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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730887
Species: Mus musculus
RGD Object: Gene
Symbol: Creb1
Name: cAMP responsive element binding protein 1
Acc ID: CHEBI:64312
Term: memantine
Definition: A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
Chemical ID: MESH:D008559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Creb1multiple interactionsISOCreb1 (Rattus norvegicus)6480464CTDMemantine inhibits the reaction [Streptozocin results in decreased phosphorylation of CREB1 protein]PMID:23562514
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