H2ac18 (H2A clustered histone 18) - Rat Genome Database

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Gene: H2ac18 (H2A clustered histone 18) Mus musculus
Analyze
Symbol: H2ac18
Name: H2A clustered histone 18
RGD ID: 732082
MGI Page MGI
Description: Predicted to be located in nucleus. Is expressed in dentate gyrus subgranular zone. Orthologous to human H2AC18 (H2A clustered histone 18) and H2AC19 (H2A clustered histone 19).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI448581; H2a-61; H2a-614; H2a-615; His; Hist2; Hist2h; Hist2h2aa1; Hist2h2aa2; histone 2, H2aa1; histone cluster 2, H2aa1; histone gene complex 2; histone H2A type 2-A; histone H2A.2
RGD Orthologs
Human
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,152,853 - 96,153,439 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,152,813 - 96,153,398 (+)EnsemblGRCm39 Ensembl
GRCm38396,245,497 - 96,246,052 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,245,497 - 96,246,082 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,043,639 - 96,044,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,325,121 - 96,325,698 (-)NCBIMGSCv36mm8
Celera397,669,758 - 97,670,335 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2578291   PMID:2587235   PMID:2707490   PMID:2989540   PMID:3027355   PMID:6314253   PMID:7217105   PMID:7667083   PMID:8065931   PMID:8858345   PMID:8918223   PMID:10075934  
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12408966   PMID:12477932   PMID:15489334   PMID:15509584   PMID:15525528   PMID:15601857   PMID:15657431   PMID:16141072   PMID:16141073  
PMID:16699504   PMID:18644788   PMID:24154525   PMID:26267271   PMID:26474655   PMID:29497044   PMID:30713523   PMID:36417873  


Genomics

Comparative Map Data
H2ac18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,152,853 - 96,153,439 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,152,813 - 96,153,398 (+)EnsemblGRCm39 Ensembl
GRCm38396,245,497 - 96,246,052 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,245,497 - 96,246,082 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,043,639 - 96,044,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,325,121 - 96,325,698 (-)NCBIMGSCv36mm8
Celera397,669,758 - 97,670,335 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.69NCBI
H2AC18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381149,842,218 - 149,842,750 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1149,842,218 - 149,842,750 (-)EnsemblGRCh38hg38GRCh38
GRCh371149,813,785 - 149,814,317 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,080,409 - 148,080,942 (-)NCBINCBI36Build 36hg18NCBI36
Build 341146,635,700 - 146,636,234NCBI
Celera1122,548,196 - 122,548,729 (-)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1121,205,342 - 121,205,875 (+)NCBIHuRef
CHM1_11151,210,344 - 151,210,877 (-)NCBICHM1_1
T2T-CHM13v2.01148,966,358 - 148,966,890 (-)NCBIT2T-CHM13v2.0
H2ac18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,497,271 - 186,497,865 (+)NCBIGRCr8
mRatBN7.22183,808,398 - 183,808,992 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2191,464,916 - 191,465,440 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,269,261 - 189,269,787 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,097,452 - 184,097,976 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,388,766 - 198,389,293 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,388,809 - 198,389,201 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,381,798 - 198,382,190 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,874,386 - 217,875,083 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,052,007 - 191,052,604 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,013,304 - 191,015,174 (+)NCBI
Celera2176,336,056 - 176,336,580 (+)NCBICelera
Cytogenetic Map2q34NCBI
H2AC19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,156,821 - 59,157,523 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,147,111 - 59,147,503 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,594,993 - 58,595,586 (-)NCBIDog10K_Boxer_Tasha

Variants

.
Variants in H2ac18
13 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse

Markers in Region
AI448581  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38396,245,999 - 96,246,080UniSTSGRCm38
GRCm38396,239,751 - 96,239,832UniSTSGRCm38
MGSCv37396,049,922 - 96,050,003UniSTSGRCm37
MGSCv37396,043,674 - 96,043,755UniSTSGRCm37
Celera397,669,793 - 97,669,874UniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map3F1-F2UniSTS
Whitehead/MRC_RH31089.9UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK006728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK016171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY158925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z30940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000078756   ⟹   ENSMUSP00000077814
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl396,152,813 - 96,153,398 (+)Ensembl
GRCm38.p6 Ensembl396,245,497 - 96,246,082 (+)Ensembl
RefSeq Acc Id: NM_013549   ⟹   NP_038577
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39396,152,853 - 96,153,439 (+)NCBI
GRCm38396,245,497 - 96,246,052 (+)NCBI
MGSCv37396,043,639 - 96,044,216 (-)RGD
Celera397,675,540 - 97,698,728 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_038577   ⟸   NM_013549
- UniProtKB: Q811M3 (UniProtKB/Swiss-Prot),   Q6GSS7 (UniProtKB/Swiss-Prot),   B2RWH3 (UniProtKB/TrEMBL),   A0AUV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000077814   ⟸   ENSMUST00000078756
Protein Domains
Histone H2A C-terminal   Histone H2A/H2B/H3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6GSS7-F1-model_v2 AlphaFold Q6GSS7 1-130 view protein structure

Promoters
RGD ID:6833971
Promoter ID:MM_KWN:35363
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_013549.1,   NM_178212.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36396,043,646 - 96,045,107 (-)MPROMDB
RGD ID:6833974
Promoter ID:MM_KWN:35364
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_013549,   NM_178212,   NM_178216.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36396,049,061 - 96,052,362 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96097 AgrOrtholog
Ensembl Genes ENSMUSG00000063954 UniProtKB/Swiss-Prot
  ENSMUSG00000064220 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000074976.8 UniProtKB/Swiss-Prot
  ENSMUST00000078756 ENTREZGENE
  ENSMUST00000078756.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Histone-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A/H2B/H3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:319192 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96097 ENTREZGENE
NCBI Gene 15267 ENTREZGENE
PANTHER HISTONE H2A TYPE 2-A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Histone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen H2ac18 PhenoGen
PRINTS HISTONEH2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HISTONE_H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0AUV1 ENTREZGENE
  B2RWH3 ENTREZGENE, UniProtKB/TrEMBL
  H2A2A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q811M3 ENTREZGENE
UniProt Secondary P20670 UniProtKB/Swiss-Prot
  Q811M3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-13 H2ac18  H2A clustered histone 18  Hist2h2aa1  histone cluster 2, H2aa1  Symbol and/or name change 5135510 APPROVED