Bcl6 (BCL6 transcription repressor) - Rat Genome Database

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Gene: Bcl6 (BCL6 transcription repressor) Chinchilla lanigera
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Symbol: Bcl6
Name: BCL6 transcription repressor
RGD ID: 9056748
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); B cell differentiation (ortholog); B cell proliferation (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH B-cell lymphoma (ortholog); diffuse large B-cell lymphoma (ortholog); Gastrointestinal Hemorrhage (ortholog); FOUND IN Golgi apparatus (ortholog); nucleolus (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: B cell CLL/lymphoma 6; B-cell CLL/lymphoma 6; BCL6, transcription repressor
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542019,998,742 - 20,022,259 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542019,998,960 - 20,021,200 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
B cell differentiation  (ISO)
B cell proliferation  (ISO)
cell morphogenesis  (ISO)
cell motility  (ISO)
cell population proliferation  (ISO)
cell-matrix adhesion  (ISO)
DNA damage response  (ISO)
erythrocyte development  (ISO)
germinal center formation  (ISO)
heterochromatin formation  (ISO)
isotype switching to IgE isotypes  (ISO)
mononuclear cell proliferation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell-matrix adhesion  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of isotype switching to IgE isotypes  (ISO)
negative regulation of mast cell cytokine production  (ISO)
negative regulation of mononuclear cell proliferation  (ISO)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of plasma cell differentiation  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
negative regulation of T-helper 2 cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of type 2 immune response  (ISO)
plasma cell differentiation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell motility  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of regulatory T cell differentiation  (ISO)
protein localization  (ISO)
pyramidal neuron differentiation  (ISO)
regulation of inflammatory response  (ISO)
regulation of memory T cell differentiation  (ISO)
regulation of T cell proliferation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
Rho protein signal transduction  (ISO)
spermatogenesis  (ISO)
T-helper 2 cell differentiation  (ISO)
transcription by RNA polymerase II  (ISO)
type 2 immune response  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Bcl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542019,998,742 - 20,022,259 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542019,998,960 - 20,021,200 (+)NCBIChiLan1.0ChiLan1.0
BCL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383187,721,377 - 187,745,468 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3187,721,377 - 187,745,725 (-)EnsemblGRCh38hg38GRCh38
GRCh373187,439,165 - 187,463,256 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363188,921,859 - 188,946,169 (-)NCBINCBI36Build 36hg18NCBI36
Build 343188,921,866 - 188,936,950NCBI
Celera3185,870,167 - 185,894,514 (-)NCBICelera
Cytogenetic Map3q27.3NCBI
HuRef3184,843,368 - 184,867,718 (-)NCBIHuRef
CHM1_13187,402,407 - 187,426,738 (-)NCBICHM1_1
T2T-CHM13v2.03190,538,887 - 190,562,977 (-)NCBIT2T-CHM13v2.0
Bcl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391623,780,058 - 23,807,602 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1623,783,802 - 23,807,602 (-)EnsemblGRCm39 Ensembl
GRCm381623,965,050 - 23,988,866 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1623,965,052 - 23,988,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371623,965,138 - 23,988,698 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361623,880,401 - 23,903,961 (-)NCBIMGSCv36mm8
Celera1624,514,447 - 24,538,188 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1615.26NCBI
Bcl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,358,753 - 90,382,049 (+)NCBIGRCr8
mRatBN7.21176,854,090 - 76,877,389 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,854,090 - 76,877,389 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,634,592 - 85,657,897 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,269,810 - 78,293,116 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,348,906 - 77,372,205 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01180,255,790 - 80,279,075 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1180,255,790 - 80,279,075 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01180,454,014 - 80,477,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,006,123 - 79,030,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11179,063,711 - 79,088,148 (+)NCBI
Celera1175,736,211 - 75,759,558 (+)NCBICelera
Cytogenetic Map11q23NCBI
BCL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22185,592,401 - 185,616,789 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13185,596,633 - 185,622,262 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03184,748,135 - 184,772,375 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13193,308,296 - 193,332,452 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3193,308,296 - 193,332,124 (-)Ensemblpanpan1.1panPan2
BCL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13420,112,302 - 20,135,705 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3420,113,322 - 20,124,704 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3424,206,192 - 24,217,557 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03420,032,420 - 20,123,667 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3420,007,243 - 20,047,268 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13420,061,949 - 20,073,314 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03420,055,728 - 20,067,098 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03420,295,606 - 20,306,970 (-)NCBIUU_Cfam_GSD_1.0
Bcl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602116,280,077 - 116,303,180 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365782,371,945 - 2,395,071 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365782,371,976 - 2,395,034 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13125,377,250 - 125,393,330 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113125,377,247 - 125,401,328 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213134,660,904 - 134,685,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11581,997,659 - 82,022,059 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1581,998,545 - 82,009,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604155,495,443 - 55,520,875 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473069,154,080 - 69,167,689 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473069,145,035 - 69,167,583 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000018167   ⟹   ENSCLAP00000017989
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542019,998,742 - 20,022,259 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000018168   ⟹   ENSCLAP00000017990
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542019,998,742 - 20,022,259 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000018169   ⟹   ENSCLAP00000017991
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542020,006,981 - 20,022,259 (+)Ensembl
RefSeq Acc Id: XM_005383244   ⟹   XP_005383301
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542019,998,960 - 20,021,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005383245   ⟹   XP_005383302
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542020,006,981 - 20,021,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005383246   ⟹   XP_005383303
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542020,007,949 - 20,021,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005383247   ⟹   XP_005383304
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542020,003,223 - 20,021,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005383248   ⟹   XP_005383305
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542019,998,960 - 20,021,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013513551   ⟹   XP_013369005
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542020,003,223 - 20,021,200 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005383301   ⟸   XM_005383244
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VMY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005383305   ⟸   XM_005383248
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VMV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005383304   ⟸   XM_005383247
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VMY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005383302   ⟸   XM_005383245
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VMY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005383303   ⟸   XM_005383246
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VMY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369005   ⟸   XM_013513551
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VMY7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000017990   ⟸   ENSCLAT00000018168
Ensembl Acc Id: ENSCLAP00000017991   ⟸   ENSCLAT00000018169
Ensembl Acc Id: ENSCLAP00000017989   ⟸   ENSCLAT00000018167
Protein Domains
BTB   C2H2-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012339 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000018167 ENTREZGENE
  ENSCLAT00000018167.1 UniProtKB/TrEMBL
  ENSCLAT00000018168 ENTREZGENE
  ENSCLAT00000018168.1 UniProtKB/TrEMBL
  ENSCLAT00000018169 ENTREZGENE
  ENSCLAT00000018169.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
  Potassium Channel Kv1.1, Chain A UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene Bcl6 ENTREZGENE
PANTHER BCL6A TRANSCRIPTION REPRESSOR A UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam BTB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8C2VMV4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VMY7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Bcl6  BCL6 transcription repressor    BCL6, transcription repressor  Symbol and/or name change 5135510 APPROVED
2018-11-06 Bcl6  BCL6, transcription repressor    B cell CLL/lymphoma 6  Symbol and/or name change 5135510 APPROVED
2017-12-19 Bcl6  B cell CLL/lymphoma 6    B-cell CLL/lymphoma 6  Symbol and/or name change 5135510 APPROVED