Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of UNKL mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of UNKL mRNA | CTD | PMID:20404318 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of UNKL mRNA | CTD | PMID:21570461 | 2-palmitoylglycerol | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of UNKL mRNA | CTD | PMID:37199045 | 3,3',5,5'-tetrabromobisphenol A | increases expression | ISO | Unkl (Rattus norvegicus) | 6480464 | tetrabromobisphenol A results in increased expression of UNKL mRNA | CTD | PMID:27914987 | 6-propyl-2-thiouracil | decreases expression | ISO | Unkl (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of UNKL mRNA | CTD | PMID:30047161 | acrylamide | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | Acrylamide results in increased expression of UNKL mRNA | CTD | PMID:32763439 | amitrole | decreases expression | ISO | Unkl (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of UNKL mRNA | CTD | PMID:30047161 | arsane | affects methylation | ISO | UNKL (Homo sapiens) | 6480464 | Arsenic affects the methylation of UNKL gene | CTD | PMID:25304211 | arsane | decreases methylation | ISO | UNKL (Homo sapiens) | 6480464 | Arsenic results in decreased methylation of UNKL promoter | CTD | PMID:31135185 | arsenic atom | affects methylation | ISO | UNKL (Homo sapiens) | 6480464 | Arsenic affects the methylation of UNKL gene | CTD | PMID:25304211 | arsenic atom | decreases methylation | ISO | UNKL (Homo sapiens) | 6480464 | Arsenic results in decreased methylation of UNKL promoter | CTD | PMID:31135185 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of UNKL mRNA | CTD | PMID:19770486 and PMID:21715664 | benzo[a]pyrene | decreases methylation | EXP | | 6480464 | Benzo(a)pyrene results in decreased methylation of UNKL exon and Benzo(a)pyrene results in decreased methylation of UNKL intron | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | UNKL (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of UNKL 3' UTR and Benzo(a)pyrene affects the methylation of UNKL promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | UNKL (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of UNKL 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of UNKL mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene diol epoxide I | decreases expression | ISO | UNKL (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | benzo[e]pyrene | increases methylation | ISO | UNKL (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of UNKL intron | CTD | PMID:30157460 | beta-naphthoflavone | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | beta-Naphthoflavone results in increased expression of UNKL mRNA | CTD | PMID:32858204 | bisphenol A | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of UNKL gene | CTD | PMID:31601247 | bortezomib | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | Bortezomib results in increased expression of UNKL mRNA | CTD | PMID:20977926 | butanal | decreases expression | ISO | UNKL (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of UNKL mRNA | CTD | PMID:26079696 | cadmium dichloride | increases expression | ISO | Unkl (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased expression of UNKL mRNA | CTD | PMID:33453195 | cadmium dichloride | affects expression | ISO | UNKL (Homo sapiens) | 6480464 | Cadmium Chloride affects the expression of UNKL mRNA | CTD | PMID:25596134 | chlorpromazine | decreases expression | ISO | Unkl (Rattus norvegicus) | 6480464 | Chlorpromazine results in decreased expression of UNKL mRNA | CTD | PMID:25596134 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of UNKL mRNA | CTD | PMID:37019170 | cidofovir anhydrous | affects expression | ISO | UNKL (Homo sapiens) | 6480464 | Cidofovir affects the expression of UNKL mRNA | CTD | PMID:25596134 | cisplatin | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of UNKL mRNA | CTD | PMID:27392435 | clodronic acid | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | Clodronic Acid results in increased expression of UNKL mRNA | CTD | PMID:25596134 | cobalt dichloride | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of UNKL mRNA | CTD | PMID:19376846 | copper(II) chloride | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | cupric chloride results in increased expression of UNKL mRNA | CTD | PMID:17211630 | copper(II) sulfate | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of UNKL mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of UNKL mRNA | CTD | PMID:20106945 and PMID:25596134 | cyclosporin A | decreases expression | ISO | Unkl (Rattus norvegicus) | 6480464 | Cyclosporine results in decreased expression of UNKL mRNA | CTD | PMID:25596134 | dicrotophos | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | dicrotophos results in increased expression of UNKL mRNA | CTD | PMID:28302478 | dioxygen | affects expression | ISO | UNKL (Homo sapiens) | 6480464 | Oxygen deficiency affects the expression of UNKL mRNA | CTD | PMID:25596134 | diquat | decreases expression | EXP | | 6480464 | Diquat results in decreased expression of UNKL protein | CTD | PMID:36851058 | dorsomorphin | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of UNKL mRNA | CTD | PMID:30319688 | flutamide | increases expression | ISO | Unkl (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of UNKL mRNA | CTD | PMID:24136188 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of UNKL mRNA | CTD | PMID:25629700 | FR900359 | increases phosphorylation | ISO | UNKL (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of UNKL protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of UNKL gene | CTD | PMID:31601247 | ifosfamide | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | Ifosfamide results in increased expression of UNKL mRNA | CTD | PMID:25596134 | lead(0) | decreases expression | ISO | UNKL (Homo sapiens) | 6480464 | Lead results in decreased expression of UNKL mRNA | CTD | PMID:19921347 | lipopolysaccharide | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | mercury dibromide | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of UNKL mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNKL mRNA | CTD | PMID:27188386 | metformin | decreases expression | ISO | Unkl (Rattus norvegicus) | 6480464 | Metformin results in decreased expression of UNKL mRNA | CTD | PMID:25596134 | methapyrilene | increases methylation | ISO | UNKL (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of UNKL intron | CTD | PMID:30157460 | methimazole | decreases expression | ISO | Unkl (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of UNKL mRNA | CTD | PMID:30047161 | methylmercury chloride | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of UNKL mRNA | CTD | PMID:23179753 more ... | methylmercury chloride | decreases expression | ISO | UNKL (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of UNKL mRNA | CTD | PMID:28001369 | N-ethyl-N-nitrosourea | increases mutagenesis | EXP | | 6480464 | Ethylnitrosourea results in increased mutagenesis of UNKL gene | CTD | PMID:27776689 | nefazodone | increases expression | ISO | Unkl (Rattus norvegicus) | 6480464 | nefazodone results in increased expression of UNKL mRNA | CTD | PMID:24136188 | orphenadrine | affects expression | ISO | Unkl (Rattus norvegicus) | 6480464 | Orphenadrine affects the expression of UNKL mRNA | CTD | PMID:23665939 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of UNKL mRNA | CTD | PMID:34911549 | ozone | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of UNKL mRNA | CTD | PMID:35430440 | p-chloromercuribenzoic acid | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in increased expression of UNKL mRNA | CTD | PMID:26272509 | p-chloromercuribenzoic acid | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNKL mRNA | CTD | PMID:27188386 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of UNKL mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of UNKL mRNA | CTD | PMID:21420995 | paracetamol | decreases expression | ISO | UNKL (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of UNKL mRNA | CTD | PMID:22230336 | phenylmercury acetate | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNKL mRNA | CTD | PMID:27188386 | potassium dichromate | decreases expression | EXP | | 6480464 | Potassium Dichromate results in decreased expression of UNKL mRNA | CTD | PMID:23608068 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silver atom | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | Silver results in increased expression of UNKL mRNA | CTD | PMID:26014281 | silver(0) | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | Silver results in increased expression of UNKL mRNA | CTD | PMID:26014281 | sodium arsenite | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of UNKL mRNA | CTD | PMID:25493608 and PMID:29301061 | sulfadimethoxine | decreases expression | ISO | Unkl (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in decreased expression of UNKL mRNA | CTD | PMID:30047161 | sulforaphane | increases expression | ISO | UNKL (Homo sapiens) | 6480464 | sulforaphane results in increased expression of UNKL mRNA | CTD | PMID:31838189 | trichostatin A | decreases expression | ISO | UNKL (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of UNKL mRNA | CTD | PMID:24935251 | trovafloxacin | increases expression | EXP | | 6480464 | trovafloxacin results in increased expression of UNKL mRNA | CTD | PMID:35537566 | valdecoxib | increases expression | ISO | Unkl (Rattus norvegicus) | 6480464 | valdecoxib results in increased expression of UNKL mRNA | CTD | PMID:24136188 | valproic acid | increases methylation | ISO | UNKL (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of UNKL gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | UNKL (Homo sapiens) | 6480464 | Valproic Acid affects the expression of UNKL mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | UNKL (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of UNKL mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | UNKL (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UNKL mRNA | CTD | PMID:27188386 | | 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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 3. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 4. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 5. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:12477932 | PMID:12520002 | PMID:14610273 | PMID:15489334 | PMID:16141072 | PMID:16141073 | PMID:17967808 | PMID:18799693 |
| PMID:21267068 | PMID:21873635 | PMID:25210733 | PMID:31138677 | PMID:34381067 |
Genomics
Comparative Map Data
| Unkl (Mus musculus - house mouse) |
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| UNKL (Homo sapiens - human) |
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| Unkl (Rattus norvegicus - Norway rat) |
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| Unkl (Chinchilla lanigera - long-tailed chinchilla) |
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| UNKL (Pan paniscus - bonobo/pygmy chimpanzee) |
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| UNKL (Canis lupus familiaris - dog) |
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| Unkl (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| UNKL (Sus scrofa - pig) |
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| UNKL (Chlorocebus sabaeus - green monkey) |
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| Unkl (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Unkl
1275 total Variants 
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