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Gene: Gdnf (glial cell line derived neurotrophic factor) Mus musculus
Symbol: Gdnf
Name: glial cell line derived neurotrophic factor
Description: Predicted to have protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including nephron epithelium morphogenesis; nervous system development; and positive regulation of animal organ morphogenesis. Predicted to localize to Golgi apparatus; extracellular space; and receptor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in Hirschsprung's disease; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Orthologous to human GDNF (glial cell derived neurotrophic factor).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI385739; astrocyte-derived trophic factor; ATF; glial cell line-derived neurotrophic factor; mGDNF; neurotrophic factor
Homo sapiens (human) : GDNF (glial cell derived neurotrophic factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gdnf (glial cell derived neurotrophic factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gdnf (glial cell derived neurotrophic factor)
Pan paniscus (bonobo/pygmy chimpanzee) : GDNF (glial cell derived neurotrophic factor)
Canis lupus familiaris (dog) : GDNF (glial cell derived neurotrophic factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gdnf (glial cell derived neurotrophic factor)
Sus scrofa (pig) : GDNF (glial cell derived neurotrophic factor)
Chlorocebus sabaeus (African green monkey) : GDNF (glial cell derived neurotrophic factor)
Heterocephalus glaber (naked mole-rat) : Gdnf (glial cell derived neurotrophic factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl157,810,846 - 7,837,575 (+)EnsemblGRCm38mm10GRCm38
GRCm38157,810,048 - 7,837,580 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37157,761,011 - 7,787,575 (+)NCBIGRCm37mm9NCBIm37
MGSCv36157,758,226 - 7,784,790 (+)NCBImm8
Celera157,656,819 - 7,683,345 (+)NCBICelera
Cytogenetic Map15A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gdnf
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10631
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.