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Accession:CHEBI:313639 term browser browse the term
Definition:A member of the class of phenothiazines that is phenothiazine in which the hydrogen attached to the nitrogen is substituted by a 2-(diethylamino)propyl group. An antimuscarinic, it is used as the hydrochloride for the symptomatic treatment of Parkinson's disease.
Synonyms:exact_synonym: N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
 related_synonym: 10-(2-diethylaminopropyl)phenothiazine;   10-[2-(diethylamino)-1-propyl]phenothiazine;   10-[2-(diethylamino)-2-methylethyl]phenothiazine;   10-[2-(diethylamino)propyl]phenothiazine;   2-diethylamino-1-propyl-N-dibenzoparathiazine;   Formula=C19H24N2S;   InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3;   InChIKey=CDOZDBSBBXSXLB-UHFFFAOYSA-N;   N,N-diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine;   N,N-diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine;   SMILES=CCN(CC)C(C)CN1c2ccccc2Sc2ccccc12;   ethopropazine;   profenamina;   profenaminum
 xref: CAS:522-00-9 "ChemIDplus";   CAS:522-00-9 "KEGG DRUG";   CAS:522-00-9 "NIST Chemistry WebBook";   DrugBank:DB00392;   Drug_Central:1086 "DrugCentral";   HMDB:HMDB0014536;   KEGG:D08426;   LINCS:LSM-1342
 xref_mesh: MESH:C084820
 xref: PMID:17459789 "Europe PMC";   PMID:6539933 "Europe PMC";   Patent:US2607773;   Reaxys:89828 "Reaxys";   Wikipedia:Ethopropazine

show annotations for term's descendants       view all columns           Sort by:
profenamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      biological role 19621
        pharmacological role 18695
          antagonist 15808
            histamine antagonist 4484
              profenamine 2
                (R)-profenamine 0
                (S)-profenamine 0
                profenamine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    main group molecular entity 19555
                      s-block molecular entity 19336
                        hydrogen molecular entity 19325
                          hydrides 18249
                            inorganic hydride 17113
                              pnictogen hydride 17071
                                nitrogen hydride 16891
                                  azane 16568
                                    ammonia 16565
                                      organic amino compound 16564
                                        tertiary amino compound 8523
                                          profenamine 2
                                            (R)-profenamine 0
                                            (S)-profenamine 0
                                            profenamine hydrochloride 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.