Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase) - Rat Genome Database

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Gene: Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase) Mus musculus
Analyze
Symbol: Cnp
Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
RGD ID: 736299
MGI Page MGI
Description: Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Acts upstream of or within adult locomotory behavior; neurogenesis; and response to toxic substance. Located in cytoplasm; membrane; and myelin sheath. Is expressed in adrenal gland; gut; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to human CNP (2',3'-cyclic nucleotide 3' phosphodiesterase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2',3'-cyclic-nucleotide 3'-phosphodiesterase; CN; Cnp-1; Cnp1; CNPase; cyclic nucleotide phosphodiesterase 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,465,765 - 100,472,565 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,465,730 - 100,482,555 (+)EnsemblGRCm39 Ensembl
GRCm3811100,574,909 - 100,591,875 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,574,904 - 100,591,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,436,253 - 100,443,053 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,391,065 - 100,397,815 (+)NCBIMGSCv36mm8
Celera11111,195,104 - 111,201,904 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
aniline  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbofuran  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (EXP)
clozapine  (EXP,ISO)
copper(II) sulfate  (ISO)
corticotropin  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyldithiocarbamic acid  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
fenthion  (EXP)
folic acid  (EXP)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
haloperidol  (EXP)
isoflurane  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phencyclidine  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
rac-lactic acid  (ISO)
rimonabant  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
SR 144528  (EXP)
sunitinib  (ISO)
Temsirolimus  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
tributylstannane  (EXP)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
triptonide  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axolemma morphology  (IAGP)
abnormal axon morphology  (IAGP)
abnormal behavior  (IEA)
abnormal brain white matter morphology  (IAGP)
abnormal breathing pattern  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal gait  (IAGP)
abnormal galactolipid level  (IAGP)
abnormal glial cell morphology  (IAGP)
abnormal hippocampal fimbria morphology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal internode morphology  (IAGP)
abnormal limb posture  (IAGP)
abnormal lipid level  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal oligodendrocyte morphology  (IAGP)
abnormal paranodal axoglial junction morphology  (IAGP)
abnormal paranode morphology  (IAGP)
abnormal PNS glial cell morphology  (IAGP)
abnormal Purkinje cell axon morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal Schwann cell morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal visual evoked potential  (IAGP)
absent oligodendrocytes  (IAGP)
astrocytosis  (IAGP)
ataxia  (IAGP)
axon degeneration  (IAGP)
axonal spheroids  (IAGP)
cataract  (IAGP)
convulsive seizures  (IAGP)
decreased body size  (IAGP)
decreased locomotor activity  (IAGP)
decreased mitochondrial DNA content  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased neuron mitochondrial DNA content  (IAGP)
decreased neuron number  (IAGP)
decreased Purkinje cell size  (IAGP)
decreased Schwann cell number  (IAGP)
decreased thigmotaxis  (IEA)
decreased vertical activity  (IAGP)
demyelination  (IAGP)
distended abdomen  (IAGP)
dysmyelination  (IAGP)
gliosis  (IAGP)
hindlimb paralysis  (IAGP)
hindlimb paresis  (IAGP)
hypermyelination  (IAGP)
impaired balance  (IAGP)
impaired coordination  (IAGP)
impaired limb coordination  (IAGP)
increased brain size  (IAGP)
increased fatty acids level  (IAGP)
increased Schwann cell number  (IAGP)
increased T cell number  (IAGP)
kyphosis  (IAGP)
megacolon  (IAGP)
microgliosis  (IAGP)
muscle weakness  (IAGP)
neurodegeneration  (IAGP)
paraparesis  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
reduced fertility  (IAGP)
seizures  (IAGP)
tomacula  (IAGP)
tonic seizures  (IAGP)
tremors  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues. Bernier L, etal., J Neurosci 1987 Sep;7(9):2703-10.
2. Allopregnanolone promotes regeneration and reduces beta-amyloid burden in a preclinical model of Alzheimer's disease. Chen S, etal., PLoS One. 2011;6(8):e24293. Epub 2011 Aug 30.
3. Postmortem and imaging based analyses reveal CNS decreased myelination in restless legs syndrome. Connor JR, etal., Sleep Med. 2011 Jun;12(6):614-9. Epub 2011 May 12.
4. Passive transfer of experimental autoimmune encephalomyelitis in Wistar rats: dissociation of clinical symptoms and biochemical alterations. Degano AL and Roth GA, J Neurosci Res. 2000 Jan 15;59(2):283-90.
5. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Georgieva L, etal., Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12469-74. Epub 2006 Aug 4.
6. A myelin gene causative of a catatonia-depression syndrome upon aging. Hagemeyer N, etal., EMBO Mol Med. 2012 Apr 4. doi: 10.1002/emmm.201200230.
7. Long-term cognitive impairment and myelination deficiency in a rat model of perinatal hypoxic-ischemic brain injury. Huang Z, etal., Brain Res. 2009 Dec 8;1301:100-9. Epub 2009 Sep 10.
8. Abundant extracellular myelin in the meninges of patients with multiple sclerosis. Kooi EJ, etal., Neuropathol Appl Neurobiol. 2009 Jun;35(3):283-95. Epub 2008 Sep 17.
9. Concurrent administration of cilostazol with donepezil effectively improves cognitive dysfunction with increased neuroprotection after chronic cerebral hypoperfusion in rats. Lee JH, etal., Brain Res. 2007 Dec 14;1185:246-55. Epub 2007 Sep 20.
10. Expression of MBP, PLP, MAG, CNP, and GFAP in the Human Alcoholic Brain. Lewohl JM, etal., Alcohol Clin Exp Res. 2005 Sep;29(9):1698-705.
11. Induction of 2',3'-cyclic nucleotide 3'-phosphodiesterase in demyelination of BALB/c mice caused by Angiostrongylus cantonensis. Lin KY and Lai SC, J Comp Pathol. 2009 Nov;141(4):248-53. Epub 2009 Jul 9.
12. Transketolase and 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I isoforms are specifically recognized by IgG autoantibodies in multiple sclerosis patients. Lovato L, etal., Mol Cell Proteomics. 2008 Dec;7(12):2337-49. Epub 2008 Jul 31.
13. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. MGD IEA MGD IEA
16. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
17. Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia. Peirce TR, etal., Arch Gen Psychiatry. 2006 Jan;63(1):18-24.
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Upregulation of CSPG3 accompanies neuronal progenitor proliferation and migration in EAE. Sajad M, etal., J Mol Neurosci. 2011 Mar;43(3):531-40. Epub 2010 Nov 25.
22. Morphologic and biochemical characterization of brain injury in a model of controlled blast overpressure exposure. Svetlov SI, etal., J Trauma. 2010 Oct;69(4):795-804.
23. Case-control association study of the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population. Tang F, etal., Neurosci Lett. 2007 Apr 12;416(2):113-6. Epub 2007 Jan 30.
24. Limited remyelination in Theiler's murine encephalomyelitis due to insufficient oligodendroglial differentiation of nerve/glial antigen 2 (NG2)-positive putative oligodendroglial progenitor cells. Ulrich R, etal., Neuropathol Appl Neurobiol. 2008 Dec;34(6):603-20. Epub 2008 May 5.
25. Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis. Yao DL, etal., Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6190-4.
Additional References at PubMed
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PMID:25232125   PMID:25256100   PMID:25257170   PMID:25274820   PMID:25362471   PMID:25411504   PMID:25429144   PMID:25568100   PMID:25807062   PMID:25810530   PMID:25913734   PMID:25995471  
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Genomics

Comparative Map Data
Cnp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,465,765 - 100,472,565 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,465,730 - 100,482,555 (+)EnsemblGRCm39 Ensembl
GRCm3811100,574,909 - 100,591,875 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,574,904 - 100,591,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,436,253 - 100,443,053 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,391,065 - 100,397,815 (+)NCBIMGSCv36mm8
Celera11111,195,104 - 111,201,904 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
CNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,966,795 - 41,977,740 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,966,763 - 41,977,740 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,118,813 - 40,129,758 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,372,285 - 37,383,280 (+)NCBINCBI36Build 36hg18NCBI36
Build 341737,372,284 - 37,383,280NCBI
Celera1736,773,458 - 36,784,455 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,884,123 - 35,895,118 (+)NCBIHuRef
CHM1_11740,354,523 - 40,365,518 (+)NCBICHM1_1
T2T-CHM13v2.01742,823,292 - 42,834,237 (+)NCBIT2T-CHM13v2.0
Cnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,011,504 - 86,018,063 (+)NCBIGRCr8
mRatBN7.21085,511,164 - 85,517,723 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,511,160 - 85,517,720 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,548,000 - 90,554,559 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,026,520 - 90,033,080 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,419,429 - 85,425,988 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,490,798 - 88,497,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,490,798 - 88,497,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,284,045 - 88,290,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,519,421 - 89,525,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,533,790 - 89,540,348 (+)NCBI
Celera1084,227,529 - 84,234,088 (+)NCBICelera
RH 3.4 Map10859.8RGD
Cytogenetic Map10q31NCBI
Cnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,114,454 - 16,118,622 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,115,137 - 16,119,261 (+)NCBIChiLan1.0ChiLan1.0
CNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,008,706 - 23,017,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,898,864 - 24,907,379 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,338,085 - 15,349,089 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,560,056 - 15,569,108 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,560,056 - 15,568,916 (-)Ensemblpanpan1.1panPan2
CNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,888,350 - 20,896,139 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,886,574 - 20,896,079 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,349,053 - 20,356,835 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,606,902 - 21,614,689 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,594,095 - 21,614,688 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,392,407 - 20,400,181 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,659,216 - 20,666,990 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,762,355 - 20,770,140 (-)NCBIUU_Cfam_GSD_1.0
Cnp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,233,405 - 20,240,592 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,834,540 - 16,841,810 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649016,834,570 - 16,841,734 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,758,083 - 20,765,553 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,758,081 - 20,765,655 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,048,293 - 21,055,830 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,288,583 - 64,296,940 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,289,828 - 64,296,922 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607735,106,165 - 35,114,853 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,855,992 - 1,861,053 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,856,455 - 1,861,142 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnp
140 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:893
Count of miRNA genes:509
Interacting mature miRNAs:619
Transcripts:ENSMUST00000103120, ENSMUST00000147403, ENSMUST00000148034, ENSMUST00000150414
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse

Markers in Region
RH127905  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811100,581,427 - 100,581,632UniSTSGRCm38
MGSCv3711100,442,741 - 100,442,946UniSTSGRCm37
Celera11111,201,592 - 111,201,797UniSTS
Cytogenetic Map11DUniSTS
cM Map1160.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001146318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF332055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF332056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX842667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY333311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY596086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ887820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000103120   ⟹   ENSMUSP00000099409
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11100,465,730 - 100,472,554 (+)Ensembl
GRCm38.p6 Ensembl11100,574,904 - 100,581,728 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147403
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11100,466,717 - 100,482,555 (+)Ensembl
GRCm38.p6 Ensembl11100,575,891 - 100,591,729 (+)Ensembl
RefSeq Acc Id: ENSMUST00000148034
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11100,465,938 - 100,467,276 (+)Ensembl
GRCm38.p6 Ensembl11100,575,112 - 100,576,450 (+)Ensembl
RefSeq Acc Id: ENSMUST00000150414
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11100,466,350 - 100,472,554 (+)Ensembl
GRCm38.p6 Ensembl11100,575,524 - 100,581,728 (+)Ensembl
RefSeq Acc Id: NM_001146318   ⟹   NP_001139790
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911100,466,717 - 100,472,565 (+)NCBI
GRCm3811100,575,891 - 100,581,739 (+)NCBI
MGSCv3711100,436,253 - 100,443,053 (+)RGD
Celera11111,195,104 - 111,201,904 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_009923   ⟹   NP_034053
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911100,465,765 - 100,472,565 (+)NCBI
GRCm3811100,574,939 - 100,581,739 (+)NCBI
MGSCv3711100,436,253 - 100,443,053 (+)RGD
Celera11111,195,104 - 111,201,904 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034053   ⟸   NM_009923
- Peptide Label: isoform 2
- UniProtKB: Q91V42 (UniProtKB/Swiss-Prot),   Q8C7C9 (UniProtKB/Swiss-Prot),   Q61424 (UniProtKB/Swiss-Prot),   Q923F3 (UniProtKB/Swiss-Prot),   P16330 (UniProtKB/Swiss-Prot),   Q3TYV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139790   ⟸   NM_001146318
- Peptide Label: isoform 1
- UniProtKB: Q3TYL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000099409   ⟸   ENSMUST00000103120
Protein Domains
Cyclic nucleotide phosphodiesterase catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16330-F1-model_v2 AlphaFold P16330 1-420 view protein structure

Promoters
RGD ID:6820632
Promoter ID:MM_KWN:9795
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:OTTMUST00000004035,   OTTMUST00000004036,   OTTMUST00000004037,   OTTMUST00000004090
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611100,436,061 - 100,437,782 (+)MPROMDB
RGD ID:8676704
Promoter ID:EPDNEW_M16382
Type:initiation region
Name:Cnp_1
Description:Mus musculus 2',3'-cyclic nucleotide 3' phosphodiesterase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16383  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811100,574,973 - 100,575,033EPDNEW
RGD ID:8676706
Promoter ID:EPDNEW_M16383
Type:initiation region
Name:Cnp_2
Description:Mus musculus 2',3'-cyclic nucleotide 3' phosphodiesterase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16382  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811100,575,810 - 100,575,870EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88437 AgrOrtholog
Ensembl Genes ENSMUSG00000006782 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000103120 ENTREZGENE
  ENSMUST00000103120.5 UniProtKB/Swiss-Prot
  ENSMUST00000150414 ENTREZGENE
Gene3D-CATH 2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CNPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNPase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNuc_Pdiesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88437 ENTREZGENE
NCBI Gene 12799 ENTREZGENE
PANTHER 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA_33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cnp PhenoGen
PIRSF CNPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55144 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CN37_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q09J73_MOUSE UniProtKB/TrEMBL
  Q3TYL9 ENTREZGENE, UniProtKB/TrEMBL
  Q3TYV5 ENTREZGENE, UniProtKB/TrEMBL
  Q61424 ENTREZGENE
  Q8C7C9 ENTREZGENE
  Q91V42 ENTREZGENE
  Q923F3 ENTREZGENE
UniProt Secondary Q61424 UniProtKB/Swiss-Prot
  Q8C7C9 UniProtKB/Swiss-Prot
  Q91V42 UniProtKB/Swiss-Prot
  Q923F3 UniProtKB/Swiss-Prot