortilin 1
affects expression
ISO
Orphenadrine affects the expression of SORT1 mRNA
CTD
PMID:23665939
NCBI chr 3:108,191,272...108,268,835
Ensembl chr 3:108,191,398...108,268,827
G
Sox18
SRY (sex determining region Y)-box 18
affects expression
ISO
Orphenadrine affects the expression of SOX18 mRNA
CTD
PMID:23665939
NCBI chr 2:181,311,630...181,313,433
Ensembl chr 2:181,311,629...181,313,433
G
Sox4
SRY (sex determining region Y)-box 4
affects expression
ISO
Orphenadrine affects the expression of SOX4 mRNA
CTD
PMID:23665939
NCBI chr13:29,132,902...29,137,682
Ensembl chr13:29,132,902...29,137,696
G
Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
affects expression
ISO
Orphenadrine affects the expression of SPC25 mRNA
CTD
PMID:23665939
NCBI chr 2:69,009,753...69,036,583
Ensembl chr 2:69,024,239...69,036,538
G
Spink12
serine peptidase inhibitor, Kazal type 12
affects expression
ISO
Orphenadrine affects the expression of SPINK9 mRNA
CTD
PMID:23665939
NCBI chr18:44,237,357...44,241,610
Ensembl chr18:44,237,474...44,241,610
G
Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
affects expression
ISO
Orphenadrine affects the expression of SPOCK2 mRNA
CTD
PMID:23665939
NCBI chr10:59,942,079...59,971,020
Ensembl chr10:59,942,041...59,971,020
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Srcin1
SRC kinase signaling inhibitor 1
affects expression
ISO
Orphenadrine affects the expression of SRCIN1 mRNA
CTD
PMID:23665939
NCBI chr11:97,400,166...97,466,059
Ensembl chr11:97,400,166...97,467,012
G
Srd5a1
steroid 5 alpha-reductase 1
affects expression
ISO
Orphenadrine affects the expression of SRD5A1 mRNA
CTD
PMID:23665939
NCBI chr13:69,721,568...69,759,611
Ensembl chr13:69,721,568...69,759,561
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Stac3
SH3 and cysteine rich domain 3
affects expression
ISO
Orphenadrine affects the expression of STAC3 mRNA
CTD
PMID:23665939
NCBI chr10:127,337,505...127,344,692
Ensembl chr10:127,337,555...127,344,692
G
Stard9
StAR related lipid transfer domain containing 9
affects expression
ISO
Orphenadrine affects the expression of STARD9 mRNA
CTD
PMID:23665939
NCBI chr 2:120,459,567...120,562,371
Ensembl chr 2:120,459,602...120,562,376
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Stxbp1
syntaxin binding protein 1
affects expression
ISO
Orphenadrine affects the expression of STXBP1 mRNA
CTD
PMID:23665939
NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257
G
Sult1e1
sulfotransferase family 1E, member 1
affects expression
ISO
Orphenadrine affects the expression of SULT1E1 mRNA
CTD
PMID:23665939
NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453
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Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
affects expression
ISO
Orphenadrine affects the expression of SYDE1 mRNA
CTD
PMID:23665939
NCBI chr10:78,420,336...78,427,798
Ensembl chr10:78,420,337...78,427,798
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Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat)
affects expression
ISO
Orphenadrine affects the expression of SYNGAP1 mRNA
CTD
PMID:23665939
NCBI chr17:27,160,186...27,191,408
Ensembl chr17:27,160,227...27,191,408
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Synj2
synaptojanin 2
affects expression
ISO
Orphenadrine affects the expression of SYNJ2 mRNA
CTD
PMID:23665939
NCBI chr17:5,991,555...6,106,041
Ensembl chr17:5,991,555...6,094,565
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Synm
synemin, intermediate filament protein
affects expression
ISO
Orphenadrine affects the expression of SYNM mRNA
CTD
PMID:23665939
NCBI chr 7:67,379,909...67,409,490
Ensembl chr 7:67,379,908...67,409,490
G
Tbcel
tubulin folding cofactor E-like
affects expression
ISO
Orphenadrine affects the expression of TBCEL mRNA
CTD
PMID:23665939
NCBI chr 9:42,323,612...42,383,534
Ensembl chr 9:42,323,612...42,419,105
G
Tead2
TEA domain family member 2
affects expression
ISO
Orphenadrine affects the expression of TEAD2 mRNA
CTD
PMID:23665939
NCBI chr 7:44,865,216...44,882,892
Ensembl chr 7:44,865,177...44,883,068
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Tenm2
teneurin transmembrane protein 2
affects expression
ISO
Orphenadrine affects the expression of TENM2 mRNA
CTD
PMID:23665939
NCBI chr11:35,897,483...37,881,486
Ensembl chr11:35,897,483...37,126,791
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Tex13b
testis expressed 13B
affects expression
ISO
Orphenadrine affects the expression of TEX13B mRNA
CTD
PMID:23665939
NCBI chr X:139,709,056...139,714,182
Ensembl chr X:139,709,056...139,714,182
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Tex36
testis expressed 36
affects expression
ISO
Orphenadrine affects the expression of TEX36 mRNA
CTD
PMID:23665939
NCBI chr 7:133,188,753...133,203,844
Ensembl chr 7:133,188,753...133,203,887
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Them6
thioesterase superfamily member 6
affects expression
ISO
Orphenadrine affects the expression of THEM6 mRNA
CTD
PMID:23665939
NCBI chr15:74,593,083...74,596,222
Ensembl chr15:74,593,053...74,596,488
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Tifa
TRAF-interacting protein with forkhead-associated domain
affects expression
ISO
Orphenadrine affects the expression of TIFA mRNA
CTD
PMID:23665939
NCBI chr 3:127,582,524...127,592,043
Ensembl chr 3:127,583,454...127,625,813
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Tlcd4
TLC domain containing 4
affects expression
ISO
Orphenadrine affects the expression of TLCD4 mRNA
CTD
PMID:23665939
NCBI chr 3:120,995,657...121,076,756
Ensembl chr 3:120,995,410...121,076,747
G
Tlnrd1
talin rod domain containing 1
affects expression
ISO
Orphenadrine affects the expression of TLNRD1 mRNA
CTD
PMID:23665939
NCBI chr 7:83,529,703...83,533,549
Ensembl chr 7:83,529,081...83,533,513
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Tmbim1
transmembrane BAX inhibitor motif containing 1
affects expression
ISO
Orphenadrine affects the expression of TMBIM1 mRNA
CTD
PMID:23665939
NCBI chr 1:74,327,406...74,343,495
Ensembl chr 1:74,327,406...74,344,781
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Tmem184b
transmembrane protein 184b
affects expression
ISO
Orphenadrine affects the expression of TMEM184B mRNA
CTD
PMID:23665939
NCBI chr15:79,244,884...79,287,503
Ensembl chr15:79,244,884...79,287,769
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Tmem184c
transmembrane protein 184C
affects expression
ISO
Orphenadrine affects the expression of TMEM184C mRNA
CTD
PMID:23665939
NCBI chr 8:78,322,607...78,337,343
Ensembl chr 8:78,322,611...78,337,327
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Tmem200b
transmembrane protein 200B
affects expression
ISO
Orphenadrine affects the expression of TMEM200B mRNA
CTD
PMID:23665939
NCBI chr 4:131,648,515...131,651,267
Ensembl chr 4:131,648,511...131,650,451
G
Tnfaip2
tumor necrosis factor, alpha-induced protein 2
affects expression
ISO
Orphenadrine affects the expression of TNFAIP2 mRNA
CTD
PMID:23665939
NCBI chr12:111,408,898...111,421,452
Ensembl chr12:111,408,903...111,421,452
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Tnfrsf11b
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
affects expression
ISO
Orphenadrine affects the expression of TNFRSF11B mRNA
CTD
PMID:23665939
NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880
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Tnfrsf12a
tumor necrosis factor receptor superfamily, member 12a
affects expression
ISO
Orphenadrine affects the expression of TNFRSF12A mRNA
CTD
PMID:23665939
NCBI chr17:23,894,419...23,896,423
Ensembl chr17:23,894,419...23,896,442
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Tnk1
tyrosine kinase, non-receptor, 1
affects expression
ISO
Orphenadrine affects the expression of TNK1 mRNA
CTD
PMID:23665939
NCBI chr11:69,741,389...69,749,556
Ensembl chr11:69,741,831...69,749,556
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Tns1
tensin 1
affects expression
ISO
Orphenadrine affects the expression of TNS1 mRNA
CTD
PMID:23665939
NCBI chr 1:73,949,391...74,163,707
Ensembl chr 1:73,949,390...74,163,608
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Togaram2
TOG array regulator of axonemal microtubules 2
affects expression
ISO
Orphenadrine affects the expression of TOGARAM2 mRNA
CTD
PMID:23665939
NCBI chr17:71,980,153...72,036,666
Ensembl chr17:71,980,256...72,036,664
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Tox3
TOX high mobility group box family member 3
affects expression
ISO
Orphenadrine affects the expression of TOX3 mRNA
CTD
PMID:23665939
NCBI chr 8:90,973,665...91,075,746
Ensembl chr 8:90,973,668...91,074,971
G
Tpm1
tropomyosin 1, alpha
affects expression
ISO
Orphenadrine affects the expression of TPM1 mRNA
CTD
PMID:23665939
NCBI chr 9:66,929,872...66,956,954
Ensembl chr 9:66,929,872...66,956,688
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Traf4
TNF receptor associated factor 4
affects expression
ISO
Orphenadrine affects the expression of TRAF4 mRNA
CTD
PMID:23665939
NCBI chr11:78,049,249...78,056,405
Ensembl chr11:78,049,325...78,056,415
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Trim36
tripartite motif-containing 36
affects expression
ISO
Orphenadrine affects the expression of TRIM36 mRNA
CTD
PMID:23665939
NCBI chr18:46,298,367...46,345,674
Ensembl chr18:46,298,367...46,345,674
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Trim54
tripartite motif-containing 54
affects expression
ISO
Orphenadrine affects the expression of TRIM54 mRNA
CTD
PMID:23665939
NCBI chr 5:31,273,956...31,294,970
Ensembl chr 5:31,274,056...31,294,974
G
Trpm2
transient receptor potential cation channel, subfamily M, member 2
affects expression
ISO
Orphenadrine affects the expression of TRPM2 mRNA
CTD
PMID:23665939
NCBI chr10:77,743,556...77,805,746
Ensembl chr10:77,743,556...77,806,397
G
Trpv2
transient receptor potential cation channel, subfamily V, member 2
affects expression
ISO
Orphenadrine affects the expression of TRPV2 mRNA
CTD
PMID:23665939
NCBI chr11:62,465,312...62,491,131
Ensembl chr11:62,465,312...62,491,341
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Tsc22d3
TSC22 domain family, member 3
affects expression
ISO
Orphenadrine affects the expression of TSC22D3 mRNA
CTD
PMID:23665939
NCBI chr X:139,440,277...139,501,257
Ensembl chr X:139,440,277...139,501,408
G
Ttpal
tocopherol (alpha) transfer protein-like
affects expression
ISO
Orphenadrine affects the expression of TTPAL mRNA
CTD
PMID:23665939
NCBI chr 2:163,444,206...163,460,933
Ensembl chr 2:163,444,234...163,460,933
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Uba7
ubiquitin-like modifier activating enzyme 7
affects expression
ISO
Orphenadrine affects the expression of UBA7 mRNA
CTD
PMID:23665939
NCBI chr 9:107,852,766...107,861,255
Ensembl chr 9:107,852,704...107,861,259
G
Ugt2a3
UDP glucuronosyltransferase 2 family, polypeptide A3
affects expression
ISO
Orphenadrine affects the expression of UGT2A3 mRNA
CTD
PMID:23665939
NCBI chr 5:87,472,694...87,485,054
Ensembl chr 5:87,472,831...87,485,054
G
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
affects expression
ISO
Orphenadrine affects the expression of UGT2B1 mRNA
CTD
PMID:23665939
NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389
G
Unc5b
unc-5 netrin receptor B
affects expression
ISO
Orphenadrine affects the expression of UNC5B mRNA
CTD
PMID:23665939
NCBI chr10:60,598,373...60,667,360
Ensembl chr10:60,598,372...60,667,360
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Unkl
unkempt family like zinc finger
affects expression
ISO
Orphenadrine affects the expression of UNKL mRNA
CTD
PMID:23665939
NCBI chr17:25,407,336...25,453,417
Ensembl chr17:25,407,371...25,453,417
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Upp2
uridine phosphorylase 2
affects expression
ISO
Orphenadrine affects the expression of UPP2 mRNA
CTD
PMID:23665939
NCBI chr 2:58,456,329...58,685,858
Ensembl chr 2:58,457,310...58,682,983
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Usp18
ubiquitin specific peptidase 18
affects expression
ISO
Orphenadrine affects the expression of USP18 mRNA
CTD
PMID:23665939
NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876
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Vav2
vav 2 oncogene
affects expression
ISO
Orphenadrine affects the expression of VAV2 mRNA
CTD
PMID:23665939
NCBI chr 2:27,152,116...27,317,620
Ensembl chr 2:27,152,116...27,317,045
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Vipr1
vasoactive intestinal peptide receptor 1
affects expression
ISO
Orphenadrine affects the expression of VIPR1 mRNA
CTD
PMID:23665939
NCBI chr 9:121,471,782...121,502,020
Ensembl chr 9:121,471,782...121,502,020
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Vnn1
vanin 1
affects expression
ISO
Orphenadrine affects the expression of VNN1 mRNA
CTD
PMID:23665939
NCBI chr10:23,770,586...23,781,242
Ensembl chr10:23,770,586...23,781,241
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Wfdc1
WAP four-disulfide core domain 1
affects expression
ISO
Orphenadrine affects the expression of WFDC1 mRNA
CTD
PMID:23665939
NCBI chr 8:120,393,104...120,414,759
Ensembl chr 8:120,393,104...120,414,961
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Wipf3
WAS/WASL interacting protein family, member 3
affects expression
ISO
Orphenadrine affects the expression of WIPF3 mRNA
CTD
PMID:23665939
NCBI chr 6:54,406,206...54,480,753
Ensembl chr 6:54,406,588...54,480,753
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Xpnpep2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
affects expression
ISO
Orphenadrine affects the expression of XPNPEP2 mRNA
CTD
PMID:23665939
NCBI chr X:47,195,790...47,225,859
Ensembl chr X:47,197,602...47,225,858
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Zbtb10
zinc finger and BTB domain containing 10
affects expression
ISO
Orphenadrine affects the expression of ZBTB10 mRNA
CTD
PMID:23665939
NCBI chr 3:9,315,627...9,350,393
Ensembl chr 3:9,315,662...9,350,393
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Zbtb42
zinc finger and BTB domain containing 42
affects expression
ISO
Orphenadrine affects the expression of ZBTB42 mRNA
CTD
PMID:23665939
NCBI chr12:112,645,042...112,649,181
Ensembl chr12:112,645,262...112,649,181
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Zc2hc1a
zinc finger, C2HC-type containing 1A
affects expression
ISO
Orphenadrine affects the expression of ZC2HC1A mRNA
CTD
PMID:23665939
NCBI chr 3:7,568,475...7,618,908
Ensembl chr 3:7,568,543...7,618,896
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Zdhhc8
zinc finger, DHHC domain containing 8
affects expression
ISO
Orphenadrine affects the expression of ZDHHC8 mRNA
CTD
PMID:23665939
NCBI chr16:18,038,612...18,056,471
Ensembl chr16:18,038,617...18,053,000
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Zfp319
zinc finger protein 319
affects expression
ISO
Orphenadrine affects the expression of ZFP319 mRNA
CTD
PMID:23665939
NCBI chr 8:96,052,759...96,058,439
Ensembl chr 8:96,049,639...96,058,578
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Zfp334
zinc finger protein 334
affects expression
ISO
Orphenadrine affects the expression of ZFP334 mRNA
CTD
PMID:23665939
NCBI chr 2:165,216,184...165,230,234
Ensembl chr 2:165,216,184...165,230,179
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Zfp354a
zinc finger protein 354A
affects expression
ISO
Orphenadrine affects the expression of ZFP354A mRNA
CTD
PMID:23665939
NCBI chr11:50,950,052...50,963,626
Ensembl chr11:50,950,084...50,963,626
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Zfp36
zinc finger protein 36
affects expression
ISO
Orphenadrine affects the expression of ZFP36 mRNA
CTD
PMID:23665939
NCBI chr 7:28,076,208...28,078,680
Ensembl chr 7:28,076,209...28,079,678
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Zfp36l2
zinc finger protein 36, C3H type-like 2
affects expression
ISO
Orphenadrine affects the expression of ZFP36L2 mRNA
CTD
PMID:23665939
NCBI chr17:84,491,352...84,495,375
Ensembl chr17:84,491,359...84,495,375
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Zfp503
zinc finger protein 503
affects expression
ISO
Orphenadrine affects the expression of ZFP503 mRNA
CTD
PMID:23665939
NCBI chr14:22,034,030...22,039,669
Ensembl chr14:22,034,027...22,039,669
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Zfp668
zinc finger protein 668
affects expression
ISO
Orphenadrine affects the expression of ZFP668 mRNA
CTD
PMID:23665939
NCBI chr 7:127,460,197...127,476,008
Ensembl chr 7:127,462,219...127,476,000
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Bax
BCL2-associated X protein
multiple interactions
ISO EXP
Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein] Pergolide inhibits the reaction [Levodopa results in increased expression of BAX protein]
CTD
PMID:15081873 PMID:15672541
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Cdkn1a
cyclin dependent kinase inhibitor 1A
multiple interactions
ISO
Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein]
CTD
PMID:15081873
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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Drd1
dopamine receptor D1
increases activity
ISO
Pergolide results in increased activity of DRD1 protein
CTD
PMID:16129789
NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
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Drd2
dopamine receptor D2
increases activity
ISO
Pergolide results in increased activity of DRD2 protein
CTD
PMID:16129789
NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
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Gdnf
glial cell line derived neurotrophic factor
increases expression increases secretion
EXP
Pergolide results in increased expression of GDNF mRNA Pergolide results in increased secretion of GDNF protein
CTD
PMID:12770616
NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056
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Kcna5
potassium voltage-gated channel, shaker-related subfamily, member 5
decreases activity
ISO
Pergolide results in decreased activity of KCNA5 protein
CTD
PMID:16129789
NCBI chr 6:126,509,514...126,512,518
Ensembl chr 6:126,509,514...126,512,375
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Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
decreases activity
ISO
Pergolide results in decreased activity of KCNMA1 protein
CTD
PMID:16129789
NCBI chr14:23,342,356...24,055,173
Ensembl chr14:23,339,499...24,064,559
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Msh2
mutS homolog 2
multiple interactions
ISO
Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]
CTD
PMID:15081873
NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141
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Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
multiple interactions
ISO
Pergolide inhibits the reaction [Hydrogen Peroxide affects the localization of NFKB1 protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of NFKB1 protein]
CTD
PMID:15081873
NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
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Ngf
nerve growth factor
increases expression increases secretion
EXP
Pergolide results in increased expression of NGF mRNA Pergolide results in increased secretion of NGF protein
CTD
PMID:12770616
NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
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Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
Pergolide inhibits the reaction [Hydrogen Peroxide affects the localization of RELA protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of RELA protein]
CTD
PMID:15081873
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Pergolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Trp53
transformation related protein 53
multiple interactions
ISO EXP
Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein] Pergolide inhibits the reaction [Levodopa results in increased expression of TRP53 protein]
CTD
PMID:15081873 PMID:15672541
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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Bcl2
B cell leukemia/lymphoma 2
decreases expression
ISO
Pimozide results in decreased expression of BCL2 mRNA
CTD
PMID:12130671
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Fos
FBJ osteosarcoma oncogene
multiple interactions increases expression
ISO
istradefylline inhibits the reaction [Pimozide results in increased expression of FOS protein]; Tropicamide promotes the reaction [Pimozide results in increased expression of FOS protein]
CTD
PMID:19467297
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
G
Kcna10
potassium voltage-gated channel, shaker-related subfamily, member 10
multiple interactions
ISO
Pimozide inhibits the reaction [KCNA10 protein results in increased transport of Potassium]
CTD
PMID:10836990
NCBI chr 3:107,090,459...107,103,037
Ensembl chr 3:107,090,372...107,103,037
G
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
multiple interactions decreases activity
ISO
Pimozide inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Pimozide results in decreased activity of KCNH2 protein
CTD
PMID:15671647 PMID:19583963 PMID:21158687 PMID:24052561
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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Lhb
luteinizing hormone beta
multiple interactions
ISO
Pimozide results in decreased secretion of and results in decreased glycosylation of LHB protein
CTD
PMID:3896764
NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
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Prl
prolactin
increases expression
ISO
Pimozide results in increased expression of PRL protein
CTD
PMID:8915564
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
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Ache
acetylcholinesterase
multiple interactions
ISO
Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in increased activity of ACHE protein]
CTD
PMID:35868426
NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
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Atp5f1a
ATP synthase F1 subunit alpha
multiple interactions
ISO
Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of ATP5F1A protein]
CTD
PMID:35868426
NCBI chr18:77,861,468...77,870,569
Ensembl chr18:77,861,429...77,870,569
G
Casp3
caspase 3
multiple interactions
ISO
pramipexole inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
CTD
PMID:16362428
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Drd2
dopamine receptor D2
multiple interactions
ISO
pramipexole binds to and results in increased activity of DRD2 protein
CTD
PMID:10728880
NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
G
Drd3
dopamine receptor D3
multiple interactions
ISO
pramipexole binds to and results in increased activity of DRD3 protein
CTD
PMID:10728880
NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
G
Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]
CTD
PMID:16362428
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
G
Mapk9
mitogen-activated protein kinase 9
multiple interactions
ISO
pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]
CTD
PMID:16362428
NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
G
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
increases expression
ISO
Pramipexole results in increased expression of PPARGC1A protein
CTD
PMID:35868426
NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
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Ptprd
protein tyrosine phosphatase receptor type D
increases expression
ISO
[Pramipexole cotreated with exercise] increases expression of Ptprd protein in the striatum
RGD
PMID:37633178
RGD:401976430
NCBI chr 4:75,859,474...78,132,282
Ensembl chr 4:75,859,475...78,130,198
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Sdhb
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
multiple interactions
ISO
Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of SDHB protein]
CTD
PMID:35868426
NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504
G
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
pridinol results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
G
Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
pridinol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Abcb4
ATP-binding cassette, sub-family B member 4
decreases activity
ISO
Procyclidine results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
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Bmp6
bone morphogenetic protein 6
increases expression
ISO
Procyclidine results in increased expression of BMP6 mRNA
CTD
PMID:32816093
NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278
G
Cxcl15
C-X-C motif chemokine ligand 15
increases expression
ISO
Procyclidine results in increased expression of CXCL8 mRNA
CTD
PMID:32816093
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Ereg
epiregulin
increases expression
ISO
Procyclidine results in increased expression of EREG mRNA
CTD
PMID:32816093
NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
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Il1a
interleukin 1 alpha
increases expression
ISO
Procyclidine results in increased expression of IL1A mRNA
CTD
PMID:32816093
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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Il1b
interleukin 1 beta
increases expression
ISO
Procyclidine results in increased expression of IL1B mRNA
CTD
PMID:32816093
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Il24
interleukin 24
increases expression
ISO
Procyclidine results in increased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
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Met
met proto-oncogene
increases expression
ISO
Procyclidine results in increased expression of MET mRNA
CTD
PMID:32816093
NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
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Pid1
phosphotyrosine interaction domain containing 1
increases expression
ISO
Procyclidine results in increased expression of PID1 mRNA
CTD
PMID:32816093
NCBI chr 1:84,014,014...84,317,550
Ensembl chr 1:84,014,017...84,341,901
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
Procyclidine results in increased expression of PTGS2 mRNA
CTD
PMID:32816093
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
G
Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Procyclidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
G
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
increases expression
ISO
Procyclidine results in increased expression of SLC7A11 mRNA
CTD
PMID:32816093
NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
G
Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
Procyclidine results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
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Tnfaip6
tumor necrosis factor alpha induced protein 6
increases expression
ISO
Procyclidine results in increased expression of TNFAIP6 mRNA
CTD
PMID:32816093
NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698
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Bche
butyrylcholinesterase
decreases activity multiple interactions
ISO EXP
profenamine results in decreased activity of BCHE protein profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]
CTD
PMID:18656440 PMID:22407886 PMID:28299395 PMID:32278739 PMID:32795450
NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
G
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
profenamine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
G
Bcl2
B cell leukemia/lymphoma 2
increases expression
ISO
ropinirole results in increased expression of BCL2 protein
CTD
PMID:18242171
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
G
Casp3
caspase 3
multiple interactions
ISO
ropinirole inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]
CTD
PMID:18242171
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Casp9
caspase 9
multiple interactions
ISO
ropinirole inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein]
CTD
PMID:18242171
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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Cat
catalase
multiple interactions
ISO
ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]]
CTD
PMID:25053526
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
G
Drd2
dopamine receptor D2
multiple interactions
ISO
ropinirole binds to and results in increased activity of DRD2 protein
CTD
PMID:18393062
NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
G
Drd3
dopamine receptor D3
multiple interactions
ISO
ropinirole binds to and results in increased activity of DRD3 protein
CTD
PMID:18242171 PMID:18393062
NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
G
Drd4
dopamine receptor D4
multiple interactions
ISO
ropinirole binds to and results in increased activity of DRD4 protein
CTD
PMID:18393062
NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377
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Egr1
early growth response 1
decreases expression
ISO
ropinirole results in decreased expression of EGR1 mRNA
CTD
PMID:20452347
NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
G
Il1b
interleukin 1 beta
multiple interactions
ISO
ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]]
CTD
PMID:25053526
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Jun
jun proto-oncogene
multiple interactions
ISO
ropinirole inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]
CTD
PMID:18242171
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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Mapk1
mitogen-activated protein kinase 1
increases phosphorylation
ISO
ropinirole results in increased phosphorylation of MAPK1 protein
CTD
PMID:18242171
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
G
Mapk3
mitogen-activated protein kinase 3
increases phosphorylation
ISO
ropinirole results in increased phosphorylation of MAPK3 protein
CTD
PMID:18242171
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
G
Tnf
tumor necrosis factor
multiple interactions
ISO
ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]]
CTD
PMID:25053526
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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1110059G10Rik
RIKEN cDNA 1110059G10 gene
decreases expression
ISO
tolcapone results in decreased expression of RGD1311745 mRNA
CTD
PMID:24136188
NCBI chr 9:122,774,154...122,780,065
Ensembl chr 9:122,774,154...122,780,065
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2300009A05Rik
RIKEN cDNA 2300009A05 gene
decreases expression
ISO
Tolcapone results in decreased expression of C8H15ORF61 mRNA
CTD
PMID:24136188
NCBI chr 9:63,301,729...63,306,526
Ensembl chr 9:63,301,729...63,306,528
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Aadac
arylacetamide deacetylase
decreases expression
ISO
tolcapone results in decreased expression of AADAC mRNA
CTD
PMID:24136188
NCBI chr 3:59,939,209...59,947,578
Ensembl chr 3:59,933,138...59,947,581
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Aars1
alanyl-tRNA synthetase 1
increases expression
ISO
Tolcapone results in increased expression of AARS1 mRNA
CTD
PMID:24136188
NCBI chr 8:111,759,781...111,784,237
Ensembl chr 8:111,759,776...111,784,296
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Abcb11
ATP-binding cassette, sub-family B member 11
decreases activity
ISO
tolcapone results in decreased activity of ABCB11 protein
CTD
PMID:20829430
NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
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Abcd2
ATP-binding cassette, sub-family D member 2
affects binding
ISO
tolcapone binds to ABCD2 protein
CTD
PMID:19783845
NCBI chr15:91,029,874...91,076,013
Ensembl chr15:91,030,074...91,076,002
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Abhd10
abhydrolase domain containing 10
affects binding
ISO
Tolcapone binds to ABHD10 protein
CTD
PMID:19783845
NCBI chr16:45,550,088...45,563,355
Ensembl chr16:45,550,088...45,563,318
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Acat2
acetyl-Coenzyme A acetyltransferase 2
increases expression
ISO
tolcapone results in increased expression of ACAT2 mRNA
CTD
PMID:24136188
NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634
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Acox3
acyl-Coenzyme A oxidase 3, pristanoyl
affects binding
ISO
tolcapone binds to ACOX3 protein
CTD
PMID:19783845
NCBI chr 5:35,740,293...35,772,397
Ensembl chr 5:35,740,384...35,772,696
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Acsl1
acyl-CoA synthetase long-chain family member 1
affects binding decreases expression
ISO
tolcapone binds to ACSL1 protein tolcapone results in decreased expression of ACSL1 mRNA; tolcapone results in decreased expression of ACSL1 protein
CTD
PMID:19783845 PMID:29688484
NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088
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Acsl5
acyl-CoA synthetase long-chain family member 5
decreases expression
ISO
tolcapone results in decreased expression of ACSL5 protein
CTD
PMID:29688484
NCBI chr19:55,240,298...55,285,060
Ensembl chr19:55,240,370...55,286,152
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Acss2
acyl-CoA synthetase short-chain family member 2
increases expression
ISO
tolcapone results in increased expression of ACSS2 mRNA
CTD
PMID:24136188
NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644
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Acta2
actin alpha 2, smooth muscle, aorta
affects binding
ISO
tolcapone binds to ACTA2 protein
CTD
PMID:19783845
NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
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Adprhl1
ADP-ribosylhydrolase like 1
affects binding
ISO
tolcapone binds to ADPRHL1 protein
CTD
PMID:19783845
NCBI chr 8:13,268,449...13,304,079
Ensembl chr 8:13,271,663...13,304,162
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Aga
aspartylglucosaminidase
decreases expression
ISO
tolcapone results in decreased expression of AGA mRNA
CTD
PMID:24136188
NCBI chr 8:53,964,718...53,976,457
Ensembl chr 8:53,964,762...53,976,456
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Aif1
allograft inflammatory factor 1
decreases expression
ISO
tolcapone results in decreased expression of AIF1 mRNA
CTD
PMID:24136188
NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
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Ak2
adenylate kinase 2
affects binding
ISO
tolcapone binds to AK2 protein
CTD
PMID:19783845
NCBI chr 4:128,887,017...128,905,322
Ensembl chr 4:128,885,751...128,905,322
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Akr1c18
aldo-keto reductase family 1, member C18
decreases expression
ISO
tolcapone results in decreased expression of AKR1C3 mRNA
CTD
PMID:24136188
NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
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Akr1c6
aldo-keto reductase family 1, member C6
affects binding
ISO
Tolcapone binds to AKR1C1 protein
CTD
PMID:19783845
NCBI chr13:4,484,354...4,507,529
Ensembl chr13:4,484,305...4,507,876
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Akr1d1
aldo-keto reductase family 1, member D1
affects binding
ISO
tolcapone binds to AKR1D1 protein
CTD
PMID:19783845
NCBI chr 6:37,506,913...37,551,856
Ensembl chr 6:37,507,108...37,545,750
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Aldh18a1
aldehyde dehydrogenase 18 family, member A1
affects binding
ISO
tolcapone binds to ALDH18A1 protein
CTD
PMID:19783845
NCBI chr19:40,538,701...40,576,907
Ensembl chr19:40,538,701...40,576,907
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Aldh1b1
aldehyde dehydrogenase 1 family, member B1
affects binding
ISO
tolcapone binds to ALDH1B1 protein
CTD
PMID:19783845
NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604
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Aldh1l1
aldehyde dehydrogenase 1 family, member L1
increases expression
ISO
tolcapone results in increased expression of ALDH1L1 mRNA
CTD
PMID:24136188
NCBI chr 6:90,527,751...90,576,153
Ensembl chr 6:90,463,409...90,577,185
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Aldh3a2
aldehyde dehydrogenase family 3, subfamily A2
affects binding
ISO
tolcapone binds to ALDH3A2 protein
CTD
PMID:19783845
NCBI chr11:61,114,240...61,158,267
Ensembl chr11:61,114,243...61,158,290
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Alg13
asparagine-linked glycosylation 13
decreases expression
ISO
Tolcapone results in decreased expression of ALG13 mRNA
CTD
PMID:24136188
NCBI chr X:143,100,962...143,157,446
Ensembl chr X:143,100,800...143,157,446
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Amfr
autocrine motility factor receptor
increases expression
ISO
tolcapone results in increased expression of AMFR mRNA
CTD
PMID:24136188
NCBI chr 8:94,698,216...94,739,301
Ensembl chr 8:94,698,216...94,739,470
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Apmap
adipocyte plasma membrane associated protein
affects binding
ISO
tolcapone binds to APMAP protein
CTD
PMID:19783845
NCBI chr 2:150,425,000...150,450,487
Ensembl chr 2:150,425,000...150,450,487
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Apoa1
apolipoprotein A-I
affects binding
ISO
tolcapone binds to APOA1 protein
CTD
PMID:19783845
NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
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Apob
apolipoprotein B
decreases expression decreases secretion
ISO
tolcapone results in decreased expression of APOB mRNA tolcapone results in decreased secretion of APOB protein alternative form
CTD
PMID:29688484
NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835
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Apoc2
apolipoprotein C2
decreases expression
ISO
tolcapone results in decreased expression of APOC2 mRNA
CTD
PMID:24136188
NCBI chr 7:19,405,504...19,411,866
Ensembl chr 7:19,405,504...19,411,866
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Apoe
apolipoprotein E
affects binding
ISO
tolcapone binds to APOE protein
CTD
PMID:19783845
NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
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Apool
apolipoprotein O-like
decreases expression
ISO
tolcapone results in decreased expression of APOOL mRNA
CTD
PMID:24136188
NCBI chr X:111,221,049...111,282,452
Ensembl chr X:111,221,031...111,282,452
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Arf4
ADP-ribosylation factor 4
affects binding
ISO
tolcapone binds to ARF4 protein
CTD
PMID:19783845
NCBI chr14:26,359,289...26,377,997
Ensembl chr14:26,359,229...26,386,239
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Arl1
ADP-ribosylation factor-like 1
affects binding
ISO
tolcapone binds to ARL1 protein
CTD
PMID:19783845
NCBI chr10:88,566,720...88,579,956
Ensembl chr10:88,566,720...88,579,956
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Atad1
ATPase family, AAA domain containing 1
affects binding
ISO
tolcapone binds to ATAD1 protein
CTD
PMID:19783845
NCBI chr19:32,649,958...32,717,187
Ensembl chr19:32,649,038...32,717,186
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Atad3a
ATPase family, AAA domain containing 3A
affects binding
ISO
tolcapone binds to ATAD3A protein
CTD
PMID:19783845
NCBI chr 4:155,825,097...155,845,579
Ensembl chr 4:155,825,098...155,845,550
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Atf5
activating transcription factor 5
increases expression
ISO
tolcapone results in increased expression of ATF5 mRNA
CTD
PMID:24136188
NCBI chr 7:44,461,680...44,466,082
Ensembl chr 7:44,461,680...44,466,082
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Atp1b3
ATPase, Na+/K+ transporting, beta 3 polypeptide
affects binding
ISO
tolcapone binds to ATP1B3 protein
CTD
PMID:19783845
NCBI chr 9:96,214,708...96,246,368
Ensembl chr 9:96,214,708...96,246,495
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Atp5f1b
ATP synthase F1 subunit beta
affects binding
ISO
tolcapone binds to ATP5F1B protein
CTD
PMID:19783845
NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260
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Atp5f1c
ATP synthase F1 subunit gamma
affects binding
ISO
Tolcapone binds to ATP5F1C protein
CTD
PMID:19783845
NCBI chr 2:10,060,841...10,085,321
Ensembl chr 2:10,060,827...10,085,321
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Atp5f1e
ATP synthase F1 subunit epsilon
decreases expression
ISO
tolcapone results in decreased expression of ATP5F1E mRNA
CTD
PMID:24136188
NCBI chr 2:174,302,868...174,305,894
Ensembl chr 2:174,302,865...174,305,898
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Atp5me
ATP synthase membrane subunit e
affects binding decreases expression
ISO
tolcapone binds to ATP5ME protein tolcapone results in decreased expression of ATP5ME mRNA
CTD
PMID:19783845 PMID:24136188
NCBI chr 5:108,581,112...108,582,265
Ensembl chr 5:108,581,110...108,582,314
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Atp5mf
ATP synthase membrane subunit f
affects binding
ISO
tolcapone binds to ATP5MF protein
CTD
PMID:19783845
NCBI chr 5:145,120,514...145,128,351
Ensembl chr 5:145,120,508...145,128,872
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Atp5mg
ATP synthase membrane subunit g
decreases expression affects binding
ISO
tolcapone results in decreased expression of ATP5MG mRNA tolcapone binds to ATP5MG protein
CTD
PMID:19783845 PMID:24136188
NCBI chr 9:44,824,546...44,832,470
Ensembl chr 9:44,823,855...44,832,040
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Atp5mk
ATP synthase membrane subunit k
decreases expression
ISO
Tolcapone results in decreased expression of ATP5MK mRNA
CTD
PMID:24136188
NCBI chr19:47,071,910...47,079,086
Ensembl chr19:47,071,903...47,079,086
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Atp5pf
ATP synthase peripheral stalk subunit F6
decreases expression
ISO
tolcapone results in decreased expression of ATP5PF mRNA
CTD
PMID:24136188
NCBI chr16:84,624,754...84,632,495
Ensembl chr16:84,624,754...84,632,513
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Atp5po
ATP synthase peripheral stalk subunit OSCP
affects binding
ISO
tolcapone binds to ATP5PO protein
CTD
PMID:19783845
NCBI chr16:91,722,111...91,728,518
Ensembl chr16:91,722,102...91,728,575 Ensembl chr16:91,722,102...91,728,575
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Auh
AU RNA binding protein/enoyl-coenzyme A hydratase
affects binding
ISO
tolcapone binds to AUH protein
CTD
PMID:19783845
NCBI chr13:52,989,155...53,083,742
Ensembl chr13:52,989,155...53,083,717
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Bbox1
gamma-butyrobetaine hydroxylase 1
decreases expression
ISO
tolcapone results in decreased expression of BBOX1 mRNA
CTD
PMID:24136188
NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905
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Bcam
basal cell adhesion molecule
affects binding
ISO
tolcapone binds to BCAM protein
CTD
PMID:19783845
NCBI chr 7:19,490,063...19,504,457
Ensembl chr 7:19,490,056...19,504,941
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Bcap29
B cell receptor associated protein 29
decreases expression
ISO
tolcapone results in decreased expression of BCAP29 mRNA
CTD
PMID:24136188
NCBI chr12:31,645,353...31,684,657
Ensembl chr12:31,640,966...31,684,657
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Bcas2
BCAS2 pre-mRNA processing factor
decreases expression
ISO
tolcapone results in decreased expression of BCAS2 mRNA
CTD
PMID:24136188
NCBI chr 3:103,078,971...103,086,479
Ensembl chr 3:103,078,971...103,086,482
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Bltp1
bridge-like lipid transfer protein family member 1
increases expression
ISO
Tolcapone results in increased expression of BLTP1 mRNA
CTD
PMID:24136188
NCBI chr 3:36,917,212...37,107,182
Ensembl chr 3:36,917,253...37,107,182
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Bmper
BMP-binding endothelial regulator
affects binding
ISO
tolcapone binds to BMPER protein
CTD
PMID:19783845
NCBI chr 9:23,134,372...23,396,511
Ensembl chr 9:23,134,372...23,396,496
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Bms1
BMS1, ribosome biogenesis factor
affects binding
ISO
tolcapone binds to BMS1 protein
CTD
PMID:19783845
NCBI chr 6:118,360,342...118,396,772
Ensembl chr 6:118,360,342...118,396,435
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Bpgm
2,3-bisphosphoglycerate mutase
decreases expression
ISO
tolcapone results in decreased expression of BPGM mRNA
CTD
PMID:24136188
NCBI chr 6:34,453,291...34,482,071
Ensembl chr 6:34,453,142...34,482,548
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Btf3l4
basic transcription factor 3-like 4
decreases expression
ISO
tolcapone results in decreased expression of BTF3L4 mRNA
CTD
PMID:24136188
NCBI chr 4:108,671,489...108,691,445
Ensembl chr 4:108,671,492...108,690,811
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C1d
C1D nuclear receptor co-repressor
decreases expression
ISO
tolcapone results in decreased expression of C1D mRNA
CTD
PMID:24136188
NCBI chr11:17,207,547...17,219,176
Ensembl chr11:17,207,579...17,219,176
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C1galt1c1
C1GALT1-specific chaperone 1
decreases expression
ISO
tolcapone results in decreased expression of C1GALT1C1 mRNA
CTD
PMID:24136188
NCBI chr X:37,719,660...37,724,020
Ensembl chr X:37,719,662...37,723,964
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C4b
complement C4B (Chido blood group)
increases expression
ISO
tolcapone results in increased expression of C4B mRNA
CTD
PMID:24136188
NCBI chr17:34,947,249...34,962,876
Ensembl chr17:34,947,354...34,962,856
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C8a
complement component 8, alpha polypeptide
increases expression
ISO
tolcapone results in increased expression of C8A mRNA
CTD
PMID:24136188
NCBI chr 4:104,672,876...104,733,684
Ensembl chr 4:104,672,876...104,733,595
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Cbr4
carbonyl reductase 4
decreases expression
ISO
tolcapone results in decreased expression of CBR4 mRNA
CTD
PMID:24136188
NCBI chr 8:61,940,768...61,956,534
Ensembl chr 8:61,940,768...61,959,728
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Ccnl2
cyclin L2
increases expression
ISO
tolcapone results in increased expression of CCNL2 mRNA
CTD
PMID:24136188
NCBI chr 4:155,894,468...155,909,005
Ensembl chr 4:155,896,946...155,909,000
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Cct7
chaperonin containing TCP1 subunit 7
affects binding
ISO
tolcapone binds to CCT7 protein
CTD
PMID:19783845
NCBI chr 6:85,428,487...85,445,459
Ensembl chr 6:85,428,496...85,445,457
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Cd36
CD36 molecule
increases expression
ISO
tolcapone results in increased expression of CD36 mRNA
CTD
PMID:29688484
NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
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Cfb
complement factor B
increases expression
ISO
tolcapone results in increased expression of CFB mRNA
CTD
PMID:24136188
NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494
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Chchd1
coiled-coil-helix-coiled-coil-helix domain containing 1
decreases expression
ISO
tolcapone results in decreased expression of CHCHD1 mRNA
CTD
PMID:24136188
NCBI chr14:20,753,095...20,754,493
Ensembl chr14:20,753,074...20,754,493
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Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
decreases expression
ISO
tolcapone results in decreased expression of CHCHD7 mRNA
CTD
PMID:24136188
NCBI chr 4:3,938,847...3,951,382
Ensembl chr 4:3,938,888...3,951,046
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Chrac1
chromatin accessibility complex 1
decreases expression
ISO
tolcapone results in decreased expression of CHRAC1 mRNA
CTD
PMID:24136188
NCBI chr15:72,962,261...72,965,924
Ensembl chr15:72,962,241...72,969,403
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Churc1
churchill domain containing 1
decreases expression
ISO
tolcapone results in decreased expression of CHURC1 mRNA
CTD
PMID:24136188
NCBI chr12:76,812,312...76,829,954
Ensembl chr12:76,812,312...76,829,954
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Ciao2a
cytosolic iron-sulfur assembly component 2A
decreases expression
ISO
tolcapone results in decreased expression of CIAO2A mRNA
CTD
PMID:24136188
NCBI chr 9:66,033,878...66,046,250
Ensembl chr 9:66,033,893...66,046,237
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Cidea
cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
increases expression
ISO
tolcapone results in increased expression of CIDEA mRNA
CTD
PMID:29688484
NCBI chr18:67,476,634...67,500,864
Ensembl chr18:67,476,674...67,500,855
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Cisd1
CDGSH iron sulfur domain 1
affects binding
ISO
tolcapone binds to CISD1 protein
CTD
PMID:19783845
NCBI chr10:71,166,324...71,180,679
Ensembl chr10:71,166,310...71,180,784
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Clec4a3
C-type lectin domain family 4, member a3
decreases expression
ISO
Tolcapone results in decreased expression of CLEC4A3 mRNA
CTD
PMID:24136188
NCBI chr 6:122,929,474...122,946,837
Ensembl chr 6:122,929,474...122,946,834
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Cltc
clathrin heavy chain
affects binding
ISO
tolcapone binds to CLTC protein
CTD
PMID:19783845
NCBI chr11:86,585,178...86,648,637
Ensembl chr11:86,585,177...86,648,391
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Cnih4
cornichon family AMPA receptor auxiliary protein 4
decreases expression
ISO
tolcapone results in decreased expression of CNIH4 mRNA
CTD
PMID:24136188
NCBI chr 1:180,977,437...180,996,559
Ensembl chr 1:180,972,258...180,996,559
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Commd6
COMM domain containing 6
decreases expression
ISO
tolcapone results in decreased expression of COMMD6 mRNA
CTD
PMID:24136188
NCBI chr14:101,871,202...101,877,907
Ensembl chr14:101,870,417...101,878,122
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Comt
catechol-O-methyltransferase
decreases activity multiple interactions increases methylation affects binding
EXP ISO
tolcapone results in decreased activity of COMT protein [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]; [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine; tolcapone inhibits the reaction [COMT protein results in increased methylation of Levodopa] [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine] COMT protein results in increased methylation of tolcapone tolcapone binds to COMT protein
CTD
PMID:2089102 PMID:7566641 PMID:7768073 PMID:8821542 PMID:9333106 PMID:10047930 PMID:10064789 PMID:10809409 PMID:10872643 PMID:11248589 PMID:11432539 PMID:11793163 PMID:11793426 PMID:12584150 PMID:12898346 PMID:14975680 PMID:15190105 PMID:15566291 PMID:16012872 PMID:16758261 PMID:19783845 PMID:20334432 PMID:23206800 PMID:29688484 More...
NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
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Copg1
coatomer protein complex, subunit gamma 1
affects binding
ISO
tolcapone binds to COPG1 protein
CTD
PMID:19783845
NCBI chr 6:87,864,801...87,890,577
Ensembl chr 6:87,864,796...87,890,577
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Copg2
coatomer protein complex, subunit gamma 2
decreases expression
ISO
tolcapone results in decreased expression of COPG2 mRNA
CTD
PMID:24136188
NCBI chr 6:30,747,552...30,873,712
Ensembl chr 6:30,747,553...30,873,729
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Coq10a
coenzyme Q10A
decreases expression
ISO
tolcapone results in decreased expression of COQ10A mRNA
CTD
PMID:24136188
NCBI chr10:128,198,965...128,204,849
Ensembl chr10:128,198,969...128,204,866
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Coq3
coenzyme Q3 methyltransferase
decreases expression
ISO
tolcapone results in decreased expression of COQ3 mRNA
CTD
PMID:24136188
NCBI chr 4:21,879,646...21,912,163
Ensembl chr 4:21,879,673...21,912,162
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Cox6c
cytochrome c oxidase subunit 6C
affects binding decreases expression
ISO
tolcapone binds to COX6C protein tolcapone results in decreased expression of COX6C mRNA
CTD
PMID:19783845 PMID:24136188
NCBI chr15:35,932,122...35,938,392
Ensembl chr15:35,926,032...35,938,392
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Cox7a2
cytochrome c oxidase subunit 7A2
decreases expression
ISO
tolcapone results in decreased expression of COX7A2 mRNA
CTD
PMID:24136188
NCBI chr 9:79,662,523...79,667,135
Ensembl chr 9:79,662,643...79,667,160
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Cox7b
cytochrome c oxidase subunit 7B
decreases expression
ISO
tolcapone results in decreased expression of COX7B mRNA
CTD
PMID:24136188
NCBI chr X:105,059,306...105,066,056
Ensembl chr X:105,059,306...105,066,056
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Cp
ceruloplasmin
increases expression
ISO
tolcapone results in increased expression of CP mRNA
CTD
PMID:24136188
NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309
G
Crem
cAMP responsive element modulator
decreases expression
ISO
tolcapone results in decreased expression of CREM mRNA
CTD
PMID:24136188
NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748
G
Crip2
cysteine rich protein 2
increases expression
ISO
tolcapone results in increased expression of CRIP2 mRNA
CTD
PMID:24136188
NCBI chr12:113,103,856...113,109,126
Ensembl chr12:113,103,856...113,109,126
G
Cse1l
chromosome segregation 1 like
affects binding
ISO
tolcapone binds to CSE1L protein
CTD
PMID:19783845
NCBI chr 2:166,747,961...166,788,309
Ensembl chr 2:166,747,960...166,788,309
G
Cstb
cystatin B
decreases expression
ISO
tolcapone results in decreased expression of CSTB mRNA
CTD
PMID:24136188
NCBI chr10:78,261,504...78,263,456
Ensembl chr10:78,261,503...78,263,456
G
Cxcl15
C-X-C motif chemokine ligand 15
increases expression
ISO
Tolcapone results in increased expression of CXCL8 mRNA
CTD
PMID:32816093
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
G
Cyc1
cytochrome c-1
affects binding
ISO
tolcapone binds to CYC1 protein
CTD
PMID:19783845
NCBI chr15:76,227,711...76,230,460
Ensembl chr15:76,227,723...76,230,460
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases activity
ISO
tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] Tolcapone results in decreased activity of CYP1A1 protein
CTD
PMID:18493746 PMID:33814510
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions increases expression
ISO
tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] tolcapone results in increased expression of CYP1A2 mRNA
CTD
PMID:18493746 PMID:24136188
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Tolcapone results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
G
Cyp51
cytochrome P450, family 51
increases expression
ISO
tolcapone results in increased expression of CYP51 mRNA
CTD
PMID:24136188
NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746
G
Dap
death-associated protein
increases expression
ISO
tolcapone results in increased expression of DAP mRNA
CTD
PMID:24136188
NCBI chr15:31,224,531...31,274,484
Ensembl chr15:31,224,460...31,274,487
G
Dctd
dCMP deaminase
affects binding
ISO
tolcapone binds to DCTD protein
CTD
PMID:19783845
NCBI chr 8:48,552,127...48,594,702
Ensembl chr 8:48,552,127...48,606,268
G
Ddost
dolichyl-di-phosphooligosaccharide-protein glycotransferase
affects binding
ISO
tolcapone binds to DDOST protein
CTD
PMID:19783845
NCBI chr 4:138,032,049...138,039,930
Ensembl chr 4:138,032,041...138,039,939
G
Ddx18
DEAD box helicase 18
affects binding
ISO
tolcapone binds to DDX18 protein
CTD
PMID:19783845
NCBI chr 1:121,481,564...121,495,709
Ensembl chr 1:121,481,564...121,495,718
G
Dhcr24
24-dehydrocholesterol reductase
affects binding increases expression
ISO
tolcapone binds to DHCR24 protein tolcapone results in increased expression of DHCR24 mRNA
CTD
PMID:19783845 PMID:24136188
NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310
G
Dhcr7
7-dehydrocholesterol reductase
affects binding
ISO
tolcapone binds to DHCR7 protein
CTD
PMID:19783845
NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147
G
Dmac1
distal membrane arm assembly complex 1
decreases expression
ISO
tolcapone results in decreased expression of DMAC1 mRNA
CTD
PMID:24136188
NCBI chr 4:75,195,588...75,196,529
Ensembl chr 4:75,195,591...75,196,542
G
Dnajc15
DnaJ heat shock protein family (Hsp40) member C15
decreases expression
ISO
tolcapone results in decreased expression of DNAJC15 mRNA
CTD
PMID:24136188
NCBI chr14:78,063,657...78,112,357
Ensembl chr14:78,058,121...78,112,565
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Dock11
dedicator of cytokinesis 11
decreases expression
ISO
tolcapone results in decreased expression of DOCK11 mRNA
CTD
PMID:24136188
NCBI chr X:35,150,924...35,340,223
Ensembl chr X:35,152,485...35,340,215
G
Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
decreases expression
ISO
tolcapone results in decreased expression of DPM3 mRNA
CTD
PMID:24136188
NCBI chr 3:89,166,567...89,174,386
Ensembl chr 3:89,166,665...89,174,386
G
Dpy30
dpy-30, histone methyltransferase complex regulatory subunit
decreases expression
ISO
tolcapone results in decreased expression of DPY30 mRNA
CTD
PMID:24136188
NCBI chr17:74,606,469...74,630,939
Ensembl chr17:74,606,469...74,630,939
G
Dtymk
deoxythymidylate kinase
decreases expression
ISO
tolcapone results in decreased expression of DTYMK mRNA
CTD
PMID:24136188
NCBI chr 1:93,720,298...93,730,246
Ensembl chr 1:93,720,298...93,729,656
G
Dynll1
dynein light chain LC8-type 1
decreases expression
ISO
tolcapone results in decreased expression of DYNLL1 mRNA
CTD
PMID:24136188
NCBI chr 5:115,435,129...115,438,995
Ensembl chr 5:115,435,169...115,439,058
G
Dynlt3
dynein light chain Tctex-type 3
decreases expression
ISO
tolcapone results in decreased expression of DYNLT3 mRNA
CTD
PMID:24136188
NCBI chr X:9,520,509...9,529,222
Ensembl chr X:9,520,506...9,529,242
G
Ebp
EBP cholestenol delta-isomerase
increases expression
ISO
tolcapone results in increased expression of EBP mRNA
CTD
PMID:24136188
NCBI chr X:8,051,568...8,059,751
Ensembl chr X:8,051,568...8,059,751
G
Echs1
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
affects binding
ISO
tolcapone binds to ECHS1 protein
CTD
PMID:19783845
NCBI chr 7:139,685,623...139,696,334
Ensembl chr 7:139,685,623...139,696,389
G
Eloc
elongin C
decreases expression
ISO
tolcapone results in decreased expression of ELOC mRNA
CTD
PMID:24136188
NCBI chr 1:16,711,949...16,727,652
Ensembl chr 1:16,711,949...16,727,266
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Ereg
epiregulin
decreases expression
ISO
Tolcapone results in decreased expression of EREG mRNA
CTD
PMID:32816093
NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
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F5
coagulation factor V
increases expression
ISO
tolcapone results in increased expression of F5 mRNA
CTD
PMID:24136188
NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846
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Fam162a
family with sequence similarity 162, member A
affects binding
ISO
tolcapone binds to FAM162A protein
CTD
PMID:19783845
NCBI chr16:35,864,214...35,891,931
Ensembl chr16:35,864,131...35,891,964
G
Fbll1
fibrillarin-like 1
affects binding
ISO
tolcapone binds to FBLL1 protein
CTD
PMID:19783845
NCBI chr11:35,688,207...35,689,711
Ensembl chr11:35,688,209...35,689,711
G
Fcf1
FCF1 rRNA processing protein
decreases expression
ISO
tolcapone results in decreased expression of FCF1 mRNA
CTD
PMID:24136188
NCBI chr12:85,017,704...85,030,077
Ensembl chr12:85,017,671...85,030,077
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Fga
fibrinogen alpha chain
affects binding
ISO
tolcapone binds to FGA protein
CTD
PMID:19783845
NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934
G
Fmc1
formation of mitochondrial complex V assembly factor 1
decreases expression
ISO
tolcapone results in decreased expression of FMC1 mRNA
CTD
PMID:24136188
NCBI chr 6:38,511,796...38,516,384
Ensembl chr 6:38,510,437...38,516,384
G
Gcdh
glutaryl-Coenzyme A dehydrogenase
affects binding
ISO
tolcapone binds to GCDH protein
CTD
PMID:19783845
NCBI chr 8:85,613,016...85,629,378
Ensembl chr 8:85,613,022...85,620,550
G
Glg1
golgi apparatus protein 1
affects binding
ISO
tolcapone binds to GLG1 protein
CTD
PMID:19783845
NCBI chr 8:111,879,916...111,985,842
Ensembl chr 8:111,881,053...111,985,848
G
Gm20348
predicted gene, 20348
decreases expression
ISO
Tolcapone results in decreased expression of TP53I3 mRNA
CTD
PMID:24136188
NCBI chr12:4,860,475...4,867,155
Ensembl chr12:4,860,494...4,867,142
G
Gm5617
predicted gene 5617
decreases expression
ISO
Tolcapone results in decreased expression of C8H11ORF71 mRNA
CTD
PMID:24136188
NCBI chr 9:48,406,643...48,407,275
Ensembl chr 9:48,406,742...48,407,272
G
Gmfg
glia maturation factor, gamma
decreases expression
ISO
tolcapone results in decreased expression of GMFG mRNA
CTD
PMID:24136188
NCBI chr 7:28,136,894...28,147,655
Ensembl chr 7:28,136,872...28,147,658
G
Gng10
guanine nucleotide binding protein (G protein), gamma 10
decreases expression
ISO
tolcapone results in decreased expression of GNG10 mRNA
CTD
PMID:24136188
NCBI chr 4:59,035,156...59,041,899
Ensembl chr 4:59,035,088...59,041,903
G
Gng5
G protein subunit gamma 5
decreases expression
ISO
tolcapone results in decreased expression of GNG5 mRNA
CTD
PMID:24136188
NCBI chr 3:146,205,591...146,211,298
Ensembl chr 3:146,205,562...146,211,327
G
Gpc3
glypican 3
affects binding
ISO
tolcapone binds to GPC3 protein
CTD
PMID:19783845
NCBI chr X:51,361,303...51,702,851
Ensembl chr X:51,361,303...51,702,827
G
Gtf2h5
general transcription factor IIH, polypeptide 5
decreases expression
ISO
tolcapone results in decreased expression of GTF2H5 mRNA
CTD
PMID:24136188
NCBI chr17:6,130,103...6,135,763
Ensembl chr17:6,130,061...6,136,792
G
H2az2
H2A.Z histone variant 2
affects binding
ISO
Tolcapone binds to H2AZ2 protein
CTD
PMID:19783845
NCBI chr11:6,377,226...6,394,511
Ensembl chr11:6,377,229...6,394,443
G
H4c8
H4 clustered histone 8
decreases expression
ISO
Tolcapone results in decreased expression of HIST1H4B mRNA
CTD
PMID:24136188
NCBI chr13:23,715,214...23,715,648
Ensembl chr13:23,715,220...23,715,689
G
Hbb-b1
hemoglobin, beta adult major chain
affects binding
ISO
tolcapone binds to HBB protein
CTD
PMID:19783845
G
Hc
hemolytic complement
increases expression
ISO
tolcapone results in increased expression of C5 mRNA
CTD
PMID:24136188
NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450
G
Higd1a
HIG1 domain family, member 1A
decreases expression
ISO
tolcapone results in decreased expression of HIGD1A mRNA
CTD
PMID:24136188
NCBI chr 9:121,677,623...121,686,862
Ensembl chr 9:121,677,629...121,687,428
G
Hint3
histidine triad nucleotide binding protein 3
decreases expression
ISO
tolcapone results in decreased expression of HINT3 mRNA
CTD
PMID:24136188
NCBI chr10:30,479,191...30,499,526
Ensembl chr10:30,484,137...30,505,628
G
Hnrnph1
heterogeneous nuclear ribonucleoprotein H1
affects binding
ISO
tolcapone binds to HNRNPH1 protein
CTD
PMID:19783845
NCBI chr11:50,266,084...50,277,355
Ensembl chr11:50,267,817...50,277,355
G
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
affects binding
ISO
tolcapone binds to HSD17B11 protein
CTD
PMID:19783845
NCBI chr 5:104,137,631...104,169,662
Ensembl chr 5:104,137,628...104,169,785
G
Hsd17b12
hydroxysteroid (17-beta) dehydrogenase 12
affects binding
ISO
tolcapone binds to HSD17B12 protein
CTD
PMID:19783845
NCBI chr 2:93,863,042...93,988,254
Ensembl chr 2:93,863,034...93,988,309
G
Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
affects binding
ISO
tolcapone binds to HSD17B13 protein
CTD
PMID:19783845
NCBI chr 5:104,103,308...104,125,254
Ensembl chr 5:104,103,306...104,125,276
G
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
affects binding
ISO
tolcapone binds to HSD17B4 protein
CTD
PMID:19783845
NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
G
Hsdl2
hydroxysteroid dehydrogenase like 2
increases expression
ISO
tolcapone results in increased expression of HSDL2 mRNA
CTD
PMID:24136188
NCBI chr 4:59,581,515...59,618,694
Ensembl chr 4:59,581,563...59,618,689
G
Iftap
intraflagellar transport associated protein
decreases expression
ISO
Tolcapone results in decreased expression of IFTAP mRNA
CTD
PMID:24136188
NCBI chr 2:101,391,124...101,459,376
Ensembl chr 2:101,391,126...101,479,877
G
Igfbp1
insulin-like growth factor binding protein 1
increases expression
ISO
tolcapone results in increased expression of IGFBP1 mRNA
CTD
PMID:24136188
NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546
G
Il24
interleukin 24
decreases expression
ISO
Tolcapone results in decreased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
G
Ipo7
importin 7
affects binding
ISO
tolcapone binds to IPO7 protein
CTD
PMID:19783845
NCBI chr 7:109,617,522...109,655,816
Ensembl chr 7:109,617,481...109,655,816
G
Itm2a
integral membrane protein 2A
affects binding
ISO
tolcapone binds to ITM2A protein
CTD
PMID:19783845
NCBI chr X:106,440,801...106,446,966
Ensembl chr X:106,440,705...106,446,982
G
Jagn1
jagunal homolog 1
affects binding
ISO
tolcapone binds to JAGN1 protein
CTD
PMID:19783845
NCBI chr 6:113,419,478...113,425,190
Ensembl chr 6:113,419,530...113,425,190
G
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
tolcapone results in decreased activity of KCNH2 protein
CTD
PMID:24052561
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
G
Kng1
kininogen 1
increases expression
ISO
Tolcapone results in increased expression of KNG1 mRNA
CTD
PMID:24136188
NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828
G
Lage3
L antigen family, member 3
decreases expression
ISO
tolcapone results in decreased expression of LAGE3 mRNA
CTD
PMID:24136188
NCBI chr X:73,395,768...73,397,224
Ensembl chr X:73,394,882...73,397,224
G
Lbp
lipopolysaccharide binding protein
increases expression
ISO
tolcapone results in increased expression of LBP mRNA
CTD
PMID:24136188
NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772
G
Lrrc59
leucine rich repeat containing 59
affects binding
ISO
tolcapone binds to LRRC59 protein
CTD
PMID:19783845
NCBI chr11:94,520,603...94,536,049
Ensembl chr11:94,520,593...94,536,042
G
Lsm3
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
decreases expression
ISO
tolcapone results in decreased expression of LSM3 mRNA
CTD
PMID:24136188
NCBI chr 6:91,493,017...91,499,602
Ensembl chr 6:91,492,910...91,499,607
G
Lsm5
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
decreases expression
ISO
tolcapone results in decreased expression of LSM5 mRNA
CTD
PMID:24136188
NCBI chr 6:56,678,048...56,681,684
Ensembl chr 6:56,678,048...56,681,695
G
Lsm7
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
decreases expression
ISO
tolcapone results in decreased expression of LSM7 mRNA
CTD
PMID:24136188
NCBI chr10:80,688,659...80,691,043
Ensembl chr10:80,688,655...80,691,043
G
Magoh
mago homolog, exon junction complex core component
decreases expression
ISO
tolcapone results in decreased expression of MAGOH mRNA
CTD
PMID:24136188
NCBI chr 4:107,736,952...107,744,621
Ensembl chr 4:107,736,952...107,744,621
G
Masp1
MBL associated serine protease 1
increases expression
ISO
tolcapone results in increased expression of MASP1 mRNA
CTD
PMID:24136188
NCBI chr16:23,261,778...23,340,127
Ensembl chr16:23,268,167...23,339,565
G
Matr3
matrin 3
decreases expression
ISO
tolcapone results in decreased expression of MATR3 mRNA
CTD
PMID:24136188
NCBI chr18:35,686,462...35,724,526
Ensembl chr18:35,695,191...35,726,888
G
Mcee
methylmalonyl CoA epimerase
decreases expression
ISO
tolcapone results in decreased expression of MCEE mRNA
CTD
PMID:24136188
NCBI chr 7:64,042,370...64,061,869
Ensembl chr 7:64,042,355...64,061,873
G
Mcts1
malignant T cell amplified sequence 1
decreases expression
ISO
tolcapone results in decreased expression of MCTS1 mRNA
CTD
PMID:24136188
NCBI chr X:37,653,682...37,702,401
Ensembl chr X:37,689,455...37,702,303
G
Med21
mediator complex subunit 21
decreases expression
ISO
tolcapone results in decreased expression of MED21 mRNA
CTD
PMID:24136188
NCBI chr 6:146,544,077...146,552,098
Ensembl chr 6:146,544,045...146,552,230
G
Med28
mediator complex subunit 28
decreases expression
ISO
tolcapone results in decreased expression of MED28 mRNA
CTD
PMID:24136188
NCBI chr 5:45,677,571...45,686,626
Ensembl chr 5:45,677,571...45,686,618
G
Med31
mediator complex subunit 31
decreases expression
ISO
tolcapone results in decreased expression of MED31 mRNA
CTD
PMID:24136188
NCBI chr11:72,102,550...72,106,418
Ensembl chr11:72,102,550...72,106,418
G
Met
met proto-oncogene
increases expression
ISO
Tolcapone results in increased expression of MET mRNA
CTD
PMID:32816093
NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
G
Mettl5
methyltransferase 5, N6-adenosine
decreases expression
ISO
tolcapone results in decreased expression of METTL5 mRNA
CTD
PMID:24136188
NCBI chr 2:69,701,539...69,717,961
Ensembl chr 2:69,701,542...69,715,959
G
Mfsd5
major facilitator superfamily domain containing 5
decreases expression
ISO
tolcapone results in decreased expression of MFSD5 mRNA
CTD
PMID:24136188
NCBI chr15:102,187,891...102,190,179
Ensembl chr15:102,187,889...102,190,189
G
Mgst1
microsomal glutathione S-transferase 1
affects binding
ISO
tolcapone binds to MGST1 protein
CTD
PMID:19783845
NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753
G
Mia3
MIA SH3 domain ER export factor 3
decreases expression
ISO
tolcapone results in decreased expression of MIA3 mRNA
CTD
PMID:24136188
NCBI chr 1:183,107,091...183,151,091
Ensembl chr 1:183,107,682...183,150,894
G
Mkks
McKusick-Kaufman syndrome
decreases expression
ISO
tolcapone results in decreased expression of MKKS mRNA
CTD
PMID:24136188
NCBI chr 2:136,715,700...136,733,422
Ensembl chr 2:136,715,700...136,733,309
G
Mkrn1
makorin, ring finger protein, 1
decreases expression
ISO
tolcapone results in decreased expression of MKRN1 mRNA
CTD
PMID:24136188
NCBI chr 6:39,374,738...39,400,480
Ensembl chr 6:39,374,738...39,397,396
G
Mmadhc
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
decreases expression
ISO
tolcapone results in decreased expression of MMADHC mRNA
CTD
PMID:24136188
NCBI chr 2:50,169,893...50,189,033
Ensembl chr 2:50,169,893...50,186,813
G
Mrpl1
mitochondrial ribosomal protein L1
decreases expression
ISO
tolcapone results in decreased expression of MRPL1 mRNA
CTD
PMID:24136188
NCBI chr 5:96,357,357...96,414,586
Ensembl chr 5:96,357,352...96,414,586
G
Mrpl13
mitochondrial ribosomal protein L13
decreases expression
ISO
tolcapone results in decreased expression of MRPL13 mRNA
CTD
PMID:24136188
NCBI chr15:55,397,491...55,420,708
Ensembl chr15:55,397,490...55,421,144
G
Mrpl14
mitochondrial ribosomal protein L14
decreases expression
ISO
tolcapone results in decreased expression of MRPL14 mRNA
CTD
PMID:24136188
NCBI chr17:45,991,689...46,009,421
Ensembl chr17:45,997,248...46,009,421
G
Mrpl18
mitochondrial ribosomal protein L18
decreases expression
ISO
tolcapone results in decreased expression of MRPL18 mRNA
CTD
PMID:24136188
NCBI chr17:13,130,232...13,136,674
Ensembl chr17:13,130,236...13,135,232
G
Mrpl20
mitochondrial ribosomal protein L20
decreases expression
ISO
tolcapone results in decreased expression of MRPL20 mRNA
CTD
PMID:24136188
NCBI chr 4:155,887,335...155,893,288
Ensembl chr 4:155,887,335...155,894,432
G
Mrpl22
mitochondrial ribosomal protein L22
decreases expression
ISO
tolcapone results in decreased expression of MRPL22 mRNA
CTD
PMID:24136188
NCBI chr11:58,060,850...58,070,406
Ensembl chr11:58,062,487...58,070,391
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Mrpl23
mitochondrial ribosomal protein L23
decreases expression
ISO
tolcapone results in decreased expression of MRPL23 mRNA
CTD
PMID:24136188
NCBI chr 7:142,086,423...142,094,484
Ensembl chr 7:142,086,423...142,094,484
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Mrpl30
mitochondrial ribosomal protein L30
decreases expression
ISO
tolcapone results in decreased expression of MRPL30 mRNA
CTD
PMID:24136188
NCBI chr 1:37,929,558...37,937,419
Ensembl chr 1:37,929,558...37,937,616
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Mrpl32
mitochondrial ribosomal protein L32
decreases expression
ISO
tolcapone results in decreased expression of MRPL32 mRNA
CTD
PMID:24136188
NCBI chr13:14,784,886...14,787,622
Ensembl chr13:14,782,769...14,787,750
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Mrpl36
mitochondrial ribosomal protein L36
decreases expression
ISO
tolcapone results in decreased expression of MRPL36 mRNA
CTD
PMID:24136188
NCBI chr13:73,479,128...73,480,297
Ensembl chr13:73,476,632...73,480,297
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Mrpl40
mitochondrial ribosomal protein L40
decreases expression
ISO
tolcapone results in decreased expression of MRPL40 mRNA
CTD
PMID:24136188
NCBI chr16:18,690,767...18,695,875
Ensembl chr16:18,690,768...18,695,612
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Mrpl53
mitochondrial ribosomal protein L53
decreases expression
ISO
tolcapone results in decreased expression of MRPL53 mRNA
CTD
PMID:24136188
NCBI chr 6:83,086,089...83,086,913
Ensembl chr 6:83,086,021...83,086,920
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Mrps14
mitochondrial ribosomal protein S14
decreases expression
ISO
tolcapone results in decreased expression of MRPS14 mRNA
CTD
PMID:24136188
NCBI chr 1:160,022,785...160,028,756
Ensembl chr 1:160,022,785...160,029,740
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Mrps18c
mitochondrial ribosomal protein S18C
decreases expression
ISO
tolcapone results in decreased expression of MRPS18C mRNA
CTD
PMID:24136188
NCBI chr 5:100,946,625...100,952,333
Ensembl chr 5:100,946,493...100,952,337
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Mrps24
mitochondrial ribosomal protein S24
decreases expression
ISO
tolcapone results in decreased expression of MRPS24 mRNA
CTD
PMID:24136188
NCBI chr11:5,653,982...5,657,701
Ensembl chr11:5,653,983...5,665,680
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Mrps33
mitochondrial ribosomal protein S33
decreases expression
ISO
tolcapone results in decreased expression of MRPS33 mRNA
CTD
PMID:24136188
NCBI chr 6:39,778,738...39,787,870
Ensembl chr 6:39,778,738...39,787,922
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Mrps36
mitochondrial ribosomal protein S36
decreases expression
ISO
Tolcapone results in decreased expression of KGD4 mRNA
CTD
PMID:24136188
NCBI chr13:100,872,448...100,881,167
Ensembl chr13:100,872,463...100,881,167
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Mtap
methylthioadenosine phosphorylase
affects binding
ISO
tolcapone binds to MTAP protein
CTD
PMID:19783845
NCBI chr 4:89,055,607...89,099,327
Ensembl chr 4:89,055,359...89,099,318
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Mttp
microsomal triglyceride transfer protein
increases expression
ISO
tolcapone results in increased expression of MTTP protein
CTD
PMID:29688484
NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729
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Mvk
mevalonate kinase
increases expression
ISO
tolcapone results in increased expression of MVK mRNA
CTD
PMID:24136188
NCBI chr 5:114,582,324...114,598,652
Ensembl chr 5:114,582,330...114,598,652
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Naa20
N(alpha)-acetyltransferase 20, NatB catalytic subunit
decreases expression
ISO
tolcapone results in decreased expression of NAA20 mRNA
CTD
PMID:24136188
NCBI chr 2:145,743,454...145,758,345
Ensembl chr 2:145,744,019...145,758,345
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Nat10
N-acetyltransferase 10
affects binding
ISO
tolcapone binds to NAT10 protein
CTD
PMID:19783845
NCBI chr 2:103,551,603...103,593,292
Ensembl chr 2:103,551,601...103,591,615
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Ndufa1
NADH:ubiquinone oxidoreductase subunit A1
decreases expression
ISO
tolcapone results in decreased expression of NDUFA1 mRNA
CTD
PMID:24136188
NCBI chr X:36,451,241...36,454,891
Ensembl chr X:36,451,241...36,454,816
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Ndufa2
NADH:ubiquinone oxidoreductase subunit A2
decreases expression
ISO
tolcapone results in decreased expression of NDUFA2 mRNA
CTD
PMID:24136188
NCBI chr18:36,875,385...36,877,640
Ensembl chr18:36,875,385...36,877,610
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Ndufa6
NADH:ubiquinone oxidoreductase subunit A6
decreases expression
ISO
tolcapone results in decreased expression of NDUFA6 mRNA
CTD
PMID:24136188
NCBI chr15:82,234,342...82,238,438
Ensembl chr15:82,234,341...82,238,523
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Ndufa7
NADH:ubiquinone oxidoreductase subunit A7
decreases expression
ISO
tolcapone results in decreased expression of NDUFA7 mRNA
CTD
PMID:24136188
NCBI chr17:34,043,546...34,057,290
Ensembl chr17:34,043,546...34,057,291
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Ndufa9
NADH:ubiquinone oxidoreductase subunit A9
affects binding
ISO
tolcapone binds to NDUFA9 protein
CTD
PMID:19783845
NCBI chr 6:126,798,826...126,826,107
Ensembl chr 6:126,798,684...126,826,099
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Ndufb6
NADH:ubiquinone oxidoreductase subunit B6
decreases expression
ISO
tolcapone results in decreased expression of NDUFB6 mRNA
CTD
PMID:24136188
NCBI chr 4:40,270,591...40,279,421
Ensembl chr 4:40,270,591...40,279,421
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Ndufc2
NADH:ubiquinone oxidoreductase subunit C2
decreases expression
ISO
tolcapone results in decreased expression of NDUFC2 mRNA
CTD
PMID:24136188
NCBI chr 7:97,049,210...97,057,007
Ensembl chr 7:97,049,210...97,057,009
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Ndufs4
NADH:ubiquinone oxidoreductase core subunit S4
decreases expression
ISO
tolcapone results in decreased expression of NDUFS4 mRNA
CTD
PMID:24136188
NCBI chr13:114,424,331...114,524,630
Ensembl chr13:114,424,331...114,524,794
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Ndufs5
NADH:ubiquinone oxidoreductase core subunit S5
decreases expression
ISO
tolcapone results in decreased expression of NDUFS5 mRNA
CTD
PMID:24136188
NCBI chr 4:123,606,503...123,611,979
Ensembl chr 4:123,606,503...123,611,995
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Nfe2l2
nuclear factor, erythroid derived 2, like 2
decreases expression
ISO
tolcapone results in decreased expression of NFE2L2 mRNA
CTD
PMID:28526448
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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Nipsnap1
nipsnap homolog 1
affects binding
ISO
tolcapone binds to NIPSNAP1 protein
CTD
PMID:19783845
NCBI chr11:4,823,951...4,844,201
Ensembl chr11:4,823,951...4,844,200
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Nipsnap2
nipsnap homolog 2
affects binding
ISO
tolcapone binds to NIPSNAP2 protein
CTD
PMID:19783845
NCBI chr 5:129,802,080...129,835,391
Ensembl chr 5:129,802,127...129,835,391
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Nme3
NME/NM23 nucleoside diphosphate kinase 3
decreases expression
ISO
tolcapone results in decreased expression of NME3 mRNA
CTD
PMID:24136188
NCBI chr17:25,115,474...25,116,505
Ensembl chr17:25,115,474...25,116,496
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Nop56
NOP56 ribonucleoprotein
affects binding
ISO
tolcapone binds to NOP56 protein
CTD
PMID:19783845
NCBI chr 2:130,112,904...130,121,233
Ensembl chr 2:130,116,350...130,121,233
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Nphp1
nephronophthisis 1 (juvenile) homolog (human)
decreases expression
ISO
tolcapone results in decreased expression of NPHP1 mRNA
CTD
PMID:24136188
NCBI chr 2:127,582,652...127,630,833
Ensembl chr 2:127,582,652...127,630,817
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Nploc4
NPL4 homolog, ubiquitin recognition factor
increases expression
ISO
tolcapone results in increased expression of NPLOC4 mRNA
CTD
PMID:24136188
NCBI chr11:120,270,624...120,328,526
Ensembl chr11:120,271,196...120,328,534
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
decreases expression
ISO
tolcapone results in decreased expression of NR3C1 mRNA
CTD
PMID:24136188
NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
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Nupr2
nuclear protein transcriptional regulator 2
decreases expression
ISO
tolcapone results in decreased expression of NUPR2 mRNA
CTD
PMID:24136188
NCBI chr 5:129,937,381...129,942,629
Ensembl chr 5:129,937,381...129,942,630
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P4ha1
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
affects binding
ISO
tolcapone binds to P4HA1 protein
CTD
PMID:19783845
NCBI chr10:59,159,019...59,209,126
Ensembl chr10:59,159,118...59,209,126
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Pcna
proliferating cell nuclear antigen
decreases expression
ISO
tolcapone results in decreased expression of PCNA mRNA
CTD
PMID:24136188
NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
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Pcx
pyruvate carboxylase
affects binding
ISO
tolcapone binds to PC protein
CTD
PMID:19783845
NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780
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Pcyt1a
phosphate cytidylyltransferase 1, choline, alpha isoform
affects binding
ISO
tolcapone binds to PCYT1A protein
CTD
PMID:19783845
NCBI chr16:32,249,739...32,293,883
Ensembl chr16:32,249,739...32,293,888
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Pdzd11
PDZ domain containing 11
decreases expression
ISO
tolcapone results in decreased expression of PDZD11 mRNA
CTD
PMID:24136188
NCBI chr X:99,665,949...99,673,667
Ensembl chr X:99,666,489...99,670,174
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Pfdn1
prefoldin 1
decreases expression
ISO
tolcapone results in decreased expression of PFDN1 mRNA
CTD
PMID:24136188
NCBI chr18:36,536,732...36,587,548
Ensembl chr18:36,536,729...36,587,577
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Pfdn5
prefoldin 5
decreases expression
ISO
tolcapone results in decreased expression of PFDN5 mRNA
CTD
PMID:24136188
NCBI chr15:102,234,551...102,239,925
Ensembl chr15:102,234,551...102,240,308
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Pgm1
phosphoglucomutase 1
increases expression
ISO
tolcapone results in increased expression of PGM1 mRNA
CTD
PMID:24136188
NCBI chr 4:99,786,648...99,844,491
Ensembl chr 4:99,786,611...99,844,491
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Pgr
progesterone receptor
multiple interactions
ISO
tolcapone binds to and results in decreased activity of PGR protein
CTD
PMID:25752796
NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
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Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
decreases expression
ISO
tolcapone results in decreased expression of PIGP mRNA
CTD
PMID:24136188
NCBI chr16:94,159,622...94,171,874
Ensembl chr16:94,159,622...94,172,701
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Pigs
phosphatidylinositol glycan anchor biosynthesis, class S
affects binding
ISO
tolcapone binds to PIGS protein
CTD
PMID:19783845
NCBI chr11:78,219,272...78,233,602
Ensembl chr11:78,219,241...78,233,608
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Pin4
peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin)
decreases expression
ISO
tolcapone results in decreased expression of PIN4 mRNA
CTD
PMID:24136188
NCBI chr X:101,163,075...101,171,276
Ensembl chr X:101,163,053...101,171,275
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Plin2
perilipin 2
affects binding
ISO
tolcapone binds to PLIN2 protein
CTD
PMID:19783845
NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297
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Plin3
perilipin 3
affects binding
ISO
tolcapone binds to PLIN3 protein
CTD
PMID:19783845
NCBI chr17:56,585,962...56,597,511
Ensembl chr17:56,584,476...56,599,873
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Pnpla2
patatin-like phospholipase domain containing 2
increases expression
ISO
tolcapone results in increased expression of PNPLA2 mRNA
CTD
PMID:24136188
NCBI chr 7:141,035,101...141,040,656
Ensembl chr 7:141,035,111...141,040,656
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Polr1h
RNA polymerase I subunit H
decreases expression
ISO
Tolcapone results in decreased expression of POLR1H mRNA
CTD
PMID:24136188
NCBI chr17:37,265,250...37,269,417
Ensembl chr17:37,265,248...37,269,451
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Polr2g
polymerase (RNA) II (DNA directed) polypeptide G
decreases expression
ISO
tolcapone results in decreased expression of POLR2G mRNA
CTD
PMID:24136188
NCBI chr19:8,770,493...8,775,921
Ensembl chr19:8,770,491...8,775,941
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Prpf8
pre-mRNA processing factor 8
affects binding
ISO
tolcapone binds to PRPF8 protein
CTD
PMID:19783845
NCBI chr11:75,377,603...75,400,273
Ensembl chr11:75,377,642...75,400,275
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Prxl2a
peroxiredoxin like 2A
affects binding
ISO
tolcapone binds to PRXL2A protein
CTD
PMID:19783845
NCBI chr14:40,715,692...40,735,790
Ensembl chr14:40,715,697...40,735,745
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Psmc5
protease (prosome, macropain) 26S subunit, ATPase 5
affects binding
ISO
tolcapone binds to PSMC5 protein
CTD
PMID:19783845
NCBI chr11:106,147,011...106,153,938
Ensembl chr11:106,146,980...106,153,946
G
Psme2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
affects binding
ISO
tolcapone binds to PSME2 protein
CTD
PMID:19783845
NCBI chr14:55,824,897...55,828,558
Ensembl chr14:55,824,898...55,828,570
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
Tolcapone results in increased expression of PTGS2 mRNA
CTD
PMID:32816093
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
G
Ptrh2
peptidyl-tRNA hydrolase 2
affects binding
ISO
tolcapone binds to PTRH2 protein
CTD
PMID:19783845
NCBI chr11:86,574,900...86,583,283
Ensembl chr11:86,574,811...86,583,283
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Ramac
RNA guanine-7 methyltransferase activating subunit
decreases expression
ISO
tolcapone results in decreased expression of RAMAC mRNA
CTD
PMID:24136188
NCBI chr 7:81,412,701...81,419,238
Ensembl chr 7:81,412,673...81,419,239
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Ran
RAN, member RAS oncogene family
affects binding
ISO
tolcapone binds to RAN protein
CTD
PMID:19783845
NCBI chr 5:129,097,264...129,101,388
Ensembl chr 5:129,097,133...129,101,387
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Rap1a
RAS-related protein 1a
decreases expression
ISO
tolcapone results in decreased expression of RAP1A mRNA
CTD
PMID:24136188
NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652
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Rbis
ribosomal biogenesis factor
decreases expression
ISO
Tolcapone results in decreased expression of RBIS mRNA
CTD
PMID:24136188
NCBI chr 3:14,671,349...14,676,419
Ensembl chr 3:14,671,344...14,676,345
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Rbm8a
RNA binding motif protein 8a
decreases expression
ISO
tolcapone results in decreased expression of RBM8A mRNA
CTD
PMID:24136188
NCBI chr 3:96,537,244...96,541,107
Ensembl chr 3:96,537,249...96,541,107
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Rbp1
retinol binding protein 1, cellular
decreases expression
ISO
tolcapone results in decreased expression of RBP1 mRNA
CTD
PMID:24136188
NCBI chr 9:98,305,014...98,328,604
Ensembl chr 9:98,305,014...98,328,628
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Reep6
receptor accessory protein 6
affects binding
ISO
tolcapone binds to REEP6 protein
CTD
PMID:19783845
NCBI chr10:80,165,831...80,172,275
Ensembl chr10:80,165,787...80,172,275
G
Rnf7
ring finger protein 7
decreases expression
ISO
tolcapone results in decreased expression of RNF7 mRNA
CTD
PMID:24136188
NCBI chr 9:96,352,990...96,360,728
Ensembl chr 9:96,352,990...96,360,728
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Rnls
renalase, FAD-dependent amine oxidase
decreases expression
ISO
tolcapone results in decreased expression of RNLS mRNA
CTD
PMID:24136188
NCBI chr19:33,115,140...33,369,695
Ensembl chr19:33,115,147...33,369,665
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Romo1
reactive oxygen species modulator 1
decreases expression
ISO
tolcapone results in decreased expression of ROMO1 mRNA
CTD
PMID:24136188
NCBI chr 2:155,986,073...155,987,714
Ensembl chr 2:155,985,959...155,987,717
G
Rpa3
replication protein A3
decreases expression
ISO
tolcapone results in decreased expression of RPA3 mRNA
CTD
PMID:24136188
NCBI chr 6:8,255,936...8,259,141
Ensembl chr 6:8,255,936...8,259,173
G
Rpl10a
ribosomal protein L10A
affects binding
ISO
tolcapone binds to RPL10A protein
CTD
PMID:19783845
NCBI chr17:28,547,557...28,550,007
Ensembl chr17:28,547,445...28,550,007
G
Rpl15
ribosomal protein L15
affects binding
ISO
tolcapone binds to RPL15 protein
CTD
PMID:19783845
NCBI chr14:4,198,710...4,201,873
Ensembl chr14:4,198,305...4,201,873
G
Rpl18a
ribosomal protein L18A
affects binding
ISO
tolcapone binds to RPL18A protein
CTD
PMID:19783845
NCBI chr 8:71,347,366...71,350,087
Ensembl chr 8:71,347,366...71,350,056
G
Rpl22
ribosomal protein L22
affects binding
ISO
tolcapone binds to RPL22 protein
CTD
PMID:19783845
NCBI chr 4:152,408,893...152,418,539
Ensembl chr 4:152,410,199...152,418,528
G
Rpl22l1
ribosomal protein L22 like 1
decreases expression
ISO
tolcapone results in decreased expression of RPL22L1 mRNA
CTD
PMID:24136188
NCBI chr 3:28,859,660...28,861,573
Ensembl chr 3:28,859,585...28,861,573
G
Rpl23
ribosomal protein L23
affects binding
ISO
tolcapone binds to RPL23 protein
CTD
PMID:19783845
NCBI chr11:97,668,352...97,673,265
Ensembl chr11:97,668,353...97,673,263
G
Rpl35a
ribosomal protein L35A
decreases expression
ISO
tolcapone results in decreased expression of RPL35A mRNA
CTD
PMID:24136188
NCBI chr16:32,876,823...32,880,559
Ensembl chr16:32,876,823...32,880,559
G
Rpl36a
ribosomal protein L36A
decreases expression
ISO
tolcapone results in decreased expression of RPL36A mRNA
CTD
PMID:24136188
NCBI chr X:133,486,403...133,488,811
Ensembl chr X:133,486,403...133,488,811
G
Rpl41
ribosomal protein L41
decreases expression
ISO
tolcapone results in decreased expression of RPL41 mRNA
CTD
PMID:24136188
NCBI chr10:128,383,979...128,385,037
Ensembl chr10:128,383,983...128,385,174
G
Rpl7a
ribosomal protein L7A
affects binding
ISO
tolcapone binds to RPL7A protein
CTD
PMID:19783845
NCBI chr 2:26,800,697...26,803,330
Ensembl chr 2:26,800,776...26,803,330
G
Rpl7l1
ribosomal protein L7-like 1
affects binding
ISO
tolcapone binds to RPL7L1 protein
CTD
PMID:19783845
NCBI chr17:47,084,833...47,093,582
Ensembl chr17:47,084,833...47,093,598
G
Rpl9
ribosomal protein L9
decreases expression
ISO
tolcapone results in decreased expression of RPL9 mRNA
CTD
PMID:24136188
NCBI chr 5:65,545,707...65,548,774
Ensembl chr 5:65,545,707...65,548,787
G
Rpp21
ribonuclease P 21 subunit
decreases expression
ISO
tolcapone results in decreased expression of RPP21 mRNA
CTD
PMID:24136188
NCBI chr17:36,566,565...36,568,738
Ensembl chr17:36,566,537...36,568,961
G
Rps11
ribosomal protein S11
affects binding
ISO
tolcapone binds to RPS11 protein
CTD
PMID:19783845
NCBI chr 7:44,771,812...44,773,813
Ensembl chr 7:44,771,803...44,773,863
G
Rps14
ribosomal protein S14
affects binding
ISO
tolcapone binds to RPS14 protein
CTD
PMID:19783845
NCBI chr18:60,907,668...60,911,618
Ensembl chr18:60,880,170...60,911,618
G
Rps15a
ribosomal protein S15A
decreases expression
ISO
tolcapone results in decreased expression of RPS15A mRNA
CTD
PMID:24136188
NCBI chr 7:117,703,597...117,715,370
Ensembl chr 7:117,703,595...117,715,411
G
Rps20
ribosomal protein S20
affects binding
ISO
tolcapone binds to RPS20 protein
CTD
PMID:19783845
NCBI chr 4:3,831,334...3,835,600
Ensembl chr 4:3,831,334...3,835,665
G
Rps21
ribosomal protein S21
decreases expression
ISO
tolcapone results in decreased expression of RPS21 mRNA
CTD
PMID:24136188
NCBI chr 2:179,899,172...179,900,237
Ensembl chr 2:179,899,170...179,900,238
G
Rps24
ribosomal protein S24
decreases expression
ISO
tolcapone results in decreased expression of RPS24 mRNA
CTD
PMID:24136188
NCBI chr14:24,540,786...24,545,925
Ensembl chr14:24,537,193...24,547,027
G
Rps25
ribosomal protein S25
decreases expression
ISO
tolcapone results in decreased expression of RPS25 mRNA
CTD
PMID:24136188
NCBI chr 9:44,319,011...44,321,703
Ensembl chr 9:44,318,436...44,321,724
G
Rps27
ribosomal protein S27
decreases expression
ISO
Tolcapone results in decreased expression of RPS27 mRNA
CTD
PMID:24136188
NCBI chr 3:90,119,974...90,120,955
Ensembl chr 3:90,119,829...90,120,958
G
Rps27a
ribosomal protein S27A
affects binding
ISO
tolcapone binds to RPS27A protein
CTD
PMID:19783845
NCBI chr11:29,495,842...29,498,040
Ensembl chr11:29,495,846...29,498,109
G
S100a10
S100 calcium binding protein A10 (calpactin)
decreases expression
ISO
tolcapone results in decreased expression of S100A10 mRNA
CTD
PMID:24136188
NCBI chr 3:93,462,424...93,471,952
Ensembl chr 3:93,462,387...93,471,950
G
Sc5d
sterol-C5-desaturase
increases expression
ISO
tolcapone results in increased expression of SC5D mRNA
CTD
PMID:24136188
NCBI chr 9:42,162,888...42,175,607
Ensembl chr 9:42,162,891...42,175,552
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Scd1
stearoyl-Coenzyme A desaturase 1
affects binding decreases expression
ISO
tolcapone binds to SCD protein tolcapone results in decreased expression of SCD1 mRNA
CTD
PMID:19783845 PMID:24136188
NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
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Sdha
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
affects binding
ISO
tolcapone binds to SDHA protein
CTD
PMID:19783845
NCBI chr13:74,470,374...74,498,359
Ensembl chr13:74,470,373...74,498,399
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Sdhb
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
affects binding
ISO
tolcapone binds to SDHB protein
CTD
PMID:19783845
NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504
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Sec11c
SEC11 homolog C, signal peptidase complex subunit
affects binding
ISO
tolcapone binds to SEC11C protein
CTD
PMID:19783845
NCBI chr18:65,933,649...65,950,731
Ensembl chr18:65,933,586...65,950,755
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Sec31a
SEC31 homolog A, COPII coat complex component
affects binding
ISO
tolcapone binds to SEC31A protein
CTD
PMID:19783845
NCBI chr 5:100,509,508...100,564,132
Ensembl chr 5:100,509,508...100,564,093
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Serbp1
serpine1 mRNA binding protein 1
affects binding
ISO
tolcapone binds to SERBP1 protein
CTD
PMID:19783845
NCBI chr 6:67,243,963...67,266,286
Ensembl chr 6:67,215,160...67,274,720
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Sf3b6
splicing factor 3B, subunit 6
affects binding
ISO
tolcapone binds to SF3B6 protein
CTD
PMID:19783845
NCBI chr12:4,867,608...4,877,659
Ensembl chr12:4,867,544...4,877,659
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Sfxn1
sideroflexin 1
affects binding
ISO
tolcapone binds to SFXN1 protein
CTD
PMID:19783845
NCBI chr13:54,225,675...54,262,365
Ensembl chr13:54,225,888...54,262,361
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Sik3
SIK family kinase 3
increases expression
ISO
tolcapone results in increased expression of SIK3 mRNA
CTD
PMID:24136188
NCBI chr 9:45,924,099...46,135,492
Ensembl chr 9:45,924,118...46,135,492
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Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
affects binding
ISO
tolcapone binds to SLC1A5 protein
CTD
PMID:19783845
NCBI chr 7:16,515,259...16,532,199
Ensembl chr 7:16,515,265...16,532,199
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Slc25a1
solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
affects binding
ISO
tolcapone binds to SLC25A1 protein
CTD
PMID:19783845
NCBI chr16:17,743,075...17,746,083
Ensembl chr16:17,743,087...17,746,083
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Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
affects binding
ISO
tolcapone binds to SLC25A13 protein
CTD
PMID:19783845
NCBI chr 6:6,041,218...6,217,304
Ensembl chr 6:6,041,218...6,217,173
G
Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
affects binding
ISO
tolcapone binds to SLC25A4 protein
CTD
PMID:19783845
NCBI chr 8:46,660,205...46,664,099
Ensembl chr 8:46,659,834...46,664,321
G
Slc25a5
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
affects binding
ISO
tolcapone binds to SLC25A5 protein
CTD
PMID:19783845
NCBI chr X:36,059,250...36,062,461
Ensembl chr X:36,059,304...36,062,460
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Slc39a7
solute carrier family 39 (zinc transporter), member 7
affects binding
ISO
tolcapone binds to SLC39A7 protein
CTD
PMID:19783845
NCBI chr17:34,247,240...34,250,664
Ensembl chr17:34,247,243...34,250,656
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Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
decreases expression
ISO
Tolcapone results in decreased expression of SLC7A11 mRNA
CTD
PMID:32816093
NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
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Slpi
secretory leukocyte peptidase inhibitor
decreases expression
ISO
Tolcapone results in decreased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
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Smim26
small integral membrane protein 26
decreases expression
ISO
tolcapone results in decreased expression of SMIM26 mRNA
CTD
PMID:24136188
NCBI chr 2:144,435,985...144,437,286
Ensembl chr 2:144,435,974...144,437,286
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Snapin
SNAP-associated protein
decreases expression
ISO
tolcapone results in decreased expression of SNAPIN mRNA
CTD
PMID:24136188
NCBI chr 3:90,395,333...90,398,320
Ensembl chr 3:90,395,333...90,398,340
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Snca
synuclein, alpha
multiple interactions
ISO
tolcapone inhibits the reaction [SNCA protein binds to SNCA protein]
CTD
PMID:20150427
NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
G
Snrnp27
small nuclear ribonucleoprotein 27 (U4/U6.U5)
decreases expression
ISO
Tolcapone results in decreased expression of SNRNP27 mRNA
CTD
PMID:24136188
NCBI chr 6:86,652,151...86,661,473
Ensembl chr 6:86,652,133...86,661,504
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Snrpb2
U2 small nuclear ribonucleoprotein B
decreases expression
ISO
tolcapone results in decreased expression of SNRPB2 mRNA
CTD
PMID:24136188
NCBI chr 2:142,904,989...142,913,972
Ensembl chr 2:142,904,959...142,914,773
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Snrpd3
small nuclear ribonucleoprotein D3
decreases expression
ISO
tolcapone results in decreased expression of SNRPD3 mRNA
CTD
PMID:24136188
NCBI chr10:75,353,852...75,371,300
Ensembl chr10:75,353,385...75,373,215
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Snrpe
small nuclear ribonucleoprotein E
decreases expression
ISO
tolcapone results in decreased expression of SNRPE mRNA
CTD
PMID:24136188
NCBI chr 1:133,531,609...133,538,018
Ensembl chr 1:133,531,609...133,538,029
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Snrpf
small nuclear ribonucleoprotein polypeptide F
decreases expression
ISO
tolcapone results in decreased expression of SNRPF mRNA
CTD
PMID:24136188
NCBI chr10:93,418,891...93,425,520
Ensembl chr10:93,418,891...93,425,568
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Snrpg
small nuclear ribonucleoprotein polypeptide G
decreases expression
ISO
tolcapone results in decreased expression of SNRPG mRNA
CTD
PMID:24136188
NCBI chr 6:86,348,522...86,355,884
Ensembl chr 6:86,348,286...86,356,310
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Sod1
superoxide dismutase 1, soluble
decreases expression
ISO
tolcapone results in decreased expression of SOD1 mRNA
CTD
PMID:28526448
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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Sod2
superoxide dismutase 2, mitochondrial
decreases expression
ISO
tolcapone results in decreased expression of SOD2 mRNA
CTD
PMID:28526448
NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
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Srp14
signal recognition particle 14
decreases expression
ISO
tolcapone results in decreased expression of SRP14 mRNA
CTD
PMID:24136188
NCBI chr 2:118,306,324...118,310,177
Ensembl chr 2:118,306,331...118,310,192
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Srprb
signal recognition particle receptor, B subunit
affects binding
ISO
tolcapone binds to SRPRB protein
CTD
PMID:19783845
NCBI chr 9:103,065,232...103,079,264
Ensembl chr 9:103,065,231...103,079,336
G
Ss18l2
SS18, nBAF chromatin remodeling complex subunit like 2
decreases expression
ISO
tolcapone results in decreased expression of SS18L2 mRNA
CTD
PMID:24136188
NCBI chr 9:121,539,455...121,541,987
Ensembl chr 9:121,539,395...121,542,454
G
Ssr1
signal sequence receptor, alpha
affects binding
ISO
tolcapone binds to SSR1 protein
CTD
PMID:19783845
NCBI chr13:38,155,377...38,178,184
Ensembl chr13:38,150,581...38,178,193
G
Stac3
SH3 and cysteine rich domain 3
decreases expression
ISO
tolcapone results in decreased expression of STAC3 mRNA
CTD
PMID:24136188
NCBI chr10:127,337,505...127,344,692
Ensembl chr10:127,337,555...127,344,692
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Stat3
signal transducer and activator of transcription 3
increases expression
ISO
tolcapone results in increased expression of STAT3 mRNA
CTD
PMID:24136188
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
G
Sult2a1
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
affects binding
ISO
tolcapone binds to SULT2A1 protein
CTD
PMID:19783845
NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334
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Taf9
TATA-box binding protein associated factor 9
decreases expression
ISO
tolcapone results in decreased expression of TAF9 mRNA
CTD
PMID:24136188
NCBI chr13:100,787,851...100,792,568
Ensembl chr13:100,788,087...100,792,568 Ensembl chr13:100,788,087...100,792,568
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Tbca
tubulin cofactor A
decreases expression
ISO
tolcapone results in decreased expression of TBCA mRNA
CTD
PMID:24136188
NCBI chr13:94,925,428...94,979,431
Ensembl chr13:94,925,418...94,979,430
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Tceal8
transcription elongation factor A (SII)-like 8
decreases expression
ISO
tolcapone results in decreased expression of TCEAL8 mRNA
CTD
PMID:24136188
NCBI chr X:135,069,733...135,073,000
Ensembl chr X:135,069,733...135,073,091
G
Tfr2
transferrin receptor 2
increases expression
ISO
tolcapone results in increased expression of TFR2 mRNA
CTD
PMID:24136188
NCBI chr 5:137,568,127...137,586,344
Ensembl chr 5:137,568,102...137,585,743
G
Timm10
translocase of inner mitochondrial membrane 10
decreases expression
ISO
tolcapone results in decreased expression of TIMM10 mRNA
CTD
PMID:24136188
NCBI chr 2:84,657,365...84,660,557
Ensembl chr 2:84,657,341...84,660,557
G
Timm44
translocase of inner mitochondrial membrane 44
affects binding
ISO
tolcapone binds to TIMM44 protein
CTD
PMID:19783845
NCBI chr 8:4,309,731...4,325,905
Ensembl chr 8:4,309,731...4,325,913
G
Timm8b
translocase of inner mitochondrial membrane 8B
decreases expression
ISO
tolcapone results in decreased expression of TIMM8B mRNA
CTD
PMID:24136188
NCBI chr 9:50,515,227...50,516,620
Ensembl chr 9:50,515,210...50,516,620
G
Tk2
thymidine kinase 2, mitochondrial
affects binding
ISO
tolcapone binds to TK2 protein
CTD
PMID:19783845
NCBI chr 8:104,953,323...104,975,224
Ensembl chr 8:104,953,317...104,975,190
G
Tm2d1
TM2 domain containing 1
decreases expression
ISO
tolcapone results in decreased expression of TM2D1 mRNA
CTD
PMID:24136188
NCBI chr 4:98,243,607...98,271,523
Ensembl chr 4:98,243,607...98,271,543
G
Tmed10
transmembrane p24 trafficking protein 10
affects binding
ISO
tolcapone binds to TMED10 protein
CTD
PMID:19783845
NCBI chr12:85,387,388...85,421,491
Ensembl chr12:85,387,388...85,421,621
G
Tmed4
transmembrane p24 trafficking protein 4
affects binding
ISO
tolcapone binds to TMED4 protein
CTD
PMID:19783845
NCBI chr11:6,220,714...6,224,837
Ensembl chr11:6,220,369...6,224,870
G
Tmed9
transmembrane p24 trafficking protein 9
affects binding
ISO
tolcapone binds to TMED9 protein
CTD
PMID:19783845
NCBI chr13:55,740,948...55,745,510
Ensembl chr13:55,721,545...55,745,510
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Tmem126a
transmembrane protein 126A
decreases expression
ISO
tolcapone results in decreased expression of TMEM126A mRNA
CTD
PMID:24136188
NCBI chr 7:90,099,908...90,106,411
Ensembl chr 7:90,099,908...90,106,437
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Tmem126b
transmembrane protein 126B
decreases expression
ISO
tolcapone results in decreased expression of TMEM126B mRNA
CTD
PMID:24136188
NCBI chr 7:90,118,041...90,125,203
Ensembl chr 7:90,116,646...90,125,209
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Tmem128
transmembrane protein 128
decreases expression
ISO
tolcapone results in decreased expression of TMEM128 mRNA
CTD
PMID:24136188
NCBI chr 5:38,417,529...38,426,978
Ensembl chr 5:38,417,529...38,426,978
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Tmem203
transmembrane protein 203
decreases expression
ISO
tolcapone results in decreased expression of TMEM203 mRNA
CTD
PMID:24136188
NCBI chr 2:25,145,451...25,146,364
Ensembl chr 2:25,145,451...25,146,304
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Tmem238
transmembrane protein 238
decreases expression
ISO
tolcapone results in decreased expression of TMEM238 mRNA
CTD
PMID:24136188
NCBI chr 7:4,787,784...4,792,559
Ensembl chr 7:4,787,556...4,792,655
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Tmem256
transmembrane protein 256
decreases expression
ISO
tolcapone results in decreased expression of TMEM256 mRNA
CTD
PMID:24136188
NCBI chr11:69,729,375...69,730,813
Ensembl chr11:69,729,340...69,730,444
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Tmsb4x
thymosin, beta 4, X chromosome
decreases expression
ISO
tolcapone results in decreased expression of TMSB4X mRNA
CTD
PMID:24136188
NCBI chr X:165,990,089...165,996,475
Ensembl chr X:165,990,089...165,992,311
G
Tnfaip8
tumor necrosis factor, alpha-induced protein 8
affects binding
ISO
tolcapone binds to TNFAIP8 protein
CTD
PMID:19783845
NCBI chr18:50,112,494...50,226,296
Ensembl chr18:50,112,494...50,240,240
G
Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
increases expression
ISO
tolcapone results in increased expression of TNFRSF1A mRNA
CTD
PMID:24136188
NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
G
Tomm20
translocase of outer mitochondrial membrane 20
affects binding
ISO
tolcapone binds to TOMM20 protein
CTD
PMID:19783845
NCBI chr 8:127,657,414...127,672,671
Ensembl chr 8:127,657,417...127,672,594
G
Tomm40
translocase of outer mitochondrial membrane 40
affects binding
ISO
tolcapone binds to TOMM40 protein
CTD
PMID:19783845
NCBI chr 7:19,435,238...19,449,370
Ensembl chr 7:19,435,238...19,449,363
G
Tomm7
translocase of outer mitochondrial membrane 7
affects binding
ISO
tolcapone binds to TOMM7 protein
CTD
PMID:19783845
NCBI chr 5:24,043,942...24,049,143
Ensembl chr 5:24,043,942...24,049,159
G
Trappc2l
trafficking protein particle complex 2L
decreases expression
ISO
tolcapone results in decreased expression of TRAPPC2L mRNA
CTD
PMID:24136188
NCBI chr 8:123,338,365...123,342,330
Ensembl chr 8:123,338,379...123,343,399
G
Tspan6
tetraspanin 6
decreases expression
ISO
tolcapone results in decreased expression of TSPAN6 mRNA
CTD
PMID:24136188
NCBI chr X:132,791,817...132,801,957
Ensembl chr X:132,791,817...132,799,178
G
Tubb6
tubulin, beta 6 class V
affects binding
ISO
tolcapone binds to TUBB6 protein
CTD
PMID:19783845
NCBI chr18:67,523,801...67,535,819
Ensembl chr18:67,523,787...67,535,819
G
Txndc17
thioredoxin domain containing 17
decreases expression
ISO
tolcapone results in decreased expression of TXNDC17 mRNA
CTD
PMID:24136188
NCBI chr11:72,098,380...72,101,313
Ensembl chr11:72,098,373...72,100,841
G
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
decreases glucuronidation increases glucuronidation
ISO
UGT1A9 protein mutant form results in decreased glucuronidation of tolcapone UGT1A9 protein results in increased glucuronidation of tolcapone
CTD
PMID:16344532
NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719
G
Uqcrc2
ubiquinol cytochrome c reductase core protein 2
affects binding
ISO
tolcapone binds to UQCRC2 protein
CTD
PMID:19783845
NCBI chr 7:120,234,412...120,258,746
Ensembl chr 7:120,234,399...120,258,747
G
Uqcrfs1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
affects binding
ISO
tolcapone binds to UQCRFS1 protein
CTD
PMID:19783845
NCBI chr13:30,724,295...30,729,299
Ensembl chr13:30,724,291...30,729,345
G
Uvrag
UV radiation resistance associated gene
increases expression
ISO
tolcapone results in increased expression of UVRAG mRNA
CTD
PMID:24136188
NCBI chr 7:98,535,949...98,790,373
Ensembl chr 7:98,534,228...98,790,348
G
Vdac2
voltage-dependent anion channel 2
affects binding
ISO
tolcapone binds to VDAC2 protein
CTD
PMID:19783845
NCBI chr14:21,881,629...21,895,947
Ensembl chr14:21,875,306...21,895,947
G
Vdac3
voltage-dependent anion channel 3
affects binding
ISO
tolcapone binds to VDAC3 protein
CTD
PMID:19783845
NCBI chr 8:23,067,091...23,083,829
Ensembl chr 8:23,067,102...23,083,774
G
Vsnl1
visinin-like 1
affects binding
ISO
tolcapone binds to VSNL1 protein
CTD
PMID:19783845
NCBI chr12:11,375,258...11,486,579
Ensembl chr12:11,375,243...11,486,614
G
Washc3
WASH complex subunit 3
decreases expression
ISO
tolcapone results in decreased expression of WASHC3 mRNA
CTD
PMID:24136188
NCBI chr10:88,036,954...88,160,001
Ensembl chr10:88,036,955...88,082,020
G
Wfs1
wolframin ER transmembrane glycoprotein
affects binding
ISO
tolcapone binds to WFS1 protein
CTD
PMID:19783845
NCBI chr 5:37,123,448...37,146,326
Ensembl chr 5:37,123,448...37,146,549
G
Yars1
tyrosyl-tRNA synthetase 1
increases expression
ISO
Tolcapone results in increased expression of YARS1 mRNA
CTD
PMID:24136188
NCBI chr 4:129,083,595...129,113,033
Ensembl chr 4:129,083,553...129,113,400
G
Yeats4
YEATS domain containing 4
decreases expression
ISO
tolcapone results in decreased expression of YEATS4 mRNA
CTD
PMID:24136188
NCBI chr10:117,051,046...117,060,412
Ensembl chr10:117,051,126...117,060,412
G
Znrf1
zinc and ring finger 1
increases expression
ISO
tolcapone results in increased expression of ZNRF1 mRNA
CTD
PMID:24136188
NCBI chr 8:112,262,652...112,352,352
Ensembl chr 8:112,262,729...112,352,662
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