Gene: Calm2 (calmodulin 2) Mus musculus
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Symbol:
Calm2
Name:
calmodulin 2
Description:
Predicted to have several functions, including enzyme binding activity; ion channel binding activity; and type 3 metabotropic glutamate receptor binding activity. Involved in G2/M transition of mitotic cell cycle. Localizes to the myelin sheath and voltage-gated potassium channel complex. Predicted to colocalize with the mitochondrial membrane and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in long QT syndrome 15. Is expressed in several structures, including alimentary system; metanephros; nervous system; respiratory system; and sensory organ. Orthologous to human CALM2 (calmodulin 2); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254; benzo[a]pyrene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
1500001E21Rik; AL024017; Calm1; Calm3; calmodulin; calmodulin-2; caM; Cam2; CamC
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CALM2 (calmodulin 2) HGNC
HGNC, NCBI, OrthoDB, Treefam
Rattus norvegicus (Norway rat):
Calm2 (calmodulin 2) HGNC
NCBI
Chinchilla lanigera (long-tailed chinchilla):
Calm2 (calmodulin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CALM2 (calmodulin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CALM2 (calmodulin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Calm2 (calmodulin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CALM2 (calmodulin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
CALM2 (calmodulin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Calm2 (calmodulin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
CALM3 (calmodulin 3) HGNC
OMA, OrthoDB, OrthoMCL
Homo sapiens (human):
CALM1 (calmodulin 1) HGNC
OMA, OrthoDB
Alliance orthologs 3
Homo sapiens (human):
CALM2 (calmodulin 2)
Alliance
DIOPT (HGNC, OMA, OrthoFinder, TreeFam)
Danio rerio (zebrafish):
calm3b (calmodulin 3b (phosphorylase kinase, delta))
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, TreeFam)
Danio rerio (zebrafish):
calm2a (calmodulin 2a (phosphorylase kinase, delta))
Alliance
DIOPT (OMA, OrthoFinder, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
CMD1
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder)
Drosophila melanogaster (fruit fly):
Cam
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, TreeFam)
Caenorhabditis elegans (roundworm):
cmd-1
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder)
Related Pseudogenes:
Gm14480
Gm3010
Gm5881
Gm7039
Gm7308
Gm7743
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 12 100,199,435 - 100,209,814 (+) Ensembl GRCm38 Ensembl 17 87,433,412 - 87,446,935 (-) Ensembl GRCm38 17 87,433,401 - 87,446,935 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 17 87,832,741 - 87,846,275 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 17 87,341,743 - 87,355,168 (-) NCBI mm8 Celera 17 91,831,455 - 91,844,939 (-) NCBI Celera Cytogenetic Map 17 E4 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
genetic disease ISO RGD:736342 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:15316014 more ... long QT syndrome 1 ISO RGD:736342 8554872 ClinVar Annotator: match by term: Long QT syndrome 1 ClinVar PMID:28492532 long QT syndrome 1 ISO RGD:736342 8554872 ClinVar Annotator: match by term: Long QT syndrome 1 ClinVar PMID:15316014 more ... long QT syndrome 1 ISO RGD:736342 8554872 ClinVar Annotator: match by term: Long QT syndrome 1 ClinVar PMID:24917665 long QT syndrome 1 ISO RGD:736342 8554872 ClinVar Annotator: match by term: Long QT syndrome 1 ClinVar PMID:25741868 , PMID:28492532 long QT syndrome 15 ISO RGD:736342 8554872 ClinVar Annotator: match by term: Long QT syndrome 15 ClinVar PMID:25741868 , PMID:28492532 long QT syndrome 15 ISO RGD:736342 8554872 ClinVar Annotator: match by term: Long QT syndrome 15 ClinVar PMID:23388215 long QT syndrome 15 ISO RGD:736342 8554872 ClinVar Annotator: match by term: Long QT syndrome 15 ClinVar PMID:24917665 long QT syndrome 15 ISO RGD:736342 8554872 ClinVar Annotator: match by term: Long QT syndrome 15 ClinVar Romano-Ward Syndrome ISO RGD:736342 8554872 ClinVar Annotator: match by term: Romano-Ward syndrome ClinVar PMID:28492532 Romano-Ward Syndrome ISO RGD:736342 8554872 ClinVar Annotator: match by term: Romano-Ward syndrome ClinVar PMID:23388215 , PMID:28492532
Imported Annotations - CTD
cannabis abuse ISO RGD:736342 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17205118 Cocaine-Related Disorders ISO RGD:736342 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17205118 phencyclidine abuse ISO RGD:736342 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17205118 Imported Annotations - OMIM
long QT syndrome 15 ISO RGD:736342 7240710 OMIM
17beta-estradiol multiple interactions ISO RGD:736342 6480464 3 more ... CTD PMID:11179685 17beta-estradiol multiple interactions ISO RGD:2258 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of CALM2 mRNA CTD PMID:26496021 17beta-estradiol decreases expression ISO RGD:736342 6480464 Estradiol results in decreased expression of CALM2 mRNA CTD PMID:11179685 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CALM2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736342 6480464 Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of CALM2 mRNA] CTD PMID:11179685 2,6-dinitrotoluene affects expression ISO RGD:2258 6480464 2, 6-dinitrotoluene affects the expression of CALM2 mRNA CTD PMID:21346803 3,3'-diindolylmethane multiple interactions ISO RGD:736342 6480464 3, 3'-diindolylmethane promotes the reaction [Estradiol results in decreased expression of CALM2 mRNA] CTD PMID:11179685 aflatoxin B1 decreases methylation ISO RGD:736342 6480464 Aflatoxin B1 results in decreased methylation of CALM2 gene CTD PMID:27153756 aflatoxin M1 decreases expression ISO RGD:736342 6480464 Aflatoxin M1 results in decreased expression of CALM2 mRNA CTD PMID:30928695 aldehydo-D-glucose multiple interactions ISO RGD:2258 6480464 CALM2 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency] CTD PMID:21124846 ammonium chloride affects expression ISO RGD:2258 6480464 Ammonium Chloride affects the expression of CALM2 mRNA CTD PMID:16483693 amphetamine increases expression ISO RGD:2258 6480464 Amphetamine results in increased expression of CALM2 mRNA CTD PMID:30779732 amphetamine affects expression ISO RGD:2258 6480464 Amphetamine affects the expression of CALM2 mRNA CTD PMID:10854758 antirheumatic drug decreases expression ISO RGD:736342 6480464 Antirheumatic Agents results in decreased expression of CALM2 mRNA CTD PMID:25339124 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of CALM2 mRNA CTD PMID:23650126 arsenite(3-) increases methylation ISO RGD:736342 6480464 arsenite results in increased methylation of CALM2 promoter CTD PMID:23974009 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CALM2 mRNA CTD PMID:22228805 bisphenol A multiple interactions ISO RGD:2258 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of CALM2 mRNA CTD PMID:26496021 bisphenol A affects expression ISO RGD:736342 6480464 bisphenol A affects the expression of CALM2 mRNA CTD PMID:30903817 bisphenol A increases methylation ISO RGD:2258 6480464 bisphenol A results in increased methylation of CALM2 gene CTD PMID:28505145 buspirone decreases expression ISO RGD:2258 6480464 Buspirone results in decreased expression of CALM2 mRNA CTD PMID:24136188 butan-1-ol multiple interactions ISO RGD:736342 6480464 [[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of CALM2 mRNA CTD PMID:29432896 cerium trichloride increases expression EXP 6480464 cerous chloride results in increased expression of CALM2 mRNA CTD PMID:23573234 chloropicrin increases expression ISO RGD:736342 6480464 chloropicrin results in increased expression of CALM2 mRNA CTD PMID:26352163 cisplatin multiple interactions ISO RGD:736342 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of CALM2 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:736342 6480464 Cisplatin results in decreased expression of CALM2 mRNA CTD PMID:27392435 clofibric acid multiple interactions ISO RGD:2258 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CALM2 mRNA CTD PMID:17602206 clozapine increases expression ISO RGD:2258 6480464 Clozapine results in increased expression of CALM2 mRNA CTD PMID:19289156 cocaine decreases expression ISO RGD:736342 6480464 Cocaine results in decreased expression of CALM2 mRNA CTD PMID:17205118 copper(II) sulfate decreases expression ISO RGD:736342 6480464 Copper Sulfate results in decreased expression of CALM2 mRNA CTD PMID:19549813 D-glucose multiple interactions ISO RGD:2258 6480464 CALM2 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency] CTD PMID:21124846 dicrotophos decreases expression ISO RGD:736342 6480464 dicrotophos results in decreased expression of CALM2 mRNA CTD PMID:28302478 dieldrin affects expression ISO RGD:2258 6480464 Dieldrin affects the expression of CALM2 mRNA CTD PMID:22546817 dimethylarsinic acid increases expression ISO RGD:2258 6480464 Cacodylic Acid results in increased expression of CALM2 mRNA CTD PMID:16122865 dioxygen multiple interactions ISO RGD:2258 6480464 CALM2 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency] CTD PMID:21124846 diuron increases expression ISO RGD:2258 6480464 Diuron results in increased expression of CALM2 mRNA CTD PMID:21551480 ethanol decreases expression ISO RGD:2258 6480464 Ethanol results in decreased expression of CALM2 mRNA CTD PMID:20655511 ethanol multiple interactions EXP 6480464 Ethanol affects the expression of and affects the splicing of CALM2 mRNA CTD PMID:30319688 ethanol increases expression EXP 6480464 Ethanol results in increased expression of CALM2 mRNA CTD PMID:30319688 ethanol multiple interactions ISO RGD:736342 6480464 [[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of CALM2 mRNA CTD PMID:29432896 fumonisin B1 increases expression EXP 6480464 fumonisin B1 results in increased expression of CALM2 mRNA CTD PMID:16221962 gentamycin increases expression ISO RGD:2258 6480464 Gentamicins results in increased expression of CALM2 mRNA CTD PMID:22061828 glucose multiple interactions ISO RGD:2258 6480464 CALM2 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency] CTD PMID:21124846 haloperidol increases expression ISO RGD:2258 6480464 Haloperidol results in increased expression of CALM2 mRNA CTD PMID:19289156 hydrogen peroxide affects expression ISO RGD:736342 6480464 Hydrogen Peroxide affects the expression of CALM2 mRNA CTD PMID:20044591 maneb multiple interactions EXP 6480464 [Paraquat co-treated with Maneb] results in increased expression of CALM2 mRNA CTD PMID:18386188 methotrexate increases expression ISO RGD:736342 6480464 Methotrexate results in increased expression of CALM2 mRNA CTD PMID:21678067 microcystin-LR increases expression EXP 6480464 cyanoginosin LR results in increased expression of CALM2 mRNA CTD PMID:17654400 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Progesterone results in decreased expression of CALM2 mRNA] CTD PMID:27264040 N-nitrosodiethylamine multiple interactions ISO RGD:2258 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CALM2 mRNA CTD PMID:17602206 nefazodone decreases expression ISO RGD:2258 6480464 nefazodone results in decreased expression of CALM2 mRNA CTD PMID:24136188 nickel dichloride affects expression ISO RGD:2258 6480464 nickel chloride affects the expression of CALM2 mRNA CTD PMID:22546817 nimesulide decreases expression ISO RGD:2258 6480464 nimesulide results in decreased expression of CALM2 mRNA CTD PMID:24136188 nitroglycerin increases expression ISO RGD:2258 6480464 Nitroglycerin results in increased expression of CALM2 mRNA CTD PMID:12102619 okadaic acid decreases expression ISO RGD:736342 6480464 Okadaic Acid results in decreased expression of CALM2 mRNA CTD PMID:23561263 paraquat multiple interactions EXP 6480464 [Paraquat co-treated with Maneb] results in increased expression of CALM2 mRNA CTD PMID:18386188 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:2258 6480464 perfluorooctane sulfonic acid results in decreased expression of CALM2 mRNA CTD PMID:19756518 perfluorooctane-1-sulfonic acid increases expression ISO RGD:2258 6480464 perfluorooctane sulfonic acid results in increased expression of CALM2 mRNA CTD PMID:19756518 phencyclidine decreases expression ISO RGD:736342 6480464 Phencyclidine results in decreased expression of CALM2 mRNA CTD PMID:17205118 phenobarbital affects expression ISO RGD:736342 6480464 Phenobarbital affects the expression of CALM2 mRNA CTD PMID:19159669 phenytoin decreases expression ISO RGD:736342 6480464 Phenytoin results in decreased expression of CALM2 mRNA CTD PMID:14741686 progesterone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Progesterone results in decreased expression of CALM2 mRNA] CTD PMID:27264040 progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of CALM2 mRNA CTD PMID:27264040 risperidone increases expression ISO RGD:2258 6480464 Risperidone results in increased expression of CALM2 mRNA CTD PMID:19289156 rotenone decreases expression ISO RGD:2258 6480464 Rotenone results in decreased expression of CALM2 mRNA CTD PMID:28374803 sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of CALM2 mRNA CTD PMID:21340527 Tributyltin oxide decreases expression EXP 6480464 bis(tri-n-butyltin)oxide results in decreased expression of CALM2 mRNA CTD PMID:18958704 trichloroethene increases methylation ISO RGD:2258 6480464 Trichloroethylene results in increased methylation of CALM2 gene CTD PMID:27618143 tunicamycin decreases expression ISO RGD:736342 6480464 Tunicamycin results in decreased expression of CALM2 mRNA CTD PMID:22378314 uranium atom affects expression ISO RGD:736342 6480464 Uranium affects the expression of CALM2 mRNA CTD PMID:15672453 valproic acid decreases methylation ISO RGD:736342 6480464 Valproic Acid results in decreased methylation of CALM2 gene CTD PMID:29154799 valproic acid increases expression ISO RGD:736342 6480464 Valproic Acid results in increased expression of CALM2 mRNA CTD PMID:19101580 vincristine decreases expression ISO RGD:736342 6480464 Vincristine results in decreased expression of CALM2 mRNA CTD PMID:23649840
Biological Process calcium-mediated signaling IBA PANTHER:PTN000549861 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 G2/M transition of mitotic cell cycle IDA 2290270 (MGI:MGI:2155066, PMID:2469574) MGI MGI:MGI:2155066 , PMID:2469574 Cellular Component cytoplasm ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cytoplasm ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cytoplasm ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 growth cone ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 growth cone ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 growth cone ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 mitochondrial membrane colocalizes_with ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 mitochondrial membrane colocalizes_with ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 mitochondrial membrane colocalizes_with ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 myelin sheath ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 myelin sheath IDA 2290270 (MGI:MGI:5883208, PMID:19855925) CAFA MGI:MGI:5883208 , PMID:19855925 myelin sheath ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 myelin sheath ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 neuron projection ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 neuron projection ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 neuron projection ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleus ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleus ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleus ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 synaptic vesicle membrane colocalizes_with ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 synaptic vesicle membrane colocalizes_with ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 synaptic vesicle membrane colocalizes_with ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 voltage-gated potassium channel complex IGI MGI:MGI:103249 , MGI:MGI:88251 2290270 (MGI:MGI:2387278, PMID:12223552) MGI MGI:MGI:2387278 , PMID:12223552 Molecular Function adenylate cyclase binding ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 adenylate cyclase binding ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 adenylate cyclase binding ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 calcium ion binding TAS 2290270 (MGI:MGI:2155066, PMID:2469574) MGI MGI:MGI:2155066 , PMID:2469574 calcium ion binding IBA FB:FBgn0000253 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 calcium ion binding ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 calcium ion binding ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 calcium ion binding ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 calcium-dependent protein binding ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 ion channel binding ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 ion channel binding ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 ion channel binding ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nitric-oxide synthase binding ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nitric-oxide synthase binding ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nitric-oxide synthase binding ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nitric-oxide synthase regulator activity ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nitric-oxide synthase regulator activity ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nitric-oxide synthase regulator activity ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 phosphatidylinositol 3-kinase binding ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein domain specific binding ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein N-terminus binding ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein N-terminus binding ISO RGD:2259 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein N-terminus binding ISO RGD:2258 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 type 3 metabotropic glutamate receptor binding ISO RGD:2257 2290270 RGD GO_REF:0000096, MGI:MGI:4417868
Gene-Chemical Interaction Annotations
