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Gene: Rasgrp1 (RAS guanyl releasing protein 1) Mus musculus
Symbol: Rasgrp1
Name: RAS guanyl releasing protein 1
Description: Predicted to have several functions, including cation binding activity; diacylglycerol binding activity; and protein homodimerization activity. Involved in several processes, including activation of GTPase activity; mast cell degranulation; and positive regulation of lymphocyte differentiation. Predicted to localize to the Golgi apparatus; cytosol; and plasma membrane. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in brain; olfactory epithelium; olfactory lobe; and telencephalon mantle layer. Orthologous to human RASGRP1 (RAS guanyl releasing protein 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 1,1-dichloroethene; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: calcium and DAG-regulated guanine nucleotide exchange factor II; calDAG-GEFII; RAS guanyl-releasing protein 1; Rasgrp
Homo sapiens (human) : RASGRP1 (RAS guanyl releasing protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rasgrp1 (RAS guanyl releasing protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rasgrp1 (RAS guanyl releasing protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RASGRP1 (RAS guanyl releasing protein 1)
Canis lupus familiaris (dog) : RASGRP1 (RAS guanyl releasing protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rasgrp1 (RAS guanyl releasing protein 1)
Sus scrofa (pig) : RASGRP1 (RAS guanyl releasing protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl2117,279,993 - 117,343,001 (-)Ensembl
GRCm382117,279,983 - 117,342,877 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372117,105,729 - 117,168,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv362116,971,434 - 117,034,318 (-)NCBImm8
Celera2118,408,657 - 118,471,539 (-)NCBICelera
Cytogenetic Map2 E5NCBI
cM Map259.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Rasgrp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69138
Created: 2001-11-08
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.