Ctsk (cathepsin K) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ctsk (cathepsin K) Mus musculus
Analyze
Symbol: Ctsk
Name: cathepsin K
RGD ID: 62102
MGI Page MGI
Description: Predicted to enable several functions, including collagen binding activity; cysteine-type endopeptidase activator activity involved in apoptotic process; and fibronectin binding activity. Involved in proteolysis involved in protein catabolic process and thyroid hormone generation. Acts upstream of or within bone resorption; collagen catabolic process; and negative regulation of cartilage development. Located in external side of plasma membrane; extracellular space; and lysosome. Is expressed in several structures, including bone; central nervous system; connective tissue; gut; and sensory organ. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI323530; cat; Cat K; catK; minisatellite 10q detected by probe MMS10; MMS10-Q; Ms10q
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,406,521 - 95,416,698 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,406,567 - 95,416,673 (+)EnsemblGRCm39 Ensembl
GRCm38395,499,210 - 95,509,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,499,256 - 95,509,362 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,303,208 - 95,313,284 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,584,690 - 95,594,766 (+)NCBIMGSCv36mm8
Celera396,930,391 - 96,940,481 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(R)-adrenaline  (ISO)
(S)-amphetamine  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-tert-butylhydroquinone  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aluminium oxide  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anagliptin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
belinostat  (ISO)
benzamide  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
betulinic acid  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brusatol  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP)
chlorpromazine  (EXP)
choline  (EXP)
chondroitin sulfate  (ISO)
cisapride  (EXP)
clozapine  (ISO)
Cuprizon  (ISO)
cyanamide  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP)
dimethyl fumarate  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
ellagic acid  (EXP)
endosulfan  (ISO)
ethanol  (EXP)
fluoxetine  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formononetin  (EXP)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
graphite  (ISO)
guanethidine  (ISO)
haloperidol  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
imiquimod  (EXP)
ketamine  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lead(0)  (EXP)
lipopolysaccharide  (EXP,ISO)
mangiferin  (EXP)
mercaptopurine  (ISO)
methylglyoxal  (EXP,ISO)
methylseleninic acid  (ISO)
Morroniside  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
naringin  (EXP)
niclosamide  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
puerarin  (ISO)
purine-6-thiol  (ISO)
quartz  (ISO)
quercetin  (EXP)
raloxifene  (EXP)
resveratrol  (ISO)
rubiadin  (ISO)
SB 203580  (EXP)
sclareol  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
Soman  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
telmisartan  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
tetradecane  (ISO)
Theaflavin 3,3'-digallate  (EXP)
thioacetamide  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium dioxide  (EXP,ISO)
tofacitinib  (EXP)
topotecan  (ISO)
tremolite asbestos  (EXP)
tributylstannane  (EXP)
triclosan  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin D  (EXP)
xanthohumol  (EXP)
zinc atom  (ISO)
zinc sulfate  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alveolar process morphology  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal bone resorption  (IAGP)
abnormal bone structure  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lysosome morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal osteoid morphology  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal thyroid follicle morphology  (IAGP)
abnormal thyroid follicular cell morphology  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal thyroid hormone level  (IAGP)
abnormal tibia morphology  (IAGP)
abnormal tooth development  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal uterus morphology  (IEA)
absent mandibular angle  (IAGP)
amyloidosis  (IAGP)
decreased body height  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased bone mass  (IAGP)
decreased bone mineral density of femur  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone ossification  (IAGP)
decreased bone resorption  (IAGP)
decreased bone trabecula number  (IAGP)
decreased bone trabecular spacing  (IAGP)
decreased bone volume  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased lysosomal enzyme secretion  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased prepulse inhibition  (IEA)
decreased thyroxine level  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased trabecular bone volume  (IAGP)
failure of tooth eruption  (IAGP)
fragile skeleton  (IAGP)
increased bone mineral density  (IAGP)
increased bone mineralization  (IAGP)
increased bone ossification  (IAGP)
increased bone resorption  (IAGP)
increased bone trabecula number  (IAGP)
increased bone trabecular spacing  (IAGP)
increased bone volume  (IAGP)
increased compact bone area  (IAGP)
increased compact bone volume  (IAGP)
increased diameter of tibia  (IAGP)
increased long bone epiphyseal plate size  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased trabecular bone connectivity density  (IAGP)
increased trabecular bone mass  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
large fontanelles  (IAGP)
malocclusion  (IAGP)
osteopetrosis  (IAGP)
osteoporosis  (IAGP)
postnatal growth retardation  (IAGP)
pulmonary fibrosis  (IAGP)
short tibia  (IEA)
spondylolysis  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thin neurocranium  (IAGP)
ulcerated autopod  (IAGP)
wide cranial sutures  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2008 Sep;39(9):2603-10. Epub 2008 Jul 17.
2. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Gene expression relevant to osteoclastogenesis in the synovium and bone marrow of mature rats with collagen-induced arthritis. Kishimoto Y, etal., Rheumatology (Oxford). 2004 Dec;43(12):1496-503. Epub 2004 Sep 7.
5. Osteopetrosis and osteoporosis: two sides of the same coin. Lazner F, etal., Hum Mol Genet 1999;8(10):1839-46.
6. Cathepsin gene expression profile in rat acute pneumococcal otitis media. Li-Korotky HS, etal., Laryngoscope 2004 Jun;114(6):1032-6.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Nakashima K, etal., Cell 2002 Jan 11;108(1):17-29.
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P. Sol-Church K, etal., Biochim Biophys Acta 2000 Apr 25;1491(1-3):289-94.
Additional References at PubMed
PMID:8703060   PMID:8814310   PMID:8986645   PMID:9537446   PMID:9556067   PMID:9811821   PMID:10097072   PMID:10234569   PMID:10349636   PMID:10372556   PMID:11042159   PMID:11076861  
PMID:11082042   PMID:11210178   PMID:11472890   PMID:11908948   PMID:12477932   PMID:12652657   PMID:12719657   PMID:12782676   PMID:14584055   PMID:15161653   PMID:15265002   PMID:15489334  
PMID:15582152   PMID:15664014   PMID:15826870   PMID:16045809   PMID:16141072   PMID:16141073   PMID:16329095   PMID:16365196   PMID:16435023   PMID:16602821   PMID:16680826   PMID:16753017  
PMID:16829211   PMID:16939398   PMID:16972305   PMID:17068745   PMID:17098827   PMID:17210673   PMID:17668061   PMID:17803905   PMID:17897792   PMID:18239127   PMID:18240253   PMID:18291403  
PMID:18818416   PMID:18840928   PMID:18845279   PMID:18927151   PMID:19015136   PMID:19028686   PMID:19118660   PMID:19122179   PMID:19172215   PMID:19358841   PMID:19563866   PMID:19661463  
PMID:19700761   PMID:19759519   PMID:19775691   PMID:19834056   PMID:20039311   PMID:20133620   PMID:20200944   PMID:20203298   PMID:20230792   PMID:20368579   PMID:20440000   PMID:20501942  
PMID:20721934   PMID:20937352   PMID:20939024   PMID:21151480   PMID:21246657   PMID:21251246   PMID:21267068   PMID:21447555   PMID:21627832   PMID:21695131   PMID:21718816   PMID:21721952  
PMID:21794126   PMID:21817099   PMID:21873635   PMID:21876000   PMID:21968827   PMID:22126332   PMID:22174188   PMID:22308018   PMID:22308398   PMID:22344299   PMID:22349694   PMID:22484689  
PMID:22806935   PMID:22806988   PMID:22860046   PMID:22916010   PMID:22988253   PMID:23069627   PMID:23152408   PMID:23166301   PMID:23230271   PMID:23269702   PMID:23321671   PMID:23341620  
PMID:23526406   PMID:23529168   PMID:23599343   PMID:23722907   PMID:23728177   PMID:23863940   PMID:23908115   PMID:24023068   PMID:24316970   PMID:24327965   PMID:24343118   PMID:24367002  
PMID:24590570   PMID:24675074   PMID:24719048   PMID:24894568   PMID:24928497   PMID:24938130   PMID:24982128   PMID:25278057   PMID:25282358   PMID:25287300   PMID:25593124   PMID:25692548  
PMID:25737953   PMID:25800988   PMID:25811986   PMID:25896020   PMID:25951977   PMID:25958043   PMID:26002583   PMID:26102028   PMID:26195726   PMID:26255596   PMID:26460818   PMID:26892148  
PMID:27085457   PMID:27117872   PMID:27273006   PMID:27435916   PMID:27621061   PMID:27626380   PMID:27636705   PMID:27677594   PMID:27731422   PMID:27777970   PMID:27804995   PMID:27879318  
PMID:27930311   PMID:27942992   PMID:28071724   PMID:28093526   PMID:28095448   PMID:28102206   PMID:28177161   PMID:28322464   PMID:28574598   PMID:28821796   PMID:28835281   PMID:28851822  
PMID:28880886   PMID:29149593   PMID:29297601   PMID:29358671   PMID:29479711   PMID:29504949   PMID:29514215   PMID:29724825   PMID:29781506   PMID:29800693   PMID:29880809   PMID:30075049  
PMID:30188920   PMID:30250253   PMID:30465799   PMID:30636333   PMID:30659979   PMID:30830877   PMID:30850734   PMID:30971820   PMID:31065924   PMID:31074883   PMID:31112135   PMID:31112308  
PMID:31134061   PMID:31239337   PMID:31299383   PMID:31346562   PMID:31360740   PMID:31737959   PMID:31808010   PMID:31887784   PMID:31919867   PMID:31941964   PMID:32024800   PMID:32186512  
PMID:32212276   PMID:32582715   PMID:32853181   PMID:32900814   PMID:33077625   PMID:33466458   PMID:33486152   PMID:33563875   PMID:33605542   PMID:33607650   PMID:33682794   PMID:34071318  
PMID:34183355   PMID:34260913   PMID:34321999   PMID:34327196   PMID:34742737   PMID:34755658   PMID:35098692   PMID:35689447   PMID:35726642   PMID:35758636   PMID:35851381   PMID:36104423  
PMID:36127325   PMID:36147479   PMID:36245435   PMID:36726200   PMID:37001042   PMID:37704707   PMID:37948912   PMID:38444130  


Genomics

Comparative Map Data
Ctsk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,406,521 - 95,416,698 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,406,567 - 95,416,673 (+)EnsemblGRCm39 Ensembl
GRCm38395,499,210 - 95,509,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,499,256 - 95,509,362 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,303,208 - 95,313,284 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,584,690 - 95,594,766 (+)NCBIMGSCv36mm8
Celera396,930,391 - 96,940,481 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
CTSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,796,208 - 150,808,260 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1150,794,880 - 150,809,577 (-)EnsemblGRCh38hg38GRCh38
GRCh371150,768,684 - 150,780,736 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,035,311 - 149,047,436 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,581,759 - 147,593,885NCBI
Celera1123,884,715 - 123,896,850 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,146,309 - 122,158,545 (-)NCBIHuRef
CHM1_11152,164,010 - 152,176,259 (-)NCBICHM1_1
T2T-CHM13v2.01149,919,861 - 149,931,947 (-)NCBIT2T-CHM13v2.0
Ctsk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,747,548 - 185,758,512 (+)NCBIGRCr8
mRatBN7.22183,058,586 - 183,069,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,058,569 - 183,069,550 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,723,332 - 190,734,303 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,518,632 - 188,529,601 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,355,824 - 183,366,795 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,655,469 - 196,666,447 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,655,469 - 196,666,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02216,154,168 - 216,164,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,394,854 - 190,405,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,357,607 - 190,368,421 (+)NCBI
Celera2175,591,773 - 175,602,552 (+)NCBICelera
Cytogenetic Map2q34NCBI
Ctsk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955588148,748 - 158,093 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955588149,036 - 158,093 (-)NCBIChiLan1.0ChiLan1.0
CTSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,022,154 - 99,036,182 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,777,588 - 98,789,833 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01126,146,555 - 126,158,662 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11129,795,966 - 129,808,316 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,795,966 - 129,808,316 (-)Ensemblpanpan1.1panPan2
CTSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,928,725 - 59,938,293 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,929,287 - 59,938,507 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,375,185 - 59,382,593 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,945,042 - 60,954,711 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,945,043 - 61,028,017 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,774,900 - 59,782,304 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,859,083 - 59,866,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,587,454 - 60,594,862 (-)NCBIUU_Cfam_GSD_1.0
Ctsk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,992,384 - 22,005,049 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365801,022,762 - 1,034,984 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365801,022,762 - 1,038,020 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,391,428 - 98,404,961 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,389,459 - 98,404,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,639,430 - 107,653,109 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,471,719 - 12,484,331 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477219,015,835 - 19,025,588 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477219,013,189 - 19,026,756 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ctsk
353 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:417
Count of miRNA genes:276
Interacting mature miRNAs:293
Transcripts:ENSMUST00000015664
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse

Markers in Region
AI323530  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,509,019 - 95,509,164UniSTSGRCm38
MGSCv37395,312,941 - 95,313,086UniSTSGRCm37
Celera396,940,138 - 96,940,283UniSTS
Cytogenetic Map3F2.1UniSTS
Whitehead/MRC_RH31085.92UniSTS
Whitehead/MRC_RH31085.81UniSTS
PMC24840P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,506,410 - 95,506,776UniSTSGRCm38
MGSCv37395,310,332 - 95,310,698UniSTSGRCm37
Celera396,937,523 - 96,937,889UniSTS
Cytogenetic Map3F2.1UniSTS
Ctsk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,502,591 - 95,502,691UniSTSGRCm38
MGSCv37395,306,513 - 95,306,613UniSTSGRCm37
Celera396,933,696 - 96,933,796UniSTS
Cytogenetic Map3F2.1UniSTS
cM Map347.9UniSTS
Ctsk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,508,883 - 95,509,226UniSTSGRCm38
MGSCv37395,312,805 - 95,313,148UniSTSGRCm37
Celera396,940,002 - 96,940,345UniSTS
Cytogenetic Map3F2.1UniSTS
Ctsk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,502,709 - 95,502,773UniSTSGRCm38
MGSCv37395,306,631 - 95,306,695UniSTSGRCm37
Celera396,933,814 - 96,933,878UniSTS
Cytogenetic Map3F2.1UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000015664   ⟹   ENSMUSP00000015664
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,406,567 - 95,416,673 (+)Ensembl
GRCm38.p6 Ensembl395,499,256 - 95,509,362 (+)Ensembl
RefSeq Acc Id: NM_007802   ⟹   NP_031828
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,406,521 - 95,416,698 (+)NCBI
GRCm38395,499,210 - 95,509,387 (+)NCBI
MGSCv37395,303,208 - 95,313,284 (+)RGD
Celera396,930,315 - 96,940,506 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031828   ⟸   NM_007802
- Peptide Label: preproprotein
- UniProtKB: O88718 (UniProtKB/Swiss-Prot),   P55097 (UniProtKB/Swiss-Prot),   Q545T0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000015664   ⟸   ENSMUST00000015664
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55097-F1-model_v2 AlphaFold P55097 1-329 view protein structure

Promoters
RGD ID:6833612
Promoter ID:MM_KWN:35306
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000015664
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,302,521 - 95,303,487 (+)MPROMDB
RGD ID:6881590
Promoter ID:EPDNEW_M4246
Type:multiple initiation site
Name:Ctsk_1
Description:Mus musculus cathepsin K , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4247  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38395,499,281 - 95,499,341EPDNEW
RGD ID:6881592
Promoter ID:EPDNEW_M4247
Type:multiple initiation site
Name:Ctsk_2
Description:Mus musculus cathepsin K , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4246  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38395,499,800 - 95,499,860EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107823 AgrOrtholog
Ensembl Genes ENSMUSG00000028111 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000015664 ENTREZGENE
  ENSMUST00000015664.5 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13038 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107823 ENTREZGENE
NCBI Gene 13038 ENTREZGENE
PANTHER CATHEPSIN K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ctsk PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CATK_MOUSE UniProtKB/Swiss-Prot
  O88718 ENTREZGENE
  P55097 ENTREZGENE
  Q545T0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O88718 UniProtKB/Swiss-Prot