Ins2 (insulin II) - Rat Genome Database

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Gene: Ins2 (insulin II) Mus musculus
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Symbol: Ins2
Name: insulin II
RGD ID: 10812
MGI Page MGI
Description: Predicted to enable identical protein binding activity; protease binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of phosphorylation. Located in cytosol; nucleus; and secretory granule. Part of sno(s)RNA-containing ribonucleoprotein complex. Is expressed in several structures, including brain; extraembryonic component; gut; immune system; and testis. Used to study maturity-onset diabetes of the young; neonatal diabetes; permanent neonatal diabetes mellitus; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA986540; In; Ins-2; InsII; insulin-2; Mod; Mody; Mody4; proinsulin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,232,393 - 142,233,463 (-)NCBIGRCm39mm39
GRCm39 Ensembl7142,232,393 - 142,297,118 (-)Ensembl
GRCm387142,678,656 - 142,679,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,678,656 - 142,743,381 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,864,561 - 149,865,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv367142,488,051 - 142,489,098 (-)NCBImm8
Celera7142,434,985 - 142,436,037 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
adenoma  (IEP)
Albuminuria  (EXP,ISO)
Alzheimer's disease  (ISO)
bipolar disorder  (ISO)
bladder disease  (ISO)
cardiac arrest  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
cystic kidney disease  (ISO)
developmental and epileptic encephalopathy  (ISO)
diabetes mellitus  (EXP,IAGP,ISO)
Diabetic Cardiomyopathies  (ISO)
diabetic ketoacidosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (EXP,ISO)
disease of metabolism  (ISO)
early infantile epileptic encephalopathy  (ISO)
Edema  (ISO)
Experimental Liver Cirrhosis  (ISO)
fatty liver disease  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
hyperglycemia  (EXP,ISO)
hyperinsulinism  (ISO)
Hyperkalemia  (ISO)
Hyperproinsulinemia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hyperuricemia  (ISO)
hypoglycemia  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
immunodeficiency 39  (ISO)
Insulin Resistance  (ISO)
insulinoma  (ISO)
kidney failure  (ISO)
Lewy body dementia  (ISO)
liver disease  (ISO)
maturity-onset diabetes of the young  (IEA,ISO)
maturity-onset diabetes of the young type 10  (ISO)
Memory Disorders  (ISO)
Metabolic Syndrome  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
MPTP Poisoning  (ISO)
muscular disease  (ISO)
neonatal diabetes  (IEA,ISO)
Neoplasm Invasiveness  (ISO)
neural tube defect  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
pancreatic cancer  (IDA,ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
panic disorder  (ISO)
Paralysis  (ISO)
Paresthesia  (ISO)
Parkinson's disease  (ISO)
permanent neonatal diabetes mellitus  (IEA,ISO)
Permanent Neonatal Diabetes Mellitus 4  (ISO)
Phelan-McDermid syndrome  (ISO)
polycystic ovary syndrome  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Rhabdomyolysis  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
Tachycardia  (ISO)
transient neonatal diabetes mellitus  (ISO)
type 1 diabetes mellitus  (EXP,IMP,ISO)
type 1 diabetes mellitus 2  (IAGP,ISO)
type 2 diabetes mellitus  (IEA,ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Outflow Obstruction  (ISO)
visual epilepsy  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-deoxy-D-glucose  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
5-iodotubercidin  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
5-oxo-L-proline  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
9-cis-retinoic acid  (EXP,ISO)
AACOCF3  (ISO)
acetaminophen O-beta-D-glucosiduronic acid  (ISO)
acetic acid  (EXP)
acrolein  (EXP)
actinomycin D  (EXP)
albuterol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (EXP)
amino acid  (EXP)
amiodarone  (EXP)
amlodipine  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
arachidonic acid  (ISO)
arotinoid acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
aspartame  (EXP,ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acid  (EXP)
bromochloroacetic acid  (EXP)
bromocriptine  (ISO)
butan-1-amine  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamic acid  (EXP)
carvedilol  (ISO)
chlorpropamide  (ISO)
chlorpyrifos  (ISO)
chlorzoxazone  (ISO)
cholesterol  (EXP)
chromium atom  (ISO)
chromium(3+) trichloride  (ISO)
ciprofibrate  (ISO)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (ISO)
co-trimoxazole  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
corticotropin  (ISO)
cortisol  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyproterone acetate  (ISO)
D-glucose  (EXP,ISO)
D-mannopyranose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
demethoxycurcumin  (ISO)
desmosterol  (EXP)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibenziodolium  (ISO)
dicamba  (ISO)
Didymin  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP)
digoxin  (ISO)
dimercaprol  (ISO)
diphosphoric acid  (EXP)
disodium selenite  (EXP,ISO)
dopamine  (ISO)
elemental selenium  (ISO)
enalaprilat dihydrate  (ISO)
equilin  (ISO)
ethanol  (EXP)
ethyl dihydrogen phosphate  (EXP)
ethylamine  (EXP)
farnesol  (ISO)
fenofibrate  (ISO)
fentin hydroxide  (EXP)
ferric ammonium citrate  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
gatifloxacin  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
glimepiride  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (ISO)
glycerol 2-phosphate  (EXP,ISO)
glycine  (EXP)
glycogen  (ISO)
glyoxylic acid  (EXP)
glyphosate  (ISO)
GW 7647  (EXP,ISO)
harmine  (ISO)
hemin  (ISO)
heptadecanoic acid  (EXP)
hexadecanoic acid  (EXP,ISO)
hispidulin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
inositol  (EXP)
isoflavones  (ISO)
isoprenaline  (ISO)
isopropyl palmitate  (EXP)
kynurenic acid  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cystathionine  (EXP)
lanthanum atom  (ISO)
lercanidipine  (ISO)
levonorgestrel  (ISO)
Licarin A  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
magnesium atom  (ISO)
magnesium oxide  (ISO)
Magnolol  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
Melengestrol acetate  (ISO)
mercaptopurine  (ISO)
metformin  (ISO)
methadone  (ISO)
methotrexate  (ISO)
methyl dihydrogen phosphate  (EXP)
methylarsonite  (EXP)
methylglyoxal  (ISO)
metoclopramide  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
miquelianin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monosodium L-glutamate  (EXP)
Moxonidine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nateglinide  (ISO)
neomycin  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
norethisterone  (ISO)
norgestrel  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (EXP,ISO)
octreotide  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
orlistat  (ISO)
orotic acid  (ISO)
oxybenzone  (ISO)
palmitoleic acid  (EXP)
paracetamol  (ISO)
paroxetine  (ISO)
Pentagastrin  (ISO)
pentolinium tartrate  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylarsonous acid  (ISO)
PhIP  (EXP)
phloretin  (ISO)
phosphoric acid  (EXP)
pioglitazone  (EXP,ISO)
potassium chloride  (ISO)
prallethrin  (EXP)
prednisone  (ISO)
progesterone  (ISO)
propranolol  (ISO)
Ptaquiloside  (EXP)
purine-6-thiol  (ISO)
pyridine  (ISO)
pyruvic acid  (ISO)
quercetin  (ISO)
quinoxyfen  (EXP)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
risperidone  (ISO)
ritodrine  (ISO)
Ro 41-5253  (EXP,ISO)
Rutamarin  (EXP)
ruthenium red  (ISO)
saquinavir  (ISO)
saroglitazar  (ISO)
SB 203580  (ISO)
sebacic acid  (EXP)
selenium atom  (ISO)
sertraline  (ISO)
sirolimus  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
Sodium oleate  (ISO)
Sodium salicylate  (ISO)
spironolactone  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulforaphane  (ISO)
sulpiride  (ISO)
tacrolimus hydrate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (ISO)
terbutaline  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
Thiocarbohydrazide  (ISO)
tolbutamide  (ISO)
tolylfluanid  (ISO)
triamcinolone  (ISO)
tributylstannane  (EXP,ISO)
triciribine  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vandetanib  (ISO)
vanillic acid  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
acute-phase response  (ISO)
alpha-beta T cell activation  (ISO)
canonical Wnt signaling pathway  (IGI)
carbohydrate metabolic process  (IEA)
ER overload response  (IMP)
fatty acid homeostasis  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (IBA,IMP)
glucose metabolic process  (IMP)
glucose transmembrane transport  (TAS)
glycoprotein biosynthetic process  (ISO)
insulin receptor signaling pathway  (IDA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IMP)
lactate biosynthetic process  (ISO)
lipid biosynthetic process  (ISO)
lipid catabolic process  (IDA)
lipoprotein biosynthetic process  (ISO)
myoblast fusion  (IGI)
myotube differentiation  (IGI)
negative regulation of acute inflammatory response  (ISO)
negative regulation of fatty acid metabolic process  (ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of glycogen catabolic process  (ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of NAD(P)H oxidase activity  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of proteolysis  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of respiratory burst involved in inflammatory response  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
neuron projection maintenance  (ISO)
nitric oxide-cGMP-mediated signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular protein metabolic process  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of dendritic spine maintenance  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of lipoprotein lipase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide mediated signal transduction  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA,ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein secretion  (IBA)
positive regulation of respiratory burst  (ISO)
protein hexamerization  (ISO)
regulation of cellular amino acid metabolic process  (ISO)
regulation of gene expression  (IDA)
regulation of phosphorylation  (IDA)
regulation of protein binding  (IDA)
regulation of protein localization  (ISO)
regulation of protein localization to plasma membrane  (ISO)
regulation of protein secretion  (ISO)
regulation of transmembrane transporter activity  (ISO)
vasodilation  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal cardiac muscle contractility  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal glomerular capillary morphology  (IAGP)
abnormal glomerular mesangium morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal interferon-gamma secretion  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal kidney interstitium morphology  (IAGP)
abnormal Leydig cell morphology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal mitochondrial chromosome morphology  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal pancreas physiology  (IAGP)
abnormal pancreatic alpha cell morphology  (IAGP)
abnormal pancreatic beta cell mass  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic islet cell apoptosis  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal response to transplant  (IAGP)
abnormal retinal ganglion layer morphology  (IAGP)
abnormal retinal neuronal layer morphology  (IAGP)
abnormal retinal vasculature morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatogonia morphology  (IAGP)
abnormal T cell physiology  (IAGP)
absent mature B cells  (IAGP)
absent pancreatic beta cells  (IAGP)
absent T cells  (IAGP)
acidosis  (IAGP)
akinesia  (IAGP)
albuminuria  (IAGP)
alopecia  (IAGP)
autoimmune response  (IAGP)
decreased adipocyte glucose uptake  (IAGP)
decreased anti-insulin autoantibody level  (IAGP)
decreased birth weight  (IAGP)
decreased body fat mass  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased fetal weight  (IAGP)
decreased insulin secretion  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased muscle cell glucose uptake  (IAGP)
decreased pancreatic alpha cell number  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased pancreatic beta cell proliferation  (IAGP)
decreased pancreatic islet cell apoptosis  (IAGP)
decreased respiratory quotient  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased triglyceride level  (IAGP)
degranulated pancreatic beta cells  (IAGP)
dehydration  (IAGP)
disorganized pancreatic islets  (IAGP)
embryonic growth retardation  (IAGP)
enlarged liver  (IAGP)
enlarged pancreatic islets  (IAGP)
expanded mesangial matrix  (IAGP)
glomerulosclerosis  (IAGP)
heart left ventricle hypertrophy  (IAGP)
hematoma  (IAGP)
hepatic steatosis  (IAGP)
hydronephrosis  (IAGP)
hyperglycemia  (IAGP)
hypoactivity  (IAGP)
impaired glucose tolerance  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased anti-insulin autoantibody level  (IAGP)
increased anxiety-related response  (IAGP)
increased body weight  (IAGP)
increased carbon dioxide production  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating ketone body level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased energy expenditure  (IAGP)
increased erythrocyte cell number  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased granulocyte number  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased leukocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased oxygen consumption  (IAGP)
increased pancreatic alpha cell mass  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased pancreatic alpha cell proliferation  (IAGP)
increased pancreatic beta cell apoptosis  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased pancreatic beta cell number  (IAGP)
increased pancreatic beta cell proliferation  (IAGP)
increased pancreatic islet cell apoptosis  (IAGP)
increased renal glomerular filtration rate  (IAGP)
increased renal glomerulus basement membrane thickness  (IAGP)
increased retinal apoptosis  (IAGP)
increased susceptibility to atherosclerosis  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased urine glucose level  (IAGP)
increased vascular permeability  (IAGP)
insulin resistance  (IAGP)
insulitis  (IAGP)
kyphosis  (IAGP)
mesangiolysis  (IAGP)
no abnormal phenotype detected  (IAGP)
pancreas inflammation  (IAGP)
polydipsia  (IAGP)
polyphagia  (IAGP)
polyuria  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
renal glomerular protein deposits  (IAGP)
salivary gland inflammation  (IAGP)
small pancreatic islets  (IAGP)
thick interventricular septum  (IAGP)
References

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PMID:28535269   PMID:28576773   PMID:28580283   PMID:28624504   PMID:28630133   PMID:28700945   PMID:28705881   PMID:28793255   PMID:28837672   PMID:28883608   PMID:28893946   PMID:28922976  
PMID:29029025   PMID:29058721   PMID:29061652   PMID:29074590   PMID:29079704   PMID:29122848   PMID:29133483   PMID:29180572   PMID:29203863   PMID:29207116   PMID:29211719   PMID:29211853  
PMID:29231167   PMID:29272356   PMID:29304075   PMID:29330353   PMID:29348399   PMID:29348593   PMID:29371604   PMID:29373286   PMID:29420703   PMID:29434227   PMID:29434323   PMID:29439088  
PMID:29507125   PMID:29590218   PMID:29632144   PMID:29654303   PMID:29675273   PMID:29761600   PMID:29851956   PMID:29875100   PMID:29891593   PMID:29910119   PMID:29913163   PMID:29972779  
PMID:29975570   PMID:29995913   PMID:30019207   PMID:30022165   PMID:30065034   PMID:30065074   PMID:30135482   PMID:30168649   PMID:30207172   PMID:30293775   PMID:30305368   PMID:30361701  
PMID:30412050   PMID:30420428   PMID:30425063   PMID:30425286   PMID:30463601   PMID:30480744   PMID:30487608   PMID:30488085   PMID:30498224   PMID:30504829   PMID:30532991   PMID:30576241  
PMID:30590051   PMID:30620636   PMID:30620902   PMID:30665571   PMID:30733468   PMID:30773020   PMID:30796028   PMID:30853440   PMID:30862678   PMID:30886059   PMID:30899071   PMID:30914477  
PMID:30978208   PMID:31039005   PMID:31040360   PMID:31069235   PMID:31091127   PMID:31116975   PMID:31160417   PMID:31160421   PMID:31166707   PMID:31185088   PMID:31186351   PMID:31187215  
PMID:31201281   PMID:31208980   PMID:31217360   PMID:31311313   PMID:31323030   PMID:31345937   PMID:31380462   PMID:31412250   PMID:31506549   PMID:31509011   PMID:31509750   PMID:31519700  
PMID:31604927   PMID:31610731   PMID:31624141   PMID:31682591   PMID:31726870   PMID:31806622   PMID:31806625   PMID:31836691   PMID:31875961   PMID:31882119   PMID:31914588   PMID:31923647  
PMID:31974143   PMID:32059775   PMID:32060653   PMID:32072744   PMID:32165492   PMID:32169892   PMID:32183843   PMID:32198206   PMID:32241676   PMID:32245798   PMID:32313051   PMID:32321760  
PMID:32332156   PMID:32332159   PMID:32350257   PMID:32375022   PMID:32404350   PMID:32439763   PMID:32467243   PMID:32546815   PMID:32640216   PMID:32644973   PMID:32699230   PMID:32708537  
PMID:32715748   PMID:32857951   PMID:32913274   PMID:32994272   PMID:33028844   PMID:33057429   PMID:33060607   PMID:33069809   PMID:33485967   PMID:33505018   PMID:33527355   PMID:33567267  
PMID:33606210   PMID:33658226   PMID:33662611   PMID:33667344   PMID:33810480   PMID:33811703   PMID:33852861   PMID:33859429   PMID:33932339   PMID:34071003   PMID:34086738   PMID:34446743  


Genomics

Comparative Map Data
Ins2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,232,393 - 142,233,463 (-)NCBIGRCm39mm39
GRCm39 Ensembl7142,232,393 - 142,297,118 (-)Ensembl
GRCm387142,678,656 - 142,679,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,678,656 - 142,743,381 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,864,561 - 149,865,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv367142,488,051 - 142,489,098 (-)NCBImm8
Celera7142,434,985 - 142,436,037 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.0NCBI
INS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl112,159,779 - 2,161,221 (-)EnsemblGRCh38hg38GRCh38
GRCh38112,159,779 - 2,161,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,181,009 - 2,182,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,137,585 - 2,139,015 (-)NCBINCBI36hg18NCBI36
Build 34112,137,584 - 2,139,000NCBI
Celera112,217,516 - 2,218,946 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef111,971,272 - 1,972,702 (-)NCBIHuRef
CHM1_1112,179,957 - 2,181,387 (-)NCBICHM1_1
Ins2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21197,843,277 - 197,992,522 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1197,843,281 - 197,864,775 (-)Ensembl
Rnor_6.01215,856,967 - 215,858,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,856,971 - 215,858,034 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,751,786 - 222,756,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,935,548 - 202,936,379 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,123,613 - 203,124,445 (-)NCBI
Celera1195,461,309 - 195,462,376 (-)NCBICelera
Cytogenetic Map1q41NCBI
Ins
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,909,407 - 13,910,419 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542213,909,408 - 13,910,419 (-)NCBIChiLan1.0ChiLan1.0
INS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1112,230,309 - 2,231,666 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,218,117 - 2,231,666 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0112,200,785 - 2,202,579 (-)NCBIMhudiblu_PPA_v0panPan3
INS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,324,047 - 46,324,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,324,041 - 46,325,122 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,933,843 - 44,934,720 (-)NCBI
ROS_Cfam_1.01847,003,520 - 47,004,406 (-)NCBI
UMICH_Zoey_3.11846,452,280 - 46,453,156 (-)NCBI
UNSW_CanFamBas_1.01846,032,597 - 46,033,483 (-)NCBI
UU_Cfam_GSD_1.01846,779,045 - 46,779,926 (-)NCBI
Ins
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,748,017 - 1,749,237 (-)NCBI
SpeTri2.0NW_0049368161,002,137 - 1,003,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,496,842 - 1,497,841 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,496,842 - 1,498,052 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
INS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,965,128 - 1,969,090 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603899,163,059 - 99,164,540 (-)NCBIVero_WHO_p1.0
Ins
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476714,999,088 - 15,000,035 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
AA986540  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,677 - 142,678,816UniSTSGRCm38
MGSCv377149,864,582 - 149,864,721UniSTSGRCm37
Celera7142,435,006 - 142,435,145UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.1UniSTS
Whitehead/MRC_RH71441.15UniSTS
RH94799  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,613 - 52,264,906UniSTSGRCm38
GRCm387142,678,757 - 142,679,544UniSTSGRCm38
MGSCv377149,864,662 - 149,865,449UniSTSGRCm37
MGSCv371952,339,103 - 52,339,396UniSTSGRCm37
Celera1954,451,782 - 54,452,075UniSTS
Celera7142,435,086 - 142,435,873UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS
cM Map769.1UniSTS
cM Map1949.0UniSTS
Ins2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371952,339,299 - 52,339,477UniSTSGRCm37
MGSCv377149,864,639 - 149,865,426UniSTSGRCm37
MGSCv377149,864,621 - 149,865,362UniSTSGRCm37
MGSCv377149,864,663 - 149,865,612UniSTSGRCm37
MGSCv377149,864,611 - 149,864,734UniSTSGRCm37
MGSCv377149,864,525 - 149,864,804UniSTSGRCm37
MGSCv377149,864,581 - 149,864,765UniSTSGRCm37
MGSCv377149,864,625 - 149,865,400UniSTSGRCm37
Celera7142,435,035 - 142,435,158UniSTS
Celera7142,435,045 - 142,435,786UniSTS
Celera7142,435,087 - 142,436,036UniSTS
Celera1954,451,978 - 54,452,156UniSTS
Celera7142,435,049 - 142,435,824UniSTS
Celera7142,435,063 - 142,435,850UniSTS
Celera7142,435,005 - 142,435,189UniSTS
Celera7142,434,949 - 142,435,228UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.1UniSTS
cM Map769.1UniSTS
cM Map1949.0UniSTS
cM Map769.1UniSTS
cM Map769.1UniSTS
cM Map769.1UniSTS
PMC121419P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,510 - 142,679,366UniSTSGRCm38
MGSCv377149,864,415 - 149,865,271UniSTSGRCm37
Celera7142,434,839 - 142,435,695UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.1UniSTS
PMC123023P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,803 - 142,679,497UniSTSGRCm38
MGSCv377149,864,708 - 149,865,402UniSTSGRCm37
Celera7142,435,132 - 142,435,826UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.1UniSTS
PMC123023P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,714 - 142,679,533UniSTSGRCm38
MGSCv377149,864,619 - 149,865,438UniSTSGRCm37
Celera7142,435,043 - 142,435,862UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.1UniSTS
PMC153767P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,808 - 142,679,508UniSTSGRCm38
MGSCv377149,864,713 - 149,865,413UniSTSGRCm37
Celera7142,435,137 - 142,435,837UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.1UniSTS
PMC21231P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,737 - 142,679,525UniSTSGRCm38
MGSCv377149,864,642 - 149,865,430UniSTSGRCm37
Celera7142,435,066 - 142,435,854UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.1UniSTS
PMC312732P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,685 - 52,264,903UniSTSGRCm38
GRCm387142,678,760 - 142,679,472UniSTSGRCm38
MGSCv377149,864,665 - 149,865,377UniSTSGRCm37
MGSCv371952,339,175 - 52,339,393UniSTSGRCm37
Celera1954,451,854 - 54,452,072UniSTS
Celera7142,435,089 - 142,435,801UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS
cM Map769.1UniSTS
cM Map1949.0UniSTS
PMC317250P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,751 - 142,679,709UniSTSGRCm38
MGSCv377149,864,656 - 149,865,614UniSTSGRCm37
Celera7142,435,080 - 142,436,038UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.1UniSTS
PMC86965P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,679,716 - 142,679,941UniSTSGRCm38
MGSCv377149,865,621 - 149,865,846UniSTSGRCm37
Celera7142,436,045 - 142,436,270UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.1UniSTS
Ins2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,716 - 142,679,457UniSTSGRCm38
MGSCv377149,864,621 - 149,865,362UniSTSGRCm37
Celera7142,435,045 - 142,435,786UniSTS
Cytogenetic Map7F5UniSTS
Ins2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,706 - 142,678,829UniSTSGRCm38
MGSCv377149,864,611 - 149,864,734UniSTSGRCm37
Celera7142,435,035 - 142,435,158UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.1UniSTS
Ins2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,720 - 142,679,495UniSTSGRCm38
MGSCv377149,864,625 - 149,865,400UniSTSGRCm37
Celera7142,435,049 - 142,435,824UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.1UniSTS
Ins2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,809 - 52,264,987UniSTSGRCm38
GRCm387142,678,676 - 142,678,860UniSTSGRCm38
MGSCv371952,339,299 - 52,339,477UniSTSGRCm37
MGSCv377149,864,581 - 149,864,765UniSTSGRCm37
Celera1954,451,978 - 54,452,156UniSTS
Celera7142,435,005 - 142,435,189UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS
cM Map769.1UniSTS
Ins2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,620 - 142,678,899UniSTSGRCm38
MGSCv377149,864,525 - 149,864,804UniSTSGRCm37
Celera7142,434,949 - 142,435,228UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.1UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,733 - 142,679,522UniSTSGRCm38
MGSCv377149,864,638 - 149,865,427UniSTSGRCm37
Celera7142,435,062 - 142,435,851UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,643 - 52,264,948UniSTSGRCm38
GRCm387142,678,715 - 142,679,514UniSTSGRCm38
MGSCv371952,339,133 - 52,339,438UniSTSGRCm37
MGSCv377149,864,620 - 149,865,419UniSTSGRCm37
Celera1954,451,812 - 54,452,117UniSTS
Celera7142,435,044 - 142,435,843UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS
Ins2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,758 - 142,679,707UniSTSGRCm38
MGSCv377149,864,663 - 149,865,612UniSTSGRCm37
Celera7142,435,087 - 142,436,036UniSTS
Cytogenetic Map7F5UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D2