Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:profenamine
go back to main search page
Accession:CHEBI:313639 term browser browse the term
Definition:A member of the class of phenothiazines that is phenothiazine in which the hydrogen attached to the nitrogen is substituted by a 2-(diethylamino)propyl group. An antimuscarinic, it is used as the hydrochloride for the symptomatic treatment of Parkinson's disease.
Synonyms:exact_synonym: N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
 related_synonym: 10-(2-diethylaminopropyl)phenothiazine;   10-[2-(diethylamino)-1-propyl]phenothiazine;   10-[2-(diethylamino)-2-methylethyl]phenothiazine;   10-[2-(diethylamino)propyl]phenothiazine;   2-diethylamino-1-propyl-N-dibenzoparathiazine;   Formula=C19H24N2S;   InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3;   InChIKey=CDOZDBSBBXSXLB-UHFFFAOYSA-N;   N,N-diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine;   N,N-diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine;   SMILES=CCN(CC)C(C)CN1c2ccccc2Sc2ccccc12;   ethopropazine;   profenamina;   profenaminum
 xref: CAS:522-00-9;   DrugBank:DB00392;   Drug_Central:1086;   HMDB:HMDB0014536;   KEGG:D08426;   LINCS:LSM-1342
 xref_mesh: MESH:C084820
 xref: PMID:17459789;   PMID:6539933;   Patent:US2607773;   Reaxys:89828;   Wikipedia:Ethopropazine


show annotations for term's descendants           Sort by:
 
profenamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity
multiple interactions
ISO profenamine results in decreased activity of BCHE protein
profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]
CTD PMID:18656440, PMID:22407886, PMID:28299395, PMID:32278739 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO profenamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        pharmacological role 18825
          antagonist 16213
            histamine antagonist 4607
              profenamine 2
                (R)-profenamine 0
                (S)-profenamine 0
                profenamine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  azane 16960
                                    ammonia 16959
                                      organic amino compound 16958
                                        tertiary amino compound 8643
                                          profenamine 2
                                            (R)-profenamine 0
                                            (S)-profenamine 0
                                            profenamine hydrochloride 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.