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Gene: Vip (vasoactive intestinal polypeptide) Mus musculus
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Symbol: Vip
Name: vasoactive intestinal polypeptide
Description: This gene encodes a neuropeptide of the glucagon/secretin superfamily with potent bronchodilator, immunomodulator and anti-inflammatory properties. The encoded protein is proteolytically processed to generate two structurally similar neuropeptides - vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). In the digestive tract, VIP stimulates relaxation of enteric smooth muscle, secretion of water and electrolytes, release of insulin and glucagon, and inhibition of gastric acid secretion. In the cardiovascular system, VIP causes coronary vasodilation and stimulates contractility in the heart. Mice lacking VIP exhibit airway hyperresponsiveness and airway inflammation. Male mice lacking VIP exhibit moderate pulmonary arterial hypertension resulting in increased mortality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC107202; PHI, peptide histidine isoleucine; VIP peptides
Orthologs:
Homo sapiens (human) : VIP (vasoactive intestinal peptide)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Vip (vasoactive intestinal peptide)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vip (vasoactive intestinal peptide)
Pan paniscus (bonobo/pygmy chimpanzee) : VIP (vasoactive intestinal peptide)
Canis lupus familiaris (dog) : VIP (vasoactive intestinal peptide)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vip (vasoactive intestinal peptide)
Sus scrofa (pig) : VIP (vasoactive intestinal peptide)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38105,639,193 - 5,647,617 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37104,698,927 - 4,707,323 (-)NCBIGRCm37mm9NCBIm37
MGSCv36104,698,927 - 4,707,323 (-)NCBImm8
Celera105,575,276 - 5,583,675 (+)NCBICelera
Cytogenetic Map10 A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Vip
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732375
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.