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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11152
Species: Mus musculus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:3181
Term: bromocriptine
Definition: An indole alkaloid that has formula C32H40BrN5O5.
Chemical ID: MESH:D001971
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prldecreases expressionEXP 6480464CTDBromocriptine results in decreased expression of PRL proteinPMID:11786374
Prldecreases expressionISOPrl (Rattus norvegicus)6480464CTDBromocriptine results in decreased expression of PRL proteinPMID:15046398 PMID:1874184 PMID:21427058 PMID:3019639 PMID:3776530
Prldecreases expressionISOPRL (Homo sapiens)6480464CTDBromocriptine results in decreased expression of PRL proteinPMID:12161478 PMID:1407345 PMID:2042694 PMID:3745407 PMID:4072572 PMID:6507109 PMID:6669217 PMID:6693536 PMID:6986893 PMID:7243090 PMID:86031 PMID:86795 PMID:8914150 PMID:90217
Prldecreases secretionISOPrl (Rattus norvegicus)6480464CTDBromocriptine results in decreased secretion of PRL proteinPMID:11685661 PMID:12742521 PMID:12824819 PMID:2887062 PMID:7670571
Prldecreases secretionISOPRL (Homo sapiens)6480464CTDBromocriptine results in decreased secretion of PRL proteinPMID:3660204
Prlmultiple interactionsISOPrl (Rattus norvegicus)6480464CTDBromocriptine inhibits the reaction [Amisulpride results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Estradiol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of PRL protein]; Estradiol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Ethanol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]PMID:12106810 PMID:12824819 PMID:15677882 PMID:21427058 PMID:3208992 PMID:3625096 PMID:6477585 PMID:7670571
Prlmultiple interactionsISOPRL (Homo sapiens)6480464CTDBromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Nalorphine results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein]PMID:6441721 PMID:7106173 PMID:7168914
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