Dhcr24 (24-dehydrocholesterol reductase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Dhcr24 (24-dehydrocholesterol reductase) Mus musculus
Analyze
Symbol: Dhcr24
Name: 24-dehydrocholesterol reductase
RGD ID: 1315198
MGI Page MGI
Description: Predicted to enable enzyme binding activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; and peptide antigen binding activity. Involved in cholesterol biosynthetic process and skin development. Acts upstream of or within several processes, including amyloid precursor protein catabolic process; male genitalia development; and plasminogen activation. Predicted to be located in endoplasmic reticulum and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Human ortholog(s) of this gene implicated in lipid metabolism disorder. Orthologous to human DHCR24 (24-dehydrocholesterol reductase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310076D10Rik; 3-beta-hydroxysterol delta-24 reductase; 3-beta-hydroxysterol delta-24-reductase; 5830417J06Rik; delta(24)-sterol reductase; mKIAA0018; sela; seladin-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394106,418,279 - 106,446,310 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4106,418,235 - 106,446,310 (+)EnsemblGRCm39 Ensembl
GRCm384106,561,038 - 106,589,113 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4106,561,038 - 106,589,113 (+)EnsemblGRCm38mm10GRCm38
MGSCv374106,233,643 - 106,261,718 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364106,059,082 - 106,084,718 (+)NCBIMGSCv36mm8
Celera4104,921,880 - 104,950,010 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map449.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amphetamine  (ISO)
Archazolid B  (ISO)
atrazine  (ISO)
benzalkonium chloride  (EXP)
benzatropine  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A5  (ISO)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cadmium sulfide  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
celecoxib  (EXP)
cerium trichloride  (ISO)
cetrorelix  (ISO)
cholesterol  (EXP,ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
dehydroepiandrosterone  (ISO)
desmosterol  (ISO)
desogestrel  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (EXP)
diclofenac  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dutasteride  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
Febrifugine  (ISO)
fenthion  (EXP)
fluoranthene  (EXP)
fluoxetine  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gallic acid  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glafenine  (ISO)
glycidyl methacrylate  (ISO)
gold atom  (EXP,ISO)
gold(0)  (EXP,ISO)
indometacin  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (ISO)
leflunomide  (ISO)
lucanthone  (ISO)
methamphetamine  (ISO)
methidathion  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (ISO)
methylseleninic acid  (ISO)
miconazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
nebivolol  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP)
nitrofen  (ISO)
ochratoxin A  (ISO)
omeprazole  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP,ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
succimer  (EXP)
sulforaphane  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitexin  (EXP)
vorinostat  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
13. Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. Waterham HR, etal., Am J Hum Genet. 2001 Oct;69(4):685-94. Epub 2001 Aug 22.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11988087   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14681479   PMID:14684813   PMID:15577914  
PMID:16141072   PMID:16141073   PMID:16321981   PMID:16407971   PMID:16410790   PMID:16513830   PMID:16602821   PMID:16651660   PMID:17761942   PMID:17984220   PMID:18241265   PMID:18339707  
PMID:19542918   PMID:20406300   PMID:21267068   PMID:21677750   PMID:21845517   PMID:21873635   PMID:21909369   PMID:23358892   PMID:23359226   PMID:24861183   PMID:24916565   PMID:26108225  
PMID:26628388   PMID:27689697   PMID:28378742   PMID:30569161   PMID:30891795   PMID:30973865   PMID:32325033   PMID:32724824   PMID:32950573   PMID:33524375   PMID:35804281   PMID:36674444  
PMID:37086967   PMID:37344916   PMID:38032198   PMID:38355793   PMID:38649789  


Genomics

Comparative Map Data
Dhcr24
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394106,418,279 - 106,446,310 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4106,418,235 - 106,446,310 (+)EnsemblGRCm39 Ensembl
GRCm384106,561,038 - 106,589,113 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4106,561,038 - 106,589,113 (+)EnsemblGRCm38mm10GRCm38
MGSCv374106,233,643 - 106,261,718 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364106,059,082 - 106,084,718 (+)NCBIMGSCv36mm8
Celera4104,921,880 - 104,950,010 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map449.67NCBI
DHCR24
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38154,849,627 - 54,887,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl154,849,627 - 54,887,195 (-)EnsemblGRCh38hg38GRCh38
GRCh37155,315,300 - 55,352,868 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36155,087,888 - 55,125,509 (-)NCBINCBI36Build 36hg18NCBI36
Build 34155,027,320 - 55,064,926NCBI
Celera153,602,965 - 53,640,513 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef153,429,205 - 53,466,807 (-)NCBIHuRef
CHM1_1155,431,045 - 55,468,571 (-)NCBICHM1_1
T2T-CHM13v2.0154,729,905 - 54,767,373 (-)NCBIT2T-CHM13v2.0
Dhcr24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85126,573,366 - 126,599,940 (+)NCBIGRCr8
mRatBN7.25121,344,552 - 121,371,124 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5121,344,575 - 121,371,137 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5123,957,501 - 123,981,506 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05125,680,549 - 125,704,554 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05125,731,821 - 125,755,826 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05126,164,708 - 126,188,926 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,164,674 - 126,191,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05130,011,465 - 130,034,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45127,637,438 - 127,662,621 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15127,592,941 - 127,670,118 (+)NCBI
Celera5120,093,779 - 120,117,321 (+)NCBICelera
Cytogenetic Map5q34NCBI
Dhcr24
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554644,533,928 - 4,558,133 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554644,533,928 - 4,557,893 (+)NCBIChiLan1.0ChiLan1.0
DHCR24
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21171,944,470 - 171,984,159 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11171,087,542 - 171,125,109 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0154,126,170 - 54,163,713 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1155,714,693 - 55,752,075 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl155,714,693 - 55,754,698 (-)Ensemblpanpan1.1panPan2
DHCR24
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1554,294,055 - 54,324,389 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl554,294,046 - 54,321,921 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha554,362,817 - 54,393,132 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0554,481,753 - 54,512,044 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl554,481,728 - 54,545,270 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1554,478,780 - 54,509,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0554,368,590 - 54,398,883 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0554,757,309 - 54,787,616 (+)NCBIUU_Cfam_GSD_1.0
Dhcr24
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505868,968,931 - 68,992,733 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365226,423,561 - 6,444,814 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365226,423,561 - 6,447,363 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHCR24
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6157,483,783 - 157,519,061 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16157,483,794 - 157,519,060 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26145,547,688 - 145,582,947 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DHCR24
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12078,052,565 - 78,088,918 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2078,052,607 - 78,086,303 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603339,196,929 - 39,233,564 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhcr24
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248624,995,720 - 5,020,850 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248624,995,836 - 5,022,395 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1001
Count of miRNA genes:549
Interacting mature miRNAs:663
Transcripts:ENSMUST00000047973
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226782Tibl2_mtibia length 2, 5 week (mouse)490888237111257197Mouse
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)489888237118857197Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
11532708Sluc43i_msusceptibility to lung cancer 43i (mouse)474444699108444983Mouse
11532707Sluc43h_msusceptibility to lung cancer 43h (mouse)474444699108444983Mouse
27226770Tibl11_mtibia length 11, 10 week (mouse)488518237108357197Mouse
11532706Sluc43c_msusceptibility to lung cancer 43c (mouse)474444699108444983Mouse
11532705Sluc43b_msusceptibility to lung cancer 43b (mouse)474444699108444983Mouse
11532704Sluc43a_msusceptibility to lung cancer 43a (mouse)474444699108444983Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
14696687Gdq1_mgrooming duration QTL 1, males (mouse)496888237111857197Mouse
14696689Gdq2_mgrooming duration QTL 2, females (mouse)4100857197124893793Mouse
27226766Tibl17_mtibia length 17, 16 week (mouse)488518237108457197Mouse
27226760Feml19_mfemur length 19, 16 week (mouse)490888237108457197Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
1302031Bulb1_mbulb size 1 (mouse)Not determined474033887108034029Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465318237118857197Mouse
12904933Edlmmq3_mextensor digitorum longus muscle mass QTL 3 (mouse)481213991115213991Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined489969627123969747Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485428838119429037Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
1302204Spm1_msplenomegaly modifier (mouse)Not determined482244395116244582Mouse
11532703Sluc43g_msusceptibility to lung cancer 43g (mouse)474444699108444983Mouse
11532702Sluc43f_msusceptibility to lung cancer 43f (mouse)474444699108444983Mouse
11532701Sluc43e_msusceptibility to lung cancer 43e (mouse)474444699108444983Mouse
11532700Sluc43d_msusceptibility to lung cancer 43d (mouse)474444699108444983Mouse
11039517Ltpr4_mLeishmania tropica response 4 (mouse)479365751113365867Mouse
11039504Ltpr4a_mLeishmania tropica response 4a (mouse)479365751113365867Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485781167119781279Mouse
11039505Ltpr4c_mLeishmania tropica response 4c (mouse)479365751113365867Mouse
1301545Gauc_mglucose area under curve (mouse)Not determined476763107110763305Mouse
11039506Ltpr4b_mLeishmania tropica response 4b (mouse)479365751113365867Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
27226787Feml14_mfemur length 14, 10 week (mouse)484918237107157197Mouse
10412193Plep_mplasma lepin levels (mouse)Not determined474444699108444983Mouse
27095900Scvln9_msacral vertebrae length 2, 10 week (mouse)468018237107157197Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1300689Dob1_mDietary obesity 1 (mouse)Body weight4101574601123127211Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488118237118557197Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
1300697Sle2_msystemic lupus erythmatosus susceptibility 2 (mouse)Not determined477957579111957775Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
26884431Zlq8_mzygomatic length QTL 8, 16 week (mouse)474718237108357197Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
27226746Metcl8_mmetatarsal-calcaneal length 8, 10 week (mouse)487518237107157197Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
27095927Pglq7_mpelvic girdle length QTL 7, 10 week (mouse)488118237108357197Mouse
27226739Metcl14_mmetatarsal-calcaneal length 14, 16 week (mouse)487518237108357197Mouse
27095921Pglq12_mpelvic girdle length QTL 12, 16 week (mouse)483118237108357197Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485781167119781279Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)490882780124882780Mouse
11532738Abd1_mautoimmune biliary disease 1 (mouse)488982069116271120Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498545539128009280Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483604870117605006Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490590668124590781Mouse

Markers in Region
Dhcr24  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4C7UniSTS
cM Map4 UniSTS
Dhcr24  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4C7UniSTS
cM Map4 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000047973   ⟹   ENSMUSP00000038063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4106,418,235 - 106,446,310 (+)Ensembl
GRCm38.p6 Ensembl4106,561,038 - 106,589,113 (+)Ensembl
RefSeq Acc Id: NM_053272   ⟹   NP_444502
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394106,418,279 - 106,446,310 (+)NCBI
GRCm384106,561,038 - 106,589,113 (+)ENTREZGENE
MGSCv374106,233,643 - 106,261,718 (+)RGD
Celera4104,921,880 - 104,950,010 (+)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_444502 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH19797 (Get FASTA)   NCBI Sequence Viewer  
  AAK72106 (Get FASTA)   NCBI Sequence Viewer  
  BAB31012 (Get FASTA)   NCBI Sequence Viewer  
  BAC97846 (Get FASTA)   NCBI Sequence Viewer  
  EDL30812 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000038063
  ENSMUSP00000038063.4
GenBank Protein Q8VCH6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_444502   ⟸   NM_053272
- Peptide Label: precursor
- UniProtKB: Q91ZD0 (UniProtKB/Swiss-Prot),   Q6ZQK9 (UniProtKB/Swiss-Prot),   Q9CU63 (UniProtKB/Swiss-Prot),   Q8VCH6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000038063   ⟸   ENSMUST00000047973
Protein Domains
FAD-binding PCMH-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VCH6-F1-model_v2 AlphaFold Q8VCH6 1-516 view protein structure

Promoters
RGD ID:6835138
Promoter ID:MM_KWN:38778
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_053272
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364106,233,521 - 106,234,021 (+)MPROMDB
RGD ID:6849151
Promoter ID:MM_XEF:5039
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_001031288
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364106,236,826 - 106,237,326 (+)MPROMDB
RGD ID:6884044
Promoter ID:EPDNEW_M5473
Type:initiation region
Name:Dhcr24_1
Description:Mus musculus 24-dehydrocholesterol reductase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384106,561,082 - 106,561,142EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1922004 AgrOrtholog
Ensembl Genes ENSMUSG00000034926 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000047973 ENTREZGENE
  ENSMUST00000047973.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.465.10 UniProtKB/Swiss-Prot
InterPro Diminuto-like UniProtKB/Swiss-Prot
  FAD-bd_PCMH UniProtKB/Swiss-Prot
  FAD-bd_PCMH-like_sf UniProtKB/Swiss-Prot
  FAD-bd_PCMH_sub2 UniProtKB/Swiss-Prot
  Oxid_FAD_bind_N UniProtKB/Swiss-Prot
KEGG Report mmu:74754 UniProtKB/Swiss-Prot
MGD MGI:1922004 ENTREZGENE
NCBI Gene 74754 ENTREZGENE
PANTHER DELTA(24)-STEROL REDUCTASE UniProtKB/Swiss-Prot
  PTHR10801 UniProtKB/Swiss-Prot
Pfam FAD_binding_4 UniProtKB/Swiss-Prot
PhenoGen Dhcr24 PhenoGen
PROSITE FAD_PCMH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56176 UniProtKB/Swiss-Prot
UniProt DHC24_MOUSE UniProtKB/Swiss-Prot
  Q6ZQK9 ENTREZGENE
  Q8VCH6 ENTREZGENE
  Q91ZD0 ENTREZGENE
  Q9CU63 ENTREZGENE
UniProt Secondary Q6ZQK9 UniProtKB/Swiss-Prot
  Q91ZD0 UniProtKB/Swiss-Prot
  Q9CU63 UniProtKB/Swiss-Prot