Rnf7 (ring finger protein 7) - Rat Genome Database
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Gene: Rnf7 (ring finger protein 7) Mus musculus
Analyze
Symbol: Rnf7
Name: ring finger protein 7
RGD ID: 1322299
MGI Page MGI
Description: Predicted to have NEDD8 ligase activity; cullin family protein binding activity; and ubiquitin protein ligase activity. Involved in several processes, including brain development; intrinsic apoptotic signaling pathway in response to oxidative stress; and regulation of apoptotic process. Localizes to cytoplasm and nucleus. Is expressed in brain; eye; and genitourinary system. Orthologous to human RNF7 (ring finger protein 7); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Rbx; Rbx2; RING-box protein 2; S; SAG; sensitive to apoptosis gene protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm35144   Gm7075  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39996,352,990 - 96,360,728 (-)NCBIGRCm39mm39
GRCm38996,470,937 - 96,478,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl996,470,937 - 96,478,675 (-)EnsemblGRCm38mm10GRCm38
MGSCv37996,371,376 - 96,379,014 (-)NCBIGRCm37mm9NCBIm37
MGSCv36996,280,289 - 96,327,074 (-)NCBImm8
Celera996,029,356 - 96,036,994 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10082581   PMID:10349636   PMID:10506102   PMID:10851089   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11255262   PMID:12466851   PMID:12477932   PMID:12520002  
PMID:12819125   PMID:14610273   PMID:15489334   PMID:15601820   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17062627   PMID:17240529   PMID:18258608   PMID:18287559   PMID:18799693  
PMID:19037258   PMID:20638939   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22118770   PMID:22405651   PMID:23990909   PMID:24210661   PMID:24213570   PMID:24430184   PMID:24569637  
PMID:25622904   PMID:25850934   PMID:26056141   PMID:27543965   PMID:27689697   PMID:29361558   PMID:30269386   PMID:30574150   PMID:32325033  


Genomics

Comparative Map Data
Rnf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39996,352,990 - 96,360,728 (-)NCBIGRCm39mm39
GRCm38996,470,937 - 96,478,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl996,470,937 - 96,478,675 (-)EnsemblGRCm38mm10GRCm38
MGSCv37996,371,376 - 96,379,014 (-)NCBIGRCm37mm9NCBIm37
MGSCv36996,280,289 - 96,327,074 (-)NCBImm8
Celera996,029,356 - 96,036,994 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
RNF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3141,738,249 - 141,747,560 (+)EnsemblGRCh38hg38GRCh38
GRCh383141,738,298 - 141,747,560 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373141,457,051 - 141,465,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363142,939,741 - 142,947,933 (+)NCBINCBI36hg18NCBI36
Build 343142,939,748 - 142,947,940NCBI
Celera3139,880,505 - 139,888,693 (+)NCBI
Cytogenetic Map3q23NCBI
HuRef3138,830,734 - 138,839,328 (+)NCBIHuRef
CHM1_13141,420,074 - 141,428,668 (+)NCBICHM1_1
Rnf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08104,326,719 - 104,336,098 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8104,326,719 - 104,335,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08103,774,031 - 103,783,041 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48101,534,827 - 101,543,837 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18101,554,323 - 101,563,258 (-)NCBI
Celera896,481,487 - 96,490,405 (-)NCBICelera
Cytogenetic Map8q31NCBI
Rnf7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555084,001,441 - 4,003,518 (-)NCBIChiLan1.0ChiLan1.0
RNF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13146,369,779 - 146,377,233 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3146,369,779 - 146,377,233 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03138,772,581 - 138,780,763 (+)NCBIMhudiblu_PPA_v0panPan3
RNF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2337,578,273 - 37,584,523 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12337,578,222 - 37,584,862 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rnf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365403,484,422 - 3,491,162 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1382,548,548 - 82,555,685 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11382,548,475 - 82,554,888 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21390,378,331 - 90,385,390 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNF7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11548,863,402 - 48,871,321 (-)NCBI
ChlSab1.1 Ensembl1548,860,281 - 48,871,339 (-)Ensembl
Rnf7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473018,379,177 - 18,388,505 (+)NCBI

Position Markers
UniSTS:236224  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38996,503,390 - 96,503,596UniSTSGRCm38
MGSCv37996,403,809 - 96,404,015UniSTSGRCm37
Celera996,062,466 - 96,062,672UniSTS
Cytogenetic Map9D2.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96936046598819654Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:576
Count of miRNA genes:410
Interacting mature miRNAs:473
Transcripts:ENSMUST00000057500, ENSMUST00000071301, ENSMUST00000128955
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001311135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC161257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF092877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK006703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK007588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF018220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY781065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ231571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000057500   ⟹   ENSMUSP00000052856
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl996,470,937 - 96,478,675 (-)Ensembl
RefSeq Acc Id: ENSMUST00000071301   ⟹   ENSMUSP00000108581
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl996,471,763 - 96,478,610 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128955
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl996,473,862 - 96,478,588 (-)Ensembl
RefSeq Acc Id: NM_001311135   ⟹   NP_001298064
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39996,352,990 - 96,360,728 (-)NCBI
GRCm38996,470,937 - 96,478,675 (-)NCBI
Sequence:
RefSeq Acc Id: NM_011279   ⟹   NP_035409
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39996,352,990 - 96,360,728 (-)NCBI
GRCm38996,470,937 - 96,478,675 (-)NCBI
MGSCv37996,371,376 - 96,379,014 (-)RGD
Celera996,029,356 - 96,036,994 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035409   ⟸   NM_011279
- Peptide Label: isoform 1
- UniProtKB: Q9WTZ1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001298064   ⟸   NM_001311135
- Peptide Label: isoform 2
- UniProtKB: Q9WTZ1 (UniProtKB/Swiss-Prot),   D3Z392 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000108581   ⟸   ENSMUST00000071301
RefSeq Acc Id: ENSMUSP00000052856   ⟸   ENSMUST00000057500
Protein Domains
zf-ANAPC11

Promoters
RGD ID:6845049
Promoter ID:MM_KWN:58420
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000071301,   OTTMUST00000055285,   OTTMUST00000055287
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36996,378,861 - 96,379,361 (-)MPROMDB
RGD ID:8670494
Promoter ID:EPDNEW_M13278
Type:initiation region
Name:Rnf7_1
Description:Mus musculus ring finger protein 7 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38996,478,598 - 96,478,658EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1337096 AgrOrtholog
Ensembl Genes ENSMUSG00000051234 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000052856 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000108581 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000057500 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000071301 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Apc11 UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_H2 UniProtKB/Swiss-Prot
KEGG Report mmu:19823 UniProtKB/Swiss-Prot
MGD MGI:1337096 ENTREZGENE
NCBI Gene 19823 ENTREZGENE
Pfam zf-ANAPC11 UniProtKB/TrEMBL
  zf-rbx1 UniProtKB/Swiss-Prot
PhenoGen Rnf7 PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot
UniGene Mm.28235 ENTREZGENE
UniProt D3Z392 ENTREZGENE, UniProtKB/TrEMBL
  Q9WTZ1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3UKF8 UniProtKB/Swiss-Prot