Symbol:
Acox3
Name:
acyl-Coenzyme A oxidase 3, pristanoyl
RGD ID:
736893
Description:
Predicted to have fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase and lipid homeostasis. Localizes to mitochondrion. Is expressed in several structures, including brain; colon; genitourinary system; heart; and lung. Orthologous to human ACOX3 (acyl-CoA oxidase 3, pristanoyl); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
BI685180; branched-chain acyl-CoA oxidase; BRCACox; EST-s; EST-s59; PC; PCOX; peroxisomal acyl-coenzyme A oxidase 3; pristanoyl-CoA oxidase
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ACOX3 (acyl-CoA oxidase 3, pristanoyl) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Acox3 (acyl-CoA oxidase 3, pristanoyl) HGNC
EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Acox3 (acyl-CoA oxidase 3, pristanoyl) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ACOX3 (acyl-CoA oxidase 3, pristanoyl) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ACOX3 (acyl-CoA oxidase 3, pristanoyl) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Acox3 (acyl-CoA oxidase 3, pristanoyl) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ACOX3 (acyl-CoA oxidase 3, pristanoyl) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
ACOX3 (acyl-CoA oxidase 3, pristanoyl) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Acox3 (acyl-CoA oxidase 3, pristanoyl) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Acox3 (acyl-CoA oxidase 3, pristanoyl)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Homo sapiens (human):
ACOX3 (acyl-CoA oxidase 3, pristanoyl)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|Roundup|TreeFam)
Danio rerio (zebrafish):
acox3 (acyl-CoA oxidase 3, pristanoyl)
Alliance
DIOPT (PhylomeDB|TreeFam|ZFIN)
Drosophila melanogaster (fruit fly):
CG17544
Alliance
DIOPT (Hieranoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|Roundup|TreeFam)
Drosophila melanogaster (fruit fly):
CG9527
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|PANTHER|PhylomeDB|Roundup|TreeFam)
Caenorhabditis elegans (roundworm):
acox-3
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|Roundup)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38.p6 Ensembl 5 35,583,040 - 35,615,352 (+) Ensembl GRCm38 mm10 GRCm38 GRCm38 5 35,582,981 - 35,614,208 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 5 35,925,709 - 35,956,450 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 5 35,899,921 - 35,930,662 (+) NCBI mm8 Celera 5 33,056,108 - 33,087,085 (+) NCBI Celera Cytogenetic Map 5 B3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(+)-schisandrin B multiple interactions ISO RGD:69245 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ACOX3 mRNA] CTD PMID:31150632 1,2-dimethylhydrazine multiple interactions EXP 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ACOX3 mRNA CTD PMID:22206623 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:69245 6480464 Tetrachlorodibenzodioxin results in decreased expression of ACOX3 mRNA CTD PMID:21215274 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO RGD:69245 6480464 3 more ... CTD PMID:23196670 4,4'-diaminodiphenylmethane decreases expression ISO RGD:69245 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of ACOX3 mRNA CTD PMID:30723492 acetamide decreases expression ISO RGD:69245 6480464 acetamide results in decreased expression of ACOX3 mRNA CTD PMID:31881176 aflatoxin B1 increases methylation ISO RGD:736892 6480464 Aflatoxin B1 results in increased methylation of ACOX3 gene CTD PMID:27153756 aflatoxin B1 decreases methylation ISO RGD:736892 6480464 Aflatoxin B1 results in decreased methylation of ACOX3 intron, Aflatoxin B1 results in decreased methylation of ACOX3 polyA tail CTD PMID:30157460 ammonium chloride affects expression ISO RGD:69245 6480464 Ammonium Chloride affects the expression of ACOX3 mRNA CTD PMID:16483693 benzo[a]pyrene affects methylation ISO RGD:736892 6480464 Benzo(a)pyrene affects the methylation of ACOX3 intron CTD PMID:30157460 benzo[e]pyrene decreases methylation ISO RGD:736892 6480464 benzo(e)pyrene results in decreased methylation of ACOX3 intron CTD PMID:30157460 bisphenol A decreases expression ISO RGD:69245 6480464 bisphenol A results in decreased expression of ACOX3 mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:69245 6480464 bisphenol A results in increased methylation of ACOX3 gene CTD PMID:28505145 calcitriol increases expression ISO RGD:736892 6480464 Calcitriol results in increased expression of ACOX3 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:736892 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of ACOX3 mRNA CTD PMID:21592394 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of ACOX3 mRNA, Nanotubes, Carbon results in decreased expression of ACOX3 mRNA CTD PMID:25554681 crocidolite asbestos decreases expression EXP 6480464 Asbestos, Crocidolite results in decreased expression of ACOX3 mRNA CTD PMID:29279043 cyclosporin A decreases expression ISO RGD:736892 6480464 Cyclosporine results in decreased expression of ACOX3 mRNA CTD PMID:27989131 entacapone affects binding ISO RGD:69245 6480464 entacapone binds to ACOX3 protein CTD PMID:19783845 flutamide decreases expression ISO RGD:69245 6480464 Flutamide results in decreased expression of ACOX3 mRNA CTD PMID:24136188 folic acid multiple interactions EXP 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ACOX3 mRNA CTD PMID:22206623 folic acid decreases expression EXP 6480464 Folic Acid results in decreased expression of ACOX3 mRNA CTD PMID:25629700 methamphetamine increases expression ISO RGD:69245 6480464 Methamphetamine results in increased expression of ACOX3 mRNA CTD PMID:15644446 methapyrilene decreases methylation ISO RGD:736892 6480464 Methapyrilene results in decreased methylation of ACOX3 intron CTD PMID:30157460 methylmercury chloride decreases expression ISO RGD:736892 6480464 methylmercuric chloride results in decreased expression of ACOX3 mRNA CTD PMID:28001369 microcystin-LR decreases expression EXP 6480464 cyanoginosin LR results in decreased expression of ACOX3 protein CTD PMID:26984711 N-methyl-4-phenylpyridinium increases expression ISO RGD:69245 6480464 1-Methyl-4-phenylpyridinium results in increased expression of ACOX3 mRNA CTD PMID:28801915 nefazodone decreases expression ISO RGD:69245 6480464 nefazodone results in decreased expression of ACOX3 mRNA CTD PMID:24136188 nimesulide decreases expression ISO RGD:69245 6480464 nimesulide results in decreased expression of ACOX3 mRNA CTD PMID:24136188 obeticholic acid increases expression ISO RGD:736892 6480464 obeticholic acid results in increased expression of ACOX3 mRNA CTD PMID:27939613 paracetamol decreases expression ISO RGD:736892 6480464 Acetaminophen results in decreased expression of ACOX3 mRNA CTD PMID:21420995 paracetamol affects response to substance ISO RGD:736892 6480464 ACOX3 gene polymorphism affects the susceptibility to Acetaminophen CTD PMID:26104854 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of ACOX3 mRNA CTD PMID:30657992 Propiverine affects binding ISO RGD:69245 6480464 propiverine binds to ACOX3 protein CTD PMID:29273565 quercetin decreases expression ISO RGD:736892 6480464 Quercetin results in decreased expression of ACOX3 mRNA CTD PMID:21632981 sodium arsenite affects methylation ISO RGD:736892 6480464 sodium arsenite affects the methylation of ACOX3 gene CTD PMID:28589171 testosterone multiple interactions ISO RGD:736892 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of ACOX3 mRNA CTD PMID:21592394 testosterone increases expression ISO RGD:736892 6480464 Testosterone results in increased expression of ACOX3 mRNA CTD PMID:21592394 tetrachloromethane affects expression ISO RGD:69245 6480464 Carbon Tetrachloride affects the expression of ACOX3 mRNA CTD PMID:12734012 tetrachloromethane multiple interactions ISO RGD:69245 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ACOX3 mRNA] CTD PMID:31150632 tetrachloromethane decreases expression ISO RGD:69245 6480464 Carbon Tetrachloride results in decreased expression of ACOX3 mRNA CTD PMID:31150632 thioacetamide decreases expression ISO RGD:69245 6480464 Thioacetamide results in decreased expression of ACOX3 mRNA CTD PMID:23411599 tolcapone affects binding ISO RGD:69245 6480464 tolcapone binds to ACOX3 protein CTD PMID:19783845 triphenyl phosphate affects expression ISO RGD:69245 6480464 triphenyl phosphate affects the expression of ACOX3 mRNA CTD PMID:30589522 valdecoxib decreases expression ISO RGD:69245 6480464 valdecoxib results in decreased expression of ACOX3 mRNA CTD PMID:24136188 valproic acid decreases methylation ISO RGD:736892 6480464 Valproic Acid results in decreased methylation of ACOX3 gene CTD PMID:29154799 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of ACOX3 mRNA CTD PMID:24489787 valproic acid decreases expression ISO RGD:736892 6480464 Valproic Acid results in decreased expression of ACOX3 mRNA CTD PMID:29154799 
Gene-Chemical Interaction Annotations
