Ppp2r1a (protein phosphatase 2, regulatory subunit A, alpha) - Rat Genome Database

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Gene: Ppp2r1a (protein phosphatase 2, regulatory subunit A, alpha) Mus musculus
Analyze
Symbol: Ppp2r1a
Name: protein phosphatase 2, regulatory subunit A, alpha
RGD ID: 1550262
MGI Page MGI
Description: Enables protein serine/threonine phosphatase activity. Involved in T cell homeostasis and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within several processes, including nuclear division; peptidyl-serine dephosphorylation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol. Part of protein phosphatase type 2A complex. Is active in glutamatergic synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 6330556D22Rik; P; PP2A; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha; PR; PR65; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform; protein phosphatase PP2A; serine/threonine protein phosphatase A subunit type 2A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm19222  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391721,165,716 - 21,186,167 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1721,165,573 - 21,186,178 (+)EnsemblGRCm39 Ensembl
GRCm381720,945,454 - 20,965,905 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1720,945,311 - 20,965,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv371721,082,418 - 21,102,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361720,650,151 - 20,670,602 (+)NCBIMGSCv36mm8
Celera1721,977,995 - 21,998,451 (+)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map1711.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(R)-adrenaline  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (ISO)
2-bromohexadecanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
5-aza-2'-deoxycytidine  (EXP)
7H-xanthine  (ISO)
9H-xanthine  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
atrazine  (ISO)
benzene  (EXP,ISO)
bexarotene  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbon nanotube  (EXP)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP)
clobetasol  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
decabromodiphenyl ether  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
fenpyroximate  (ISO)
fenthion  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
haloperidol  (ISO)
hypochlorous acid  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
lovastatin  (EXP)
methidathion  (EXP)
miconazole  (EXP)
microcystin RR  (ISO)
microcystin-LR  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
nefazodone  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
pyrazinecarboxamide  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
thapsigargin  (ISO)
titanium dioxide  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
warfarin  (EXP)
WIN 55212-2  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Seshacharyulu P, etal., Cancer Lett. 2013 Jul 10;335(1):9-18. doi: 10.1016/j.canlet.2013.02.036. Epub 2013 Feb 20.
Additional References at PubMed
PMID:1319990   PMID:9920888   PMID:10100624   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11172053   PMID:11665638   PMID:11994459   PMID:12003782   PMID:12198769  
PMID:12477932   PMID:12885400   PMID:12944463   PMID:12952889   PMID:14610273   PMID:14681479   PMID:15024700   PMID:15247211   PMID:15367694   PMID:15489334   PMID:15516833   PMID:15782199  
PMID:15894174   PMID:15994315   PMID:16123140   PMID:16126728   PMID:16141072   PMID:16141073   PMID:16258073   PMID:16452087   PMID:16679006   PMID:16717086   PMID:16844343   PMID:16857963  
PMID:16959763   PMID:17170118   PMID:17188031   PMID:17220321   PMID:17303700   PMID:17314097   PMID:17472709   PMID:17608567   PMID:17666435   PMID:17825818   PMID:18006659   PMID:18181173  
PMID:18211894   PMID:18287559   PMID:18432318   PMID:18474609   PMID:18596935   PMID:18715506   PMID:18791203   PMID:18845789   PMID:19129191   PMID:19515997   PMID:19564615   PMID:19704004  
PMID:19750005   PMID:19762425   PMID:19794960   PMID:19818709   PMID:19825976   PMID:20059953   PMID:20100830   PMID:20360068   PMID:20362542   PMID:21157432   PMID:21172653   PMID:21267068  
PMID:21383018   PMID:21514445   PMID:21791616   PMID:21873635   PMID:21987638   PMID:22262169   PMID:22466704   PMID:23055941   PMID:23063725   PMID:23892082   PMID:23892456   PMID:24390425  
PMID:24413018   PMID:24457600   PMID:24899574   PMID:25044020   PMID:26167872   PMID:26496610   PMID:26974206   PMID:28224044   PMID:28378742   PMID:28619992   PMID:28671696   PMID:28706196  
PMID:28712289   PMID:29046336   PMID:29518331   PMID:29551267   PMID:30068389   PMID:30196744   PMID:30457570   PMID:30562941   PMID:30567741   PMID:30912768   PMID:31040226   PMID:31085588  
PMID:31138677   PMID:31586053   PMID:31905853   PMID:32161189   PMID:32325033   PMID:32582689   PMID:32654205   PMID:33095414   PMID:33601422   PMID:34079065   PMID:34911954   PMID:35286657  
PMID:35405096   PMID:36114006   PMID:36293380   PMID:37142655   PMID:38474134   PMID:39366759  


Genomics

Comparative Map Data
Ppp2r1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391721,165,716 - 21,186,167 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1721,165,573 - 21,186,178 (+)EnsemblGRCm39 Ensembl
GRCm381720,945,454 - 20,965,905 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1720,945,311 - 20,965,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv371721,082,418 - 21,102,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361720,650,151 - 20,670,602 (+)NCBIMGSCv36mm8
Celera1721,977,995 - 21,998,451 (+)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map1711.4NCBI
PPP2R1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381952,190,052 - 52,229,518 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1952,170,936 - 52,229,518 (+)EnsemblGRCh38hg38GRCh38
GRCh371952,693,305 - 52,732,771 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361957,385,046 - 57,421,483 (+)NCBINCBI36Build 36hg18NCBI36
Build 341957,385,045 - 57,421,482NCBI
Celera1949,742,609 - 49,779,232 (+)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1949,023,481 - 49,060,103 (+)NCBIHuRef
CHM1_11952,694,941 - 52,731,564 (+)NCBICHM1_1
T2T-CHM13v2.01955,277,246 - 55,316,713 (+)NCBIT2T-CHM13v2.0
Ppp2r1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,213,198 - 69,232,441 (+)NCBIGRCr8
mRatBN7.2160,540,223 - 60,559,467 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl160,540,194 - 60,560,129 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx165,329,720 - 65,348,961 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0174,024,287 - 74,043,556 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,239,755 - 67,258,997 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0160,717,386 - 60,736,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl160,717,386 - 60,736,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0161,883,998 - 61,903,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4158,442,220 - 58,461,462 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1158,458,861 - 58,463,770 (+)NCBI
Celera156,683,597 - 56,702,854 (+)NCBICelera
Cytogenetic Map1q12NCBI
Ppp2r1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955558381,794 - 410,485 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955558381,794 - 410,485 (+)NCBIChiLan1.0ChiLan1.0
PPP2R1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22058,232,259 - 58,268,655 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11960,156,718 - 60,193,105 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01949,133,295 - 49,169,447 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11958,011,383 - 58,047,577 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1958,011,383 - 58,047,577 (+)Ensemblpanpan1.1panPan2
PPP2R1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11104,974,059 - 105,013,745 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1104,974,072 - 105,013,663 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1104,546,959 - 104,586,647 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01105,482,896 - 105,522,584 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1105,481,754 - 105,522,572 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11105,155,353 - 105,195,079 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01104,809,802 - 104,849,707 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01105,597,164 - 105,636,892 (-)NCBIUU_Cfam_GSD_1.0
Ppp2r1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093493,866,510 - 3,896,513 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936901622,888 - 653,044 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936901622,893 - 653,044 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP2R1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl657,921,329 - 57,964,961 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1657,929,520 - 57,964,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2652,233,180 - 52,268,640 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP2R1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,990,402 - 45,026,210 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl644,990,367 - 45,026,227 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607325,047,701 - 25,083,506 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp2r1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,979,320 - 3,011,715 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248322,979,270 - 3,009,189 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp2r1a
145 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1389
Count of miRNA genes:681
Interacting mature miRNAs:842
Transcripts:ENSMUST00000007708, ENSMUST00000136975, ENSMUST00000138971, ENSMUST00000139293, ENSMUST00000147983, ENSMUST00000173359, ENSMUST00000173658
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558807Ceat1_mchronic experimental autoimmune thyroiditis 1 (mouse)Not determined171263668226401133Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17126189355Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17129198453Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171683545533819843Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17129198453Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
4142507Obrq13_mobesity resistance QTL 13 (mouse)Not determined1219832925076769Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17127081639Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125662076Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17485475227715939Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17397489026401133Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17126194456Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17129198453Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17127081639Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse

Markers in Region
AI747698  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381720,965,619 - 20,965,757UniSTSGRCm38
MGSCv371721,102,583 - 21,102,721UniSTSGRCm37
Celera1721,998,165 - 21,998,303UniSTS
Cytogenetic Map17A3.2UniSTS
Whitehead/MRC_RH17293.34UniSTS
D17Jcs128  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381720,964,243 - 20,964,420UniSTSGRCm38
MGSCv371721,101,207 - 21,101,384UniSTSGRCm37
Celera1721,996,785 - 21,996,964UniSTS
Cytogenetic Map17A3.2UniSTS
cM Map17 UniSTS
Ppp2r1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
cM Map17 UniSTS
Ppp2r1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37950,686,271 - 50,686,887UniSTSGRCm37
Celera948,164,522 - 48,165,138UniSTS
cM Map9 UniSTS
BF390652  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381720,955,952 - 20,956,792UniSTSGRCm38
MGSCv371721,092,916 - 21,093,756UniSTSGRCm37
Celera1721,988,501 - 21,989,341UniSTS
Cytogenetic Map17A3.2UniSTS
Ppp2r1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.2UniSTS
Ppp2r1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.2UniSTS
cM Map17 UniSTS
Ppp2r1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A5.3UniSTS
Cytogenetic Map17A3.2UniSTS
cM Map9 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_016891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB021743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC109204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000007708   ⟹   ENSMUSP00000007708
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1721,165,573 - 21,186,178 (+)Ensembl
GRCm38.p6 Ensembl1720,945,311 - 20,965,916 (+)Ensembl
Ensembl Acc Id: ENSMUST00000136975
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1721,179,003 - 21,180,860 (+)Ensembl
GRCm38.p6 Ensembl1720,958,741 - 20,960,598 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138971
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1721,180,752 - 21,181,528 (+)Ensembl
GRCm38.p6 Ensembl1720,960,490 - 20,961,266 (+)Ensembl
Ensembl Acc Id: ENSMUST00000139293
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1721,179,251 - 21,182,204 (+)Ensembl
GRCm38.p6 Ensembl1720,958,989 - 20,961,942 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147983   ⟹   ENSMUSP00000133334
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1721,177,040 - 21,179,771 (+)Ensembl
GRCm38.p6 Ensembl1720,956,778 - 20,959,509 (+)Ensembl
Ensembl Acc Id: ENSMUST00000173359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1721,176,839 - 21,179,099 (+)Ensembl
GRCm38.p6 Ensembl1720,956,577 - 20,958,837 (+)Ensembl
Ensembl Acc Id: ENSMUST00000173658   ⟹   ENSMUSP00000133778
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1721,165,749 - 21,179,046 (+)Ensembl
GRCm38.p6 Ensembl1720,945,487 - 20,958,784 (+)Ensembl
Ensembl Acc Id: ENSMUST00000231928
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1721,185,556 - 21,186,167 (+)Ensembl
GRCm38.p6 Ensembl1720,965,294 - 20,965,905 (+)Ensembl
RefSeq Acc Id: NM_016891   ⟹   NP_058587
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391721,165,716 - 21,186,167 (+)NCBI
GRCm381720,945,454 - 20,965,905 (+)ENTREZGENE
MGSCv371721,082,418 - 21,102,869 (+)RGD
Celera1721,977,995 - 21,998,451 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_058587   ⟸   NM_016891
- UniProtKB: Q76MZ3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000007708   ⟸   ENSMUST00000007708
Ensembl Acc Id: ENSMUSP00000133334   ⟸   ENSMUST00000147983
Ensembl Acc Id: ENSMUSP00000133778   ⟸   ENSMUST00000173658

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q76MZ3-F1-model_v2 AlphaFold Q76MZ3 1-589 view protein structure

Promoters
RGD ID:13674874
Promoter ID:EPDNEW_M21585
Type:initiation region
Name:Ppp2r1a_1
Description:Mus musculus protein phosphatase 2, regulatory subunit A, alpha, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381720,945,455 - 20,945,515EPDNEW
RGD ID:6828502
Promoter ID:MM_KWN:22334
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000039080
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361721,081,976 - 21,082,722 (+)MPROMDB
RGD ID:6828501
Promoter ID:MM_KWN:22335
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver
Transcripts:OTTMUST00000039081
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361721,092,901 - 21,094,052 (+)MPROMDB
RGD ID:6828505
Promoter ID:MM_KWN:22336
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000039082,   OTTMUST00000039084
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361721,095,101 - 21,095,601 (+)MPROMDB
RGD ID:6828503
Promoter ID:MM_KWN:22337
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Liver,   Lung
Transcripts:OTTMUST00000039083
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361721,096,566 - 21,097,652 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1926334 AgrOrtholog
Ensembl Genes ENSMUSG00000007564 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000007708 ENTREZGENE
  ENSMUST00000007708.14 UniProtKB/Swiss-Prot
  ENSMUST00000147983.3 UniProtKB/TrEMBL
  ENSMUST00000173658.8 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEAT_type_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2A_Regulatory_Subunit_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:51792 UniProtKB/Swiss-Prot
MGD MGI:1926334 ENTREZGENE
NCBI Gene 51792 ENTREZGENE
PANTHER PTHR10648:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPP2R1A-like_HEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp2r1a PhenoGen
PROSITE HEAT_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 2AAA_MOUSE UniProtKB/Swiss-Prot
  G3UWL2_MOUSE UniProtKB/TrEMBL
  G3UXQ1_MOUSE UniProtKB/TrEMBL
  Q76MZ3 ENTREZGENE
  Q7TMX2_MOUSE UniProtKB/TrEMBL
  Q8C2E1_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Ppp2r1a  protein phosphatase 2, regulatory subunit A, alpha    protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform  Symbol and/or name change 5135510 APPROVED