Gdnf (glial cell line derived neurotrophic factor) - Rat Genome Database

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Gene: Gdnf (glial cell line derived neurotrophic factor) Mus musculus
Analyze
Symbol: Gdnf
Name: glial cell line derived neurotrophic factor
RGD ID: 10631
MGI Page MGI
Description: Predicted to enable protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including kidney development; nervous system development; and positive regulation of morphogenesis of an epithelium. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; nephron epithelium morphogenesis; and peristalsis. Predicted to be located in Golgi apparatus and extracellular region. Predicted to be part of receptor complex. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Parkinsonism; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Orthologous to human GDNF (glial cell derived neurotrophic factor).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI385739; astrocyte-derived trophic factor; ATF; glial cell line-derived neurotrophic factor; mGDNF; neurotrophic factor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39157,839,529 - 7,867,061 (+)NCBIGRCm39mm39
GRCm39 Ensembl157,840,327 - 7,867,056 (+)Ensembl
GRCm38157,810,048 - 7,837,580 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl157,810,846 - 7,837,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37157,761,011 - 7,787,575 (+)NCBIGRCm37mm9NCBIm37
MGSCv36157,758,226 - 7,784,790 (+)NCBImm8
Celera157,656,819 - 7,683,345 (+)NCBICelera
Cytogenetic Map15A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-Salsolinol  (ISO)
(S)-AMPA  (ISO)
(S)-amphetamine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
13,14-dihydro-Delta(12)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
4,4'-sulfonyldiphenol  (EXP)
acetamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
agathisflavone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
ammonium chloride  (ISO)
amphetamine  (EXP,ISO)
apigenin  (ISO)
apomorphine  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromocriptine  (EXP)
busulfan  (EXP)
buta-1,3-diene  (EXP)
butanal  (ISO)
cabergoline  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
chondroitin sulfate  (ISO)
chrysin  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
dabigatran  (ISO)
DDE  (ISO)
dermatan sulfate  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
disodium selenite  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
echinacoside  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
excitatory amino acid agonist  (ISO)
fenvalerate  (ISO)
fisetin  (ISO)
fluoranthene  (EXP)
fluoxetine  (ISO)
folpet  (EXP)
furan  (ISO)
genistein  (EXP)
geraniol  (EXP)
hydrogen peroxide  (EXP)
indole-3-methanol  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
L-ascorbic acid  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
manganese(II) chloride  (ISO)
Mazindol  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
oxidopamine  (EXP,ISO)
paraquat  (EXP,ISO)
pergolide  (EXP)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP)
puerarin  (ISO)
rasagiline  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
rutin  (ISO)
salvianolic acid B  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
SKF 38393  (EXP)
sodium arsenite  (EXP,ISO)
sulfasalazine  (ISO)
telmisartan  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trichloroethene  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
vanoxerine dihydrochloride  (ISO)
vinclozolin  (ISO)
zearalenone  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in ureteric bud morphogenesis  (IDA,IMP)
cell population proliferation  (ISO)
cellular response to dexamethasone stimulus  (ISO)
commissural neuron axon guidance  (IGI)
dorsal spinal cord development  (IMP)
embryonic organ development  (IMP)
enteric nervous system development  (IDA,IMP)
male gonad development  (ISO)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (IEP,ISO)
metanephros development  (IGI,IMP)
midbrain development  (ISO)
mRNA stabilization  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of neuron apoptotic process  (IBA,IMP,ISO)
nervous system development  (IMP)
neural crest cell migration  (ISO)
neural crest cell migration involved in autonomic nervous system development  (ISO)
neuron differentiation  (ISO)
neuron projection development  (ISO)
organ induction  (IGI)
peripheral nervous system development  (IBA,IMP)
peristalsis  (IMP)
positive regulation of branching involved in ureteric bud morphogenesis  (IBA,IMP,ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (IMP)
positive regulation of monooxygenase activity  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of ureteric bud formation  (ISO)
postganglionic parasympathetic fiber development  (IMP)
postsynaptic membrane organization  (IDA)
regulation of dopamine uptake involved in synaptic transmission  (ISO)
regulation of gene expression  (ISO)
regulation of morphogenesis of a branching structure  (IDA)
regulation of semaphorin-plexin signaling pathway  (IGI)
regulation of ureteric bud formation  (ISO)
response to wounding  (ISO)
retina development in camera-type eye  (ISO)
sympathetic nervous system development  (IMP)
transforming growth factor beta receptor signaling pathway  (TAS)
transmembrane receptor protein tyrosine kinase signaling pathway  (TAS)
ureteric bud development  (IDA,IGI)
ureteric bud formation  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal brain morphology  (IAGP)
abnormal carotid body morphology  (IAGP)
abnormal cholinergic neuron morphology  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal dorsal striatum morphology  (IAGP)
abnormal enteric cholinergic neuron morphology  (IAGP)
abnormal enteric ganglia morphology  (IAGP)
abnormal enteric nervous system morphology  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal glomerular capillary endothelium morphology  (IAGP)
abnormal innervation pattern to muscle  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal locus ceruleus morphology  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal motor neuron innervation pattern  (IAGP)
abnormal muscle spindle morphology  (IAGP)
abnormal myenteric nerve plexus morphology  (IAGP)
abnormal neurotransmitter secretion  (IAGP)
abnormal ovary topology  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal renal corpuscle morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal spinal cord lateral motor column morphology  (IAGP)
abnormal spinal nerve morphology  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal submucous nerve plexus morphology  (IAGP)
abnormal substantia nigra morphology  (IAGP)
abnormal superior cervical ganglion morphology  (IAGP)
abnormal tegmentum morphology  (IAGP)
abnormal ureter morphology  (IAGP)
abnormal ureteric bud invasion  (IAGP)
abnormal ureteric bud morphology  (IAGP)
abnormal ventral striatum morphology  (IAGP)
absent enteric neurons  (IAGP)
absent kidney  (IAGP)
absent ureter  (IAGP)
absent ureteric bud  (IAGP)
chronic constipation  (IAGP)
decreased glomerular capillary number  (IAGP)
decreased kidney weight  (IAGP)
decreased motor neuron number  (IAGP)
decreased nephron number  (IAGP)
decreased podocyte number  (IAGP)
decreased renal glomerulus number  (IAGP)
distended duodenum  (IAGP)
distended stomach  (IAGP)
fused podocyte foot processes  (IAGP)
hypoactivity  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
increased compensatory renal growth  (IAGP)
increased kidney cell proliferation  (IAGP)
increased kidney weight  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased mesangial cell number  (IAGP)
increased renal glomerulus basement membrane thickness  (IAGP)
intestinal hypoperistalsis  (IAGP)
kidney cortex cysts  (IAGP)
megacolon  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
pyloric stenosis  (IAGP)
renal glomerulus hypertrophy  (IAGP)
renal hypoplasia  (IAGP)
renal interstitial fibrosis  (IAGP)
single kidney  (IAGP)
small dorsal root ganglion  (IAGP)
small kidney  (IAGP)
tubulointerstitial nephritis  (IAGP)
References

References - curated
1. Airavaara M, etal., J Biol Chem. 2011 Dec 30;286(52):45093-102. Epub 2011 Nov 11.
2. Backman CM, etal., Mol Cell Endocrinol. 2006 Jun 27;252(1-2):160-6. Epub 2006 Apr 27.
3. Cheng Q, etal., Neurosci Lett. 2008 Jul 4;439(1):24-9. Epub 2008 May 1.
4. Hoke A, etal., Neuroreport. 2000 Jun 5;11(8):1651-4.
5. Impellizzeri D, etal., Biochem Pharmacol. 2012 Feb 8.
6. Isajevs S, etal., Medicina (Kaunas). 2011;47(10):552-9.
7. Kanter-Schlifke I, etal., Exp Neurol. 2009 Apr;216(2):413-9. Epub 2009 Jan 7.
8. Kramer F, etal., J Neurooncol. 2010 May;98(1):31-9. doi: 10.1007/s11060-009-0063-6. Epub 2009 Nov 25.
9. Lei Z, etal., J Neuropathol Exp Neurol. 2011 Sep;70(9):736-47.
10. Lindqvist N, etal., Exp Neurol. 2004 Jun;187(2):487-99.
11. MGD and Homologene mouse data transfer
12. MGD data from the GO Consortium
13. MGD IEA
14. Milbrandt J, etal., Neuron 1998 Feb;20(2):245-53.
15. OMIM Disease Annotation Pipeline
16. Online Mendelian Inheritance in Man, OMIM (TM).
17. RGD automated import pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. Sellner J, etal., Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):267-71. Epub 2005 Apr 22.
21. Sokolov ME, etal., Front Pharmacol. 2018 Feb 15;9:111. doi: 10.3389/fphar.2018.00111. eCollection 2018.
22. Sun M, etal., Brain Res. 2005 Aug 9;1052(2):119-29.
23. Ubhi K, etal., Exp Neurol. 2012 Jan 16.
24. Yamamoto M, etal., Brain Res. 1998 Nov 2;809(2):175-81.
25. Yamamoto M, etal., Neurochem Res. 1999 Jun;24(6):785-90.
26. Zeng Q, etal., J Int Med Res. 2008 Jul-Aug;36(4):656-64.
Additional References at PubMed
PMID:7650763   PMID:8493557   PMID:8657306   PMID:8657307   PMID:8657308   PMID:8808409   PMID:8854889   PMID:8945474   PMID:8994069   PMID:9165114   PMID:9182803   PMID:9286710  
PMID:9334423   PMID:9405108   PMID:9415430   PMID:9426245   PMID:9448325   PMID:9454853   PMID:9637690   PMID:9786421   PMID:9853901   PMID:10021334   PMID:10068631   PMID:10069322  
PMID:10322633   PMID:10331972   PMID:10415156   PMID:10444438   PMID:10446341   PMID:10464134   PMID:10471511   PMID:10595945   PMID:10668924   PMID:10679429   PMID:10688798   PMID:10702420  
PMID:10704385   PMID:10712625   PMID:10749566   PMID:11003834   PMID:11044402   PMID:11072069   PMID:11146111   PMID:11150245   PMID:11160437   PMID:11237470   PMID:11309277   PMID:11422733  
PMID:11457495   PMID:11493536   PMID:11562352   PMID:11683907   PMID:11688560   PMID:11731455   PMID:11774071   PMID:11779046   PMID:11822887   PMID:11878293   PMID:11988777   PMID:12019325  
PMID:12050119   PMID:12195422   PMID:12372284   PMID:12399307   PMID:12466851   PMID:12477932   PMID:12574104   PMID:12668632   PMID:12729564   PMID:12746870   PMID:12783782   PMID:12783789  
PMID:12797383   PMID:12810600   PMID:12884298   PMID:12917363   PMID:12948444   PMID:12953790   PMID:13678594   PMID:14628042   PMID:14656760   PMID:14960346   PMID:14973275   PMID:15130495  
PMID:15201220   PMID:15201225   PMID:15327782   PMID:15337776   PMID:15342483   PMID:15381279   PMID:15389609   PMID:15525275   PMID:15530875   PMID:15541311   PMID:15561428   PMID:15582775  
PMID:15604101   PMID:15671854   PMID:15691764   PMID:15748846   PMID:15753214   PMID:15837802   PMID:15855632   PMID:15890330   PMID:15905075   PMID:15930111   PMID:15937482   PMID:15960316  
PMID:16018995   PMID:16049112   PMID:16054034   PMID:16141072   PMID:16193506   PMID:16216236   PMID:16237148   PMID:16319112   PMID:16319116   PMID:16364262   PMID:16380265   PMID:16442091  
PMID:16453021   PMID:16467260   PMID:16497298   PMID:16540576   PMID:16545622   PMID:16600854   PMID:16602821   PMID:16879618   PMID:16889771   PMID:17022962   PMID:17030186   PMID:17036046  
PMID:17101855   PMID:17103416   PMID:17131407   PMID:17172448   PMID:17184739   PMID:17190606   PMID:17222400   PMID:17229286   PMID:17300925   PMID:17314325   PMID:17322904   PMID:17356005  
PMID:17430172   PMID:17507417   PMID:17522159   PMID:17537792   PMID:17574550   PMID:17597063   PMID:17619104   PMID:17699663   PMID:17720696   PMID:17951031   PMID:17962702   PMID:18003772  
PMID:18003856   PMID:18006159   PMID:18159948   PMID:18216204   PMID:18233958   PMID:18234170   PMID:18276829   PMID:18305247   PMID:18358465   PMID:18420832   PMID:18445767   PMID:18472226  
PMID:18485340   PMID:18536709   PMID:18551627   PMID:18650792   PMID:18657279   PMID:18670373   PMID:18703596   PMID:18787044   PMID:18816441   PMID:18824086   PMID:18845535   PMID:19005738  
PMID:19073640   PMID:19110059   PMID:19124014   PMID:19302086   PMID:19538736   PMID:19710321   PMID:19715689   PMID:19721135   PMID:19729440   PMID:19741018   PMID:19809516   PMID:19829382  
PMID:19876815   PMID:19898483   PMID:19944698   PMID:19954518   PMID:20040500   PMID:20068194   PMID:20084103   PMID:20107080   PMID:20139349   PMID:20152829   PMID:20375015   PMID:20422010  
PMID:20439720   PMID:20448145   PMID:20454682   PMID:20542089   PMID:20572009   PMID:20597970   PMID:20632386   PMID:20682772   PMID:20739562   PMID:20816800   PMID:20826310   PMID:20835249  
PMID:20843830   PMID:20855470   PMID:20933580   PMID:20943767   PMID:20944551   PMID:20963849   PMID:21035938   PMID:21123517   PMID:21128305   PMID:21144620   PMID:21200028   PMID:21239429  
PMID:21262472   PMID:21267068   PMID:21281623   PMID:21289216   PMID:21303848   PMID:21343368   PMID:21350016   PMID:21420941   PMID:21523854   PMID:21533152   PMID:21552539   PMID:21613322  
PMID:21677750   PMID:21684216   PMID:21731775   PMID:21816850   PMID:21873635   PMID:21900559   PMID:21903675   PMID:21949185   PMID:21949878   PMID:22015719   PMID:22102605   PMID:22114682  
PMID:22143971   PMID:22174794   PMID:22232066   PMID:22248285   PMID:22262884   PMID:22360967   PMID:22432025   PMID:22473739   PMID:22499581   PMID:22511595   PMID:22613833   PMID:22627285  
PMID:22627288   PMID:22670840   PMID:22682244   PMID:22696295   PMID:22726126   PMID:22743091   PMID:22841315   PMID:22855506   PMID:22863354   PMID:22897442   PMID:22902718   PMID:22998873  
PMID:23040482   PMID:23197722   PMID:23290934   PMID:23333276   PMID:23344256   PMID:23426908   PMID:23429478   PMID:23468876   PMID:23525041   PMID:23537899   PMID:23555292   PMID:23590664  
PMID:23704941   PMID:23785297   PMID:23903190   PMID:23934644   PMID:24105724   PMID:24107967   PMID:24143282   PMID:24370450   PMID:24440154   PMID:24550112   PMID:24598167   PMID:24637293  
PMID:24656820   PMID:24726488   PMID:24852369   PMID:24891614   PMID:24952961   PMID:25025809   PMID:25031030   PMID:25036711   PMID:25079320   PMID:25082826   PMID:25101543   PMID:25139858  
PMID:25165119   PMID:25181385   PMID:25297108   PMID:25331604   PMID:25406395   PMID:25448159   PMID:25549043   PMID:25577412   PMID:25617721   PMID:25655216   PMID:25678108   PMID:25710828  
PMID:25775596   PMID:25822020   PMID:25838128   PMID:25944479   PMID:26047795   PMID:26116176   PMID:26527010   PMID:26564715   PMID:26592967   PMID:26604140   PMID:26681446   PMID:26706106  
PMID:26831079   PMID:26930384   PMID:27119228   PMID:27148690   PMID:27255992   PMID:27288458   PMID:27370713   PMID:27445711   PMID:27445722   PMID:27545711   PMID:27582005   PMID:27597235  
PMID:27607574   PMID:27693352   PMID:27707798   PMID:27741271   PMID:27930290   PMID:28076782   PMID:28092668   PMID:28096470   PMID:28196692   PMID:28207192   PMID:28408662   PMID:28490528  
PMID:28506996   PMID:28591570   PMID:28645787   PMID:28900034   PMID:28973166   PMID:29031500   PMID:29066960   PMID:29167169   PMID:29183737   PMID:29240767   PMID:29282324   PMID:29440301  
PMID:29483821   PMID:29564810   PMID:29593116   PMID:29615468   PMID:29638158   PMID:29768404   PMID:29771971   PMID:29913111   PMID:29945868   PMID:30089897   PMID:30169530   PMID:30377232  
PMID:30488198   PMID:30594740   PMID:30617464   PMID:30651543   PMID:30853441   PMID:30923332   PMID:30958726   PMID:31062503   PMID:31084574   PMID:31119595   PMID:31205031   PMID:31663646  
PMID:31747609   PMID:31848242   PMID:31875542   PMID:31924792   PMID:31930748   PMID:32015493   PMID:32021964   PMID:32179912   PMID:32294451   PMID:32497340   PMID:32708917   PMID:32808420  
PMID:33672854  


Genomics

Comparative Map Data
Gdnf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39157,839,529 - 7,867,061 (+)NCBIGRCm39mm39
GRCm39 Ensembl157,840,327 - 7,867,056 (+)Ensembl
GRCm38157,810,048 - 7,837,580 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl157,810,846 - 7,837,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37157,761,011 - 7,787,575 (+)NCBIGRCm37mm9NCBIm37
MGSCv36157,758,226 - 7,784,790 (+)NCBImm8
Celera157,656,819 - 7,683,345 (+)NCBICelera
Cytogenetic Map15A1NCBI
GDNF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl537,812,677 - 37,840,041 (-)EnsemblGRCh38hg38GRCh38
GRCh38537,812,677 - 37,840,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37537,812,779 - 37,840,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36537,851,510 - 37,875,539 (-)NCBINCBI36hg18NCBI36
Build 34537,851,509 - 37,870,655NCBI
Celera537,699,155 - 37,726,173 (-)NCBI
Cytogenetic Map5p13.2NCBI
HuRef537,765,313 - 37,792,316 (-)NCBIHuRef
CHM1_1537,814,804 - 37,841,806 (-)NCBICHM1_1
Gdnf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2256,893,992 - 56,919,935 (+)NCBI
Rnor_6.0 Ensembl256,887,987 - 56,910,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0256,884,181 - 56,912,964 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0276,896,991 - 76,922,471 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4257,399,312 - 57,424,030 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1257,327,544 - 57,352,263 (+)NCBI
Celera252,510,468 - 52,532,694 (+)NCBICelera
Cytogenetic Map2q16NCBI
Gdnf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542622,386,450 - 22,412,324 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542622,386,613 - 22,412,324 (-)NCBIChiLan1.0ChiLan1.0
GDNF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1577,573,466 - 77,600,478 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl577,577,313 - 77,601,362 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0572,539,374 - 72,566,918 (+)NCBIMhudiblu_PPA_v0panPan3
GDNF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1470,966,694 - 70,991,860 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl470,971,432 - 70,989,714 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0471,483,108 - 71,516,105 (+)NCBI
UMICH_Zoey_3.1471,230,252 - 71,263,217 (+)NCBI
UNSW_CanFamBas_1.0471,343,690 - 71,376,610 (+)NCBI
UU_Cfam_GSD_1.0471,882,215 - 71,915,204 (+)NCBI
Gdnf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213227,058,585 - 227,083,871 (-)NCBI
SpeTri2.0NW_0049365184,291,391 - 4,310,752 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDNF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1622,936,601 - 22,965,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11622,936,602 - 22,965,929 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21624,176,604 - 24,179,641 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GDNF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1436,662,033 - 36,691,761 (-)NCBI
ChlSab1.1 Ensembl436,665,009 - 36,684,257 (-)Ensembl
Vero_WHO_p1.0NW_02366607127,015,956 - 27,043,442 (-)NCBI
Gdnf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475917,263,570 - 17,290,046 (+)NCBI

Position Markers
AI385739  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38157,837,398 - 7,837,485UniSTSGRCm38
MGSCv37157,787,398 - 7,787,485UniSTSGRCm37
Celera157,683,168 - 7,683,255UniSTS
Cytogenetic Map15A1UniSTS
PMC186320P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38157,834,581 - 7,835,230UniSTSGRCm38
MGSCv37157,784,581 - 7,785,230UniSTSGRCm37
Celera157,680,351 - 7,681,000UniSTS
Cytogenetic Map15A1UniSTS
PMC186320P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38157,836,669 - 7,837,318UniSTSGRCm38
MGSCv37157,786,669 - 7,787,318UniSTSGRCm37
Celera157,682,439 - 7,683,088UniSTS
Cytogenetic Map15A1UniSTS
Gdnf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37157,784,494 - 7,784,831UniSTSGRCm37
MGSCv37157,784,490 - 7,784,671UniSTSGRCm37
MGSCv37157,784,591 - 7,784,828UniSTSGRCm37
Celera157,680,264 - 7,680,601UniSTS
Celera157,680,361 - 7,680,598UniSTS
Celera157,680,260 - 7,680,441UniSTS
Cytogenetic Map15A1UniSTS
cM MapUN UniSTS
GDNF_3150  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38157,834,384 - 7,834,859UniSTSGRCm38
MGSCv37157,784,384 - 7,784,859UniSTSGRCm37
Celera157,680,154 - 7,680,629UniSTS
Cytogenetic Map15A1UniSTS
Gdnf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38157,834,490 - 7,834,671UniSTSGRCm38
MGSCv37157,784,490 - 7,784,671UniSTSGRCm37
Celera157,680,260 - 7,680,441UniSTS
Cytogenetic Map15A1UniSTS
cM MapUN UniSTS
cM Map15 UniSTS
Gdnf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38157,834,591 - 7,834,828UniSTSGRCm38
MGSCv37157,784,591 - 7,784,828UniSTSGRCm37
Celera157,680,361 - 7,680,598UniSTS
Cytogenetic Map15A1UniSTS
cM MapUN UniSTS
Gdnf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38157,834,494 - 7,834,831UniSTSGRCm38
MGSCv37157,784,494 - 7,784,831UniSTSGRCm37
Celera157,680,264 - 7,680,601UniSTS
Cytogenetic Map15A1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300953Bdt5_mbone density traits 5 (mouse)Not determined15120460347Mouse
1301023Sluc24_msusceptibility to lung cancer 24 (mouse)Not determined15120460347Mouse
1302121Cliff_mcliff drop aversion (mouse)Not determined15120460347Mouse
1301662Faq8_mfluctuating asymmetry QTL 8 (mouse)Not determined15120460347Mouse
5491193Mobq4_mmultigenic obesity QTL 4 (mouse)Not determined15120460347Mouse
4141541Tglq3_mtriglyceride QTL 3 (mouse)Not determined15120460347Mouse
1357459Nhdlq7_mnon-HDL QTL 7 (mouse)Not determined15120460347Mouse
11062069Bpq31_mblood pressure QTL 31 (mouse)15126273109Mouse
4141446Ffaq4_mfree fatty acid QTL 4 (mouse)Not determined127101304Mouse
1300594Eae2_msusceptibility to experimental allergic encephalomyelitis 2 (mouse)Not determined15131218650Mouse
1301136Pgia8_mproteoglycan induced arthritis 8 (mouse)Not determined15321068524388090Mouse
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15344490771325689Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined346021278717086Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined346021278717086Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined346021278717086Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15346021278717086Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15346021278717086Mouse
4141358Ath22_matherosclerosis 22 (mouse)Not determined346456637464566Mouse
11252136Modvl4_mmodifier of vacuolated lens (mouse)15562040839620528Mouse
26884409Bzwq16_mbi-zygomatic width QTL 16, 16 week (mouse)15610000038000000Mouse
26884384Skwq12_mskull length QTL 12, 16 week (mouse)15610000050900000Mouse
26884387Skwq8_mskull length QTL 8, 10 week (mouse)15610000068400000Mouse
26884412Bzwq10_mbi-zygomatic width QTL 10, 10 week (mouse)15610000071600000Mouse
26884417Bzwq4_mbi-zygomatic width QTL 4, 5 week (mouse)15610000072600000Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15610000076000000Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15610000076500000Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15610000078800000Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15610000086800000Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
26884429Zlq6_mzygomatic length QTL 6, 10 week (mouse)15680000045100000Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15690000076000000Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15690000076000000Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15690000084700000Mouse
27095940Ulnl8_mulna length 8, 10 week (mouse)15720000055400000Mouse
27226759Feml17_mfemur length 17, 10 week (mouse)15760000055400000Mouse
27226755Feml22_mfemur length 22, 16 week (mouse)15760000059400000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1363
Count of miRNA genes:624
Interacting mature miRNAs:787
Transcripts:ENSMUST00000022744
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001301332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ061678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ093961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D49921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D88264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D88352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U36449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U75532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000022744   ⟹   ENSMUSP00000022744
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl157,810,846 - 7,837,575 (+)Ensembl
RefSeq Acc Id: NM_001301332   ⟹   NP_001288261
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39157,839,529 - 7,867,061 (+)NCBI
GRCm38157,810,048 - 7,837,580 (+)NCBI
Celera157,655,856 - 7,683,350 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001301333   ⟹   NP_001288262
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39157,843,208 - 7,867,061 (+)NCBI
GRCm38157,813,727 - 7,837,580 (+)NCBI
Celera157,655,856 - 7,683,350 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001301357   ⟹   NP_001288286
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39157,845,031 - 7,867,061 (+)NCBI
GRCm38157,815,550 - 7,837,580 (+)NCBI
Celera157,655,856 - 7,683,350 (+)NCBI
Sequence:
RefSeq Acc Id: NM_010275   ⟹   NP_034405
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39157,839,529 - 7,867,061 (+)NCBI
GRCm38157,810,048 - 7,837,580 (+)NCBI
MGSCv37157,761,011 - 7,787,575 (+)RGD
Celera157,655,856 - 7,683,350 (+)NCBI
cM Map15 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034405   ⟸   NM_010275
- Peptide Label: isoform 1
- UniProtKB: P48540 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288261   ⟸   NM_001301332
- Peptide Label: isoform 2
- UniProtKB: P48540 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288262   ⟸   NM_001301333
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: NP_001288286   ⟸   NM_001301357
- Peptide Label: isoform 4 preproprotein
- UniProtKB: P48540 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000022744   ⟸   ENSMUST00000022744

Promoters
RGD ID:6826023
Promoter ID:MM_KWN:17978
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   MEF_B4,   MEF_B6
Transcripts:NM_010275,   UC007VEF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36157,760,056 - 7,761,087 (+)MPROMDB
RGD ID:8683360
Promoter ID:EPDNEW_M19710
Type:single initiation site
Name:Gdnf_1
Description:Mus musculus glial cell line derived neurotrophic factor , transcriptvariant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38157,810,048 - 7,810,108EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107430 AgrOrtholog
Ensembl Genes ENSMUSG00000022144 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000022744 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022744 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  GDNF UniProtKB/Swiss-Prot
  GDNF_fam UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
KEGG Report mmu:14573 UniProtKB/Swiss-Prot
MGD MGI:107430 ENTREZGENE
NCBI Gene 14573 ENTREZGENE
PANTHER PTHR12173 UniProtKB/Swiss-Prot
  PTHR12173:SF1 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
PhenoGen Gdnf PhenoGen
PIRSF GDNF UniProtKB/Swiss-Prot
PROSITE TGF_BETA_2 UniProtKB/Swiss-Prot
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt GDNF_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O09058 UniProtKB/Swiss-Prot
  P70446 UniProtKB/Swiss-Prot
  P97919 UniProtKB/Swiss-Prot
  P97920 UniProtKB/Swiss-Prot
  Q6LEL9 UniProtKB/Swiss-Prot