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Gene: Map3k12 (mitogen-activated protein kinase kinase kinase 12) Mus musculus
Symbol: Map3k12
Name: mitogen-activated protein kinase kinase kinase 12
Description: Exhibits JUN kinase kinase kinase activity and protein homodimerization activity. Involved in negative regulation of motor neuron apoptotic process and protein phosphorylation. Localizes to cytosol; growth cone; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DLK; dual leucine zipper bearing kinase; leucine-zipper protein kinase; MAPK-upstream kinase; mitogen activated protein kinase kinase kinase 12; mixed lineage kinase; MUK; zipper (leucine) protein kinase; Zpk
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl15102,497,646 - 102,517,064 (-)EnsemblGRCm38mm10GRCm38
GRCm3815102,497,647 - 102,517,004 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3715102,328,078 - 102,347,435 (-)NCBIGRCm37mm9NCBIm37
MGSCv3615102,325,683 - 102,344,846 (-)NCBImm8
Celera15104,655,611 - 104,674,768 (-)NCBICelera
Cytogenetic Map15F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Map3k12
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11503
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.