Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | RGD:69245 | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ACOX3 mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ACOX3 mRNA | CTD | PMID:22206623 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:69245 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ACOX3 mRNA | CTD | PMID:21215274 | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | ISO | RGD:69245 | 6480464 | 3 more ... | CTD | PMID:23196670 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:69245 | 6480464 | 4, 4'-diaminodiphenylmethane results in decreased expression of ACOX3 mRNA | CTD | PMID:30723492 | acetamide | decreases expression | ISO | RGD:69245 | 6480464 | acetamide results in decreased expression of ACOX3 mRNA | CTD | PMID:31881176 | aflatoxin B1 | increases methylation | ISO | RGD:736892 | 6480464 | Aflatoxin B1 results in increased methylation of ACOX3 gene | CTD | PMID:27153756 | aflatoxin B1 | decreases methylation | ISO | RGD:736892 | 6480464 | Aflatoxin B1 results in decreased methylation of ACOX3 intron, Aflatoxin B1 results in decreased methylation of ACOX3 polyA tail | CTD | PMID:30157460 | ammonium chloride | affects expression | ISO | RGD:69245 | 6480464 | Ammonium Chloride affects the expression of ACOX3 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases methylation | ISO | RGD:736892 | 6480464 | Benzo(a)pyrene results in decreased methylation of ACOX3 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | RGD:736892 | 6480464 | Benzo(a)pyrene affects the methylation of ACOX3 intron | CTD | PMID:30157460 | benzo[e]pyrene | decreases methylation | ISO | RGD:736892 | 6480464 | benzo(e)pyrene results in decreased methylation of ACOX3 intron | CTD | PMID:30157460 | bisphenol A | decreases expression | ISO | RGD:69245 | 6480464 | bisphenol A results in decreased expression of ACOX3 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | ISO | RGD:69245 | 6480464 | bisphenol A results in increased methylation of ACOX3 gene | CTD | PMID:28505145 | calcitriol | increases expression | ISO | RGD:736892 | 6480464 | Calcitriol results in increased expression of ACOX3 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RGD:736892 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of ACOX3 mRNA | CTD | PMID:21592394 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | RGD:736892 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ACOX3 gene] | CTD | PMID:28238834 | crocidolite asbestos | decreases expression | EXP | | 6480464 | Asbestos, Crocidolite results in decreased expression of ACOX3 mRNA | CTD | PMID:29279043 | cyclosporin A | decreases expression | ISO | RGD:736892 | 6480464 | Cyclosporine results in decreased expression of ACOX3 mRNA | CTD | PMID:27989131 | entacapone | affects binding | ISO | RGD:69245 | 6480464 | entacapone binds to ACOX3 protein | CTD | PMID:19783845 | flutamide | decreases expression | ISO | RGD:69245 | 6480464 | Flutamide results in decreased expression of ACOX3 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | EXP | | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ACOX3 mRNA | CTD | PMID:22206623 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of ACOX3 mRNA | CTD | PMID:25629700 | gentamycin | increases expression | ISO | RGD:69245 | 6480464 | Gentamicins results in increased expression of ACOX3 mRNA | CTD | PMID:33387578 | methamphetamine | increases expression | ISO | RGD:69245 | 6480464 | Methamphetamine results in increased expression of ACOX3 mRNA | CTD | PMID:15644446 | methapyrilene | decreases methylation | ISO | RGD:736892 | 6480464 | Methapyrilene results in decreased methylation of ACOX3 intron | CTD | PMID:30157460 | methylmercury chloride | decreases expression | ISO | RGD:736892 | 6480464 | methylmercuric chloride results in decreased expression of ACOX3 mRNA | CTD | PMID:28001369 | microcystin-LR | decreases expression | EXP | | 6480464 | cyanoginosin LR results in decreased expression of ACOX3 protein | CTD | PMID:26984711 | N-methyl-4-phenylpyridinium | increases expression | ISO | RGD:69245 | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of ACOX3 mRNA | CTD | PMID:28801915 | nefazodone | decreases expression | ISO | RGD:69245 | 6480464 | nefazodone results in decreased expression of ACOX3 mRNA | CTD | PMID:24136188 | nimesulide | decreases expression | ISO | RGD:69245 | 6480464 | nimesulide results in decreased expression of ACOX3 mRNA | CTD | PMID:24136188 | obeticholic acid | increases expression | ISO | RGD:736892 | 6480464 | obeticholic acid results in increased expression of ACOX3 mRNA | CTD | PMID:27939613 | paracetamol | decreases expression | ISO | RGD:736892 | 6480464 | Acetaminophen results in decreased expression of ACOX3 mRNA | CTD | PMID:21420995 | paracetamol | increases expression | ISO | RGD:69245 | 6480464 | Acetaminophen results in increased expression of ACOX3 mRNA | CTD | PMID:33387578 | paracetamol | affects response to substance | ISO | RGD:736892 | 6480464 | ACOX3 gene polymorphism affects the susceptibility to Acetaminophen | CTD | PMID:26104854 | PCB138 | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | perfluorooctanoic acid | decreases expression | EXP | | 6480464 | perfluorooctanoic acid results in decreased expression of ACOX3 mRNA | CTD | PMID:30657992 | perfluorooctanoic acid | decreases expression | ISO | RGD:69245 | 6480464 | perfluorooctanoic acid results in decreased expression of ACOX3 mRNA | CTD | PMID:34958885 | Propiverine | affects binding | ISO | RGD:69245 | 6480464 | propiverine binds to ACOX3 protein | CTD | PMID:29273565 | quercetin | decreases expression | ISO | RGD:736892 | 6480464 | Quercetin results in decreased expression of ACOX3 mRNA | CTD | PMID:21632981 | resveratrol | multiple interactions | ISO | RGD:736892 | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of ACOX3 mRNA | CTD | PMID:23557933 | sodium arsenite | affects methylation | ISO | RGD:736892 | 6480464 | sodium arsenite affects the methylation of ACOX3 gene | CTD | PMID:28589171 | temozolomide | decreases expression | ISO | RGD:736892 | 6480464 | Temozolomide results in decreased expression of ACOX3 mRNA | CTD | PMID:31758290 | testosterone | multiple interactions | ISO | RGD:736892 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of ACOX3 mRNA | CTD | PMID:21592394 | testosterone | increases expression | ISO | RGD:736892 | 6480464 | Testosterone results in increased expression of ACOX3 mRNA | CTD | PMID:21592394 | tetrachloromethane | affects expression | ISO | RGD:69245 | 6480464 | Carbon Tetrachloride affects the expression of ACOX3 mRNA | CTD | PMID:12734012 | tetrachloromethane | multiple interactions | ISO | RGD:69245 | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ACOX3 mRNA] | CTD | PMID:31150632 | tetrachloromethane | decreases expression | ISO | RGD:69245 | 6480464 | Carbon Tetrachloride results in decreased expression of ACOX3 mRNA | CTD | PMID:31150632 | thioacetamide | decreases expression | ISO | RGD:69245 | 6480464 | Thioacetamide results in decreased expression of ACOX3 mRNA | CTD | PMID:23411599, PMID:34492290 | tolcapone | affects binding | ISO | RGD:69245 | 6480464 | tolcapone binds to ACOX3 protein | CTD | PMID:19783845 | triphenyl phosphate | affects expression | ISO | RGD:69245 | 6480464 | triphenyl phosphate affects the expression of ACOX3 mRNA | CTD | PMID:30589522 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of ACOX3 mRNA | CTD | PMID:33045310 | valdecoxib | decreases expression | ISO | RGD:69245 | 6480464 | valdecoxib results in decreased expression of ACOX3 mRNA | CTD | PMID:24136188 | valproic acid | decreases methylation | ISO | RGD:736892 | 6480464 | Valproic Acid results in decreased methylation of ACOX3 gene | CTD | PMID:29154799 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of ACOX3 mRNA | CTD | PMID:24489787 | valproic acid | decreases expression | ISO | RGD:736892 | 6480464 | Valproic Acid results in decreased expression of ACOX3 mRNA | CTD | PMID:29154799 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Biological Process
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Molecular Function
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Phenotype Annotations
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Electronic Transfer of Homolog Data | MGD and Homologene mouse data transfer |
| 2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 3. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 4. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 5. | Spermatogonia-dependent expression of testicular genes in mice. | Tanaka K, etal., Dev Biol 2002 Jun 15;246(2):466-79. |
Additional References at PubMed
| PMID:10349636 | PMID:10806321 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12477932 | PMID:14610273 | PMID:14681479 | PMID:15178647 | PMID:15489334 | PMID:15782199 | PMID:16141072 |
| PMID:16141073 | PMID:18287559 | PMID:18614015 | PMID:18799693 | PMID:21267068 | PMID:21873635 |
Genomics
Comparative Map Data
| Acox3 (Mus musculus - house mouse) |
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| ACOX3 (Homo sapiens - human) |
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| Acox3 (Rattus norvegicus - Norway rat) |
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| Acox3 (Chinchilla lanigera - long-tailed chinchilla) |
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| ACOX3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| ACOX3 (Canis lupus familiaris - dog) |
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| Acox3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| ACOX3 (Sus scrofa - pig) |
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| ACOX3 (Chlorocebus sabaeus - green monkey) |
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| Acox3 (Heterocephalus glaber - naked mole-rat) |
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miRNA Target Status
Predicted Target Of
| The detailed report is available here: |  | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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QTLs in Region (GRCm39)
| The following QTLs overlap with this region. | | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Markers in Region
| 26.MMHAP81FRA11.seq |
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| D5Mit352 |
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| Acox3 |
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