Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | multiple interactions | ISO | RGD:1352947 | 6480464 | alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA], Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] | CTD | PMID:16949557 | (S)-nicotine | increases expression | ISO | RGD:1352947 | 6480464 | Nicotine results in increased expression of GOLGA4 mRNA | CTD | PMID:16949557 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of GOLGA4 mRNA | CTD | PMID:22206623 | 1-nitropyrene | increases expression | ISO | RGD:1352947 | 6480464 | 1-nitropyrene results in increased expression of GOLGA4 mRNA | CTD | PMID:19041380 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GOLGA4 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:1591925 | 6480464 | Ethinyl Estradiol results in decreased expression of GOLGA4 mRNA | CTD | PMID:29097150 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | RGD:1352947 | 6480464 | Dihydrotestosterone results in increased expression of GOLGA4 mRNA | CTD | PMID:29581250 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GOLGA4 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of GOLGA4 mRNA | CTD | PMID:21570461 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4, 4'-diaminodiphenylmethane results in increased expression of GOLGA4 mRNA | CTD | PMID:18648102 | acrolein | multiple interactions | ISO | RGD:1352947 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of GOLGA4 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of GOLGA4 mRNA | CTD | PMID:32699268 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of GOLGA4 mRNA | CTD | PMID:19770486 | aflatoxin M1 | decreases expression | ISO | RGD:1352947 | 6480464 | Aflatoxin M1 results in decreased expression of GOLGA4 mRNA | CTD | PMID:30928695 | alpha-pinene | multiple interactions | ISO | RGD:1352947 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of GOLGA4 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of GOLGA4 mRNA | CTD | PMID:32699268 | arsane | decreases expression | ISO | RGD:1352947 | 6480464 | Arsenic results in decreased expression of GOLGA4 mRNA | CTD | PMID:16835338 | arsane | affects methylation | ISO | RGD:1352947 | 6480464 | Arsenic affects the methylation of GOLGA4 gene | CTD | PMID:25304211 | arsane | decreases expression | EXP | | 6480464 | Arsenic results in decreased expression of GOLGA4 mRNA | CTD | PMID:19654921 | arsenic atom | decreases expression | ISO | RGD:1352947 | 6480464 | Arsenic results in decreased expression of GOLGA4 mRNA | CTD | PMID:16835338 | arsenic atom | affects methylation | ISO | RGD:1352947 | 6480464 | Arsenic affects the methylation of GOLGA4 gene | CTD | PMID:25304211 | arsenic atom | decreases expression | EXP | | 6480464 | Arsenic results in decreased expression of GOLGA4 mRNA | CTD | PMID:19654921 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzoapyrene results in increased expression of GOLGA4 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | RGD:1352947 | 6480464 | Benzoapyrene affects the methylation of GOLGA4 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:1352947 | 6480464 | 7 more ... | CTD | PMID:19150397, PMID:26238291 | bisphenol A | increases expression | ISO | RGD:1591925 | 6480464 | bisphenol A results in increased expression of GOLGA4 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | ISO | RGD:1591925 | 6480464 | bisphenol A results in increased methylation of GOLGA4 gene | CTD | PMID:28505145 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of GOLGA4 mRNA | CTD | PMID:24982889 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | carmustine | increases expression | ISO | RGD:1352947 | 6480464 | Carmustine results in increased expression of GOLGA4 mRNA | CTD | PMID:15980968 | chromium(6+) | affects expression | EXP | | 6480464 | chromium hexavalent ion affects the expression of GOLGA4 mRNA | CTD | PMID:28472532 | cisplatin | decreases phosphorylation | EXP | | 6480464 | Cisplatin results in decreased phosphorylation of GOLGA4 protein | CTD | PMID:22006019 | cisplatin | decreases expression | ISO | RGD:1591925 | 6480464 | Cisplatin results in decreased expression of GOLGA4 mRNA | CTD | PMID:22023808 | clorgyline | increases expression | ISO | RGD:1352947 | 6480464 | Clorgyline results in increased expression of GOLGA4 mRNA | CTD | PMID:19691856 | copper(II) sulfate | decreases expression | ISO | RGD:1352947 | 6480464 | Copper Sulfate results in decreased expression of GOLGA4 mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | RGD:1352947 | 6480464 | Cyclosporine results in increased expression of GOLGA4 mRNA | CTD | PMID:20106945, PMID:25562108 | dorsomorphin | multiple interactions | ISO | RGD:1352947 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of GOLGA4 mRNA | CTD | PMID:27188386 | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of GOLGA4 mRNA | CTD | PMID:19277126 | formaldehyde | increases expression | ISO | RGD:1352947 | 6480464 | Formaldehyde results in increased expression of GOLGA4 mRNA | CTD | PMID:23649840 | hexadecanoic acid | decreases phosphorylation | ISO | RGD:1352947 | 6480464 | Palmitic Acid results in decreased phosphorylation of GOLGA4 protein | CTD | PMID:28073184 | hydrogen peroxide | decreases expression | ISO | RGD:1352947 | 6480464 | Hydrogen Peroxide results in decreased expression of GOLGA4 mRNA | CTD | PMID:18951874 | lead(0) | affects splicing | ISO | RGD:1352947 | 6480464 | Lead affects the splicing of GOLGA4 mRNA | CTD | PMID:28903495 | lead(2+) | affects splicing | ISO | RGD:1352947 | 6480464 | Lead affects the splicing of GOLGA4 mRNA | CTD | PMID:28903495 | linsidomine | increases oxidation | ISO | RGD:1591925 | 6480464 | linsidomine results in increased oxidation of GOLGA4 protein | CTD | PMID:28086193 | Mecamylamine | increases expression | ISO | RGD:1352947 | 6480464 | Mecamylamine results in increased expression of GOLGA4 mRNA | CTD | PMID:16949557 | methapyrilene | decreases expression | ISO | RGD:1591925 | 6480464 | Methapyrilene results in decreased expression of GOLGA4 mRNA | CTD | PMID:30467583 | methyl methanesulfonate | increases expression | ISO | RGD:1352947 | 6480464 | Methyl Methanesulfonate results in increased expression of GOLGA4 mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | RGD:1352947 | 6480464 | methylmercuric chloride results in decreased expression of GOLGA4 mRNA | CTD | PMID:28001369 | nicotine | multiple interactions | ISO | RGD:1352947 | 6480464 | alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA], Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] | CTD | PMID:16949557 | nicotine | increases expression | ISO | RGD:1352947 | 6480464 | Nicotine results in increased expression of GOLGA4 mRNA | CTD | PMID:16949557 | oxaliplatin | multiple interactions | ISO | RGD:1591925 | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of GOLGA4 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | RGD:1352947 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of GOLGA4 mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of GOLGA4 mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | RGD:1352947 | 6480464 | perfluorooctane sulfonic acid results in decreased expression of GOLGA4 mRNA | CTD | PMID:27153767 | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of GOLGA4 mRNA | CTD | PMID:23091169 | PhIP | increases expression | ISO | RGD:1591925 | 6480464 | 2-amino-1-methyl-6-phenylimidazo4, 5-bpyridine results in increased expression of GOLGA4 mRNA | CTD | PMID:15215175 | rotenone | increases expression | ISO | RGD:1591925 | 6480464 | Rotenone results in increased expression of GOLGA4 mRNA | CTD | PMID:19013527 | SB 431542 | multiple interactions | ISO | RGD:1352947 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of GOLGA4 mRNA | CTD | PMID:27188386 | sodium arsenate | increases expression | EXP | | 6480464 | sodium arsenate results in increased expression of GOLGA4 mRNA | CTD | PMID:21795629 | sodium arsenite | affects methylation | ISO | RGD:1352947 | 6480464 | sodium arsenite affects the methylation of GOLGA4 gene | CTD | PMID:28589171 | succimer | multiple interactions | EXP | | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of GOLGA4 mRNA | CTD | PMID:21641980 | sunitinib | increases expression | ISO | RGD:1352947 | 6480464 | Sunitinib results in increased expression of GOLGA4 mRNA | CTD | PMID:31533062 | testosterone enanthate | affects expression | ISO | RGD:1352947 | 6480464 | testosterone enanthate affects the expression of GOLGA4 mRNA | CTD | PMID:17440010 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of GOLGA4 mRNA | CTD | PMID:31919559 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of GOLGA4 mRNA | CTD | PMID:23131501 | toluene | increases expression | ISO | RGD:1352947 | 6480464 | Toluene results in increased expression of GOLGA4 mRNA | CTD | PMID:28245982 | topotecan | multiple interactions | ISO | RGD:1591925 | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of GOLGA4 mRNA | CTD | PMID:25729387 | trichostatin A | increases expression | ISO | RGD:1352947 | 6480464 | trichostatin A results in increased expression of GOLGA4 mRNA | CTD | PMID:24935251, PMID:26272509 | trichostatin A | multiple interactions | ISO | RGD:1352947 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of GOLGA4 mRNA | CTD | PMID:27188386 | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of GOLGA4 mRNA | CTD | PMID:28973697 | trovafloxacin | multiple interactions | EXP | | 6480464 | [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GOLGA4 mRNA | CTD | PMID:18930950 | tubocurarine | decreases expression | ISO | RGD:1352947 | 6480464 | Tubocurarine results in decreased expression of GOLGA4 mRNA | CTD | PMID:16949557 | tubocurarine | multiple interactions | ISO | RGD:1352947 | 6480464 | Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] | CTD | PMID:16949557 | tunicamycin | increases expression | ISO | RGD:1352947 | 6480464 | Tunicamycin results in increased expression of GOLGA4 mRNA | CTD | PMID:22378314 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| 1. | Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 2. | MGD data from the GO Consortium |
| 3. | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:9404721 | PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12162805 | PMID:12466851 | PMID:12477932 | PMID:12520002 | PMID:14610273 | PMID:14681479 |
| PMID:15489334 | PMID:15782199 | PMID:16141072 | PMID:16141073 | PMID:17967808 | PMID:18308930 | PMID:18554416 | PMID:18799693 | PMID:21565611 | PMID:21873635 | PMID:28671696 | PMID:32325033 |
Genomics
