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Gene: Rapgef4 (Rap guanine nucleotide exchange factor (GEF) 4) Mus musculus
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Symbol: Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Description: Exhibits Ras guanyl-nucleotide exchange factor activity and cAMP binding activity. Involved in cAMP-mediated signaling; regulation of vesicle-mediated transport; and secretion by cell. Localizes to cytosol and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including adrenal gland; ganglia; heart; lung; and metanephros. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human RAPGEF4 (Rap guanine nucleotide exchange factor 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1300003D15Rik; 5730402K07Rik; 6330581N18Rik; cAMP-dependent Rap1 guanine-nucleotide exchange factor; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; cAMP-regulated guanine nucleotide exchange factor IIB; EPAC 2; Epac-2; Epac2; exchange factor directly activated by cAMP 2; exchange protein directly activated by cAMP 2; KIAA4040; mKIAA4040; rap guanine nucleotide exchange factor 4
Orthologs:
Homo sapiens (human) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rapgef4 (Rap guanine nucleotide exchange factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rapgef4 (Rap guanine nucleotide exchange factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Canis lupus familiaris (dog) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rapgef4 (Rap guanine nucleotide exchange factor 4)
Sus scrofa (pig) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Chlorocebus sabaeus (African green monkey) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Heterocephalus glaber (naked mole-rat) : Rapgef4 (Rap guanine nucleotide exchange factor 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl271,981,240 - 72,257,474 (+)EnsemblGRCm38mm10GRCm38
GRCm38271,981,215 - 72,257,474 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37271,819,344 - 72,094,433 (+)NCBIGRCm37mm9NCBIm37
MGSCv36271,782,126 - 72,057,215 (+)NCBImm8
Celera273,684,323 - 73,945,757 (+)NCBICelera
Cytogenetic Map2C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Rapgef4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737131
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-06-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.