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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:profenamine
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Accession:CHEBI:313639 term browser browse the term
Definition:A member of the class of phenothiazines that is phenothiazine in which the hydrogen attached to the nitrogen is substituted by a 2-(diethylamino)propyl group. An antimuscarinic, it is used as the hydrochloride for the symptomatic treatment of Parkinson's disease.
Synonyms:exact_synonym: N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
 related_synonym: 10-(2-diethylaminopropyl)phenothiazine;   10-[2-(diethylamino)-1-propyl]phenothiazine;   10-[2-(diethylamino)-2-methylethyl]phenothiazine;   10-[2-(diethylamino)propyl]phenothiazine;   2-diethylamino-1-propyl-N-dibenzoparathiazine;   Formula=C19H24N2S;   InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3;   InChIKey=CDOZDBSBBXSXLB-UHFFFAOYSA-N;   N,N-diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine;   N,N-diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine;   SMILES=CCN(CC)C(C)CN1c2ccccc2Sc2ccccc12;   ethopropazine;   profenamina;   profenaminum
 xref: CAS:522-00-9;   DrugBank:DB00392;   Drug_Central:1086;   HMDB:HMDB0014536;   KEGG:D08426;   LINCS:LSM-1342
 xref_mesh: MESH:C084820
 xref: PMID:17459789;   PMID:6539933;   Patent:US2607773;   Reaxys:89828;   Wikipedia:Ethopropazine


show annotations for term's descendants           Sort by:
profenamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity
multiple interactions		 ISO profenamine results in decreased activity of BCHE protein
profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]		 CTD PMID:18656440 PMID:22407886 PMID:28299395 PMID:32278739 PMID:32795450 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO profenamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      biological role 19902
        pharmacological role 19120
          antagonist 17268
            histamine antagonist 4896
              profenamine 2
                (R)-profenamine 0
                (S)-profenamine 0
                profenamine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    main group molecular entity 19876
                      s-block molecular entity 19705
                        hydrogen molecular entity 19686
                          hydrides 19179
                            inorganic hydride 18191
                              pnictogen hydride 18181
                                nitrogen hydride 18092
                                  azane 17895
                                    ammonia 17894
                                      organic amino compound 17894
                                        tertiary amino compound 10156
                                          profenamine 2
                                            (R)-profenamine 0
                                            (S)-profenamine 0
                                            profenamine hydrochloride 0
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