Atp1a3 (ATPase, Na+/K+ transporting, alpha 3 polypeptide) - Rat Genome Database

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Gene: Atp1a3 (ATPase, Na+/K+ transporting, alpha 3 polypeptide) Mus musculus
Analyze
Symbol: Atp1a3
Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide
RGD ID: 10207
MGI Page MGI
Description: Enables P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential and heparan sulfate proteoglycan binding activity. Involved in several processes, including intracellular sodium ion homeostasis; regulation of cardiac muscle cell membrane potential; and sodium ion export across plasma membrane. Acts upstream of or within several processes, including intracellular signaling cassette; learning or memory; and nervous system development. Located in several cellular components, including neuron to neuron synapse; photoreceptor inner segment; and sarcolemma. Part of sodium:potassium-exchanging ATPase complex. Is active in cell surface. Is expressed in several structures, including alimentary system; early conceptus; gonad; heart; and nervous system. Used to study alternating hemiplegia of childhood and bipolar disorder. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; bipolar disorder; developmental and epileptic encephalopathy 99; dystonia 12; and epilepsy. Orthologous to human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Atp; Atpa-2; MGC27631; MGC38713; MGC38914; MGC39036; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; sodium pump subunit alpha-3; sodium/potassium-transporting ATPase subunit alpha-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,677,592 - 24,705,338 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,677,592 - 24,705,383 (-)EnsemblGRCm39 Ensembl
GRCm38724,978,167 - 25,006,077 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,978,167 - 25,005,958 (-)EnsemblGRCm38mm10GRCm38
MGSCv37725,763,186 - 25,790,914 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,686,927 - 24,714,655 (-)NCBIMGSCv36mm8
Celera719,593,974 - 19,621,705 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
acetamide  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
ammonia  (EXP)
ammonium acetate  (ISO)
atrazine  (EXP,ISO)
Azoxymethane  (EXP)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brodifacoum  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcidiol  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
choline  (EXP)
cocaine  (ISO)
corticosterone  (ISO)
dextran sulfate  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
digoxin  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
ethanol  (EXP)
ethylparaben  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
haloperidol  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
Licochalcone B  (ISO)
losartan  (ISO)
lycopene  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
Mesaconitine  (ISO)
metformin  (ISO)
methoxychlor  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (EXP)
okadaic acid  (ISO)
ouabain  (ISO)
ozone  (EXP)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
potassium chloride  (ISO)
rotenone  (ISO)
S-nitrosoglutathione  (ISO)
sodium arsenite  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
triptonide  (EXP)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
XL147  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (IMP)
blood circulation  (IGI)
brain-derived neurotrophic factor receptor signaling pathway  (IMP)
calcium-mediated signaling  (IMP)
carboxylic acid transport  (IMP)
cardiac muscle contraction  (IDA)
cellular response to amyloid-beta  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to thyroid hormone stimulus  (ISO)
cerebral cortex development  (IMP,ISO)
circadian rhythm  (IGI)
cognition  (IMP)
determination of adult lifespan  (IMP)
ERK1 and ERK2 cascade  (IMP)
establishment or maintenance of transmembrane electrochemical gradient  (IEA)
fear response  (IDA,IMP)
gamma-aminobutyric acid signaling pathway  (IMP)
habituation  (IMP)
intracellular potassium ion homeostasis  (IBA,ISO)
intracellular sodium ion homeostasis  (IBA,IDA,ISO)
ionotropic glutamate receptor signaling pathway  (IMP)
L-ascorbic acid metabolic process  (IGI,IMP)
learning  (IMP)
locomotion  (IMP)
locomotory behavior  (IMP)
membrane depolarization  (IMP)
memory  (IMP)
motor behavior  (IMP)
multicellular organism growth  (IDA,IMP)
neurogenesis  (IDA,IMP)
neuromuscular process  (IMP)
neuromuscular process controlling balance  (IDA,IMP)
neuron projection maintenance  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
pore complex assembly  (IMP)
potassium ion import across plasma membrane  (IBA,ISO)
potassium ion transmembrane transport  (IEA)
potassium ion transport  (ISO)
proton transmembrane transport  (IBA)
regulation of cardiac muscle cell membrane potential  (IGI)
regulation of short-term neuronal synaptic plasticity  (IMP)
response to activity  (IMP)
response to electrical stimulus  (IMP)
response to environmental enrichment  (IMP)
response to hormone  (IMP)
response to immobilization stress  (IMP)
response to lithium ion  (IMP)
response to methamphetamine hydrochloride  (IMP)
response to monoamine  (IMP)
response to potassium ion  (IMP)
response to stress  (IMP)
response to temperature stimulus  (IMP)
response to xenobiotic stimulus  (IMP)
sleep  (IMP)
social behavior  (IMP)
sodium ion export across plasma membrane  (IBA,IDA,ISO)
sodium ion transport  (ISO)
thalamus development  (IMP)
transmission of nerve impulse  (IMP)
visual learning  (IDA,IMP)
walking behavior  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal behavior  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal gait  (IAGP)
abnormal habituation  (IAGP)
abnormal habituation to a new environment  (IAGP)
abnormal hippocampus granule cell morphology  (IAGP)
abnormal hippocampus pyramidal cell morphology  (IAGP)
abnormal locomotor behavior  (IEA)
abnormal long-term object recognition memory  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal non-rapid eye movement sleep pattern  (IAGP)
abnormal paradoxical sleep pattern  (IAGP)
abnormal respiratory function  (IAGP)
abnormal response to novel object  (IAGP)
abnormal seizure response to inducing agent  (IAGP)
abnormal sensitization to xenobiotic  (IAGP)
abnormal sensorimotor gating  (IAGP)
abnormal sleep pattern  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spike wave discharge  (IAGP)
abnormal startle reflex  (IAGP)
abnormal temporal lobe morphology  (IAGP)
abnormal xenobiotic pharmacokinetics  (IAGP)
astrocytosis  (IAGP)
ataxia  (IAGP)
convulsive seizures  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased exploration in new environment  (IAGP)
decreased frequency of paradoxical sleep  (IAGP)
decreased locomotor activity  (IAGP)
decreased prepulse inhibition  (IAGP)
dystonia  (IAGP)
enhanced behavioral response to addictive substance  (IAGP)
enhanced conditioned place preference behavior  (IAGP)
enhanced coordination  (IAGP)
environmentally induced seizures  (IAGP)
hemiparesis  (IAGP)
hemiplegia  (IAGP)
hyperactivity  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired coordination  (IAGP)
impaired passive avoidance behavior  (IAGP)
impaired spatial learning  (IAGP)
improved glucose tolerance  (IEA)
increased exploration in new environment  (IEA)
increased kindling response  (IAGP)
increased locomotor activity  (IAGP)
increased miniature inhibitory postsynaptic current frequency  (IAGP)
increased susceptibility to pharmacologically induced seizures  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased thermal nociceptive threshold  (IAGP)
increased thigmotaxis  (IAGP)
limb grasping  (IAGP)
microgliosis  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
prolonged circadian behavior period  (IAGP)
seizures  (IAGP)
short stride length  (IAGP)
tremors  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. A novel recurrent mutation in ATP1A3 causes CAPOS syndrome. Demos MK, etal., Orphanet J Rare Dis. 2014 Jan 28;9:15. doi: 10.1186/1750-1172-9-15.
2. Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications. Herrera VL, etal., J Cell Biol 1987 Oct;105(4):1855-65.
3. Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation. Kuninger D, etal., Genomics 2004 Nov;84(5):876-89.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3). Mynett-Johnson L, etal., Biol Psychiatry 1998 Jul 1;44(1):47-51.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Novel mutations in ATP1A3 associated with catastrophic early life epilepsy, episodic prolonged apnea, and postnatal microcephaly. Paciorkowski AR, etal., Epilepsia. 2015 Mar;56(3):422-30. doi: 10.1111/epi.12914. Epub 2015 Feb 5.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Genotype-phenotype correlations in alternating hemiplegia of childhood. Sasaki M, etal., Neurology. 2014 Feb 11;82(6):482-90. doi: 10.1212/WNL.0000000000000102. Epub 2014 Jan 15.
16. Genome sequencing identifies a novel mutation in ATP1A3 in a family with dystonia in females only. Wilcox R, etal., J Neurol. 2015 Jan;262(1):187-93. doi: 10.1007/s00415-014-7547-9. Epub 2014 Oct 31.
17. Chromosomal assignments of 17 structural genes and 11 related DNA fragments in rats (Rattus norvegicus) by Southern blot analysis of rat x mouse somatic cell hybrid clones. Yasue M, etal., Genomics 1992 Apr;12(4):659-64.
Additional References at PubMed
PMID:1638085   PMID:1970795   PMID:1981054   PMID:2307474   PMID:2842249   PMID:2885848   PMID:7904196   PMID:8203495   PMID:8288260   PMID:8812484   PMID:8889548   PMID:10349636  
PMID:10837135   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11591489   PMID:12458206   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15146195   PMID:15253893   PMID:15489334  
PMID:15648052   PMID:15837802   PMID:16141072   PMID:16141073   PMID:16630822   PMID:17234593   PMID:17234755   PMID:17634366   PMID:17804407   PMID:17947306   PMID:18044013   PMID:18448421  
PMID:19376779   PMID:19666602   PMID:20114047   PMID:20850480   PMID:20861386   PMID:21165980   PMID:21196491   PMID:21267068   PMID:21418141   PMID:21731499   PMID:21849490   PMID:21873635  
PMID:22025725   PMID:22520507   PMID:22797008   PMID:23527305   PMID:23652595   PMID:23761886   PMID:24194600   PMID:24342563   PMID:24983657   PMID:25190801   PMID:25523819   PMID:26463346  
PMID:26501181   PMID:26514267   PMID:26854353   PMID:26911348   PMID:26988030   PMID:27097562   PMID:27276195   PMID:27549929   PMID:27626380   PMID:27836549   PMID:28465228   PMID:28472154  
PMID:28634551   PMID:28689605   PMID:28983842   PMID:29382714   PMID:30071271   PMID:30457570   PMID:30562941   PMID:30819023   PMID:31534052   PMID:32325033   PMID:32440726   PMID:32537485  
PMID:33544780   PMID:33577387   PMID:34321999   PMID:34815492   PMID:36230906   PMID:36293380   PMID:36744866   PMID:36808153   PMID:37142655   PMID:37279265   PMID:38187761   PMID:38355793  
PMID:38804677   PMID:39111836  


Genomics

Comparative Map Data
Atp1a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,677,592 - 24,705,338 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,677,592 - 24,705,383 (-)EnsemblGRCm39 Ensembl
GRCm38724,978,167 - 25,006,077 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,978,167 - 25,005,958 (-)EnsemblGRCm38mm10GRCm38
MGSCv37725,763,186 - 25,790,914 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,686,927 - 24,714,655 (-)NCBIMGSCv36mm8
Celera719,593,974 - 19,621,705 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.73NCBI
ATP1A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,966,582 - 41,994,230 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,966,582 - 41,997,497 (-)EnsemblGRCh38hg38GRCh38
GRCh371942,470,734 - 42,498,382 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,162,574 - 47,190,222 (-)NCBINCBI36Build 36hg18NCBI36
Build 341947,162,575 - 47,190,222NCBI
Celera1939,270,362 - 39,298,001 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,902,456 - 38,930,242 (-)NCBIHuRef
CHM1_11942,472,364 - 42,500,045 (-)NCBICHM1_1
T2T-CHM13v2.01944,785,945 - 44,813,592 (-)NCBIT2T-CHM13v2.0
Atp1a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,700,645 - 89,729,782 (-)NCBIGRCr8
mRatBN7.2180,572,790 - 80,601,936 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,572,796 - 80,601,918 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,965,362 - 85,994,505 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,516,223 - 94,545,362 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,721,120 - 87,750,267 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,852,423 - 81,881,565 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,852,429 - 81,881,549 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,104,725 - 83,133,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,280,714 - 80,309,834 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,358,824 - 80,387,945 (-)NCBI
Celera175,018,852 - 75,047,865 (-)NCBICelera
RH 3.4 Map1842.5RGD
RH 2.0 Map1501.2RGD
Cytogenetic Map1q21NCBI
Atp1a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555869,325 - 893,542 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555869,508 - 892,510 (+)NCBIChiLan1.0ChiLan1.0
ATP1A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22048,071,671 - 48,099,363 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,940,042 - 49,967,977 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,854,243 - 38,882,034 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,357,926 - 47,383,736 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,358,281 - 47,384,716 (-)Ensemblpanpan1.1panPan2
ATP1A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,325,988 - 112,346,056 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,325,289 - 112,346,916 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,758,069 - 111,778,105 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,945,619 - 112,965,659 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,945,448 - 112,986,321 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,498,938 - 112,518,971 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,135,175 - 112,155,359 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,061,496 - 113,081,538 (+)NCBIUU_Cfam_GSD_1.0
Atp1a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,130,267 - 16,147,315 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706477,107 - 495,525 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936706476,473 - 494,659 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,905,847 - 49,927,633 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,905,851 - 49,927,437 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,929,174 - 45,946,082 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP1A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,166,586 - 36,195,343 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,166,262 - 36,195,363 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607314,408,818 - 14,437,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp1a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907715,094 - 736,432 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624907715,109 - 736,040 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp1a3
1710 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1014
Count of miRNA genes:407
Interacting mature miRNAs:439
Transcripts:ENSMUST00000080882, ENSMUST00000102858, ENSMUST00000125444, ENSMUST00000146595, ENSMUST00000154077
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse

Markers in Region
Atp1a3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37725,763,996 - 25,765,643UniSTSGRCm37
Celera719,594,784 - 19,596,431UniSTS
Cytogenetic Map7A3UniSTS
cM Map75.5UniSTS
cM Map75.5UniSTS
D1Bda7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38724,978,208 - 24,978,551UniSTSGRCm38
MGSCv37725,763,227 - 25,763,570UniSTSGRCm37
Celera719,594,015 - 19,594,358UniSTS
Cytogenetic Map7A3UniSTS
cM Map75.5UniSTS
Atp1a3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38724,978,977 - 24,980,624UniSTSGRCm38
MGSCv37725,763,996 - 25,765,643UniSTSGRCm37
Celera719,594,784 - 19,596,431UniSTS
Cytogenetic Map7A3UniSTS
cM Map75.5UniSTS
Atp1a3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001290469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001374627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000080882   ⟹   ENSMUSP00000079691
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,677,592 - 24,705,383 (-)Ensembl
GRCm38.p6 Ensembl724,978,167 - 25,005,958 (-)Ensembl
Ensembl Acc Id: ENSMUST00000102858   ⟹   ENSMUSP00000099922
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,677,592 - 24,705,320 (-)Ensembl
GRCm38.p6 Ensembl724,978,167 - 25,005,895 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125444
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,699,996 - 24,705,382 (-)Ensembl
GRCm38.p6 Ensembl725,000,571 - 25,005,957 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146595
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,691,602 - 24,705,332 (-)Ensembl
GRCm38.p6 Ensembl724,992,177 - 25,005,907 (-)Ensembl
Ensembl Acc Id: ENSMUST00000196684   ⟹   ENSMUSP00000143735
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,677,595 - 24,705,368 (-)Ensembl
GRCm38.p6 Ensembl724,978,170 - 25,005,943 (-)Ensembl
RefSeq Acc Id: NM_001290469   ⟹   NP_001277398
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,677,592 - 24,705,338 (-)NCBI
GRCm38724,978,167 - 25,005,937 (-)NCBI
Celera719,593,974 - 19,621,747 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001374627   ⟹   NP_001361556
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,677,592 - 24,705,338 (-)NCBI
GRCm38724,978,167 - 25,005,913 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001420792   ⟹   NP_001407721
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,677,592 - 24,705,338 (-)NCBI
RefSeq Acc Id: NM_001420793   ⟹   NP_001407722
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,677,592 - 24,705,338 (-)NCBI
RefSeq Acc Id: NM_001420794   ⟹   NP_001407723
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,677,592 - 24,705,338 (-)NCBI
RefSeq Acc Id: NM_001420795   ⟹   NP_001407724
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,677,592 - 24,705,338 (-)NCBI
RefSeq Acc Id: NR_185195
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,677,592 - 24,705,338 (-)NCBI
RefSeq Acc Id: NP_001277398   ⟸   NM_001290469
- Peptide Label: isoform 2
- UniProtKB: Q6PIC6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001361556   ⟸   NM_001374627
- Peptide Label: isoform 1
- UniProtKB: A0A0G2JGX4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000079691   ⟸   ENSMUST00000080882
Ensembl Acc Id: ENSMUSP00000143735   ⟸   ENSMUST00000196684
Ensembl Acc Id: ENSMUSP00000099922   ⟸   ENSMUST00000102858
RefSeq Acc Id: NP_001407724   ⟸   NM_001420795
- Peptide Label: isoform 7
RefSeq Acc Id: NP_001407723   ⟸   NM_001420794
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001407722   ⟸   NM_001420793
- Peptide Label: isoform 4
- UniProtKB: Q8VCE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001407721   ⟸   NM_001420792
- Peptide Label: isoform 3
Protein Domains
Cation-transporting P-type ATPase C-terminal   Cation-transporting P-type ATPase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PIC6-F1-model_v2 AlphaFold Q6PIC6 1-1013 view protein structure

Promoters
RGD ID:6892232
Promoter ID:EPDNEW_M9567
Type:initiation region
Name:Atp1a3_1
Description:Mus musculus ATPase, Na+/K+ transporting, alpha 3 polypeptide, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38725,005,913 - 25,005,973EPDNEW
RGD ID:6848084
Promoter ID:MM_ACW:43866
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell
Transcripts:ATP1A3.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36725,779,354 - 25,779,854 (-)MPROMDB
RGD ID:6848849
Promoter ID:MM_TRO:8739
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:MTR015121.7.789.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36725,782,136 - 25,782,636 (-)MPROMDB
RGD ID:6848083
Promoter ID:MM_ACW:43867
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ATP1A3.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36725,783,636 - 25,784,136 (-)MPROMDB
RGD ID:6840667
Promoter ID:MM_KWN:49413
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000039802
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36725,785,736 - 25,787,087 (-)MPROMDB
RGD ID:6840666
Promoter ID:MM_KWN:49414
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell
Transcripts:OTTMUST00000039799,   OTTMUST00000039800,   OTTMUST00000039801,   OTTMUST00000080748
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36725,790,751 - 25,791,777 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88107 AgrOrtholog
Ensembl Genes ENSMUSG00000040907 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000080882 ENTREZGENE
  ENSMUST00000080882.11 UniProtKB/Swiss-Prot
  ENSMUST00000102858 ENTREZGENE
  ENSMUST00000196684 ENTREZGENE
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot
  3.40.50.1000 UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, transmembrane domain UniProtKB/Swiss-Prot
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot
  Cation_transp_ATPase_P-type UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  P-type_ATPase_IIC UniProtKB/Swiss-Prot
  P_typ_ATPase UniProtKB/Swiss-Prot
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot
KEGG Report mmu:232975 UniProtKB/Swiss-Prot
MGD MGI:88107 ENTREZGENE
NCBI Gene Atp1a3 ENTREZGENE
PANTHER SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA UniProtKB/Swiss-Prot
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-3 UniProtKB/Swiss-Prot
Pfam Cation_ATPase UniProtKB/Swiss-Prot
  Cation_ATPase_C UniProtKB/Swiss-Prot
  Cation_ATPase_N UniProtKB/Swiss-Prot
  E1-E2_ATPase UniProtKB/Swiss-Prot
PhenoGen Atp1a3 PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot
  NAKATPASE UniProtKB/Swiss-Prot
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot
SMART Cation_ATPase_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot
  SSF81653 UniProtKB/Swiss-Prot
  SSF81660 UniProtKB/Swiss-Prot
  SSF81665 UniProtKB/Swiss-Prot
UniProt A0A0G2JGX4 ENTREZGENE, UniProtKB/TrEMBL
  AT1A3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CGD9_MOUSE UniProtKB/TrEMBL
  Q8R0B0_MOUSE UniProtKB/TrEMBL
  Q8R0E8_MOUSE UniProtKB/TrEMBL
  Q8VCE0 ENTREZGENE, UniProtKB/TrEMBL