Map3k12 (mitogen-activated protein kinase kinase kinase 12) - Rat Genome Database

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Gene: Map3k12 (mitogen-activated protein kinase kinase kinase 12) Mus musculus
Analyze
Symbol: Map3k12
Name: mitogen-activated protein kinase kinase kinase 12
RGD ID: 11503
MGI Page MGI
Description: Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in JNK cascade; positive regulation of JUN kinase activity; and protein phosphorylation. Acts upstream of or within negative regulation of motor neuron apoptotic process. Located in cytosol; growth cone; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DL; DLK; dual leucine zipper bearing kinase; leucine-zipper protein kinase; MAPK-upstream kinase; mitogen activated protein kinase kinase kinase 12; mixed lineage kinase; MUK; zipper (leucine) protein kinase; Zp; Zpk
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,406,082 - 102,425,439 (-)NCBIGRCm39mm39
GRCm39 Ensembl15102,406,081 - 102,425,499 (-)Ensembl
GRCm3815102,497,647 - 102,517,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,497,646 - 102,517,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715102,328,078 - 102,347,435 (-)NCBIGRCm37mm9NCBIm37
MGSCv3615102,325,683 - 102,344,846 (-)NCBImm8
Celera15104,655,611 - 104,674,768 (-)NCBICelera
Cytogenetic Map15F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7983011   PMID:8663324   PMID:8769565   PMID:8954939   PMID:9010475   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932  
PMID:12520002   PMID:14610273   PMID:14681479   PMID:14765123   PMID:15489334   PMID:15572411   PMID:15749080   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16931512   PMID:17108173  
PMID:17901218   PMID:18031680   PMID:18042735   PMID:18287559   PMID:18497756   PMID:18799693   PMID:18855897   PMID:18973680   PMID:19146952   PMID:19270737   PMID:19287387   PMID:19358824  
PMID:19398581   PMID:19559697   PMID:19808064   PMID:20059953   PMID:21525288   PMID:21593306   PMID:21873635   PMID:21893599   PMID:22726832   PMID:22798074   PMID:22967998   PMID:23431148  
PMID:23431164   PMID:23979718   PMID:24166713   PMID:24194600   PMID:24878510   PMID:25100604   PMID:25447942   PMID:25726747   PMID:26496610   PMID:26526390   PMID:26776303   PMID:27268300  
PMID:27468987   PMID:27511108   PMID:27519653   PMID:28440222   PMID:28641113   PMID:28814543   PMID:29968565   PMID:30735704   PMID:31164177   PMID:32659913  


Genomics

Comparative Map Data
Map3k12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,406,082 - 102,425,439 (-)NCBIGRCm39mm39
GRCm39 Ensembl15102,406,081 - 102,425,499 (-)Ensembl
GRCm3815102,497,647 - 102,517,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,497,646 - 102,517,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715102,328,078 - 102,347,435 (-)NCBIGRCm37mm9NCBIm37
MGSCv3615102,325,683 - 102,344,846 (-)NCBImm8
Celera15104,655,611 - 104,674,768 (-)NCBICelera
Cytogenetic Map15F3NCBI
MAP3K12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1253,479,669 - 53,500,063 (-)EnsemblGRCh38hg38GRCh38
GRCh381253,479,669 - 53,501,205 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371253,873,453 - 53,893,242 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361252,160,547 - 52,179,538 (-)NCBINCBI36hg18NCBI36
Build 341252,160,546 - 52,179,538NCBI
Celera1253,524,658 - 53,543,802 (-)NCBI
Cytogenetic Map12q13.13NCBI
HuRef1250,914,162 - 50,933,025 (-)NCBIHuRef
CHM1_11253,841,326 - 53,860,500 (-)NCBICHM1_1
Map3k12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27133,630,267 - 133,648,464 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7133,630,835 - 133,640,789 (-)Ensembl
Rnor_6.07144,102,275 - 144,120,306 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,102,680 - 144,109,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,894,406 - 141,912,301 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,254,451 - 141,264,979 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17141,330,887 - 141,341,418 (-)NCBI
Celera7130,056,875 - 130,075,370 (-)NCBICelera
Cytogenetic Map7q36NCBI
Map3k12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458774,478 - 785,226 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955458774,478 - 793,654 (-)NCBIChiLan1.0ChiLan1.0
MAP3K12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11236,038,595 - 36,058,210 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,038,634 - 36,058,200 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01235,253,814 - 35,273,739 (+)NCBIMhudiblu_PPA_v0panPan3
MAP3K12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,721,484 - 1,736,204 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,726,310 - 1,734,955 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,514,739 - 44,529,820 (-)NCBI
ROS_Cfam_1.0271,724,391 - 1,739,470 (+)NCBI
UMICH_Zoey_3.1271,742,889 - 1,756,986 (+)NCBI
UNSW_CanFamBas_1.0271,725,190 - 1,740,273 (+)NCBI
UU_Cfam_GSD_1.02744,916,419 - 44,931,520 (-)NCBI
Map3k12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,391,586 - 62,409,177 (+)NCBI
SpeTri2.0NW_00493651210,755,653 - 10,773,321 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,699,383 - 18,717,199 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,699,123 - 18,717,209 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2519,134,847 - 19,152,725 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,581,601 - 49,600,359 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,582,291 - 49,600,335 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037196,453,652 - 196,473,011 (+)NCBIVero_WHO_p1.0
Map3k12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249041,579,792 - 1,598,595 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH127097  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815102,504,760 - 102,504,960UniSTSGRCm38
MGSCv3715102,335,191 - 102,335,391UniSTSGRCm37
Celera15104,662,737 - 104,662,937UniSTS
Cytogenetic Map15F3UniSTS
Whitehead/MRC_RH15920.52UniSTS
AW412548  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815102,498,513 - 102,498,604UniSTSGRCm38
MGSCv3715102,328,944 - 102,329,035UniSTSGRCm37
Celera15104,656,479 - 104,656,570UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map15F1UniSTS
cM Map1561.7UniSTS
Whitehead/MRC_RH15920.65UniSTS
Map3k12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F3UniSTS
cM Map15 UniSTS
AA924752  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815102,499,746 - 102,499,941UniSTSGRCm38
MGSCv3715102,330,177 - 102,330,372UniSTSGRCm37
Celera15104,657,721 - 104,657,916UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map15F1UniSTS
cM Map1561.7UniSTS
PMC87148P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815102,500,134 - 102,500,889UniSTSGRCm38
MGSCv3715102,330,565 - 102,331,320UniSTSGRCm37
Celera15104,658,109 - 104,658,865UniSTS
Cytogenetic Map15F3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402117102988123Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556323312103517472Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564434485103517472Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570461452104043685Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570465070104043685Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570465070104043685Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572498466104043685Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573545941104043685Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577629711104043685Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78716903102993272Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578716903102993272Mouse
14928306Manh79_mmandible shape 79 (mouse)1578949676104043685Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1579000000104043685Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579265530104043685Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined80011059104043685Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580415753104043685Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580987052104043685Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580987052104043685Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82717593104043685Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585988005104043685Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585988005104043685Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585988005104043685Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585993114104043685Mouse
1301764Chab4_mcholesterol absorption 4 (mouse)Not determined1586751919104043685Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92890759103517472Mouse
14700689Carg5_mCandida albicans resistance gene 5 (mouse)1597800000103100000Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597987052102988123Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2188
Count of miRNA genes:697
Interacting mature miRNAs:859
Transcripts:ENSMUST00000023812, ENSMUST00000164343, ENSMUST00000165174, ENSMUST00000167677, ENSMUST00000169162, ENSMUST00000169367, ENSMUST00000169377, ENSMUST00000171565
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001163643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001358844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC137156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY236915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ281471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U09541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U23789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000023812   ⟹   ENSMUSP00000023812
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,406,081 - 102,425,271 (-)Ensembl
GRCm38.p6 Ensembl15102,497,646 - 102,516,836 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164343
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,414,553 - 102,425,247 (-)Ensembl
GRCm38.p6 Ensembl15102,506,118 - 102,516,812 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165174   ⟹   ENSMUSP00000130786
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,413,867 - 102,425,410 (-)Ensembl
GRCm38.p6 Ensembl15102,505,432 - 102,516,975 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167677
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,417,547 - 102,419,227 (-)Ensembl
GRCm38.p6 Ensembl15102,509,112 - 102,510,792 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169162   ⟹   ENSMUSP00000129251
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,413,904 - 102,425,251 (-)Ensembl
GRCm38.p6 Ensembl15102,505,469 - 102,516,816 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169367   ⟹   ENSMUSP00000129472
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,413,805 - 102,425,439 (-)Ensembl
GRCm38.p6 Ensembl15102,505,370 - 102,517,004 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169377   ⟹   ENSMUSP00000133209
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,407,460 - 102,425,499 (-)Ensembl
GRCm38.p6 Ensembl15102,499,025 - 102,517,064 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171565   ⟹   ENSMUSP00000127629
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,407,211 - 102,419,135 (-)Ensembl
GRCm38.p6 Ensembl15102,498,776 - 102,510,700 (-)Ensembl
RefSeq Acc Id: NM_001163643   ⟹   NP_001157115
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,406,082 - 102,425,439 (-)NCBI
GRCm3815102,497,647 - 102,517,004 (-)NCBI
MGSCv3715102,328,078 - 102,347,435 (-)RGD
Celera15104,655,611 - 104,674,768 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001358844   ⟹   NP_001345773
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,406,082 - 102,419,135 (-)NCBI
GRCm3815102,497,647 - 102,510,700 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009582   ⟹   NP_033608
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,406,082 - 102,425,439 (-)NCBI
GRCm3815102,497,647 - 102,517,004 (-)NCBI
MGSCv3715102,328,078 - 102,347,435 (-)RGD
Celera15104,655,611 - 104,674,768 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521013   ⟹   XP_006521076
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,407,878 - 102,425,311 (-)NCBI
GRCm3815102,499,443 - 102,516,897 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017316624   ⟹   XP_017172113
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,407,809 - 102,418,341 (-)NCBI
GRCm3815102,499,438 - 102,509,886 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017316625   ⟹   XP_017172114
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,407,809 - 102,418,341 (-)NCBI
GRCm3815102,499,438 - 102,509,886 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030248589   ⟹   XP_030104449
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,407,878 - 102,425,379 (-)NCBI
GRCm3815102,499,443 - 102,516,944 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030248590   ⟹   XP_030104450
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,407,809 - 102,418,341 (-)NCBI
GRCm3815102,499,384 - 102,509,886 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030248591   ⟹   XP_030104451
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,407,809 - 102,418,341 (-)NCBI
GRCm3815102,499,384 - 102,509,886 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036159430   ⟹   XP_036015323
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,407,809 - 102,421,954 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_033608   ⟸   NM_009582
- UniProtKB: Q60700 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001157115   ⟸   NM_001163643
- UniProtKB: Q60700 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521076   ⟸   XM_006521013
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017172113   ⟸   XM_017316624
- Peptide Label: isoform X1
- UniProtKB: Q60700 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017172114   ⟸   XM_017316625
- Peptide Label: isoform X1
- UniProtKB: Q60700 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001345773   ⟸   NM_001358844
RefSeq Acc Id: XP_030104450   ⟸   XM_030248590
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030104451   ⟸   XM_030248591
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030104449   ⟸   XM_030248589
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000127629   ⟸   ENSMUST00000171565
RefSeq Acc Id: ENSMUSP00000130786   ⟸   ENSMUST00000165174
RefSeq Acc Id: ENSMUSP00000129472   ⟸   ENSMUST00000169367
RefSeq Acc Id: ENSMUSP00000133209   ⟸   ENSMUST00000169377
RefSeq Acc Id: ENSMUSP00000129251   ⟸   ENSMUST00000169162
RefSeq Acc Id: ENSMUSP00000023812   ⟸   ENSMUST00000023812
RefSeq Acc Id: XP_036015323   ⟸   XM_036159430
- Peptide Label: isoform X1
Protein Domains
Protein kinase

Promoters
RGD ID:6847215
Promoter ID:MM_ACW:19529
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   MEF_B4,   MEF_B6
Transcripts:MAP3K12.ESEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615102,330,306 - 102,331,992 (-)MPROMDB
RGD ID:6826174
Promoter ID:MM_KWN:19853
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:UC007XWC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615102,340,866 - 102,342,022 (-)MPROMDB
RGD ID:6826173
Promoter ID:MM_KWN:19854
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001163643,   NM_009582
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615102,346,976 - 102,348,382 (-)MPROMDB
RGD ID:8685214
Promoter ID:EPDNEW_M20638
Type:initiation region
Name:Map3k12_1
Description:Mus musculus mitogen-activated protein kinase kinase kinase 12, transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20639  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815102,510,792 - 102,510,852EPDNEW
RGD ID:8685216
Promoter ID:EPDNEW_M20639
Type:initiation region
Name:Map3k12_2
Description:Mus musculus mitogen-activated protein kinase kinase kinase 12, transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20638  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815102,516,819 - 102,516,879EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346881 AgrOrtholog
Ensembl Genes ENSMUSG00000023050 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000023812 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000127629 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000129251 UniProtKB/TrEMBL
  ENSMUSP00000129472 UniProtKB/TrEMBL
  ENSMUSP00000130786 UniProtKB/TrEMBL
  ENSMUSP00000133209 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023812 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000165174 UniProtKB/TrEMBL
  ENSMUST00000169162 UniProtKB/TrEMBL
  ENSMUST00000169367 UniProtKB/TrEMBL
  ENSMUST00000169377 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000171565 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP3K12_MAP3K13 UniProtKB/Swiss-Prot
  MAPKKK12 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report mmu:26404 UniProtKB/Swiss-Prot
MGD MGI:1346881 ENTREZGENE
NCBI Gene 26404 ENTREZGENE
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot
PhenoGen Map3k12 PhenoGen
PIRSF MAPKKK12 UniProtKB/Swiss-Prot
  MAPKKK12_MAPKKK13 UniProtKB/Swiss-Prot
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt E9PUZ1_MOUSE UniProtKB/TrEMBL
  E9PZU4_MOUSE UniProtKB/TrEMBL
  E9QA89_MOUSE UniProtKB/TrEMBL
  M3K12_MOUSE UniProtKB/Swiss-Prot
  Q60647_MOUSE UniProtKB/TrEMBL
  Q60700 ENTREZGENE
UniProt Secondary P70286 UniProtKB/Swiss-Prot
  Q3TLL7 UniProtKB/Swiss-Prot
  Q8C4N7 UniProtKB/Swiss-Prot
  Q8CBX3 UniProtKB/Swiss-Prot
  Q8CDL6 UniProtKB/Swiss-Prot