Gsk3b (glycogen synthase kinase 3 beta)

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Gene: Gsk3b (glycogen synthase kinase 3 beta) Mus musculus

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Symbol:

Gsk3b

Name:

glycogen synthase kinase 3 beta

RGD ID:

733892

MGI Page

MGI

Description:

Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and protein kinase activity. Involved in several processes, including apoptotic signaling pathway; positive regulation of organelle organization; and regulation of macromolecule biosynthetic process. Acts upstream of with a positive effect on autosome genomic imprinting. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of protein metabolic process; and regulation of neuron projection development. Located in several cellular components, including dendritic shaft; growth cone; and neuronal cell body. Part of Wnt signalosome; beta-catenin destruction complex; and ribonucleoprotein complex. Is active in glutamatergic synapse; meiotic spindle; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

7330414F15Rik; 8430431H08Rik; C86142; glycogen synthase kinase-3 beta; GSK; GSK-; GSK-3; GSK-3 beta; GSK-3be; GSK-3beta; GSK3; serine/threonine-protein kinase GSK3B

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GSK3B (glycogen synthase kinase 3 beta)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Gsk3b (glycogen synthase kinase 3 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gsk3b (glycogen synthase kinase 3 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GSK3B (glycogen synthase kinase 3 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GSK3B (glycogen synthase kinase 3 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gsk3b (glycogen synthase kinase 3 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GSK3B (glycogen synthase kinase 3 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GSK3B (glycogen synthase kinase 3 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gsk3b (glycogen synthase kinase 3 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GSK3A (glycogen synthase kinase 3 alpha)	HGNC	OrthoMCL
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Gsk3b (glycogen synthase kinase 3 beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GSK3B (glycogen synthase kinase 3 beta)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gsk3bb (glycogen synthase kinase 3 beta, genome duplicate b)	Alliance	DIOPT (OrthoFinder\|PANTHER\|ZFIN)
Danio rerio (zebrafish):	gsk3ba (glycogen synthase kinase 3 beta, genome duplicate a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	RIM11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	gskt	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	MRK1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gsk-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	sgg	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gsk3b	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	37,909,363 - 38,066,446 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	37,909,363 - 38,066,446 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	38,089,001 - 38,246,084 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	38,089,001 - 38,246,084 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	38,089,087 - 38,246,165 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	38,008,240 - 38,165,318 (+)	NCBI		MGSCv36	mm8
Celera	16	38,497,488 - 38,655,086 (+)	NCBI		Celera
Cytogenetic Map	16	B3	NCBI
cM Map	16	26.54	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD