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Gene: Adsl (adenylosuccinate lyase) Mus musculus
Symbol: Adsl
Name: adenylosuccinate lyase
Description: Predicted to have (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity and N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Predicted to be involved in several processes, including 'de novo' AMP biosynthetic process; aerobic respiration; and protein tetramerization. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ADSL (adenylosuccinate lyase).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adenylosuccinase; adenylosuccinate lyase 1; Adl; ASase; Asl
Homo sapiens (human) : ADSL (adenylosuccinate lyase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Adsl (adenylosuccinate lyase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adsl (adenylosuccinate lyase)
Pan paniscus (bonobo/pygmy chimpanzee) : ADSL (adenylosuccinate lyase)
Canis lupus familiaris (dog) : ADSL (adenylosuccinate lyase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adsl (adenylosuccinate lyase)
Sus scrofa (pig) : ADSL (adenylosuccinate lyase)
more info ...
Related Pseudogenes: Gm18108  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381580,948,490 - 80,970,947 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371580,778,949 - 80,799,803 (+)NCBIGRCm37mm9NCBIm37
MGSCv361580,775,774 - 80,796,628 (+)NCBImm8
Celera1583,068,973 - 83,091,236 (+)NCBICelera
Cytogenetic Map15 E1NCBI
cM Map1537.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Adsl
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316917
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.