Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of STX8 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STX8 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of STX8 mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of STX8 mRNA | CTD | PMID:23019147 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STX8 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Stx8 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of STX8 mRNA | CTD | PMID:33387578 and PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of STX8 mRNA | CTD | PMID:21570461 | 2,4-dinitrotoluene | affects expression | ISO | Stx8 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of STX8 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | ISO | Stx8 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of STX8 mRNA | CTD | PMID:21346803 | 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one | increases expression | EXP | | 6480464 | Itraconazole results in increased expression of STX8 mRNA | CTD | PMID:31099283 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | STX8 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of STX8 mRNA | CTD | PMID:28628672 | 3H-1,2-dithiole-3-thione | decreases expression | ISO | Stx8 (Rattus norvegicus) | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of STX8 mRNA | CTD | PMID:19162173 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | STX8 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of STX8 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | increases expression | ISO | STX8 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of STX8 protein | CTD | PMID:34186270 | 6-propyl-2-thiouracil | decreases expression | ISO | Stx8 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of STX8 mRNA | CTD | PMID:24780913 | aflatoxin B1 | affects expression | ISO | STX8 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of STX8 protein | CTD | PMID:20106945 | aflatoxin B1 | increases methylation | ISO | STX8 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of STX8 intron | CTD | PMID:30157460 | aflatoxin B1 | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of STX8 mRNA | CTD | PMID:21641981 more ... | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of STX8 mRNA | CTD | PMID:19770486 | Aflatoxin B2 alpha | affects methylation | ISO | STX8 (Homo sapiens) | 6480464 | aflatoxin B2 affects the methylation of STX8 intron | CTD | PMID:30157460 | ammonium chloride | affects expression | ISO | Stx8 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of STX8 mRNA | CTD | PMID:16483693 | aristolochic acid A | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of STX8 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of STX8 mRNA | CTD | PMID:19770486 and PMID:21715664 | benzo[a]pyrene | affects methylation | ISO | STX8 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of STX8 intron | CTD | PMID:30157460 | benzo[a]pyrene | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of STX8 mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of STX8 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | bis(2-chloroethyl) sulfide | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | Mustard Gas results in decreased expression of STX8 mRNA | CTD | PMID:25102026 | bis(2-ethylhexyl) phthalate | decreases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in decreased expression of STX8 mRNA | CTD | PMID:28085963 | bisphenol A | affects expression | ISO | Stx8 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of STX8 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | STX8 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of STX8 protein | CTD | PMID:34186270 | bisphenol A | multiple interactions | ISO | STX8 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of STX8 gene | CTD | PMID:31601247 | bisphenol A | increases methylation | ISO | Stx8 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of STX8 gene | CTD | PMID:28505145 | bisphenol A | multiple interactions | ISO | Stx8 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Genistein] results in increased methylation of STX8 gene | CTD | PMID:28505145 | caffeine | decreases phosphorylation | ISO | STX8 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of STX8 protein | CTD | PMID:35688186 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of STX8 mRNA | CTD | PMID:21151649 | cisplatin | multiple interactions | ISO | STX8 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of STX8 mRNA | CTD | PMID:27392435 | cisplatin | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of STX8 mRNA | CTD | PMID:19561079 | clozapine | affects expression | ISO | Stx8 (Rattus norvegicus) | 6480464 | Clozapine affects the expression of STX8 mRNA | CTD | PMID:15860345 | cobalt dichloride | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of STX8 mRNA | CTD | PMID:19376846 | copper(II) sulfate | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of STX8 mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | STX8 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of STX8 mRNA | CTD | PMID:25562108 | D-mannitol | decreases expression | EXP | | 6480464 | Mannitol results in decreased expression of STX8 mRNA | CTD | PMID:25270620 | DDT | increases methylation | ISO | Stx8 (Rattus norvegicus) | 6480464 | DDT results in increased methylation of STX8 gene | CTD | PMID:30207508 | dexamethasone | multiple interactions | ISO | STX8 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of STX8 mRNA | CTD | PMID:28628672 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of STX8 mRNA | CTD | PMID:17361019 and PMID:21266533 | dicrotophos | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of STX8 mRNA | CTD | PMID:28302478 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of STX8 mRNA | CTD | PMID:25629700 | formaldehyde | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of STX8 mRNA | CTD | PMID:23649840 | FR900359 | decreases phosphorylation | ISO | STX8 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of STX8 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | STX8 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of STX8 gene | CTD | PMID:31601247 | genistein | multiple interactions | ISO | Stx8 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Genistein] results in increased methylation of STX8 gene | CTD | PMID:28505145 | haloperidol | affects expression | ISO | Stx8 (Rattus norvegicus) | 6480464 | Haloperidol affects the expression of STX8 mRNA | CTD | PMID:15860345 | indometacin | multiple interactions | ISO | STX8 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of STX8 mRNA | CTD | PMID:28628672 | isobutanol | multiple interactions | ISO | STX8 (Homo sapiens) | 6480464 | [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of STX8 mRNA | CTD | PMID:29432896 | itraconazole | increases expression | EXP | | 6480464 | Itraconazole results in increased expression of STX8 mRNA | CTD | PMID:31099283 | ivermectin | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of STX8 protein | CTD | PMID:32959892 | methidathion | decreases expression | EXP | | 6480464 | methidathion results in decreased expression of STX8 mRNA | CTD | PMID:34813904 | O-methyleugenol | decreases expression | ISO | STX8 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of STX8 mRNA | CTD | PMID:32234424 | oxaliplatin | multiple interactions | ISO | Stx8 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of STX8 mRNA | CTD | PMID:25729387 | sunitinib | increases expression | ISO | STX8 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of STX8 mRNA | CTD | PMID:31533062 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of STX8 mRNA | CTD | PMID:17555576 | thapsigargin | decreases expression | EXP | | 6480464 | Thapsigargin results in decreased expression of STX8 protein | CTD | PMID:24648495 | topotecan | multiple interactions | ISO | Stx8 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of STX8 mRNA | CTD | PMID:25729387 | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of STX8 mRNA | CTD | PMID:33045310 | valproic acid | decreases methylation | ISO | STX8 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of STX8 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | STX8 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of STX8 mRNA | CTD | PMID:25979313 | |