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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735816
Species: Mus musculus
RGD Object: Gene
Symbol: Slc22a3
Name: solute carrier family 22 (organic cation transporter), member 3
Acc ID: CHEBI:4636
Term: diphenhydramine
Definition: An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
Chemical ID: MESH:D004155
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a3multiple interactionsISOSLC22A3 (Homo sapiens)6480464CTDDiphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]PMID:16263091
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