Anxa1 (annexin A1) - Rat Genome Database

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Gene: Anxa1 (annexin A1) Mus musculus
Analyze
Symbol: Anxa1
Name: annexin A1
RGD ID: 10164
MGI Page MGI
Description: Predicted to enable several functions, including calcium-dependent phospholipid binding activity; double-stranded DNA helicase activity; and phospholipase A2 inhibitor activity. Predicted to contribute to single-stranded DNA binding activity and single-stranded RNA binding activity. Involved in several processes, including myoblast migration involved in skeletal muscle regeneration; neutrophil homeostasis; and positive regulation of neutrophil apoptotic process. Acts upstream of or within several processes, including arachidonic acid secretion; positive regulation of G1/S transition of mitotic cell cycle; and regulation of cell population proliferation. Located in several cellular components, including apical plasma membrane; lateral plasma membrane; and sarcolemma. Is active in cornified envelope. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; skeleton; and skin. Human ortholog(s) of this gene implicated in brain ischemia and pancreatic cancer. Orthologous to human ANXA1 (annexin A1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: annexin I; annexin-1; Anx; Anx-1; Anx-A1; C430014K04Rik; calpactin II; calpactin-2; chromobindin-9; lipocortin 1; lipocortin I; Lp; Lpc; Lpc-1; Lpc1; p35; phospholipase A2 inhibitory protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,350,798 - 20,368,035 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1920,350,792 - 20,368,308 (-)EnsemblGRCm39 Ensembl
GRCm381920,373,434 - 20,390,671 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,373,428 - 20,390,944 (-)EnsemblGRCm38mm10GRCm38
MGSCv371920,447,924 - 20,465,161 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361920,440,455 - 20,457,696 (-)NCBIMGSCv36mm8
Celera1921,098,423 - 21,115,607 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Animal Mammary Neoplasms  (ISO)
asthma  (IMP)
autistic disorder  (ISO)
Blister  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cataract  (IAGP,ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
colitis  (ISO)
contact dermatitis  (IMP)
COVID-19  (ISO)
Craniofacial Abnormalities  (ISO)
Delayed Hypersensitivity  (IMP)
Discoid Lupus Erythematosus  (ISO)
dry eye syndrome  (ISO)
ductal carcinoma in situ  (ISO)
encephalitis  (IMP)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypothyroidism  (ISO)
Inflammation  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
keratosis follicularis  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mouth Neoplasms  (ISO)
Myocardial Reperfusion Injury  (IMP,ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (IMP,ISO)
Ocular Toxoplasmosis  (IEP)
pancreatic cancer  (ISO)
paranasal sinus benign neoplasm  (ISO)
pleurisy  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
Rhinosinusitis  (ISO)
seborrheic keratosis  (ISO)
Skin Neoplasms  (IEP)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
stomach disease  (ISO)
transitional cell carcinoma  (ISO)
uveitis  (IMP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-lariciresinol  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(-)-lariciresinol  (ISO)
(R)-noradrenaline  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aniline  (ISO)
anthracen-2-amine  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
Bardoxolone methyl  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (ISO)
carrageenan  (EXP)
CHIR 99021  (ISO)
chloropicrin  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
D-penicillamine  (ISO)
DDT  (ISO)
Deoxycorticosterone acetate  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethyldithiocarbamic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eurycomanone  (ISO)
fluoxetine  (ISO)
flurbiprofen  (EXP)
fluticasone  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
graphite  (ISO)
hexachlorobenzene  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP)
magnesium atom  (ISO)
mercury dibromide  (ISO)
metacetamol  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosgene  (EXP)
potassium chloride  (ISO)
potassium dichromate  (ISO)
Propiverine  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rimonabant  (EXP)
rofecoxib  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tanespimycin  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thiophenes  (ISO)
titanium dioxide  (EXP)
torcetrapib  (ISO)
triadimefon  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (IBA,ISO)
adaptive immune response  (IEA)
alpha-beta T cell differentiation  (IBA,IMP)
arachidonic acid secretion  (IBA,IMP)
cell surface receptor signaling pathway  (IBA,ISO)
cellular response to glucocorticoid stimulus  (IBA,IMP,ISO)
cellular response to hydrogen peroxide  (IBA,ISO)
cellular response to vascular endothelial growth factor stimulus  (IBA,ISO)
DNA duplex unwinding  (IBA,ISO)
endocrine pancreas development  (IBA,ISO)
estrous cycle  (IBA,ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (ISO)
gliogenesis  (IBA,ISO)
granulocyte chemotaxis  (IBA,ISO)
hepatocyte differentiation  (IBA,ISO)
immune system process  (IEA)
inflammatory response  (IBA,IMP)
innate immune response  (IEA)
insulin secretion  (IBA,ISO)
keratinocyte differentiation  (IBA,ISO)
localization  (ISO)
monocyte chemotaxis  (ISO)
myoblast migration involved in skeletal muscle regeneration  (IBA,IDA)
negative regulation of exocytosis  (IBA,ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of phospholipase A2 activity  (IBA,ISO)
negative regulation of protein secretion  (ISO)
negative regulation of T-helper 2 cell differentiation  (IBA,ISO)
neutrophil activation  (ISO)
neutrophil clearance  (IBA,ISO)
neutrophil homeostasis  (IMP,ISO)
peptide cross-linking  (ISO)
phagocytosis  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IBA,ISO)
positive regulation of G1/S transition of mitotic cell cycle  (IBA,IMP)
positive regulation of interleukin-2 production  (IBA,ISO)
positive regulation of neutrophil apoptotic process  (IBA,IMP)
positive regulation of prostaglandin biosynthetic process  (IBA,ISO)
positive regulation of T cell proliferation  (IBA,ISO)
positive regulation of T-helper 1 cell differentiation  (IBA,ISO)
positive regulation of vesicle fusion  (IBA,ISO)
positive regulation of wound healing  (IBA,ISO)
prolactin secretion  (IBA,ISO)
prostate gland development  (IBA,ISO)
regulation of cell population proliferation  (IMP)
regulation of cell shape  (IBA,ISO)
regulation of hormone secretion  (IBA,ISO)
regulation of inflammatory response  (IBA,IMP)
regulation of interleukin-1 production  (IBA,IMP)
regulation of leukocyte migration  (IBA,IMP)
response to corticosteroid  (ISO)
response to estradiol  (IBA,ISO)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to interleukin-1  (IBA,ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (IBA,ISO)
response to X-ray  (IBA,ISO)
response to xenobiotic stimulus  (ISO)
sequestering of metal ion  (ISO)
signal transduction  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue morphology  (IAGP)
abnormal adipose tissue physiology  (IAGP)
abnormal adrenal gland secretion  (IAGP)
abnormal colon morphology  (IAGP)
abnormal corticotroph morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal fat pad morphology  (IAGP)
abnormal folliculo-stellate cell morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal gonadotroph morphology  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal lactotroph morphology  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal palatine bone morphology  (IAGP)
abnormal sagittal suture morphology  (IAGP)
abnormal somatotroph morphology  (IAGP)
abnormal tumor vascularization  (IAGP)
abnormal vascular endothelial cell migration  (IAGP)
abnormal vascular endothelial cell physiology  (IAGP)
decreased corticotroph cell size  (IAGP)
decreased metastatic potential  (IAGP)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased tumor growth/size  (IAGP)
decreased vascular endothelial cell proliferation  (IAGP)
delayed wound healing  (IAGP)
ectopic cranial bone  (IAGP)
impaired macrophage phagocytosis  (IAGP)
increased adrenocorticotropin level  (IAGP)
increased bone mineral density  (IAGP)
increased circulating insulin level  (IAGP)
increased inflammatory response  (IAGP)
increased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
increased susceptibility to induced colitis  (IAGP)
thin adrenal cortex  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Annexin A1 protein attenuates cyclosporine-induced renal hemodynamics changes and macrophage infiltration in rats. Araujo LP, etal., Inflamm Res. 2012 Mar;61(3):189-96. doi: 10.1007/s00011-011-0400-z. Epub 2011 Nov 19.
2. A novel effect for annexin 1-derived peptide ac2-26: reduction of allergic inflammation in the rat. Bandeira-Melo C, etal., J Pharmacol Exp Ther. 2005 Jun;313(3):1416-22. Epub 2005 Mar 22.
3. Loss of annexin A1 expression in breast cancer progression. Cao Y, etal., Appl Immunohistochem Mol Morphol. 2008 Dec;16(6):530-4. doi: 10.1097/PAI.0b013e31817432c3.
4. Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy. Chuthapisith S, etal., Eur J Cancer. 2009 May;45(7):1274-81. doi: 10.1016/j.ejca.2008.12.026. Epub 2009 Jan 24.
5. Inflammatory neutrophils secrete annexin 1 during experimentally induced colitis in rats. Comera C, etal., Dig Dis Sci. 1999 Jul;44(7):1448-57.
6. Overexpression of annexin a1 induced by terephthalic acid calculi in rat bladder cancer. Cui L, etal., Proteomics. 2007 Nov;7(22):4192-202.
7. Mast cells modulate the inflammatory process in endotoxin-induced uveitis. da Silva PS, etal., Mol Vis. 2011;17:1310-9. Epub 2011 May 8.
8. Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells. de Graauw M, etal., Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6340-5. doi: 10.1073/pnas.0913360107. Epub 2010 Mar 22.
9. In vivo modulation of annexins I, II and V expression by thyroxine and methylthiouracil. el Btaouri H, etal., Eur J Biochem. 1996 Dec 15;242(3):506-11.
10. Annexin 1 mimetic peptide protects against renal ischemia/reperfusion injury in rats. Facio FN Jr, etal., J Mol Med (Berl). 2011 Jan;89(1):51-63. doi: 10.1007/s00109-010-0684-4. Epub 2010 Oct 16.
11. Expression of genes that encode the annexin-1 and galectin-1 proteins in nasal polyposis and their modulation by glucocorticoid. Fernandes AM, etal., Braz J Otorhinolaryngol. 2010 Mar-Apr;76(2):213-8.
12. Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone. Ferreira SH, etal., Br J Pharmacol. 1997 Jul;121(5):883-8.
13. Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1-FPR2/ALX anti-inflammatory system. Gavins FN, etal., FASEB J. 2012 Dec;26(12):4977-89. doi: 10.1096/fj.12-205971. Epub 2012 Sep 10.
14. Actin and annexins I and II are among the main endothelial plasmalemma-associated proteins forming early glucose adducts in experimental diabetes. Ghitescu LD, etal., Diabetes. 2001 Jul;50(7):1666-74.
15. Anti-inflammatory mechanisms of the annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro. Girol AP, etal., J Immunol. 2013 Jun 1;190(11):5689-701. doi: 10.4049/jimmunol.1202030. Epub 2013 May 3.
16. Increased lipocortin-1 (annexin-1) expression in the sciatic nerve of Lewis rats with experimental autoimmune neuritis. Gold R, etal., Acta Neuropathol. 1999 Dec;98(6):583-9.
17. Identification of proteins that modify cataract of mouse eye lens. Hoehenwarter W, etal., Proteomics. 2008 Dec;8(23-24):5011-24. doi: 10.1002/pmic.200800380.
18. Effect of annexin-1 on experimental autoimmune encephalomyelitis (EAE) in the rat. Huitinga I, etal., Clin Exp Immunol. 1998 Jan;111(1):198-204.
19. Prolonged gaseous hypothermia prevents the upregulation of phagocytosis-specific protein annexin 1 and causes low-amplitude EEG activity in the aged rat brain after cerebral ischemia. Joseph C, etal., J Cereb Blood Flow Metab. 2012 Aug;32(8):1632-42. doi: 10.1038/jcbfm.2012.65. Epub 2012 May 23.
20. Global gene expression profiling of ischemic preconditioning in the rat retina. Kamphuis W, etal., Mol Vis. 2007 Jun 28;13:1020-30.
21. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
22. Involvement of lipocortin I in development of galactose-induced cataracts in rat. Koshimoto HN, etal., Exp Eye Res. 1992 May;54(5):817-20.
23. Anti-annexin 1 antibodies: a new diagnostic marker in the serum of patients with discoid lupus erythematosus. Kretz CC, etal., Exp Dermatol. 2010 Oct;19(10):919-21. doi: 10.1111/j.1600-0625.2010.01145.x.
24. Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: analysis of their mechanism of action. La M, etal., FASEB J. 2001 Oct;15(12):2247-56.
25. Upregulation of annexins I, II, and V after traumatic spinal cord injury in adult rats. Liu N, etal., J Neurosci Res. 2004 Aug 1;77(3):391-401.
26. Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury. Liu NK, etal., J Neuropathol Exp Neurol. 2007 Oct;66(10):932-43.
27. [In vivo effect of annexin I down-regulation on the growth of human pancreatic cancer in nude mice] Liu Q, etal., Zhonghua Zhong Liu Za Zhi. 2008 Dec;30(12):897-900.
28. Brain genomics of intracerebral hemorrhage. Lu A, etal., J Cereb Blood Flow Metab. 2006 Feb;26(2):230-52.
29. Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. Lu J, etal., J Biol Chem 2005 Feb 11;280(6):4834-41. Epub 2004 Nov 19.
30. Annexin A1 attenuates EMT and metastatic potential in breast cancer. Maschler S, etal., EMBO Mol Med. 2010 Oct;2(10):401-14. doi: 10.1002/emmm.201000095.
31. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
32. MGDs mouse GO annotations MGD data from the GO Consortium
33. MGD IEA MGD IEA
34. The involvement of anti-inflammatory protein, annexin A1, in ocular toxoplasmosis. Mimura KK, etal., Mol Vis. 2012;18:1583-93. Epub 2012 Jun 15.
35. Annexin-1-deficient mice exhibit spontaneous airway hyperresponsiveness and exacerbated allergen-specific antibody responses in a mouse model of asthma. Ng FS, etal., Clin Exp Allergy. 2011 Dec;41(12):1793-803. doi: 10.1111/j.1365-2222.2011.03855.x. Epub 2011 Sep 20.
36. Molecules in focus: cytosolic phospholipase A2-alpha. Niknami M, etal., Int J Biochem Cell Biol. 2009 May;41(5):994-7. doi: 10.1016/j.biocel.2008.07.017. Epub 2008 Aug 8.
37. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
38. An immunocytochemical and in situ hybridization analysis of annexin 1 expression in rat mast cells: modulation by inflammation and dexamethasone. Oliani SM, etal., Lab Invest. 2000 Sep;80(9):1429-38.
39. Changes in gene expression during chemical-induced nephrocarcinogenicity in the Eker rat. Patel SK, etal., Mol Carcinog. 2003 Nov;38(3):141-54.
40. Annexin 1 exerts anti-nociceptive effects after peripheral inflammatory pain through formyl-peptide-receptor-like 1 in rat dorsal root ganglion. Pei L, etal., Br J Anaesth. 2011 Dec;107(6):948-58. doi: 10.1093/bja/aer299. Epub 2011 Oct 11.
41. Elevated levels of annexin I protein in vitro and in vivo in rat and human mammary adenocarcinoma. Pencil SD and Toth M, Clin Exp Metastasis. 1998 Feb;16(2):113-21.
42. Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions. Perretti M, etal., J Leukoc Biol. 1999 May;65(5):583-9.
43. A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation. Pfisterer P, etal., J Biol Chem 2002 Feb 22;277(8):6637-44. Epub 2001 Dec 10.
44. Myenteric denervation in gastric carcinogenesis: differential modulation of nitric oxide and annexin-A1. Polli-Lopes AC, etal., Int J Clin Exp Pathol. 2013;6(1):13-23. Epub 2012 Nov 20.
45. Reperfusion-induced myocardial dysfunction is prevented by endogenous annexin-A1 and its N-terminal-derived peptide Ac-ANX-A1(2-26). Qin C, etal., Br J Pharmacol. 2013 Jan;168(1):238-52. doi: 10.1111/j.1476-5381.2012.02176.x.
46. Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain. Relton JK, etal., J Exp Med. 1991 Aug 1;174(2):305-10.
47. Mouse MP Annotation Import Pipeline RGD automated import pipeline
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Down-regulation of annexin A1 and A2 protein expression in intestinal-type sinonasal adenocarcinomas. Rodrigo JP, etal., Hum Pathol. 2011 Jan;42(1):88-94. doi: 10.1016/j.humpath.2010.05.017. Epub 2010 Oct 20.
51. Localization of annexin I (lipocortin I, p35) mRNA in normal and diseased human skin by in situ hybridization. Sato-Matsumura KC, etal., Arch Dermatol Res. 1996 Sep;288(10):565-9.
52. Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. Shan L, etal., Toxicol Pathol. 2005;33(7):768-75.
53. Proteomic and pathway analyses reveal a network of inflammatory genes associated with differences in skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice. Shen J, etal., Carcinogenesis. 2012 Nov;33(11):2208-19. doi: 10.1093/carcin/bgs213. Epub 2012 Jul 10.
54. Tear proteome and protein network analyses reveal a novel pentamarker panel for tear film characterization in dry eye and meibomian gland dysfunction. Soria J, etal., J Proteomics. 2013 Jan 14;78:94-112. doi: 10.1016/j.jprot.2012.11.017. Epub 2012 Nov 29.
55. Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats. Touyz RM, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R73-8. Epub 2005 Aug 18.
56. Annexin I in fibrotic rat lung and cultured lung fibroblasts following irradiation. Ts'ao C, etal., Int J Radiat Biol. 1997 Aug;72(2):227-34.
57. Novel proteins regulated by mTOR in subependymal giant cell astrocytomas of patients with tuberous sclerosis complex and new therapeutic implications. Tyburczy ME, etal., Am J Pathol. 2010 Apr;176(4):1878-90. doi: 10.2353/ajpath.2010.090950. Epub 2010 Feb 4.
58. Chronic rhinosinusitis with nasal polyps: a proteomic analysis. Upton DC, etal., Ann Otol Rhinol Laryngol. 2011 Dec;120(12):780-6.
59. Liver cirrhosis induces renal and liver phospholipase A2 activity in rats. Vishwanath BS, etal., J Clin Invest. 1996 Jul 15;98(2):365-71.
60. Annexin A1 expression and its prognostic significance in human breast cancer. Wang LP, etal., Neoplasma. 2010;57(3):253-9.
61. Zhonghua zhong liu za zhi [Chinese journal of oncology] Xue LY, etal., Zhonghua Zhong Liu Za Zhi. 2007 Jun;29(6):444-8.
62. Inhibitory effect of annexin I on synovial inflammation in rat adjuvant arthritis. Yang Y, etal., Arthritis Rheum. 1999 Jul;42(7):1538-44.
63. Deficiency of annexin A1 in CD4+ T cells exacerbates T cell-dependent inflammation. Yang YH, etal., J Immunol. 2013 Feb 1;190(3):997-1007. doi: 10.4049/jimmunol.1202236. Epub 2012 Dec 24.
64. Clinical significance of annexin A1 expression in breast cancer. Yom CK, etal., J Breast Cancer. 2011 Dec;14(4):262-8. doi: 10.4048/jbc.2011.14.4.262. Epub 2011 Dec 27.
Additional References at PubMed
PMID:1676980   PMID:2522299   PMID:2974946   PMID:7592984   PMID:7698766   PMID:7706559   PMID:7768185   PMID:7774911   PMID:7782070   PMID:7894166   PMID:8013374   PMID:8043949  
PMID:8075499   PMID:8499657   PMID:8587144   PMID:8634333   PMID:8719346   PMID:9107690   PMID:9525630   PMID:9606417   PMID:9624122   PMID:9763662   PMID:9826670   PMID:9924185  
PMID:10349636   PMID:10725249   PMID:10876093   PMID:10922068   PMID:10956639   PMID:11042159   PMID:11076861   PMID:11423996   PMID:11440986   PMID:12475898   PMID:12477932   PMID:12516535  
PMID:12553880   PMID:12560218   PMID:12586783   PMID:14506282   PMID:14967753   PMID:15022342   PMID:15064349   PMID:15169834   PMID:15197108   PMID:15485879   PMID:15489334   PMID:15749912  
PMID:15920146   PMID:16000391   PMID:16014420   PMID:16141072   PMID:16141073   PMID:16210453   PMID:16547279   PMID:16601136   PMID:16602821   PMID:16720734   PMID:16829211   PMID:16835395  
PMID:17008549   PMID:17026533   PMID:17114490   PMID:17158208   PMID:17218541   PMID:17317721   PMID:17384087   PMID:17405164   PMID:17948261   PMID:18056401   PMID:18081892   PMID:18307411  
PMID:18469846   PMID:18794802   PMID:18802107   PMID:18827967   PMID:18952200   PMID:19029200   PMID:19095957   PMID:19103997   PMID:19104500   PMID:19208747   PMID:19244132   PMID:19553536  
PMID:19625660   PMID:19805119   PMID:19912648   PMID:20139728   PMID:20405035   PMID:20489160   PMID:20558817   PMID:20578244   PMID:20962261   PMID:21245195   PMID:21267068   PMID:21370880  
PMID:21383699   PMID:21398608   PMID:21565611   PMID:21677750   PMID:21873635   PMID:21957127   PMID:22011168   PMID:22159717   PMID:22493082   PMID:22511458   PMID:22539796   PMID:22562975  
PMID:22673621   PMID:22791338   PMID:22897118   PMID:23038751   PMID:23077482   PMID:23144744   PMID:23222458   PMID:23241962   PMID:23277424   PMID:23277546   PMID:23487789   PMID:23638088  
PMID:23777345   PMID:24048896   PMID:24187664   PMID:24312665   PMID:24464914   PMID:24648446   PMID:24668763   PMID:24790181   PMID:24997993   PMID:25124533   PMID:25129480   PMID:25184992  
PMID:25520364   PMID:25533809   PMID:25562320   PMID:25616869   PMID:25619792   PMID:25664854   PMID:25795053   PMID:25818588   PMID:26102067   PMID:26386311   PMID:26410627   PMID:26458561  
PMID:26470781   PMID:26606969   PMID:26644517   PMID:26667898   PMID:26677751   PMID:26803520   PMID:26892496   PMID:26943321   PMID:27012521   PMID:27343762   PMID:27426034   PMID:27435504  
PMID:27451051   PMID:27633771   PMID:27833268   PMID:27995621   PMID:28062503   PMID:28071719   PMID:28289158   PMID:28320709   PMID:28373208   PMID:28378742   PMID:28389361   PMID:28432199  
PMID:28489004   PMID:28655761   PMID:29030970   PMID:29085990   PMID:29101233   PMID:29115663   PMID:29192208   PMID:29213013   PMID:29249464   PMID:29263330   PMID:29781578   PMID:30254199  
PMID:30419240   PMID:30595499   PMID:30623413   PMID:30650525   PMID:30896112   PMID:30972066   PMID:31040226   PMID:31154815   PMID:31162944   PMID:31196457   PMID:31303498   PMID:31398292  
PMID:31645615   PMID:31738896   PMID:31908042   PMID:32015229   PMID:32107769   PMID:32283822   PMID:32325033   PMID:32497150   PMID:32512864   PMID:32552056   PMID:32554809   PMID:32758484  
PMID:33333231   PMID:33440601   PMID:33523920   PMID:33675846   PMID:33757117   PMID:33968020   PMID:34022892   PMID:34103347   PMID:34158860   PMID:34237247   PMID:34526398   PMID:34603288  
PMID:35179426   PMID:35293862   PMID:35352285   PMID:35664067   PMID:35798730   PMID:35864088  


Genomics

Comparative Map Data
Anxa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,350,798 - 20,368,035 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1920,350,792 - 20,368,308 (-)EnsemblGRCm39 Ensembl
GRCm381920,373,434 - 20,390,671 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,373,428 - 20,390,944 (-)EnsemblGRCm38mm10GRCm38
MGSCv371920,447,924 - 20,465,161 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361920,440,455 - 20,457,696 (-)NCBIMGSCv36mm8
Celera1921,098,423 - 21,115,607 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.83NCBI
ANXA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38973,151,865 - 73,170,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl973,151,865 - 73,170,393 (+)EnsemblGRCh38hg38GRCh38
GRCh37975,766,781 - 75,785,309 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36974,956,601 - 74,975,127 (+)NCBINCBI36Build 36hg18NCBI36
Build 34972,996,334 - 73,014,861NCBI
Celera946,339,417 - 46,357,944 (+)NCBICelera
Cytogenetic Map9q21.13ENTREZGENE
HuRef945,589,147 - 45,607,684 (+)NCBIHuRef
CHM1_1975,913,630 - 75,932,174 (+)NCBICHM1_1
T2T-CHM13v2.0985,303,301 - 85,321,829 (+)NCBIT2T-CHM13v2.0
Anxa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21217,861,175 - 217,877,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,861,175 - 217,877,343 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1226,201,607 - 226,217,642 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01233,138,171 - 233,154,203 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01225,956,194 - 225,972,229 (-)NCBIRnor_WKY
Rnor_6.01237,893,983 - 237,910,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,893,966 - 237,910,012 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01245,192,875 - 245,220,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,478,436 - 223,494,455 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,642,460 - 223,658,478 (-)NCBI
Celera1215,138,950 - 215,154,969 (-)NCBICelera
Cytogenetic Map1q51NCBI
Anxa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555125,686,508 - 5,703,645 (-)NCBIChiLan1.0ChiLan1.0
ANXA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1971,930,148 - 71,948,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl971,929,728 - 71,948,779 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0951,647,404 - 51,665,990 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ANXA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1184,744,159 - 84,763,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl184,744,163 - 84,763,011 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,210,169 - 85,229,021 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,194,249 - 85,213,101 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,194,253 - 85,213,101 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1184,963,509 - 84,982,291 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0184,666,120 - 84,684,901 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,425,388 - 85,444,242 (-)NCBIUU_Cfam_GSD_1.0
Anxa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947132,030,632 - 132,048,702 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365039,124,314 - 9,142,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANXA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,414,306 - 226,432,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,414,200 - 226,431,963 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,989,694 - 253,007,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANXA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11284,207,818 - 84,226,438 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1284,207,820 - 84,226,562 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603872,640,484 - 72,659,219 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anxa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624811764,940 - 782,198 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624811765,338 - 782,203 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH129631  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera1921,098,458 - 21,098,643UniSTS
Cytogenetic Map19BUniSTS
cM Map1918.0UniSTS
Anxa1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381920,383,822 - 20,384,758UniSTSGRCm38
MGSCv371920,458,312 - 20,459,248UniSTSGRCm37
Celera1921,108,757 - 21,109,693UniSTS
Cytogenetic Map19BUniSTS
cM Map1918.0UniSTS
cM Map1918.0UniSTS
cM Map1918.0UniSTS
Anxa1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381920,390,955 - 20,391,246UniSTSGRCm38
MGSCv371920,465,445 - 20,465,736UniSTSGRCm37
Celera1921,115,891 - 21,116,080UniSTS
Cytogenetic Map19BUniSTS
cM Map1918.0UniSTS
Anxa1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381920,373,488 - 20,373,643UniSTSGRCm38
MGSCv371920,447,978 - 20,448,133UniSTSGRCm37
Celera1921,098,477 - 21,098,632UniSTS
Cytogenetic Map19BUniSTS
cM Map1918.0UniSTS
Anxa1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381920,373,692 - 20,373,768UniSTSGRCm38
MGSCv371920,448,182 - 20,448,258UniSTSGRCm37
Cytogenetic Map19BUniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
12801464Rta2_mretinal aging 2 (mouse)141230287425302874Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir196a-1mmu-miR-196a-5pOncomiRDBexternal_infoNANA18663355
Mir196a-2mmu-miR-196a-5pOncomiRDBexternal_infoNANA18663355

Predicted Target Of
Summary Value
Count of predictions:507
Count of miRNA genes:257
Interacting mature miRNAs:290
Transcripts:ENSMUST00000025561, ENSMUST00000163902, ENSMUST00000164587, ENSMUST00000165518, ENSMUST00000167668, ENSMUST00000168020, ENSMUST00000171423
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC158775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT009771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU684130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000025561   ⟹   ENSMUSP00000025561
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,350,792 - 20,368,308 (-)Ensembl
GRCm38.p6 Ensembl1920,373,428 - 20,390,944 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163902
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,350,920 - 20,352,951 (-)Ensembl
GRCm38.p6 Ensembl1920,373,556 - 20,375,587 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164587
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,357,023 - 20,368,015 (-)Ensembl
GRCm38.p6 Ensembl1920,379,659 - 20,390,651 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165518
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,355,044 - 20,357,385 (-)Ensembl
GRCm38.p6 Ensembl1920,377,680 - 20,380,021 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167668
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,355,044 - 20,355,953 (-)Ensembl
GRCm38.p6 Ensembl1920,377,680 - 20,378,589 (-)Ensembl
RefSeq Acc Id: ENSMUST00000168020
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,355,482 - 20,359,489 (-)Ensembl
GRCm38.p6 Ensembl1920,378,118 - 20,382,125 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171423   ⟹   ENSMUSP00000158429
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,350,794 - 20,368,125 (-)Ensembl
GRCm38.p6 Ensembl1920,373,430 - 20,390,761 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235280   ⟹   ENSMUSP00000158305
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,350,792 - 20,368,037 (-)Ensembl
GRCm38.p6 Ensembl1920,373,428 - 20,390,673 (-)Ensembl
RefSeq Acc Id: NM_010730   ⟹   NP_034860
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391920,350,798 - 20,368,035 (-)NCBI
GRCm381920,373,434 - 20,390,671 (-)ENTREZGENE
MGSCv371920,447,924 - 20,465,161 (-)RGD
Celera1921,098,423 - 21,115,607 (-)RGD
cM Map19 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034860   ⟸   NM_010730
- UniProtKB: P10107 (UniProtKB/Swiss-Prot),   Q4FJV4 (UniProtKB/TrEMBL),   A0A8C6MU63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000158429   ⟸   ENSMUST00000171423
RefSeq Acc Id: ENSMUSP00000025561   ⟸   ENSMUST00000025561
RefSeq Acc Id: ENSMUSP00000158305   ⟸   ENSMUST00000235280

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10107-F1-model_v2 AlphaFold P10107 1-346 view protein structure

Promoters
RGD ID:13679080
Promoter ID:EPDNEW_M23689
Type:initiation region
Name:Anxa1_1
Description:Mus musculus annexin A1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381920,390,672 - 20,390,732EPDNEW
RGD ID:6829836
Promoter ID:MM_KWN:26622
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000025561,   ENSMUST00000099584,   UC008GYJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361920,462,926 - 20,465,177 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96819 AgrOrtholog
Ensembl Genes ENSMUSG00000024659 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000025561 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000158305 UniProtKB/Swiss-Prot
  ENSMUSP00000158429.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025561 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000171423.9 UniProtKB/TrEMBL
  ENSMUST00000235280 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.220.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Annexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96819 ENTREZGENE
NCBI Gene 16952 ENTREZGENE
PANTHER PTHR10502:SF17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Annexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Anxa1 PhenoGen
PRINTS ANNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANNEXINI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANNEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494BBD8_MOUSE UniProtKB/TrEMBL
  A0A8C6MU63 ENTREZGENE
  ANXA1_MOUSE UniProtKB/Swiss-Prot
  B7STB7_MOUSE UniProtKB/TrEMBL
  P10107 ENTREZGENE
  Q3U5N9_MOUSE UniProtKB/TrEMBL
  Q3US43_MOUSE UniProtKB/TrEMBL
  Q4FJV4 ENTREZGENE, UniProtKB/TrEMBL
  Q4FK88_MOUSE UniProtKB/TrEMBL