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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10731
Species: Mus musculus
RGD Object: Gene
Symbol: Hrh1
Name: histamine receptor H1
Acc ID: CHEBI:4636
Term: diphenhydramine
Definition: An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
Chemical ID: MESH:D004155
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hrh1multiple interactionsISOHrh1 (Rattus norvegicus)6480464CTD[Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to ErythromycinPMID:12856827
Hrh1multiple interactionsISOHRH1 (Homo sapiens)6480464CTDDiphenhydramine binds to and results in decreased activity of HRH1 protein; Diphenhydramine binds to and results in increased activity of HRH1 protein; Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein]PMID:1912125 PMID:2419744 PMID:2461127 PMID:7522859 PMID:9609743
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