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Gene: Gdnf (glial cell line derived neurotrophic factor) Mus musculus
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Symbol: Gdnf
Name: glial cell line derived neurotrophic factor
Description: Predicted to have protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including nephron epithelium morphogenesis; nervous system development; and positive regulation of animal organ morphogenesis. Predicted to localize to Golgi apparatus; extracellular space; and receptor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in Hirschsprung's disease; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Orthologous to human GDNF (glial cell derived neurotrophic factor).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI385739; astrocyte-derived trophic factor; ATF; glial cell line-derived neurotrophic factor; mGDNF; neurotrophic factor
Orthologs:
Homo sapiens (human) : GDNF (glial cell derived neurotrophic factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gdnf (glial cell derived neurotrophic factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gdnf (glial cell derived neurotrophic factor)
Pan paniscus (bonobo/pygmy chimpanzee) : GDNF (glial cell derived neurotrophic factor)
Canis lupus familiaris (dog) : GDNF (glial cell derived neurotrophic factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gdnf (glial cell derived neurotrophic factor)
Sus scrofa (pig) : GDNF (glial cell derived neurotrophic factor)
Chlorocebus sabaeus (African green monkey) : GDNF (glial cell derived neurotrophic factor)
Heterocephalus glaber (naked mole-rat) : Gdnf (glial cell derived neurotrophic factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl157,810,846 - 7,837,575 (+)EnsemblGRCm38mm10GRCm38
GRCm38157,810,048 - 7,837,580 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37157,761,011 - 7,787,575 (+)NCBIGRCm37mm9NCBIm37
MGSCv36157,758,226 - 7,784,790 (+)NCBImm8
Celera157,656,819 - 7,683,345 (+)NCBICelera
Cytogenetic Map15A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Gdnf
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10631
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.