Ins2 (insulin II) - Rat Genome Database

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Gene: Ins2 (insulin II) Mus musculus
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Symbol: Ins2
Name: insulin II
RGD ID: 10812
MGI Page MGI
Description: Enables zinc ion binding activity. Involved in insulin processing. Acts upstream of with a positive effect on receptor internalization. Acts upstream of or within several processes, including intracellular signal transduction; positive regulation of intracellular signal transduction; and positive regulation of phosphorylation. Located in cytosol; nucleus; and secretory granule. Part of sno(s)RNA-containing ribonucleoprotein complex. Is active in extracellular space. Is expressed in several structures, including brain; extraembryonic component; gut; immune system; and testis. Used to study maturity-onset diabetes of the young; neonatal diabetes; permanent neonatal diabetes mellitus; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AA986540; In; Ins-2; InsII; insulin-2; Mod; Mody; Mody4; proinsulin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,232,393 - 142,233,463 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,232,393 - 142,297,118 (-)EnsemblGRCm39 Ensembl
GRCm387142,678,656 - 142,679,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,678,656 - 142,743,381 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,864,561 - 149,865,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,488,051 - 142,489,098 (-)NCBIMGSCv36mm8
Celera7142,434,985 - 142,436,037 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
adenoma  (IEP)
Albuminuria  (EXP,ISO)
Alzheimer's disease  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
bipolar disorder  (ISO)
bladder disease  (ISO)
cardiac arrest  (ISO)
cholangiocarcinoma  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
cystic kidney disease  (ISO)
delta beta-thalassemia  (ISO)
developmental and epileptic encephalopathy  (ISO)
diabetes mellitus  (EXP,IAGP,ISO)
Diabetic Cardiomyopathies  (ISO)
diabetic ketoacidosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (EXP,ISO)
disease of metabolism  (ISO)
early infantile epileptic encephalopathy  (ISO)
Edema  (ISO)
Experimental Liver Cirrhosis  (ISO)
generalized dystonia  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
hyperglycemia  (EXP,ISO)
hyperinsulinism  (ISO)
Hyperkalemia  (ISO)
Hyperproinsulinemia  (ISO)
hypertension  (EXP,ISO)
Hypertriglyceridemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hyperuricemia  (ISO)
hypoglycemia  (ISO)
Hypoinsulinemia  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
immunodeficiency 39  (ISO)
Insulin Resistance  (ISO)
insulinoma  (ISO)
kidney disease  (EXP)
kidney failure  (ISO)
Lewy body dementia  (ISO)
liver disease  (ISO)
maturity-onset diabetes of the young  (IAGP,ISO)
maturity-onset diabetes of the young type 1  (ISO)
maturity-onset diabetes of the young type 10  (ISO)
Memory Disorders  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
MPTP Poisoning  (ISO)
muscular disease  (ISO)
neonatal diabetes  (IAGP,ISO)
Neoplasm Invasiveness  (ISO)
neural tube defect  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
pancreatic cancer  (IDA,ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
panic disorder  (ISO)
Paralysis  (ISO)
Paresthesia  (ISO)
Parkinson's disease  (ISO)
permanent neonatal diabetes mellitus  (IAGP,ISO)
Permanent Neonatal Diabetes Mellitus 4  (ISO)
Phelan-McDermid syndrome  (ISO)
polycystic ovary syndrome  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Rhabdomyolysis  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
steatotic liver disease  (ISO)
Tachycardia  (ISO)
transient neonatal diabetes mellitus  (ISO)
type 1 diabetes mellitus  (EXP,IAGP,IMP,ISO)
type 1 diabetes mellitus 2  (IAGP,ISO)
type 2 diabetes mellitus  (IAGP,ISO)
Type 2 Diabetes Mellitus 1  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Outflow Obstruction  (ISO)
Weight Loss  (EXP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1-Oleoyl-2-acetyl-sn-glycerol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-deoxy-D-glucose  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
5-iodotubercidin  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
5-oxo-L-proline  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Hydroxychlorzoxazone  (ISO)
9-cis-retinoic acid  (EXP,ISO)
AACOCF3  (ISO)
acetaminophen O-beta-D-glucosiduronic acid  (ISO)
acetic acid  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
actinomycin D  (EXP)
albuterol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (EXP)
amino acid  (EXP)
amiodarone  (EXP)
amlodipine  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
arachidonic acid  (ISO)
arotinoid acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
aspartame  (EXP,ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bismuth atom  (ISO)
bismuthane  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acid  (EXP)
bromochloroacetic acid  (EXP)
bromocriptine  (ISO)
butan-1-amine  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (ISO)
cannabidiolic acid  (EXP)
cannabigerol  (EXP)
cannabigerolic acid  (EXP)
capsaicin  (ISO)
capsazepine  (ISO)
carbamic acid  (EXP)
carvedilol  (ISO)
chlorpropamide  (ISO)
chlorpyrifos  (ISO)
chlorzoxazone  (ISO)
cholesterol  (EXP)
chromium atom  (ISO)
chromium(3+) trichloride  (ISO)
ciprofibrate  (ISO)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (ISO)
co-trimoxazole  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
corticotropin  (ISO)
cortisol  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyproterone acetate  (ISO)
D-glucose  (EXP,ISO)
D-mannopyranose  (ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (EXP)
demethoxycurcumin  (ISO)
desmosterol  (EXP)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
diazoxide  (ISO)
dibenziodolium  (ISO)
dicamba  (ISO)
Didymin  (ISO)
diethyl maleate  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP)
digoxin  (ISO)
dimercaprol  (ISO)
diphosphoric acid  (EXP)
disodium selenite  (EXP,ISO)
dopamine  (ISO)
elemental selenium  (ISO)
enalaprilat dihydrate  (ISO)
equilin  (ISO)
ethanol  (EXP)
ethyl dihydrogen phosphate  (EXP)
ethylamine  (EXP)
farnesol  (ISO)
fenofibrate  (ISO)
fentin hydroxide  (EXP)
ferric ammonium citrate  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
gatifloxacin  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
Gingerenone A  (EXP,ISO)
glimepiride  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP,ISO)
glycerol 2-phosphate  (EXP,ISO)
glycine  (EXP)
glycogen  (ISO)
glyoxylic acid  (EXP)
glyphosate  (ISO)
GSK2656157  (ISO)
GW 7647  (EXP,ISO)
harmine  (ISO)
hemin  (ISO)
heptadecanoic acid  (EXP)
hexadecanoic acid  (EXP,ISO)
hispidulin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
inositol  (EXP)
isoflavones  (ISO)
isoprenaline  (ISO)
isopropyl palmitate  (EXP)
kynurenic acid  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cystathionine  (EXP)
lanthanum atom  (ISO)
lercanidipine  (ISO)
Licarin A  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
magnesium atom  (ISO)
magnesium oxide  (ISO)
Magnolol  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
Melengestrol acetate  (ISO)
mercaptopurine  (ISO)
metformin  (ISO)
methadone  (ISO)
methotrexate  (ISO)
methyl dihydrogen phosphate  (EXP)
methylarsonite  (EXP)
methylglyoxal  (ISO)
metoclopramide  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
miquelianin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monosodium L-glutamate  (EXP)
Moxonidine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methylnicotinate  (EXP)
N-Phenylmaleimide  (ISO)
nateglinide  (ISO)
neomycin  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
norethisterone  (ISO)
norgestrel  (ISO)
norwogonin  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (EXP,ISO)
octocrylene  (ISO)
octreotide  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
oltipraz  (EXP)
orlistat  (ISO)
orotic acid  (ISO)
oxybenzone  (ISO)
palmitoleic acid  (EXP)
paracetamol  (ISO)
paroxetine  (ISO)
Pentagastrin  (ISO)
pentolinium tartrate  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylarsonous acid  (ISO)
PhIP  (EXP)
phloretin  (ISO)
phosphoric acid  (EXP)
pioglitazone  (EXP,ISO)
potassium chloride  (ISO)
prallethrin  (EXP)
prednisone  (ISO)
progesterone  (ISO)
propranolol  (ISO)
Ptaquiloside  (EXP)
purine-6-thiol  (ISO)
pyridine  (ISO)
pyruvic acid  (ISO)
quercetin  (ISO)
quinoxyfen  (EXP)
rac-lactic acid  (ISO)
RES-701-1  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
rimonabant  (EXP)
risperidone  (ISO)
ritodrine  (ISO)
Ro 41-5253  (EXP,ISO)
rosmarinic acid  (ISO)
Rutamarin  (EXP)
ruthenium red  (ISO)
saquinavir  (ISO)
saroglitazar  (ISO)
SB 203580  (ISO)
sebacic acid  (EXP)
selenium atom  (ISO)
sertraline  (ISO)
sirolimus  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
Sodium oleate  (ISO)
Sodium salicylate  (ISO)
spironolactone  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulforaphane  (ISO)
sulpiride  (ISO)
tacrolimus hydrate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (ISO)
terbutaline  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
Thiocarbohydrazide  (ISO)
tolbutamide  (ISO)
tolylfluanid  (ISO)
triamcinolone  (ISO)
tributylstannane  (EXP,ISO)
triciribine  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vandetanib  (ISO)
vanillic acid  (ISO)
vitamin D  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
acute-phase response  (ISO)
alpha-beta T cell activation  (ISO)
D-glucose transmembrane transport  (TAS)
ER overload response  (IMP)
fatty acid homeostasis  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (IBA,IMP,ISO)
glucose metabolic process  (IMP)
glycoprotein biosynthetic process  (ISO)
insulin processing  (IGI,ISO)
insulin receptor signaling pathway  (IDA,IMP,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IMP)
lactate biosynthetic process  (ISO)
lipid biosynthetic process  (ISO)
lipid catabolic process  (IDA)
lipoprotein biosynthetic process  (ISO)
myoblast fusion  (IGI)
myotube differentiation  (IGI)
negative regulation of acute inflammatory response  (ISO)
negative regulation of fatty acid metabolic process  (ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of glycogen catabolic process  (ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of NAD(P)H oxidase activity  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of proteolysis  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of respiratory burst involved in inflammatory response  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
neuron projection maintenance  (ISO)
nitric oxide-cGMP-mediated signaling  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of D-glucose import  (ISO)
positive regulation of dendritic spine maintenance  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of lipid kinase activity  (IDA)
positive regulation of lipoprotein lipase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide mediated signal transduction  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA,ISO)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein secretion  (IBA)
positive regulation of respiratory burst  (ISO)
protein hexamerization  (ISO)
receptor internalization  (IDA)
regulation of amino acid metabolic process  (ISO)
regulation of gene expression  (IDA)
regulation of phosphorylation  (IDA)
regulation of protein localization  (ISO)
regulation of protein localization to plasma membrane  (ISO)
regulation of protein secretion  (ISO)
regulation of transmembrane transporter activity  (ISO)
vasodilation  (ISO)
wound healing  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal cardiac muscle contractility  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal glomerular capillary morphology  (IAGP)
abnormal glomerular mesangium morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal interferon-gamma secretion  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal kidney interstitium morphology  (IAGP)
abnormal Leydig cell morphology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal mitochondrial chromosome morphology  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal pancreas physiology  (IAGP)
abnormal pancreatic alpha cell morphology  (IAGP)
abnormal pancreatic beta cell mass  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic islet cell apoptosis  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal response to transplant  (IAGP)
abnormal retina ganglion layer morphology  (IAGP)
abnormal retina neuronal layer morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatic cord morphology  (IAGP)
abnormal spermatogonia morphology  (IAGP)
abnormal T cell physiology  (IAGP)
absent mature B cells  (IAGP)
absent pancreatic beta cells  (IAGP)
absent T cells  (IAGP)
acidosis  (IAGP)
akinesia  (IAGP)
albuminuria  (IAGP)
alopecia  (IAGP)
autoimmune response  (IAGP)
decreased adipocyte glucose uptake  (IAGP)
decreased anti-insulin autoantibody level  (IAGP)
decreased birth weight  (IAGP)
decreased body fat mass  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased fetal weight  (IAGP)
decreased insulin secretion  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased locomotor activity  (IAGP)
decreased pancreatic alpha cell number  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased pancreatic beta cell proliferation  (IAGP)
decreased pancreatic islet cell apoptosis  (IAGP)
decreased respiratory quotient  (IAGP)
decreased skeletal muscle cell glucose uptake  (IAGP)
decreased skeletal muscle triglyceride level  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
degranulated pancreatic beta cells  (IAGP)
dehydration  (IAGP)
disorganized pancreatic islets  (IAGP)
embryonic growth retardation  (IAGP)
enlarged liver  (IAGP)
enlarged pancreatic islets  (IAGP)
expanded mesangial matrix  (IAGP)
glomerulosclerosis  (IAGP)
heart left ventricle hypertrophy  (IAGP)
hematoma  (IAGP)
hepatic steatosis  (IAGP)
hydronephrosis  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased anti-insulin autoantibody level  (IAGP)
increased anxiety-related response  (IAGP)
increased body weight  (IAGP)
increased carbon dioxide production  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating ketone body level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased energy expenditure  (IAGP)
increased erythrocyte cell number  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased granulocyte number  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased leukocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased oxygen consumption  (IAGP)
increased pancreatic alpha cell mass  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased pancreatic alpha cell proliferation  (IAGP)
increased pancreatic beta cell apoptosis  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased pancreatic beta cell number  (IAGP)
increased pancreatic beta cell proliferation  (IAGP)
increased pancreatic islet cell apoptosis  (IAGP)
increased renal glomerular filtration rate  (IAGP)
increased renal glomerulus basement membrane thickness  (IAGP)
increased retina apoptosis  (IAGP)
increased susceptibility to atherosclerosis  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased urine glucose level  (IAGP)
increased vascular permeability  (IAGP)
insulin resistance  (IAGP)
insulitis  (IAGP)
kyphosis  (IAGP)
mesangiolysis  (IAGP)
no abnormal phenotype detected  (IAGP)
pancreas inflammation  (IAGP)
polydipsia  (IAGP)
polyphagia  (IAGP)
polyuria  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
renal glomerular protein deposits  (IAGP)
salivary gland inflammation  (IAGP)
small pancreatic islets  (IAGP)
thick interventricular septum  (IAGP)
References

References - curated
# Reference Title Reference Citation
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32. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
33. MGDs mouse GO annotations MGD data from the GO Consortium
34. MGD IEA MGD IEA
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37. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
43. Mouse MP Annotation Import Pipeline RGD automated import pipeline
44. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
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