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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732175
Species: Mus musculus
RGD Object: Gene
Symbol: Bche
Name: butyrylcholinesterase
Acc ID: CHEBI:313639
Term: profenamine
Definition: A member of the class of phenothiazines that is phenothiazine in which the hydrogen attached to the nitrogen is substituted by a 2-(diethylamino)propyl group. An antimuscarinic, it is used as the hydrochloride for the symptomatic treatment of Parkinson's disease.
Chemical ID: MESH:C084820
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bchedecreases activityEXP 6480464CTDprofenamine results in decreased activity of BCHE proteinPMID:18656440
Bchedecreases activityISOBCHE (Homo sapiens)6480464CTDprofenamine results in decreased activity of BCHE proteinPMID:18656440 PMID:22407886 PMID:28299395 PMID:32795450
Bchemultiple interactionsISOBCHE (Homo sapiens)6480464CTDprofenamine inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]PMID:28299395 PMID:32278739
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