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Gene: Dtnbp1 (dystrobrevin binding protein 1) Mus musculus
Symbol: Dtnbp1
Name: dystrobrevin binding protein 1
RGD ID: 1619063
Description: Involved in several processes, including anterograde synaptic vesicle transport; regulation of protein serine/threonine kinase activity; and regulation of secretion by cell. Localizes to several cellular components, including BLOC-1 complex; Schaffer collateral - CA1 synapse; and hippocampal mossy fiber to CA3 synapse. Is expressed in central nervous system and retina. Used to study Hermansky-Pudlak syndrome 7; platelet storage pool deficiency; and schizophrenia. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 7 and schizophrenia. Orthologous to human DTNBP1 (dystrobrevin binding protein 1); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5430437B18Rik; AW048963; biogenesis of lysosome-related organelles complex 1 subunit 8; Bloc; BLOC-1 subunit 8; Bloc1s8; dysb; dysbindin; dysbindin-1; dystrobrevin-binding protein 1; hermansky-Pudlak syndrome 7 protein homolog; HPS7 protein homolog; sandy; sd; sdy
Homo sapiens (human) : DTNBP1 (dystrobrevin binding protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dtnbp1 (dystrobrevin binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dtnbp1 (dystrobrevin binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DTNBP1 (dystrobrevin binding protein 1)
Canis lupus familiaris (dog) : DTNBP1 (dystrobrevin binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dtnbp1 (dystrobrevin binding protein 1)
Sus scrofa (pig) : DTNBP1 (dystrobrevin binding protein 1)
Chlorocebus sabaeus (African green monkey) : DTNBP1 (dystrobrevin binding protein 1)
Heterocephalus glaber (naked mole-rat) : Dtnbp1 (dystrobrevin binding protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1344,922,075 - 45,002,147 (-)EnsemblGRCm38mm10GRCm38
GRCm381344,922,079 - 45,002,096 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371345,017,448 - 45,097,465 (-)NCBIGRCm37mm9NCBIm37
MGSCv361344,933,051 - 45,013,068 (-)NCBImm8
Celera1345,997,733 - 46,077,631 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1321.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dtnbp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1619063
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-09-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.