RGD Reference Report - Expression of the bcl-6 and MUM1/IRF4 proteins correlate with overall and disease-specific survival in patients with primary cutaneous large B-cell lymphoma: a tissue microarray study.

Advanced Search (OLGA)

General

Expression of the bcl-6 and MUM1/IRF4 proteins correlate with overall and disease-specific survival in patients with primary cutaneous large B-cell lymphoma: a tissue microarray study.
Authors:	Sundram, U Kim, Y Mraz-Gernhard, S Hoppe, R Natkunam, Y Kohler, S
Citation:	Sundram U, etal., J Cutan Pathol. 2005 Mar;32(3):227-34.
RGD ID:	11530023
Pubmed:	PMID:15701085 (View Abstract at PubMed)
DOI:	DOI:10.1111/j.0303-6987.2005.00298.x (Journal Full-text)
BACKGROUND: Systemic B-cell lymphomas have been studied using microarrays, which has led to a better understanding of their molecular characteristics. Initial microarray studies of these lymphomas have implicated several genes as important predictors of outcome. In this study, we used a tissue microarray (TMA) to characterize primary cutaneous large B-cell lymphomas (PCLBCL). METHODS: We studied 14 patients for whom clinical follow up was available, including four patients whose lesions were limited to the leg on presentation. Immunohistochemical staining with CD20, CD44, CD21, CD5, CD10, bcl-2, bcl-6, Ki67, p53, and multiple myeloma 1 (MUM1) was examined. RESULTS: Our results identify two subgroups of lymphomas. The first group showed staining with bcl-6 and had an overall survival of 176 months (p = 0.003). The majority of this group was negative for MUM1. The second group lacked staining with bcl-6 and had an overall survival of 26 months, with a majority of these cases staining with MUM1. Three of four patients with PCLBCL of the leg showed no staining with bcl-6. CONCLUSIONS: Our study demonstrates the utility of TMAs in the analysis of PCLBCL and that expression of bcl-6 and MUM1 correlates with survival.

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
BCL6	Human	diffuse large B-cell lymphoma	disease_progression	IEP			RGD
Bcl6	Rat	diffuse large B-cell lymphoma	disease_progression	ISO	BCL6 (Homo sapiens)		RGD
Bcl6	Mouse	diffuse large B-cell lymphoma	disease_progression	ISO	BCL6 (Homo sapiens)		RGD
IRF4	Human	diffuse large B-cell lymphoma	disease_progression	IEP			RGD
Irf4	Rat	diffuse large B-cell lymphoma	disease_progression	ISO	IRF4 (Homo sapiens)		RGD
Irf4	Mouse	diffuse large B-cell lymphoma	disease_progression	ISO	IRF4 (Homo sapiens)		RGD

Objects Annotated

Genes (Rattus norvegicus)

Bcl6 (BCL6, transcription repressor)

Irf4 (interferon regulatory factor 4)

Genes (Mus musculus)

Bcl6 (B cell leukemia/lymphoma 6)

Irf4 (interferon regulatory factor 4)

Genes (Homo sapiens)

BCL6 (BCL6 transcription repressor)

IRF4 (interferon regulatory factor 4)

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Create Name:

Description:

Send us a Message

Expression of the bcl-6 and MUM1/IRF4 proteins correlate with overall and disease-specific survival in patients with primary cutaneous large B-cell lymphoma: a tissue microarray study.