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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:biperiden
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Accession:CHEBI:3112 term browser browse the term
Definition:A member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.
Synonyms:related_synonym: 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol;   Formula=C21H29NO;   InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;   InChIKey=YSXKPIUOCJLQIE-UHFFFAOYSA-N;   SMILES=OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1;   alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropanol;   alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol;   biperidene;   biperideno;   biperidenum
 alt_id: CHEBI:251063
 xref: Beilstein:290038;   CAS:514-65-8;   DrugBank:DB00810;   Drug_Central:374;   KEGG:C07941;   KEGG:D00779;   LINCS:LSM-1235
 xref_mesh: MESH:D001712
 xref: PMID:10877003;   PMID:12873507;   PMID:25160769;   PMID:25466702;   PMID:2579237;   PMID:26479221;   PMID:28216067;   Patent:US2789110;   Wikipedia:Biperiden


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biperiden term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Biperiden results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
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G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP Biperiden binds to and results in decreased activity of CHRM1 protein CTD PMID:21336581 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antidyskinesia agent 1131
              biperiden 2
                biperiden hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        tertiary amino compound 8630
                                          biperiden 2
                                            biperiden hydrochloride 0
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