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Gene: Gapdh (glyceraldehyde-3-phosphate dehydrogenase) Mus musculus
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Symbol: Gapdh
Name: glyceraldehyde-3-phosphate dehydrogenase
Description: This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Alternative splicing results in multiple transcript variants. Many pseudogenes similar to this locus are found throughout the mouse genome. [provided by RefSeq, Jan 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Gapd; MGC102544; MGC102546; MGC103190; MGC103191; MGC105239; peptidyl-cysteine S-nitrosylase GAPDH
Orthologs:
Homo sapiens (human) : GAPDH (glyceraldehyde-3-phosphate dehydrogenase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gapdh (glyceraldehyde-3-phosphate dehydrogenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gapdh (glyceraldehyde-3-phosphate dehydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : GAPDH (glyceraldehyde-3-phosphate dehydrogenase)
Canis lupus familiaris (dog) : LOC100688969 (glyceraldehyde-3-phosphate dehydrogenase-like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gapdh (glyceraldehyde-3-phosphate dehydrogenase)
Sus scrofa (pig) : GAPDH (glyceraldehyde-3-phosphate dehydrogenase)
more info ...
Related Pseudogenes: 3000002C10Rik   4930448K20Rik   Gapdh-ps14   Gapdh-ps15   Gm10284   Gm10290   Gm10291   Gm10293   Gm10313   Gm10327   Gm10358   Gm10359   Gm10364   Gm10481   Gm10566   Gm11185   Gm11198   Gm11214   Gm11453   Gm11550   Gm11557   Gm11658   Gm11796   Gm11907   Gm11929   Gm11953   Gm11960   Gm11996   Gm12017   Gm12033   Gm12070   Gm12117   Gm12182   Gm12266   Gm12286   Gm12297   Gm12332   Gm12416   Gm12419   Gm12464   Gm12537   Gm12634   Gm12641   Gm12671   Gm12684   Gm12717   Gm12864   Gm12969   Gm13172   Gm13292   Gm13296   Gm13326   Gm13394   Gm13464   Gm13466   Gm13501   Gm13527   Gm13592   Gm13668   Gm13677   Gm13761   Gm13870   Gm13882   Gm14006   Gm14111   Gm14113   Gm14130   Gm14148   Gm14491   Gm14760   Gm14921   Gm15191   Gm15294   Gm15593   Gm16374   Gm16470   Gm17068   Gm17794   Gm17797   Gm17798   Gm17799   Gm17800   Gm18822   Gm18828   Gm18848   Gm18859   Gm2076   Gm21045   Gm2221   Gm2308   Gm2383   Gm2445   Gm2451   Gm2467   Gm2546   Gm2574   Gm2606   Gm2875   Gm3200   Gm3222   Gm3272   Gm3534   Gm3671   Gm3695   Gm3809   Gm3839   Gm3890   Gm4217   Gm4291   Gm4335   Gm4373   Gm4398   Gm4405   Gm4518   Gm4529   Gm4575   Gm4609   Gm4654   Gm4691   Gm4795   Gm4804   Gm4819   Gm4823   Gm4842   Gm4891   Gm4908   Gm4929   Gm4960   Gm5069   Gm5138   Gm5139   Gm5173   Gm5177   Gm5183   Gm5205   Gm5210   Gm5230   Gm5262   Gm5270   Gm5272   Gm5274   Gm5300   Gm5313   Gm5327   Gm5335   Gm5342   Gm5345   Gm5350   Gm5354   Gm5430   Gm5507   Gm5523   Gm5559   Gm5650   Gm5652   Gm5674   Gm5706   Gm5710   Gm5732   Gm5760   Gm5787   Gm5839   Gm5863   Gm5944   Gm5974   Gm5976   Gm6114   Gm6216   Gm6316   Gm6317   Gm6322   Gm6441   Gm6463   Gm6498   Gm6631   Gm6669   Gm6771   Gm6773   Gm6796   Gm6931   Gm6944   Gm6946   Gm6967   Gm6981   Gm6989   Gm7069   Gm7118   Gm7129   Gm7132   Gm7150   Gm7183   Gm7189   Gm7191   Gm7251   Gm7286   Gm7293   Gm7336   Gm7456   Gm7481   Gm7497   Gm7507   Gm7508   Gm7545   Gm7572   Gm7577   Gm7656   Gm7693   Gm7713   Gm7719   Gm7734   Gm7741   Gm7745   Gm7763   Gm7765   Gm7784   Gm7788   Gm7833   Gm7874   Gm7952   Gm7985   Gm8048   Gm8055   Gm8058   Gm8079   Gm8100   Gm8153   Gm8167   Gm8170   Gm8174   Gm8183   Gm8192   Gm8245   Gm8254   Gm8318   Gm8321   Gm8330   Gm8343   Gm8349   Gm8357   Gm8365   Gm8492   Gm8513   Gm8529   Gm8565   Gm8601   Gm8604   Gm8609   Gm8614   Gm8661   Gm8707   Gm8709   Gm8756   Gm8824   Gm8825   Gm8864   Gm8907   Gm8919   Gm8927   Gm8941   Gm8955   Gm8957   Gm8984   Gm8993   Gm9022   Gm9034   Gm9061   Gm9081   Gm9114   Gm9120   Gm9127   Gm9135   Gm9142   Gm9146   Gm9149   Gm9162   Gm9164   Gm9167   Gm9192   Gm9204   Gm9211   Gm9225   Gm9274   Gm9321   Gm9341   Gm9358   Gm9381   Gm9423   Gm9439   Gm9487   Gm9499   Gm9522   Gm9556   Gm9568   Gm9578   Gm9619   Gm9621   Gm9658  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
NCBI Annotation Information: Note: GeneID 14433 was annotated on chromosome 6 on NCBI's Build 36.1 and GeneID 407972 (then associated with the functional Gapdh) was not annotated. Sequences associated with GeneID 14433 also align to chromosome 2 A3, the location of a highly related Gapdh pseudogene that was not annotated on Build 36.1. To connect the nomenclature with the annotation, GeneID 14433 was merged with GeneID 407972 and it now represents the functional Gapdh gene on chromosome 6. The RefSeq for Gapdh is NM_008084 with NM_001001303.1 being secondary to it. The Gapdh pseudogene on chromosome 2 is now represented by GeneID 100033452 and the RefSeq NG_005903.1. [13 Feb 2013]
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm386125,161,852 - 125,166,467 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376125,111,870 - 125,115,601 (-)NCBIGRCm37mm9NCBIm37
MGSCv366125,128,554 - 125,131,222 (-)NCBImm8
Celera6126,831,711 - 126,836,323 (-)NCBICelera
Cytogenetic Map6 F2NCBI
cM Map659.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Gapdh
Alliance Gene
NCBI Gene
Ensembl Gene
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MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10619
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.