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Gene: Ins2 (insulin II) Mus musculus
Symbol: Ins2
Name: insulin II
Description: Predicted to have identical protein binding activity; protease binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of phosphorylation. Localizes to several cellular components, including cytosol; secretory granule; and small nucleolar ribonucleoprotein complex. Is expressed in several structures, including brain; extraembryonic component; gut; immune system; and testis. Used to study maturity-onset diabetes of the young; permanent neonatal diabetes mellitus; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA986540; Ins-2; InsII; insulin-2; Mody; Mody4; proinsulin
Homo sapiens (human) : INS (insulin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ins2 (insulin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ins (insulin)
Pan paniscus (bonobo/pygmy chimpanzee) : INS (insulin)
Canis lupus familiaris (dog) : INS (insulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ins (insulin)
Sus scrofa (pig) : INS (insulin)
Chlorocebus sabaeus (African green monkey) : INS (insulin)
Heterocephalus glaber (naked mole-rat) : Ins (insulin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl7142,678,656 - 142,743,381 (-)EnsemblGRCm38mm10GRCm38
GRCm387142,678,656 - 142,679,726 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377149,864,561 - 149,865,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv367142,488,051 - 142,489,098 (-)NCBImm8
Celera7142,434,985 - 142,436,037 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ins2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10812
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.