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Gene: Srebf2 (sterol regulatory element binding factor 2) Mus musculus
Symbol: Srebf2
Name: sterol regulatory element binding factor 2
Description: Exhibits DNA-binding transcription factor activity and transcription regulatory region sequence-specific DNA binding activity. Involved in cholesterol homeostasis and positive regulation of pri-miRNA transcription by RNA polymerase II. Localizes to cytoplasm; membrane; and nucleus. Is expressed in several structures, including 1st branchial arch; genitourinary system; limb; nervous system; and retina. Human ortholog(s) of this gene implicated in carotid artery disease; prostate cancer; type 1 diabetes mellitus; type 2 diabetes mellitus; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2); PARTICIPATES IN altered p53 signaling pathway; sterol regulatory element-binding protein signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-hydroxy-5alpha-androstan-3-one; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI608257; bHLHd2; lop13; nuc; SREBP-2; SREBP2; SREBP2gc; sterol regulatory element-binding protein 2; sterol regulatory element-binding transcription factor 2
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1582,147,181 - 82,205,379 (+)EnsemblGRCm38mm10GRCm38
GRCm381582,147,269 - 82,205,379 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371581,977,699 - 82,035,390 (+)NCBIGRCm37mm9NCBIm37
MGSCv361581,974,524 - 82,032,215 (+)NCBImm8
Celera1584,270,919 - 84,328,680 (+)NCBICelera
Cytogenetic Map15E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Srebf2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730973
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.