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Gene: Dtnbp1 (dystrobrevin binding protein 1) Mus musculus
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Symbol: Dtnbp1
Name: dystrobrevin binding protein 1
RGD ID: 1619063
Description: Involved in several processes, including anterograde synaptic vesicle transport; regulation of protein serine/threonine kinase activity; and regulation of secretion by cell. Localizes to several cellular components, including BLOC-1 complex; Schaffer collateral - CA1 synapse; and hippocampal mossy fiber to CA3 synapse. Is expressed in central nervous system and retina. Used to study Hermansky-Pudlak syndrome 7; platelet storage pool deficiency; and schizophrenia. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 7 and schizophrenia. Orthologous to human DTNBP1 (dystrobrevin binding protein 1); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5430437B18Rik; AW048963; biogenesis of lysosome-related organelles complex 1 subunit 8; Bloc; BLOC-1 subunit 8; Bloc1s8; dysb; dysbindin; dysbindin-1; dystrobrevin-binding protein 1; hermansky-Pudlak syndrome 7 protein homolog; HPS7 protein homolog; sandy; sd; sdy
Orthologs:
Homo sapiens (human) : DTNBP1 (dystrobrevin binding protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dtnbp1 (dystrobrevin binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dtnbp1 (dystrobrevin binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DTNBP1 (dystrobrevin binding protein 1)
Canis lupus familiaris (dog) : DTNBP1 (dystrobrevin binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dtnbp1 (dystrobrevin binding protein 1)
Sus scrofa (pig) : DTNBP1 (dystrobrevin binding protein 1)
Chlorocebus sabaeus (African green monkey) : DTNBP1 (dystrobrevin binding protein 1)
Heterocephalus glaber (naked mole-rat) : Dtnbp1 (dystrobrevin binding protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1344,922,075 - 45,002,147 (-)EnsemblGRCm38mm10GRCm38
GRCm381344,922,079 - 45,002,096 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371345,017,448 - 45,097,465 (-)NCBIGRCm37mm9NCBIm37
MGSCv361344,933,051 - 45,013,068 (-)NCBImm8
Celera1345,997,733 - 46,077,631 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1321.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dtnbp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1619063
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-09-15
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.