Bcl6 (B cell leukemia/lymphoma 6) - Rat Genome Database

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Gene: Bcl6 (B cell leukemia/lymphoma 6) Mus musculus
Analyze
Symbol: Bcl6
Name: B cell leukemia/lymphoma 6
RGD ID: 1319643
MGI Page MGI
Description: Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of lymphocyte activation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B-cell leukemia/lymphoma 5; B-cell leukemia/lymphoma 6; B-cell lymphoma 6 protein homolog; Bcl; Bcl5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391623,780,058 - 23,807,602 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1623,783,802 - 23,807,602 (-)EnsemblGRCm39 Ensembl
GRCm381623,965,050 - 23,988,866 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1623,965,052 - 23,988,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371623,965,138 - 23,988,698 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361623,880,401 - 23,903,961 (-)NCBIMGSCv36mm8
Celera1624,514,447 - 24,538,188 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1615.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(E)-thiamethoxam  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
boron nitride  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium acetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (EXP,ISO)
diclofenac  (EXP)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethylbenzene  (ISO)
fluoranthene  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
GW 501516  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
indole-3-methanol  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
menadione  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
niclosamide  (EXP,ISO)
nitrofen  (ISO)
o-xylene  (ISO)
ochratoxin A  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
PF-3758309  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
Pyridostigmine bromide  (ISO)
pyrimethamine  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium stibogluconate  (ISO)
styrene  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tetrachloromethane  (EXP)
thiamethoxam  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
TMC-120A  (EXP)
toluene  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (EXP)
urethane  (ISO)
valproic acid  (EXP)
vanadyl sulfate  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IMP)
B cell differentiation  (IGI)
B cell proliferation  (IMP)
cell morphogenesis  (IGI,IMP)
cell motility  (IMP)
cell population proliferation  (IMP)
cell-matrix adhesion  (IMP)
DNA damage response  (IEA,ISO)
erythrocyte development  (IMP)
germinal center formation  (IMP)
heterochromatin formation  (IGI)
inflammatory response  (IEA)
isotype switching to IgE isotypes  (IGI,IMP)
mononuclear cell proliferation  (IMP)
negative regulation of apoptotic process  (IDA,IMP)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell-matrix adhesion  (IMP)
negative regulation of cellular senescence  (IMP)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of isotype switching to IgE isotypes  (IGI,IMP)
negative regulation of mast cell cytokine production  (IMP)
negative regulation of mononuclear cell proliferation  (IMP)
negative regulation of Notch signaling pathway  (IGI)
negative regulation of plasma cell differentiation  (IMP)
negative regulation of Rho protein signal transduction  (IMP)
negative regulation of T-helper 2 cell differentiation  (IGI)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IGI,IMP,ISO)
negative regulation of type 2 immune response  (IGI)
plasma cell differentiation  (IMP)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of B cell proliferation  (IMP)
positive regulation of cell motility  (IMP)
positive regulation of neuron differentiation  (IDA)
positive regulation of regulatory T cell differentiation  (IEA,ISO)
protein localization  (IMP)
pyramidal neuron differentiation  (IDA)
regulation of cell differentiation  (IBA)
regulation of cell population proliferation  (IBA)
regulation of cytokine production  (IBA)
regulation of immune system process  (IBA)
regulation of inflammatory response  (IBA,IMP)
regulation of memory T cell differentiation  (IMP)
regulation of T cell proliferation  (IMP)
regulation of transcription by RNA polymerase II  (IGI)
Rho protein signal transduction  (IGI,IMP)
spermatogenesis  (IMP)
T-helper 2 cell differentiation  (IGI)
transcription by RNA polymerase II  (IDA)
type 2 immune response  (IBA,IMP)

Cellular Component
Golgi apparatus  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IBA,ISO)
nucleus  (IDA,ISO)
paraspeckles  (IEA,ISO)
replication fork  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adaptive immunity  (IAGP)
abnormal apoptosis  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal chemokine level  (IAGP)
abnormal germinal center B cell physiology  (IAGP)
abnormal gonadal fat pad morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal lipid level  (IAGP)
abnormal memory B cell morphology  (IAGP)
abnormal memory B cell physiology  (IAGP)
abnormal Peyer's patch germinal center morphology  (IAGP)
abnormal Peyer's patch morphology  (IAGP)
abnormal professional antigen presenting cell physiology  (IAGP)
abnormal somatic hypermutation frequency  (IAGP)
abnormal spleen germinal center morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal T follicular helper cell differentiation  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
absent germinal center B cells  (IAGP)
absent lymph node germinal center  (IAGP)
absent spleen germinal center  (IAGP)
cardiac interstitial fibrosis  (IAGP)
decreased adipocyte glucose uptake  (IAGP)
decreased B cell proliferation  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased ceramide level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased fasting circulating glucose level  (IAGP)
decreased fertilization frequency  (IAGP)
decreased germinal center B cell number  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgM level  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased liver weight  (IAGP)
decreased respiratory quotient  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased T cell proliferation  (IAGP)
decreased T follicular helper cell number  (IAGP)
dilated heart ventricle  (IAGP)
heart inflammation  (IAGP)
impaired gluconeogenesis  (IAGP)
increased activation-induced B cell apoptosis  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased body fat mass  (IAGP)
increased circulating adiponectin level  (IAGP)
increased circulating leptin level  (IAGP)
increased eosinophil cell number  (IAGP)
increased inflammatory response  (IAGP)
increased insulin sensitivity  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased lipogenesis  (IAGP)
increased male germ cell apoptosis  (IAGP)
increased skeletal muscle cell glucose uptake  (IAGP)
increased subcutaneous adipose tissue amount  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased white adipose tissue amount  (IAGP)
increased white fat cell size  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
myocardial fiber degeneration  (IAGP)
myocarditis  (IAGP)
no abnormal phenotype detected  (IAGP)
oligozoospermia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
reduced male fertility  (IAGP)
small thymus  (IAGP)
spleen hyperplasia  (IAGP)
spleen hypoplasia  (IAGP)
thin ventricular wall  (IAGP)
white adipose tissue inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Expression of the bcl-6 and MUM1/IRF4 proteins correlate with overall and disease-specific survival in patients with primary cutaneous large B-cell lymphoma: a tissue microarray study. Sundram U, etal., J Cutan Pathol. 2005 Mar;32(3):227-34.
8. The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. Ueda C, etal., Oncogene. 2002 Jan 17;21(3):368-76.
Additional References at PubMed
PMID:7478591   PMID:8652841   PMID:8678989   PMID:8912662   PMID:9047392   PMID:9110977   PMID:9171827   PMID:9236196   PMID:9632807   PMID:9642131   PMID:9811885   PMID:9927193  
PMID:9927203   PMID:10047542   PMID:10349636   PMID:10438949   PMID:10490661   PMID:10533607   PMID:10626250   PMID:10973278   PMID:11042159   PMID:11076861   PMID:11092811   PMID:11217851  
PMID:11777915   PMID:11914273   PMID:11929873   PMID:12021781   PMID:12097386   PMID:12191569   PMID:12354385   PMID:12407182   PMID:12469325   PMID:12477932   PMID:12594267   PMID:12659862  
PMID:12817026   PMID:12970571   PMID:14647274   PMID:14681479   PMID:14737119   PMID:15142957   PMID:15240675   PMID:15240705   PMID:15489334   PMID:15507530   PMID:15567177   PMID:15611242  
PMID:15618518   PMID:15659391   PMID:15661395   PMID:15694375   PMID:15860730   PMID:15894265   PMID:15950739   PMID:16055217   PMID:16141072   PMID:16141073   PMID:16331266   PMID:16602821  
PMID:16702165   PMID:17120193   PMID:17125145   PMID:17307796   PMID:17468402   PMID:17478416   PMID:17526724   PMID:17532053   PMID:17950876   PMID:18055048   PMID:18267078   PMID:18287559  
PMID:18675787   PMID:18684923   PMID:18799693   PMID:19406940   PMID:19564417   PMID:19608860   PMID:19628815   PMID:19631565   PMID:19797315   PMID:19797429   PMID:19929250   PMID:20059953  
PMID:20142429   PMID:20151461   PMID:20156484   PMID:20211142   PMID:20212093   PMID:20368579   PMID:20505144   PMID:20519643   PMID:20615956   PMID:20880987   PMID:21106671   PMID:21131418  
PMID:21131593   PMID:21267068   PMID:21270405   PMID:21518797   PMID:21636294   PMID:21636296   PMID:21677750   PMID:21708925   PMID:21785430   PMID:21804014   PMID:21856866   PMID:21862448  
PMID:21873635   PMID:21911423   PMID:22018468   PMID:22113614   PMID:22120117   PMID:22124122   PMID:22158971   PMID:22204827   PMID:22327073   PMID:22334647   PMID:22370719   PMID:22406270  
PMID:22406686   PMID:22422878   PMID:22464170   PMID:22465074   PMID:22696295   PMID:22962683   PMID:22987803   PMID:23027924   PMID:23041630   PMID:23053511   PMID:23160044   PMID:23166356  
PMID:23209284   PMID:23341629   PMID:23382195   PMID:23416424   PMID:23431145   PMID:23455674   PMID:23487426   PMID:23499493   PMID:23589612   PMID:23818645   PMID:23852341   PMID:23980208  
PMID:24003036   PMID:24269670   PMID:24277074   PMID:24292363   PMID:24361642   PMID:24463518   PMID:24487434   PMID:24489092   PMID:24550509   PMID:24591370   PMID:24863065   PMID:24879792  
PMID:24887457   PMID:24892698   PMID:24952961   PMID:24979752   PMID:25017466   PMID:25071203   PMID:25088465   PMID:25176650   PMID:25194422   PMID:25262912   PMID:25288399   PMID:25331958  
PMID:25436971   PMID:25484301   PMID:25490446   PMID:25597995   PMID:25681338   PMID:25729925   PMID:25759025   PMID:25810298   PMID:25918344   PMID:25957170   PMID:25979336   PMID:26179907  
PMID:26188063   PMID:26214740   PMID:26214741   PMID:26257170   PMID:26320660   PMID:26410627   PMID:26426795   PMID:26460037   PMID:26471094   PMID:26631626   PMID:26646149   PMID:26714588  
PMID:26728228   PMID:26728651   PMID:26750312   PMID:26876184   PMID:26887860   PMID:26957522   PMID:27022143   PMID:27069113   PMID:27133822   PMID:27135603   PMID:27158841   PMID:27213691  
PMID:27251748   PMID:27487330   PMID:27505670   PMID:27539853   PMID:27560392   PMID:27566831   PMID:27731422   PMID:27739478   PMID:27798619   PMID:27806296   PMID:28002730   PMID:28096407  
PMID:28303891   PMID:28334989   PMID:28440396   PMID:28468971   PMID:28498098   PMID:28533444   PMID:28550121   PMID:28586108   PMID:28604718   PMID:28698369   PMID:28811467   PMID:28827447  
PMID:28848064   PMID:28875978   PMID:28888925   PMID:28892065   PMID:28892471   PMID:28978474   PMID:29042531   PMID:29054998   PMID:29133396   PMID:29378778   PMID:29408281   PMID:29434588  
PMID:29545616   PMID:29662170   PMID:29696026   PMID:29968852   PMID:30013146   PMID:30031228   PMID:30082494   PMID:30140283   PMID:30241692   PMID:30409904   PMID:30418981   PMID:30566857  
PMID:30567732   PMID:30575739   PMID:30718289   PMID:30833348   PMID:30898767   PMID:30983568   PMID:31000603   PMID:31053612   PMID:31087643   PMID:31127030   PMID:31138703   PMID:31175159  
PMID:31204070   PMID:31225793   PMID:31276232   PMID:31278058   PMID:31342012   PMID:31353074   PMID:31371561   PMID:31375635   PMID:31395741   PMID:31422869   PMID:31539517   PMID:31552021  
PMID:31563850   PMID:31722202   PMID:31732165   PMID:31937773   PMID:31954378   PMID:31980486   PMID:32023467   PMID:32130409   PMID:32139607   PMID:32179158   PMID:32210715   PMID:32255767  
PMID:32269096   PMID:32399548   PMID:32477338   PMID:32546802   PMID:32572238   PMID:32634740   PMID:32680956   PMID:32698010   PMID:32711255   PMID:32719520   PMID:32820125   PMID:32845913  
PMID:32889526   PMID:32907850   PMID:33027650   PMID:33147467   PMID:33153107   PMID:33232656   PMID:33326020   PMID:33462137   PMID:33502806   PMID:33568199   PMID:33760820   PMID:33771858  
PMID:33879579   PMID:34031614   PMID:34077723   PMID:34117110   PMID:34135058   PMID:34168370   PMID:34215813   PMID:34321999   PMID:34351428   PMID:34464595   PMID:34479995   PMID:34521812  
PMID:34558634   PMID:34625792   PMID:34644536   PMID:34665220   PMID:34792530   PMID:34852236   PMID:34861182   PMID:34983288   PMID:35112355   PMID:35145086   PMID:35301301   PMID:35436984  
PMID:35484551   PMID:35637103   PMID:35651611   PMID:35766181   PMID:35767958   PMID:35794484   PMID:35857633   PMID:35948398   PMID:36005560   PMID:36591222   PMID:36651876   PMID:36779803  
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PMID:38289985   PMID:38335269   PMID:38337096   PMID:38363680   PMID:38363829   PMID:38416647   PMID:38419581   PMID:38427718   PMID:38452514   PMID:38481058   PMID:38688934   PMID:38723638  
PMID:38761804   PMID:38898157   PMID:39319261   PMID:39723889  


Genomics

Comparative Map Data
Bcl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391623,780,058 - 23,807,602 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1623,783,802 - 23,807,602 (-)EnsemblGRCm39 Ensembl
GRCm381623,965,050 - 23,988,866 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1623,965,052 - 23,988,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371623,965,138 - 23,988,698 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361623,880,401 - 23,903,961 (-)NCBIMGSCv36mm8
Celera1624,514,447 - 24,538,188 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1615.26NCBI
BCL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383187,721,377 - 187,745,468 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3187,721,377 - 187,745,725 (-)EnsemblGRCh38hg38GRCh38
GRCh373187,439,165 - 187,463,256 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363188,921,859 - 188,946,169 (-)NCBINCBI36Build 36hg18NCBI36
Build 343188,921,866 - 188,936,950NCBI
Celera3185,870,167 - 185,894,514 (-)NCBICelera
Cytogenetic Map3q27.3NCBI
HuRef3184,843,368 - 184,867,718 (-)NCBIHuRef
CHM1_13187,402,407 - 187,426,738 (-)NCBICHM1_1
T2T-CHM13v2.03190,538,887 - 190,562,977 (-)NCBIT2T-CHM13v2.0
Bcl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,358,753 - 90,382,049 (+)NCBIGRCr8
mRatBN7.21176,854,090 - 76,877,389 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,854,090 - 76,877,389 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,634,592 - 85,657,897 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,269,810 - 78,293,116 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,348,906 - 77,372,205 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01180,255,790 - 80,279,075 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1180,255,790 - 80,279,075 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01180,454,014 - 80,477,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,006,123 - 79,030,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11179,063,711 - 79,088,148 (+)NCBI
Celera1175,736,211 - 75,759,558 (+)NCBICelera
Cytogenetic Map11q23NCBI
Bcl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542019,998,742 - 20,022,259 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542019,998,960 - 20,021,200 (+)NCBIChiLan1.0ChiLan1.0
BCL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22185,592,401 - 185,616,789 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13185,596,633 - 185,622,262 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03184,748,135 - 184,772,375 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13193,308,296 - 193,332,452 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3193,308,296 - 193,332,124 (-)Ensemblpanpan1.1panPan2
BCL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13420,112,302 - 20,135,705 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3420,113,322 - 20,124,704 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3424,206,192 - 24,217,557 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03420,032,420 - 20,123,667 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3420,007,243 - 20,047,268 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13420,061,949 - 20,073,314 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03420,055,728 - 20,067,098 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03420,295,606 - 20,306,970 (-)NCBIUU_Cfam_GSD_1.0
Bcl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602116,280,077 - 116,303,180 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365782,371,945 - 2,395,071 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365782,371,976 - 2,395,034 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13125,377,250 - 125,393,330 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113125,377,247 - 125,401,328 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213134,660,904 - 134,685,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11581,997,659 - 82,022,059 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1581,998,545 - 82,009,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604155,495,443 - 55,520,875 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473069,154,080 - 69,167,689 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473069,145,035 - 69,167,583 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcl6
1099 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:600
Count of miRNA genes:391
Interacting mature miRNAs:490
Transcripts:ENSMUST00000023151, ENSMUST00000135352
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
11565820Vasr1_mvariability in acoustic startle response 1 (mouse)161969865726368664Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
U41465  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381623,965,983 - 23,966,070UniSTSGRCm38
MGSCv371623,966,069 - 23,966,156UniSTSGRCm37
Celera1624,515,378 - 24,515,465UniSTS
Cytogenetic Map16B1UniSTS
cM Map1613.9UniSTS
Whitehead_YAC16 UniSTS
Bcl6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381623,966,116 - 23,966,252UniSTSGRCm38
MGSCv371623,966,202 - 23,966,338UniSTSGRCm37
Celera1624,515,511 - 24,515,647UniSTS
Cytogenetic Map16B1UniSTS
cM Map1613.9UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000023151   ⟹   ENSMUSP00000023151
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1623,783,802 - 23,807,602 (-)Ensembl
GRCm38.p6 Ensembl1623,965,052 - 23,988,852 (-)Ensembl
Ensembl Acc Id: ENSMUST00000135352
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1623,786,444 - 23,791,130 (-)Ensembl
GRCm38.p6 Ensembl1623,967,694 - 23,972,380 (-)Ensembl
RefSeq Acc Id: NM_001348026   ⟹   NP_001334955
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391623,783,802 - 23,799,976 (-)NCBI
GRCm381623,965,050 - 23,981,283 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001416608   ⟹   NP_001403537
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391623,783,802 - 23,807,602 (-)NCBI
RefSeq Acc Id: NM_001416610   ⟹   NP_001403539
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391623,780,058 - 23,807,383 (-)NCBI
RefSeq Acc Id: NM_009744   ⟹   NP_033874
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391623,783,802 - 23,807,383 (-)NCBI
GRCm381623,965,050 - 23,988,852 (-)NCBI
MGSCv371623,965,138 - 23,988,698 (-)RGD
Celera1624,514,447 - 24,538,188 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033874   ⟸   NM_009744
- Peptide Label: isoform 1
- UniProtKB: Q61065 (UniProtKB/Swiss-Prot),   P41183 (UniProtKB/Swiss-Prot),   Q544F9 (UniProtKB/TrEMBL),   Q8CB25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001334955   ⟸   NM_001348026
- Peptide Label: isoform 1
- UniProtKB: Q61065 (UniProtKB/Swiss-Prot),   P41183 (UniProtKB/Swiss-Prot),   Q544F9 (UniProtKB/TrEMBL),   Q8CB25 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000023151   ⟸   ENSMUST00000023151
RefSeq Acc Id: NP_001403539   ⟸   NM_001416610
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001403537   ⟸   NM_001416608
- Peptide Label: isoform 1
- UniProtKB: P41183 (UniProtKB/Swiss-Prot),   Q61065 (UniProtKB/Swiss-Prot),   Q8CB25 (UniProtKB/TrEMBL),   Q544F9 (UniProtKB/TrEMBL)
Protein Domains
BTB   C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41183-F1-model_v2 AlphaFold P41183 1-707 view protein structure

Promoters
RGD ID:6826850
Promoter ID:MM_KWN:20601
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver
Transcripts:OTTMUST00000067153
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361623,972,196 - 23,973,112 (-)MPROMDB
RGD ID:6847298
Promoter ID:MM_ACW:20175
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:BCL6.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361623,980,889 - 23,981,389 (-)MPROMDB
RGD ID:8685860
Promoter ID:EPDNEW_M20961
Type:single initiation site
Name:Bcl6_2
Description:Mus musculus B cell leukemia/lymphoma 6 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20962  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381623,988,234 - 23,988,294EPDNEW
RGD ID:6826848
Promoter ID:MM_KWN:20603
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000067152
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361623,988,466 - 23,989,927 (-)MPROMDB
RGD ID:8685862
Promoter ID:EPDNEW_M20962
Type:initiation region
Name:Bcl6_1
Description:Mus musculus B cell leukemia/lymphoma 6 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20961  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381623,988,633 - 23,988,693EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107187 AgrOrtholog
Ensembl Genes ENSMUSG00000022508 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023151 ENTREZGENE
  ENSMUST00000023151.6 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report mmu:12053 UniProtKB/Swiss-Prot
MGD MGI:107187 ENTREZGENE
NCBI Gene 12053 ENTREZGENE
PANTHER B-CELL CLL_LYMPHOMA 6 (ZINC FINGER PROTEIN 51)-RELATED UniProtKB/Swiss-Prot
  ZINC FINGER PROTEIN UniProtKB/Swiss-Prot
Pfam BTB UniProtKB/Swiss-Prot
  zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Bcl6 PhenoGen
PROSITE BTB UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART BTB UniProtKB/Swiss-Prot
  ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  SSF57667 UniProtKB/Swiss-Prot
UniProt BCL6_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q544F9 ENTREZGENE, UniProtKB/TrEMBL
  Q61065 ENTREZGENE
  Q8CB25 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q61065 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Bcl6  B cell leukemia/lymphoma 6  Bcl6  B-cell leukemia/lymphoma 6  Symbol and/or name change 5135510 APPROVED