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Gene: DHCR24 (24-dehydrocholesterol reductase) Homo sapiens
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Symbol: DHCR24
Name: 24-dehydrocholesterol reductase
Description: Exhibits enzyme binding activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; and peptide antigen binding activity. Involved in several processes, including cholesterol biosynthetic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; and response to oxidative stress. Localizes to the endoplasmic reticulum and nucleus. Implicated in lipid metabolism disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol delta-24-reductase; DCE; delta(24)-sterol reductase; desmosterol-to-cholesterol enzyme; diminuto/dwarf1 homolog; KIAA0018; Nbla03646; seladin 1; seladin-1; SELADIN1; selective AD indicator 1
Orthologs:
Mus musculus (house mouse) : Dhcr24 (24-dehydrocholesterol reductase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dhcr24 (24-dehydrocholesterol reductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhcr24 (24-dehydrocholesterol reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : DHCR24 (24-dehydrocholesterol reductase)
Canis lupus familiaris (dog) : DHCR24 (24-dehydrocholesterol reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhcr24 (24-dehydrocholesterol reductase)
Sus scrofa (pig) : DHCR24 (24-dehydrocholesterol reductase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38154,849,627 - 54,887,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37155,315,300 - 55,352,921 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36155,087,888 - 55,125,509 (-)NCBINCBI36hg18NCBI36
Build 34155,027,320 - 55,064,926NCBI
Celera153,602,965 - 53,640,513 (-)NCBI
Cytogenetic Map1p32.3NCBI
HuRef153,429,205 - 53,466,807 (-)NCBIHuRef
CHM1_1155,431,045 - 55,468,571 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DHCR24
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315197
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.