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Gene: Map3k12 (mitogen-activated protein kinase kinase kinase 12) Mus musculus
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Symbol: Map3k12
Name: mitogen-activated protein kinase kinase kinase 12
Description: Exhibits JUN kinase kinase kinase activity and protein homodimerization activity. Involved in negative regulation of motor neuron apoptotic process and protein phosphorylation. Localizes to cytosol; growth cone; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DLK; dual leucine zipper bearing kinase; leucine-zipper protein kinase; MAPK-upstream kinase; mitogen activated protein kinase kinase kinase 12; mixed lineage kinase; MUK; zipper (leucine) protein kinase; Zpk
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl15102,497,646 - 102,517,064 (-)EnsemblGRCm38mm10GRCm38
GRCm3815102,497,647 - 102,517,004 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3715102,328,078 - 102,347,435 (-)NCBIGRCm37mm9NCBIm37
MGSCv3615102,325,683 - 102,344,846 (-)NCBImm8
Celera15104,655,611 - 104,674,768 (-)NCBICelera
Cytogenetic Map15F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Map3k12
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11503
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.