Ddc (dopa decarboxylase) - Rat Genome Database

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Gene: Ddc (dopa decarboxylase) Mus musculus
Analyze
Symbol: Ddc
Name: dopa decarboxylase
RGD ID: 10469
MGI Page MGI
Description: Enables aromatic-L-amino-acid decarboxylase activity. Acts upstream of or within gene expression; kidney development; and response to toxic substance. Located in cytoplasm. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Used to study aromatic L-amino acid decarboxylase deficiency. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aa; Aadc; aromatic-L-amino-acid decarboxylase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391111,764,101 - 11,848,144 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1111,764,101 - 11,848,144 (-)EnsemblGRCm39 Ensembl
GRCm381111,814,101 - 11,898,144 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1111,814,101 - 11,898,144 (-)EnsemblGRCm38mm10GRCm38
MGSCv371111,714,104 - 11,798,147 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361111,714,445 - 11,780,657 (-)NCBIMGSCv36mm8
Celera1112,273,377 - 12,350,184 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map117.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (ISO)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-hydroxytryptophan  (ISO)
aflatoxin B1  (EXP,ISO)
aldrin  (EXP)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
andrographolide  (EXP)
antimycin A  (ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benserazide  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
buspirone  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (EXP)
carbidopa  (EXP,ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
cefaloridine  (ISO)
chlorpyrifos  (ISO)
chrysene  (EXP)
cisplatin  (EXP,ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
dioxygen  (ISO)
diquat  (EXP)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
fenpyroximate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glyphosate  (EXP,ISO)
gold atom  (EXP)
gold(0)  (EXP)
homocysteine  (ISO)
indole-3-methanol  (ISO)
isotretinoin  (ISO)
ketanserin  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
levofloxacin  (ISO)
malathion  (ISO)
menadione  (ISO)
metergoline  (EXP)
Mipafox  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
O-methyleugenol  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
pyridoxal 5'-phosphate  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
sarin  (ISO)
sarpogrelate  (EXP,ISO)
scopolamine  (ISO)
Securinine  (ISO)
serotonin  (ISO)
silicon dioxide  (EXP,ISO)
simazine  (EXP,ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
Soman  (ISO)
tamoxifen  (EXP)
tebufenpyrad  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (EXP)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vigabatrin  (ISO)
vorinostat  (ISO)
VX nerve agent  (ISO)
zearalenone  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal dopamine level  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal maternal nurturing  (IAGP)
abnormal motor learning  (IAGP)
abnormal noradrenaline level  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal synaptic neurotransmitter level  (IAGP)
abnormal tooth morphology  (IEA)
akinesia  (IAGP)
albuminuria  (IAGP)
blepharoptosis  (IAGP)
decreased body size  (IAGP)
decreased circulating aldosterone level  (IAGP)
decreased dopamine level  (IAGP)
decreased embryo size  (IAGP)
decreased heart rate  (IAGP)
decreased locomotor activity  (IAGP)
decreased renin activity  (IAGP)
decreased serotonin level  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
delayed eyelid opening  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
impaired adaptive thermogenesis  (IAGP)
impaired coordination  (IAGP)
increased anxiety-related response  (IAGP)
increased circulating creatinine level  (IAGP)
increased heart weight  (IAGP)
increased kidney weight  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased renin activity  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased thigmotaxis  (IAGP)
increased vertical activity  (IAGP)
induced hyperactivity  (IAGP)
jerky movement  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
limb grasping  (IAGP)
oxidative stress  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
reduced female fertility  (IAGP)
salt-sensitive hypertension  (IAGP)
tremors  (IAGP)
tubulointerstitial nephritis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mutations in the human aromatic L-amino acid decarboxylase gene J. Inherit. Metab. Dis. 21: 4 only, 1998.
2. Possible parent-of-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder. Borglum AD, etal., Am J Med Genet B Neuropsychiatr Genet 2003 Feb;117(1):18-22.
3. Clinical and biochemical features of aromatic L-amino acid decarboxylase deficiency. Brun L, etal., Neurology. 2010 Jul 6;75(1):64-71. Epub 2010 May 26.
4. Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension. Coll M, etal., J Hepatol. 2008 Jul;49(1):43-51. Epub 2008 Apr 18.
5. A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study. DasBanerjee T, etal., Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1554-63.
6. Congenital hyperinsulinism: pancreatic fluoro-L-dihydroxyphenylalanine (DOPA) positron emission tomography and immunohistochemistry study of DOPA decarboxylase and insulin secretion. de Lonlay P, etal., J Clin Endocrinol Metab. 2006 Mar;91(3):933-40. Epub 2006 Jan 10.
7. Degeneration of dopaminergic neurons triggers an expression of individual enzymes of dopamine synthesis in non-dopaminergic neurons of the arcuate nucleus in adult rats. Ershov PV, etal., J Chem Neuroanat. 2005 Jul;30(1):27-33.
8. Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors. Fan DS, etal., Hum Gene Ther. 1998 Nov 20;9(17):2527-35.
9. The roles of striatal serotonin and L -amino-acid decarboxylase on L-DOPA-induced Dyskinesia in a Hemiparkinsonian rat model. Gil S, etal., Cell Mol Neurobiol. 2010 Aug;30(6):817-25. Epub 2010 Mar 16.
10. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
11. Catecholaminergic systems in stress: structural and molecular genetic approaches. Kvetnansky R, etal., Physiol Rev. 2009 Apr;89(2):535-606.
12. Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. Ma JZ, etal., Hum Mol Genet. 2005 Jun 15;14(12):1691-8. doi: 10.1093/hmg/ddi177. Epub 2005 May 6.
13. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. MGD IEA MGD IEA
16. Renal dopaminergic system activity in rat remnant kidney up to twenty-six weeks after surgery. Moreira-Rodrigues M, etal., Life Sci. 2009 Mar 27;84(13-14):409-14. Epub 2009 Jan 8.
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Blunted renal dopaminergic system activity in puromycin aminonucleoside-induced nephrotic syndrome. Sampaio-Maia B, etal., Nephrol Dial Transplant. 2006 Feb;21(2):314-23. Epub 2005 Oct 4.
25. Effects of benserazide on L-DOPA-derived extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats. Shen H, etal., Tohoku J Exp Med. 2003 Mar;199(3):149-59.
26. Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans. Yu Y, etal., Hum Mol Genet. 2006 Jul 15;15(14):2192-9. doi: 10.1093/hmg/ddl144. Epub 2006 Jun 1.
27. DOPA decarboxylase gene is associated with nicotine dependence. Zhang H, etal., Pharmacogenomics. 2006 Dec;7(8):1159-66. doi: 10.2217/14622416.7.8.1159.
Additional References at PubMed
PMID:1497675   PMID:7904615   PMID:8199405   PMID:8499653   PMID:9520484   PMID:9712661   PMID:10349636   PMID:10591541   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12546819  
PMID:12915123   PMID:14610273   PMID:14622207   PMID:14681479   PMID:14973278   PMID:15207355   PMID:15226823   PMID:15584907   PMID:16141072   PMID:16141073   PMID:16396906   PMID:16602821  
PMID:16870172   PMID:17211625   PMID:17481897   PMID:17592014   PMID:17596284   PMID:17967881   PMID:18310457   PMID:18554416   PMID:18799693   PMID:19008461   PMID:19144721   PMID:19174477  
PMID:19542360   PMID:19692620   PMID:20016108   PMID:20080794   PMID:20456015   PMID:20818386   PMID:21192082   PMID:21270893   PMID:21322090   PMID:21512572   PMID:21677750   PMID:21701066  
PMID:21873635   PMID:21880902   PMID:22013016   PMID:22169008   PMID:22200605   PMID:22278924   PMID:22537018   PMID:22688335   PMID:22718343   PMID:22748019   PMID:22829864   PMID:23010799  
PMID:23264561   PMID:23275025   PMID:23637192   PMID:23863468   PMID:23863478   PMID:24066094   PMID:24154693   PMID:24682237   PMID:24952961   PMID:24972638   PMID:25940069   PMID:26377344  
PMID:26542012   PMID:26879466   PMID:27238716   PMID:27287879   PMID:27658936   PMID:28031476   PMID:28174244   PMID:28973165   PMID:30188322   PMID:30766478   PMID:30916783   PMID:30930745  
PMID:32094113   PMID:32499648   PMID:32522342   PMID:34239874   PMID:34564702   PMID:35263575   PMID:36108632   PMID:36568970   PMID:37045597   PMID:37601086  


Genomics

Comparative Map Data
Ddc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391111,764,101 - 11,848,144 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1111,764,101 - 11,848,144 (-)EnsemblGRCm39 Ensembl
GRCm381111,814,101 - 11,898,144 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1111,814,101 - 11,898,144 (-)EnsemblGRCm38mm10GRCm38
MGSCv371111,714,104 - 11,798,147 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361111,714,445 - 11,780,657 (-)NCBIMGSCv36mm8
Celera1112,273,377 - 12,350,184 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map117.09NCBI
DDC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38750,458,442 - 50,565,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl750,458,436 - 50,565,405 (-)EnsemblGRCh38hg38GRCh38
GRCh37750,526,140 - 50,633,102 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36750,493,628 - 50,600,648 (-)NCBINCBI36Build 36hg18NCBI36
Build 34750,300,344 - 50,402,960NCBI
Celera750,591,055 - 50,698,048 (-)NCBICelera
Cytogenetic Map7p12.2-p12.1NCBI
HuRef750,376,100 - 50,483,099 (-)NCBIHuRef
CHM1_1750,528,427 - 50,635,428 (-)NCBICHM1_1
T2T-CHM13v2.0750,619,658 - 50,726,621 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2750,532,205 - 50,639,203 (-)NCBI
Ddc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81490,592,304 - 90,682,830 (-)NCBIGRCr8
mRatBN7.21486,378,685 - 86,469,189 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1486,378,685 - 86,469,208 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1490,784,649 - 90,875,109 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01492,028,980 - 92,119,440 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01488,496,613 - 88,587,081 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01491,905,919 - 91,996,816 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1491,905,919 - 91,996,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01491,689,894 - 91,793,700 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41492,698,636 - 92,788,635 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11492,714,598 - 92,790,197 (-)NCBI
Celera1485,380,254 - 85,470,515 (-)NCBICelera
RH 3.4 Map14636.18RGD
Cytogenetic Map14q21NCBI
Ddc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554563,513,042 - 3,582,911 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554563,513,779 - 3,582,851 (+)NCBIChiLan1.0ChiLan1.0
DDC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2655,337,405 - 55,437,974 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17103,662,348 - 103,762,697 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0751,101,169 - 51,206,031 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1751,345,228 - 51,449,710 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl751,345,228 - 51,449,710 (-)Ensemblpanpan1.1panPan2
DDC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1181,802,239 - 1,876,714 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl181,803,273 - 1,867,616 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha181,793,310 - 1,867,692 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0181,860,735 - 1,935,186 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl181,860,735 - 1,933,298 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1181,833,628 - 1,907,793 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0181,830,057 - 1,904,284 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0181,966,951 - 2,041,333 (-)NCBIUU_Cfam_GSD_1.0
Ddc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118105,117,869 - 105,222,691 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366861,301,207 - 1,405,384 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366861,322,153 - 1,405,434 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9136,496,365 - 136,571,212 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19136,496,364 - 136,571,220 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29150,076,907 - 150,157,225 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DDC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,235,396 - 8,343,086 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,235,343 - 8,343,361 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606213,938,028 - 14,045,297 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247403,674,609 - 3,732,676 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247403,674,727 - 3,732,058 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ddc
2501 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1162
Count of miRNA genes:586
Interacting mature miRNAs:705
Transcripts:ENSMUST00000066237, ENSMUST00000109659, ENSMUST00000122971, ENSMUST00000134121, ENSMUST00000134401, ENSMUST00000136810, ENSMUST00000145033, ENSMUST00000146359, ENSMUST00000155690, ENSMUST00000178704
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
1357518Tgyl1_mtriglyceride level 1 (mouse)Not determined11688027733916219Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226794Feml9_mfemur length 9, 5 week (mouse)11705000016750000Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse

Markers in Region
Ddc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371111,714,460 - 11,715,248UniSTSGRCm37
Celera1112,273,733 - 12,274,521UniSTS
Cytogenetic Map11A1-A4UniSTS
cM Map117.0UniSTS
Ddc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1-A4UniSTS
cM Map117.0UniSTS
Ddc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1-A4UniSTS
Ddc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1-A4UniSTS
Ddc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381111,814,457 - 11,815,245UniSTSGRCm38
MGSCv371111,714,460 - 11,715,248UniSTSGRCm37
Celera1112,273,733 - 12,274,521UniSTS
Cytogenetic Map11A1-A4UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001190448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001417457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001417458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001417459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA986109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF012881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF012882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF071068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY373760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY129740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000066237   ⟹   ENSMUSP00000068525
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,764,101 - 11,848,044 (-)Ensembl
GRCm38.p6 Ensembl1111,814,101 - 11,898,044 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109659   ⟹   ENSMUSP00000105286
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,764,103 - 11,840,408 (-)Ensembl
GRCm38.p6 Ensembl1111,814,103 - 11,890,408 (-)Ensembl
RefSeq Acc Id: ENSMUST00000122971
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,794,977 - 11,814,907 (-)Ensembl
GRCm38.p6 Ensembl1111,844,977 - 11,864,907 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134121
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,825,276 - 11,840,398 (-)Ensembl
GRCm38.p6 Ensembl1111,875,276 - 11,890,398 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134401
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,769,351 - 11,786,280 (-)Ensembl
GRCm38.p6 Ensembl1111,819,351 - 11,836,280 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136810
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,764,103 - 11,772,921 (-)Ensembl
GRCm38.p6 Ensembl1111,814,103 - 11,822,921 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145033
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,823,337 - 11,830,629 (-)Ensembl
GRCm38.p6 Ensembl1111,873,337 - 11,880,629 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,811,841 - 11,840,401 (-)Ensembl
GRCm38.p6 Ensembl1111,861,841 - 11,890,401 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155690   ⟹   ENSMUSP00000121096
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,796,658 - 11,840,369 (-)Ensembl
GRCm38.p6 Ensembl1111,846,658 - 11,890,369 (-)Ensembl
RefSeq Acc Id: ENSMUST00000178704   ⟹   ENSMUSP00000136467
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,764,101 - 11,848,144 (-)Ensembl
GRCm38.p6 Ensembl1111,814,101 - 11,898,144 (-)Ensembl
RefSeq Acc Id: NM_001190448   ⟹   NP_001177377
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391111,764,101 - 11,848,144 (-)NCBI
GRCm381111,814,101 - 11,898,144 (-)ENTREZGENE
MGSCv371111,714,104 - 11,798,147 (-)RGD
Celera1112,273,377 - 12,350,184 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001417457   ⟹   NP_001404386
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391111,764,101 - 11,832,294 (-)NCBI
RefSeq Acc Id: NM_001417458   ⟹   NP_001404387
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391111,764,101 - 11,831,146 (-)NCBI
RefSeq Acc Id: NM_001417459   ⟹   NP_001404388
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391111,764,101 - 11,830,965 (-)NCBI
RefSeq Acc Id: NM_016672   ⟹   NP_057881
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391111,764,101 - 11,840,401 (-)NCBI
GRCm381111,814,101 - 11,890,408 (-)NCBI
MGSCv371111,714,104 - 11,798,147 (-)RGD
Celera1112,273,377 - 12,350,184 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_057881   ⟸   NM_016672
- UniProtKB: O88533 (UniProtKB/Swiss-Prot),   Q5SUV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177377   ⟸   NM_001190448
- UniProtKB: O88533 (UniProtKB/Swiss-Prot),   Q5SUV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000068525   ⟸   ENSMUST00000066237
RefSeq Acc Id: ENSMUSP00000136467   ⟸   ENSMUST00000178704
RefSeq Acc Id: ENSMUSP00000105286   ⟸   ENSMUST00000109659
RefSeq Acc Id: ENSMUSP00000121096   ⟸   ENSMUST00000155690
RefSeq Acc Id: NP_001404386   ⟸   NM_001417457
- UniProtKB: O88533 (UniProtKB/Swiss-Prot),   Q5SUV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001404387   ⟸   NM_001417458
- UniProtKB: O88533 (UniProtKB/Swiss-Prot),   Q5SUV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001404388   ⟸   NM_001417459
- UniProtKB: O88533 (UniProtKB/Swiss-Prot),   Q5SUV8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88533-F1-model_v2 AlphaFold O88533 1-480 view protein structure

Promoters
RGD ID:6820703
Promoter ID:MM_KWN:6453
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000011546
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361111,722,331 - 11,722,831 (-)MPROMDB
RGD ID:6820702
Promoter ID:MM_KWN:6459
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:ENSMUST00000066237,   UC007IAX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361111,797,764 - 11,798,264 (-)MPROMDB
RGD ID:8673970
Promoter ID:EPDNEW_M15016
Type:multiple initiation site
Name:Ddc_3
Description:Mus musculus dopa decarboxylase , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15018  EPDNEW_M15019  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381111,822,953 - 11,823,013EPDNEW
RGD ID:8673974
Promoter ID:EPDNEW_M15018
Type:initiation region
Name:Ddc_1
Description:Mus musculus dopa decarboxylase , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15016  EPDNEW_M15019  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381111,890,401 - 11,890,461EPDNEW
RGD ID:8673976
Promoter ID:EPDNEW_M15019
Type:initiation region
Name:Ddc_2
Description:Mus musculus dopa decarboxylase , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15016  EPDNEW_M15018  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381111,898,144 - 11,898,204EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:94876 AgrOrtholog
Ensembl Genes ENSMUSG00000020182 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000066237.10 UniProtKB/Swiss-Prot
  ENSMUST00000109659 ENTREZGENE
  ENSMUST00000109659.9 UniProtKB/Swiss-Prot
  ENSMUST00000155690.2 UniProtKB/TrEMBL
  ENSMUST00000178704 ENTREZGENE
  ENSMUST00000178704.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dopa decarboxylase, N-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aromatic_deC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_de-COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyridoxal-P_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13195 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:94876 ENTREZGENE
NCBI Gene 13195 ENTREZGENE
PANTHER AROMATIC-L-AMINO-ACID DECARBOXYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pyridoxal_deC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DDC RGD
PhenoGen Ddc PhenoGen
PRINTS YHDCRBOXLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DDC_GAD_HDC_YDC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DDC_MOUSE UniProtKB/Swiss-Prot
  O35958_MOUSE UniProtKB/TrEMBL
  O88533 ENTREZGENE
  Q3TUH2_MOUSE UniProtKB/TrEMBL
  Q5SUV8 ENTREZGENE, UniProtKB/TrEMBL
  Q5SUV9_MOUSE UniProtKB/TrEMBL