Pag1 (phosphoprotein associated with glycosphingolipid microdomains 1) - Rat Genome Database

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Gene: Pag1 (phosphoprotein associated with glycosphingolipid microdomains 1) Mus musculus
Analyze
Symbol: Pag1
Name: phosphoprotein associated with glycosphingolipid microdomains 1
RGD ID: 731574
MGI Page MGI
Description: Predicted to have SH2 domain binding activity. Involved in negative regulation of T cell activation. Predicted to localize to membrane raft and plasma membrane. Is expressed in several structures, including brain and spinal cord. Orthologous to human PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cb; Cbp; Csk-binding protein; F730007C19Rik; Pag; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; phosphoprotein transmembrane adaptor 1; phosphoprotein-associated with GEMs; transmembrane phosphoprotein Cbp
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3939,752,539 - 9,898,744 (-)NCBIGRCm39mm39
GRCm39 Ensembl39,752,539 - 9,898,739 (-)Ensembl
GRCm3839,687,479 - 9,833,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl39,687,479 - 9,833,679 (-)EnsemblGRCm38mm10GRCm38
MGSCv3739,691,898 - 9,833,630 (-)NCBIGRCm37mm9NCBIm37
MGSCv3639,674,971 - 9,816,162 (-)NCBImm8
Celera39,712,657 - 9,857,374 (-)NCBICelera
Cytogenetic Map3A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:10790433   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11777944   PMID:12218089   PMID:12466851   PMID:12477932   PMID:12612075   PMID:12626544   PMID:14645715  
PMID:14967142   PMID:16141072   PMID:16141073   PMID:16166631   PMID:16287865   PMID:16339530   PMID:16920712   PMID:17559841   PMID:18498747   PMID:18695048   PMID:19064729   PMID:19825940  
PMID:19874196   PMID:21267068   PMID:21388951   PMID:21549327   PMID:21677750   PMID:21873635   PMID:21915273   PMID:22006020   PMID:24675741   PMID:25246632   PMID:26372908   PMID:26410627  
PMID:26512138   PMID:27751872   PMID:27926878   PMID:31321783   PMID:32325033   PMID:32616310  


Genomics

Comparative Map Data
Pag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3939,752,539 - 9,898,744 (-)NCBIGRCm39mm39
GRCm39 Ensembl39,752,539 - 9,898,739 (-)Ensembl
GRCm3839,687,479 - 9,833,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl39,687,479 - 9,833,679 (-)EnsemblGRCm38mm10GRCm38
MGSCv3739,691,898 - 9,833,630 (-)NCBIGRCm37mm9NCBIm37
MGSCv3639,674,971 - 9,816,162 (-)NCBImm8
Celera39,712,657 - 9,857,374 (-)NCBICelera
Cytogenetic Map3A1NCBI
PAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl880,967,810 - 81,112,068 (-)EnsemblGRCh38hg38GRCh38
GRCh38880,967,810 - 81,112,068 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37881,880,045 - 82,024,303 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36882,042,600 - 82,186,858 (-)NCBINCBI36hg18NCBI36
Celera877,885,010 - 78,029,263 (-)NCBI
Cytogenetic Map8q21.13NCBI
HuRef877,369,813 - 77,514,038 (-)NCBIHuRef
CHM1_1881,932,291 - 82,076,435 (-)NCBICHM1_1
Pag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2291,935,378 - 92,076,937 (+)NCBI
Rnor_6.0 Ensembl294,266,213 - 94,277,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0294,266,104 - 94,277,680 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02114,018,219 - 114,030,544 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera287,649,094 - 87,661,699 (+)NCBICelera
Cytogenetic Map2q23NCBI
Pag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955444608,711 - 629,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955444487,028 - 636,440 (+)NCBIChiLan1.0ChiLan1.0
PAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1879,115,801 - 79,218,100 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl879,123,503 - 79,218,100 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0877,492,087 - 77,635,854 (-)NCBIMhudiblu_PPA_v0panPan3
PAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12928,207,445 - 28,340,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2928,211,031 - 28,263,322 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2928,483,198 - 28,621,159 (-)NCBI
ROS_Cfam_1.02928,333,786 - 28,471,980 (-)NCBI
UMICH_Zoey_3.12928,386,612 - 28,524,495 (-)NCBI
UNSW_CanFamBas_1.02928,418,572 - 28,556,528 (-)NCBI
UU_Cfam_GSD_1.02928,775,035 - 28,913,070 (-)NCBI
Pag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530350,820,083 - 50,961,620 (+)NCBI
SpeTri2.0NW_0049366563,010,603 - 3,152,674 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl455,450,848 - 55,619,219 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1455,450,824 - 55,619,226 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2460,465,088 - 60,627,627 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAG1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1876,404,120 - 76,541,525 (-)NCBI
ChlSab1.1 Ensembl876,409,223 - 76,426,138 (-)Ensembl
Pag1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474410,286,013 - 10,431,383 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300559Thypr3_mthymocyte proliferative response 3 (mouse)Not determined3447125538471355Mouse
1301256Skmw1_mskeletal muscle weight 1 (mouse)Not determined3125721372Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3752111468809613Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2782
Count of miRNA genes:851
Interacting mature miRNAs:1129
Transcripts:ENSMUST00000108384, ENSMUST00000159497, ENSMUST00000159825, ENSMUST00000161949, ENSMUST00000163022
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001195031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011248151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC129945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC156996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF250192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000108384   ⟹   ENSMUSP00000104021
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl39,691,898 - 9,833,630 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159497
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl39,827,436 - 9,833,630 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159825
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl39,692,767 - 9,705,002 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161949   ⟹   ENSMUSP00000124529
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl39,687,479 - 9,833,679 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163022
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl39,752,074 - 9,833,363 (-)Ensembl
RefSeq Acc Id: NM_001195031   ⟹   NP_001181960
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3939,752,539 - 9,898,739 (-)NCBI
GRCm3839,687,479 - 9,833,679 (-)NCBI
Celera39,708,244 - 9,857,423 (-)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_053182   ⟹   NP_444412
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3939,752,539 - 9,898,739 (-)NCBI
GRCm3839,687,479 - 9,833,679 (-)NCBI
MGSCv3739,691,898 - 9,833,630 (-)RGD
Celera39,708,244 - 9,857,423 (-)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530107   ⟹   XP_006530170
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3939,752,539 - 9,782,899 (-)NCBI
GRCm3839,687,479 - 9,717,839 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011248151   ⟹   XP_011246453
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3939,752,539 - 9,898,734 (-)NCBI
GRCm3839,687,479 - 9,833,676 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030252926   ⟹   XP_030108786
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3939,752,539 - 9,832,640 (-)NCBI
GRCm3839,687,479 - 9,769,495 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030252927   ⟹   XP_030108787
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3939,856,158 - 9,898,744 (-)NCBI
GRCm3839,791,098 - 9,833,684 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030252928   ⟹   XP_030108788
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3939,856,158 - 9,898,744 (-)NCBI
GRCm3839,791,098 - 9,833,684 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036163426   ⟹   XP_036019319
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3939,752,539 - 9,898,734 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_444412   ⟸   NM_053182
- UniProtKB: Q3U1F9 (UniProtKB/Swiss-Prot),   A6H659 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001181960   ⟸   NM_001195031
- UniProtKB: Q3U1F9 (UniProtKB/Swiss-Prot),   A6H659 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530170   ⟸   XM_006530107
- Peptide Label: isoform X1
- UniProtKB: Q3U1F9 (UniProtKB/Swiss-Prot),   A6H659 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011246453   ⟸   XM_011248151
- Peptide Label: isoform X1
- UniProtKB: Q3U1F9 (UniProtKB/Swiss-Prot),   A6H659 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030108786   ⟸   XM_030252926
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030108788   ⟸   XM_030252928
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030108787   ⟸   XM_030252927
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000104021   ⟸   ENSMUST00000108384
RefSeq Acc Id: ENSMUSP00000124529   ⟸   ENSMUST00000161949
RefSeq Acc Id: XP_036019319   ⟸   XM_036163426
- Peptide Label: isoform X1

Promoters
RGD ID:6834189
Promoter ID:MM_KWN:33748
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Transcripts:UC008OPC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3639,705,141 - 9,705,942 (-)MPROMDB
RGD ID:6834188
Promoter ID:MM_KWN:33750
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_053182,   OTTMUST00000085362,   OTTMUST00000085363,   OTTMUST00000085366
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3639,833,304 - 9,833,804 (-)MPROMDB
RGD ID:6880222
Promoter ID:EPDNEW_M3562
Type:initiation region
Name:Pag1_1
Description:Mus musculus phosphoprotein associated with glycosphingolipidmicrodomains 1 , transcript variant B, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3839,833,630 - 9,833,690EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443160 AgrOrtholog
Ensembl Genes ENSMUSG00000027508 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000104021 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000124529 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000108384 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000161949 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro PAG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:94212 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2443160 ENTREZGENE
NCBI Gene 94212 ENTREZGENE
PANTHER PTHR16322 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pag1 PhenoGen
UniProt A6H659 ENTREZGENE, UniProtKB/TrEMBL
  PHAG1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8BFS1 UniProtKB/Swiss-Prot
  Q9EQF3 UniProtKB/Swiss-Prot