Gsk3b (glycogen synthase kinase 3 beta) - Rat Genome Database

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Gene: Gsk3b (glycogen synthase kinase 3 beta) Mus musculus
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Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
RGD ID: 733892
MGI Page MGI
Description: Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and protein kinase activity. Involved in several processes, including apoptotic signaling pathway; negative regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of nitrogen compound metabolic process; and regulation of neuron projection development. Located in several cellular components, including dendritic shaft; glutamatergic synapse; and postsynaptic density. Part of Wnt signalosome; beta-catenin destruction complex; and ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; glycogen biosynthetic pathway; Hedgehog signaling pathway; INTERACTS WITH (R)-lipoic acid; (S)-nicotine; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 7330414F15Rik; 8430431H08Rik; C86142; glycogen synthase kinase-3 beta; GSK; GSK-; GSK-3; GSK-3 beta; GSK-3be; GSK-3beta; GSK3; serine/threonine-protein kinase GSK3B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,909,363 - 38,066,446 (+)NCBIGRCm39mm39
GRCm39 Ensembl1637,909,363 - 38,066,446 (+)Ensembl
GRCm381638,089,001 - 38,246,084 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,089,001 - 38,246,084 (+)EnsemblGRCm38mm10GRCm38
MGSCv371638,089,087 - 38,246,165 (+)NCBIGRCm37mm9NCBIm37
MGSCv361638,008,240 - 38,165,318 (+)NCBImm8
Celera1638,497,488 - 38,655,086 (+)NCBICelera
Cytogenetic Map16B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-lipoic acid  (EXP)
(R)-Salsolinol  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,8-cineole  (EXP)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (ISO)
2,6-dinitrotoluene  (ISO)
2-chloroethanol  (EXP)
2-deoxy-D-glucose  (ISO)
2-methylcholine  (ISO)
2-nitrotoluene  (ISO)
20-hydroxyecdysone  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-vinylcyclohexene dioxide  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
5alpha-pregnane-3,20-dione  (ISO)
6-aminonicotinamide  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
alachlor  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alsterpaullone  (ISO)
amino acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (EXP,ISO)
andrographolide  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
avobenzone  (ISO)
baicalein  (ISO)
BAPTA  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP,ISO)
betulin  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
brazilein  (ISO)
bromochloroacetic acid  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calyculin a  (ISO)
capsaicin  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon monoxide  (EXP)
carbon nanotube  (EXP)
celastrol  (EXP,ISO)
celecoxib  (ISO)
chaetoglobosin A  (ISO)
CHIR 99021  (EXP,ISO)
chitosan  (ISO)
chloroethene  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (EXP)
chromium atom  (EXP)
chromium(6+)  (EXP)
chrysin 5,7-dimethyl ether  (ISO)
cilostazol  (EXP)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
Deguelin  (ISO)
deoxynivalenol  (EXP)
desferrioxamine B  (ISO)
desmopressin  (EXP)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
Di-n-hexyl phthalate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
Didymin  (ISO)
dioxygen  (EXP,ISO)
disodium cromoglycate  (ISO)
disodium selenite  (ISO)
dizocilpine maleate  (ISO)
dobutamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
enzacamene  (ISO)
erlotinib hydrochloride  (ISO)
Estragole  (ISO)
ethanol  (EXP,ISO)
ethosuximide  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (EXP)
eugenol  (ISO)
excitatory amino acid agonist  (EXP,ISO)
famotidine  (ISO)
fipronil  (ISO)
fisetin  (ISO)
fluoxetine  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
Fusaric acid  (EXP)
gefitinib  (ISO)
gemcitabine  (ISO)
geraniol  (ISO)
gingerol  (EXP,ISO)
ginsenoside Re  (EXP)
ginsenoside Rg2  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
GSK690693  (ISO)
haloperidol  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
IC-87114  (EXP)
icariside II  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kaempferol  (ISO)
kahweol  (ISO)
kainic acid  (EXP)
ketamine  (ISO)
KT 5823  (ISO)
L-ascorbic acid  (ISO)
L-glutamic acid  (ISO)
L-methionine  (EXP)
L-serine  (ISO)
lead diacetate  (ISO)
lead nitrate  (EXP)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
liraglutide  (ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP,ISO)
lithocholic acid  (EXP)
lonafarnib  (ISO)
losartan  (ISO)
lovastatin  (ISO)
lupeol  (ISO)
LY294002  (EXP,ISO)
lysophosphatidylethanolamine  (ISO)
magnesium atom  (ISO)
Magnolol  (ISO)
malathion  (ISO)
malvidin  (EXP)
mancozeb  (EXP)
maneb  (EXP)
manganese(II) chloride  (ISO)
melatonin  (EXP)
memantine  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
Mizoribine  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
monodansylcadaverine  (ISO)
morin  (ISO)
morphine  (EXP)
mycophenolic acid  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naloxone  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitrofurazone  (ISO)
nitroprusside  (EXP,ISO)
notoginsenoside R1  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP,ISO)
olanzapine  (ISO)
oleic acid  (ISO)
omethoate  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentetrazol  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
phloretin  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
pioglitazone  (ISO)
Plantamajoside  (EXP,ISO)
potassium atom  (ISO)
potassium chromate  (ISO)
procyanidin B2  (ISO)
progesterone  (EXP,ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (EXP,ISO)
pterostilbene  (EXP)
puerarin  (EXP,ISO)
pyrithione  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quinacrine  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raffinose  (EXP,ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (EXP)
risperidone  (ISO)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rubimaillin  (ISO)
ruthenium atom  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 415286  (EXP,ISO)
SB 431542  (ISO)
SB-239063  (ISO)
sclareol  (ISO)
selenium atom  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sesquiterpene  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
syringic acid  (EXP)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tadalafil  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (EXP)
taurine  (EXP,ISO)
taurochenodeoxycholic acid  (EXP)
temozolomide  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
theophylline  (EXP)
thioacetamide  (EXP)
thymoquinone  (ISO)
tideglusib  (ISO)
toluene 2,4-diisocyanate  (EXP)
topiramate  (ISO)
topotecan  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (EXP,ISO)
vitamin K  (ISO)
warfarin  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
animal organ morphogenesis  (IMP)
axonogenesis  (IGI)
bone remodeling  (ISO)
canonical Wnt signaling pathway  (IDA,IGI)
carbohydrate metabolic process  (IEA)
cell differentiation  (IEA)
cell growth involved in cardiac muscle cell development  (ISO)
cell migration  (IGI)
cellular response to amyloid-beta  (ISO)
cellular response to dopamine  (ISO)
cellular response to erythropoietin  (ISO)
cellular response to hepatocyte growth factor stimulus  (IDA)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-3  (IDA)
cellular response to iron(II) ion  (ISO)
cellular response to lithium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
circadian rhythm  (IMP)
cytoskeleton organization  (TAS)
epithelial to mesenchymal transition  (ISO)
ER overload response  (IDA,ISO)
establishment of cell polarity  (ISO)
establishment or maintenance of cell polarity  (ISO)
extrinsic apoptotic signaling pathway  (IGI)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,IDA)
fat cell differentiation  (IDA)
glycogen metabolic process  (ISO)
hepatic stellate cell activation  (ISO)
hepatocyte apoptotic process  (ISO)
hippocampus development  (ISO)
hypermethylation of CpG island  (IMP)
insulin receptor signaling pathway  (IBA,IDA)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IDA)
maintenance of cell polarity  (ISO)
myoblast fusion  (IDA,IGI)
myotube differentiation  (IGI)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of calcineurin-NFAT signaling cascade  (ISO)
negative regulation of canonical Wnt signaling pathway  (IBA,IMP)
negative regulation of cardiac muscle hypertrophy  (IDA)
negative regulation of dendrite development  (ISO)
negative regulation of dendrite morphogenesis  (ISO)
negative regulation of dopaminergic neuron differentiation  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron maturation  (IGI)
negative regulation of neuron migration  (ISO)
negative regulation of neuron projection development  (IGI,IMP)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of protein acetylation  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of protein localization to centrosome  (IMP)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of signal transduction  (IEA)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of synaptic assembly at neuromuscular junction  (ISO)
negative regulation of TOR signaling  (IGI)
nervous system development  (IEA)
neuron projection development  (ISO)
neuron projection organization  (ISO)
peptidyl-serine phosphorylation  (IDA,IGI,ISO)
peptidyl-threonine phosphorylation  (ISO)
phosphorylation  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy  (IDA,IGI)
positive regulation of axon extension  (IGI)
positive regulation of cardiac muscle cell differentiation  (IMP)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of gene expression  (IGI,IMP)
positive regulation of GTPase activity  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IDA)
positive regulation of mitochondrion organization  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of osteoclast proliferation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (IDA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IGI,ISO)
positive regulation of protein binding  (IDA)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein export from nucleus  (ISO)
positive regulation of protein localization to centrosome  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stem cell differentiation  (IMP)
positive regulation of synaptic assembly at neuromuscular junction  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
protein autophosphorylation  (ISO)
protein export from nucleus  (IDA)
protein localization to microtubule  (IGI)
protein phosphorylation  (IDA,IGI,IMP,ISO)
re-entry into mitotic cell cycle  (IDA)
regulation of apoptotic process  (IMP)
regulation of axon extension  (ISO)
regulation of axonogenesis  (ISO)
regulation of cell growth  (IMP)
regulation of circadian rhythm  (IMP)
regulation of dendrite morphogenesis  (ISO)
regulation of gene expression by genetic imprinting  (IMP)
regulation of long-term synaptic potentiation  (IMP)
regulation of microtubule anchoring at centrosome  (ISO)
regulation of microtubule cytoskeleton organization  (IBA,ISO)
regulation of microtubule-based process  (IDA,ISO)
regulation of modification of postsynaptic structure  (ISO)
regulation of neuron projection development  (IBA,IGI)
regulation of neuronal synaptic plasticity  (ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
regulation of osteoblast differentiation  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to activity  (ISO)
response to angiotensin  (ISO)
response to epinephrine  (ISO)
response to estradiol  (ISO)
response to insulin  (ISO)
response to insulin-like growth factor stimulus  (ISO)
response to L-glutamate  (ISO)
response to lithium ion  (ISO)
response to ultrasound  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
rhythmic process  (IEA)
signal transduction  (IBA)
superior temporal gyrus development  (ISO)
Wnt signaling pathway  (IGI)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavioral response to xenobiotic  (IAGP)
abnormal bone healing  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal clavicle morphology  (IAGP)
abnormal contextual conditioning behavior  (IAGP)
abnormal fontanelle morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal glycogen homeostasis  (IAGP)
abnormal heart electrocardiography waveform feature  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal liver morphology  (IAGP)
abnormal long term depression  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal palatal shelf elevation  (IAGP)
abnormal palate development  (IAGP)
abnormal pancreatic islet cell apoptosis  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal response to new environment  (IAGP)
abnormal S wave  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal social investigation  (IAGP)
abnormal spatial reference memory  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal Wallerian degeneration  (IAGP)
behavioral despair  (IAGP)
cardiac fibrosis  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased coping response  (IAGP)
decreased exploration in new environment  (IAGP)
decreased myocardial infarct size  (IAGP)
decreased P wave amplitude  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased prepulse inhibition  (IAGP)
delayed bone ossification  (IAGP)
enhanced contextual conditioning behavior  (IAGP)
enhanced osteoblast differentiation  (IAGP)
hyperactivity  (IAGP)
impaired cued conditioning behavior  (IAGP)
improved glucose tolerance  (IAGP)
increased anxiety-related response  (IAGP)
increased bone mass  (IAGP)
increased bone ossification  (IAGP)
increased bone resorption  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased compact bone mass  (IAGP)
increased compact bone thickness  (IAGP)
increased compact bone volume  (IAGP)
increased glycogen level  (IAGP)
increased liver glycogen level  (IAGP)
increased myocardial infarct size  (IAGP)
increased pancreatic beta cell proliferation  (IAGP)
increased Q wave amplitude  (IAGP)
increased thigmotaxis  (IAGP)
increased trabecular bone mass  (IAGP)
increased trabecular bone volume  (IAGP)
insulin resistance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IEA)
palatal shelves fail to meet at midline  (IAGP)
preweaning lethality, complete penetrance  (IEA)
prolonged PR interval  (IAGP)
prolonged QRS complex duration  (IAGP)
split sternum  (IAGP)
xiphoid process foramen  (IAGP)
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