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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:profenamine
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Accession:CHEBI:313639 term browser browse the term
Definition:A member of the class of phenothiazines that is phenothiazine in which the hydrogen attached to the nitrogen is substituted by a 2-(diethylamino)propyl group. An antimuscarinic, it is used as the hydrochloride for the symptomatic treatment of Parkinson's disease.
Synonyms:exact_synonym: N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
 related_synonym: 10-(2-diethylaminopropyl)phenothiazine;   10-[2-(diethylamino)-1-propyl]phenothiazine;   10-[2-(diethylamino)-2-methylethyl]phenothiazine;   10-[2-(diethylamino)propyl]phenothiazine;   2-diethylamino-1-propyl-N-dibenzoparathiazine;   Formula=C19H24N2S;   InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3;   InChIKey=CDOZDBSBBXSXLB-UHFFFAOYSA-N;   N,N-diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine;   N,N-diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine;   SMILES=CCN(CC)C(C)CN1c2ccccc2Sc2ccccc12;   ethopropazine;   profenamina;   profenaminum
 xref: CAS:522-00-9;   DrugBank:DB00392;   Drug_Central:1086;   HMDB:HMDB0014536;   KEGG:D08426;   LINCS:LSM-1342
 xref_mesh: MESH:C084820
 xref: PMID:17459789;   PMID:6539933;   Patent:US2607773;   Reaxys:89828;   Wikipedia:Ethopropazine



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profenamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity
multiple interactions
ISO profenamine results in decreased activity of BCHE protein
profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]
CTD PMID:18656440 PMID:22407886 PMID:28299395 PMID:32278739 PMID:32795450 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO profenamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        pharmacological role 18837
          antagonist 16322
            histamine antagonist 4619
              profenamine 2
                (R)-profenamine 0
                (S)-profenamine 0
                profenamine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            inorganic hydride 17691
                              pnictogen hydride 17671
                                nitrogen hydride 17543
                                  azane 17278
                                    ammonia 17277
                                      organic amino compound 17277
                                        tertiary amino compound 8697
                                          profenamine 2
                                            (R)-profenamine 0
                                            (S)-profenamine 0
                                            profenamine hydrochloride 0
paths to the root