Rhoa (ras homolog family member A) - Rat Genome Database

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Gene: Rhoa (ras homolog family member A) Mus musculus
Analyze
Symbol: Rhoa
Name: ras homolog family member A
RGD ID: 731060
MGI Page MGI
Description: Enables GTPase activity. Involved in several processes, including alpha-beta T cell differentiation; negative regulation of oxidative phosphorylation; and regulation of cytoskeleton organization. Acts upstream of or within several processes, including nervous system development; positive regulation of organelle organization; and regulation of systemic arterial blood pressure by hormone. Located in several cellular components, including cytosol; lamellipodium; and ruffle membrane. Is expressed in several structures, including brain; exocrine system; genitourinary system; heart; and pericardial component. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A; aplysia ras-related homolog A; aplysia ras-related homolog A1; aplysia ras-related homolog A2; Ar; Arha; Arha1; Arha2; R; Ras family member A; ras homolog A1; ras homolog A2; ras homolog gene family, member A; ras homolog gene family, member A1; ras homolog gene family, member A2; Rho family GTPase; transforming protein RhoA
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm12844   Gm2325   Gm6137   Rhoay-ps1   Rhoay-ps2   Rhoay-ps3  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,183,359 - 108,215,142 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,183,328 - 108,215,133 (+)EnsemblGRCm39 Ensembl
GRCm389108,306,160 - 108,337,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,306,129 - 108,337,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,208,536 - 108,240,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,164,298 - 108,196,026 (+)NCBIMGSCv36mm8
Celera9107,915,249 - 107,947,041 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abnormalities, Drug-Induced  (ISO)
acute myocardial infarction  (ISO)
Aicardi-Goutieres Syndrome 1  (ISO)
alopecia  (ISO)
Animal Disease Models  (ISO)
asthma  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (IEP,ISO)
Cocaine-Related Disorders  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Craniofacial Abnormalities  (ISO)
Diabetic Nephropathies  (ISO)
ectodermal dysplasia  (ISO)
ECTODERMAL DYSPLASIA WITH FACIAL DYSMORPHISM AND ACRAL, OCULAR, AND BRAIN ANOMALIES  (ISO)
esophageal carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
fetal alcohol syndrome  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
glycine encephalopathy  (ISO)
head and neck squamous cell carcinoma  (ISO)
hypertension  (ISO)
Hypopigmentation  (ISO)
Immunoblastic Lymphadenopathy  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leukoencephalopathies  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
membranous glomerulonephritis  (ISO)
multiple sclerosis  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neurocutaneous Syndromes  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
ovarian carcinoma  (ISO)
peripheral T-cell lymphoma  (ISO)
Pierson syndrome  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
proteinuria  (ISO)
pulmonary hypertension  (ISO)
Spinal Cord Injuries  (ISO)
Stomach Neoplasms  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
tooth disease  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-(-)-perillyl alcohol  (ISO)
1,2-dimethylhydrazine  (EXP)
1,8-cineole  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP,ISO)
2-trans,6-trans-farnesyl diphosphate  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-(4-chlorophenylthio)-cGMP  (ISO)
9-cis-retinoic acid  (ISO)
acadesine  (ISO)
acetylcholine  (ISO)
Aescin  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allyl isothiocyanate  (ISO)
ammonium chloride  (ISO)
arachidonyl-2'-chloroethylamide  (EXP)
Aroclor 1254  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atropine  (ISO)
beclomethasone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beryllium sulfate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brimonidine tartrate  (ISO)
bufalin  (ISO)
cadmium dichloride  (ISO)
calcidiol  (ISO)
Calpeptin  (EXP)
cannabidiol  (ISO)
carvone  (ISO)
casticin  (EXP)
celecoxib  (ISO)
cerivastatin  (ISO)
chloropicrin  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cocaine  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cycloastragenol  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
Dimethylphosphate  (EXP)
dioxygen  (EXP,ISO)
diuron  (ISO)
dizocilpine maleate  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
everolimus  (ISO)
farnesol  (ISO)
farnesyl diphosphate  (EXP,ISO)
fasudil  (EXP,ISO)
finasteride  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
flavonol  (ISO)
flubendazole  (ISO)
fluvastatin  (EXP,ISO)
folic acid  (EXP,ISO)
fucoxanthin  (EXP)
gallic acid  (ISO)
Ganoderic acid A  (EXP)
geranylgeraniol  (ISO)
glucose  (EXP,ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
GTP  (EXP,ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
kanamycin A  (EXP)
KT 5823  (ISO)
latrunculin B  (ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (EXP,ISO)
LY294002  (ISO)
malathion  (EXP)
mebendazole  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mevalonic acid  (ISO)
mevastatin  (ISO)
microcystin-LR  (ISO)
myrtenol  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
nonanoic acid  (EXP)
oroxylin A  (ISO)
ozone  (ISO)
p-cresol  (ISO)
p-menthan-3-ol  (ISO)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PCB138  (ISO)
pentachlorophenol  (EXP)
perillic acid  (ISO)
perillyl alcohol  (ISO)
perillyl aldehyde  (ISO)
phenylephrine  (ISO)
phenytoin  (EXP)
PhIP  (ISO)
phorbol 12,13-dibutanoate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinpirole  (ISO)
raloxifene  (ISO)
ramipril  (ISO)
resveratrol  (EXP,ISO)
Risedronate sodium  (EXP,ISO)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
Sanggenon C  (ISO)
scoparone  (ISO)
sevoflurane  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (EXP)
solasodine  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
terbinafine  (ISO)
tetrachloromethane  (EXP)
thalidomide  (EXP)
Tiron  (EXP,ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
trans-piceid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP,ISO)
triptonide  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
U-73122  (ISO)
uranium atom  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
warfarin  (EXP)
Y-27632  (ISO)
zaragozic acid A  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IDA,ISO)
alpha-beta T cell lineage commitment  (IMP)
androgen receptor signaling pathway  (IDA)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (IMP)
aortic valve formation  (ISO)
apical junction assembly  (IDA,ISO)
apolipoprotein A-I-mediated signaling pathway  (ISO)
beta selection  (IMP)
bone trabecula morphogenesis  (IMP)
cell adhesion  (IMP)
cell differentiation  (IDA)
cell division  (IEA)
cell junction assembly  (ISO)
cell migration  (IBA,ISO)
cell morphogenesis  (IGI)
cell-matrix adhesion  (IDA)
cellular response to chemokine  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cerebral cortex cell migration  (IMP)
cleavage furrow formation  (ISO)
cytoplasmic microtubule organization  (ISO)
cytoskeleton organization  (IMP)
embryonic cleavage  (ISO)
endothelial cell migration  (ISO)
endothelial tube lumen extension  (ISO)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment or maintenance of actin cytoskeleton polarity  (ISO)
forebrain radial glial cell differentiation  (IMP)
GTP metabolic process  (ISO)
integrin-mediated signaling pathway  (TAS)
kidney development  (IGI)
meiotic spindle organization  (ISO)
microtubule depolymerization  (ISO)
mitotic cleavage furrow formation  (ISO)
mitotic spindle assembly  (ISO)
motor neuron apoptotic process  (IMP)
negative chemotaxis  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell size  (ISO)
negative regulation of cell-substrate adhesion  (IMP)
negative regulation of intracellular steroid hormone receptor signaling pathway  (IDA)
negative regulation of motor neuron apoptotic process  (IMP)
negative regulation of neuron differentiation  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of oxidative phosphorylation  (IMP)
negative regulation of reactive oxygen species biosynthetic process  (IMP)
negative regulation of synapse assembly  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron migration  (IMP)
neuron projection morphogenesis  (ISO)
odontogenesis  (IEP)
ossification involved in bone maturation  (IMP)
polar body extrusion after meiotic divisions  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of alpha-beta T cell differentiation  (IMP)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytokinesis  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of podosome assembly  (IGI)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of stress fiber assembly  (IDA,ISO)
positive regulation of T cell migration  (ISO)
positive regulation of translation  (ISO)
positive regulation of vascular associated smooth muscle contraction  (IMP)
positive regulation of vasoconstriction  (ISO)
regulation of actin cytoskeleton organization  (IBA,IMP,ISO)
regulation of actin polymerization or depolymerization  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cell migration  (ISO)
regulation of dendrite development  (ISO)
regulation of microtubule cytoskeleton organization  (IMP)
regulation of modification of postsynaptic actin cytoskeleton  (ISO)
regulation of modification of postsynaptic structure  (ISO)
regulation of modification of synaptic structure  (ISO)
regulation of neural precursor cell proliferation  (IMP)
regulation of neuron projection development  (IDA)
regulation of osteoblast proliferation  (IMP)
regulation of systemic arterial blood pressure by endothelin  (IMP)
regulation of transcription by RNA polymerase II  (IDA)
response to amino acid  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
response to xenobiotic stimulus  (ISO)
Rho protein signal transduction  (IBA,IMP,ISO,TAS)
Roundabout signaling pathway  (ISO)
semaphorin-plexin signaling pathway  (IMP)
skeletal muscle tissue development  (IDA)
small GTPase-mediated signal transduction  (IEA)
spindle localization  (ISO)
stress fiber assembly  (IBA,IDA,ISO)
stress-activated protein kinase signaling cascade  (ISO)
substantia nigra development  (ISO)
substrate adhesion-dependent cell spreading  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Re-expression of proteins involved in cytokinesis during cardiac hypertrophy. Ahuja P, etal., Exp Cell Res. 2007 Apr 1;313(6):1270-83. Epub 2007 Jan 27.
2. RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease. Bellizzi A, etal., Int J Mol Med. 2008 Jul;22(1):25-31.
3. Cardioprotective effect of rosuvastatin in vivo is dependent on inhibition of geranylgeranyl pyrophosphate and altered RhoA membrane translocation. Bulhak A, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3158-63. Epub 2007 Feb 23.
4. Glucocorticoids ameliorate antigen-induced bronchial smooth muscle hyperresponsiveness by inhibiting upregulation of RhoA in rats. Chiba Y, etal., J Pharmacol Sci. 2008 Apr;106(4):615-25. Epub 2008 Apr 5.
5. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Fritz G, etal., Br J Cancer. 2002 Sep 9;87(6):635-44.
6. Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats. Hilgers RH, etal., J Hypertens. 2007 Aug;25(8):1687-97.
7. Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. Homma N, etal., J Cardiovasc Pharmacol. 2007 Dec;50(6):697-702.
8. Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma. Horiuchi A, etal., Lab Invest. 2003 Jun;83(6):861-70.
9. Ethanol impairs Rho GTPase signaling and differentiation of cerebellar granule neurons in a rodent model of fetal alcohol syndrome. Joshi S, etal., Cell Mol Life Sci. 2006 Dec;63(23):2859-70.
10. RhoA is associated with invasion and lymph node metastasis in upper urinary tract cancer. Kamai T, etal., BJU Int 2003 Feb;91(3):234-8.
11. The rho/rho-kinase pathway is involved in the progression of testicular germ cell tumour. Kamai T, etal., BJU Int. 2002 Mar;89(4):449-53.
12. Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Kamai T, etal., Clin Cancer Res. 2003 Jul;9(7):2632-41.
13. Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Kamai T, etal., Clin Cancer Res. 2004 Jul 15;10(14):4799-805.
14. Rho-kinase as a molecular target for insulin resistance and hypertension. Kanda T, etal., FASEB J. 2006 Jan;20(1):169-71. Epub 2005 Nov 2.
15. Slit2/Robo1 promotes synaptogenesis and functional recovery of spinal cord injury. Li Y, etal., Neuroreport. 2017 Jan 18;28(2):75-81. doi: 10.1097/WNR.0000000000000715.
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. Nagaoka T, etal., J Appl Physiol. 2006 Mar;100(3):996-1002. Epub 2005 Dec 1.
18. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
19. Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Phillips HM, etal., Circ Res. 2005 Feb 18;96(3):292-9. Epub 2005 Jan 6.
20. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
21. Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer. Pille JY, etal., Hum Gene Ther. 2006 Oct;17(10):1019-26.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats. Ren YS, etal., J Proteomics. 2020 Jun 30;222:103691. doi: 10.1016/j.jprot.2020.103691. Epub 2020 Feb 14.
25. Mouse MP Annotation Import Pipeline RGD automated import pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors. Rihet S, etal., J Cancer Res Clin Oncol 2001 Dec;127(12):733-8.
28. Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway. Saka M, etal., Clin Exp Pharmacol Physiol. 2006 Dec;33(12):1164-71.
29. The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. Takami Y, etal., Dig Dis Sci. 2008 Feb;53(2):467-73. Epub 2007 Jun 28.
30. Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase. Trebicka J, etal., Hepatology. 2007 Jul;46(1):242-53.
31. Distribution and expression of RhoA in rat retina after optic nerve injury. Wang YH, etal., Ophthalmic Res. 2007;39(3):174-8. Epub 2007 May 25.
32. Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Wei L, etal., Development 2002 Apr;129(7):1705-14.
33. Role of Rho-GTPases in complement-mediated glomerular epithelial cell injury. Zhang H, etal., Am J Physiol Renal Physiol. 2007 Jul;293(1):F148-56. Epub 2007 Mar 20.
34. Dexamethasone suppresses infiltration of RhoA+ cells into early lesions of rat traumatic brain injury. Zhang Z, etal., Acta Neuropathol. 2008 Mar;115(3):335-43. Epub 2007 Oct 11.
35. Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis. Zhang Z, etal., J Cell Mol Med. 2007 Jan-Feb;11(1):111-9.
36. Lesional accumulation of RhoA(+) cells in brains of experimental autoimmune encephalomyelitis and multiple sclerosis. Zhang Z, etal., Neuropathol Appl Neurobiol. 2008 Apr;34(2):231-40. Epub 2007 Nov 5.
37. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
38. Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis. Zhou Q, etal., Gut. 2006 Sep;55(9):1296-305. Epub 2006 Feb 21.
Additional References at PubMed
PMID:1643657   PMID:7888179   PMID:8543060   PMID:8662891   PMID:8889548   PMID:9214622   PMID:9252129   PMID:9438836   PMID:9535835   PMID:9598304   PMID:10349636   PMID:10493740  
PMID:10559899   PMID:10699171   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11108845   PMID:11217851   PMID:11307167   PMID:11562357   PMID:11672528   PMID:11747086   PMID:11826115  
PMID:11877460   PMID:11925102   PMID:11980660   PMID:12011971   PMID:12015964   PMID:12024019   PMID:12039949   PMID:12056835   PMID:12105199   PMID:12112462   PMID:12193475   PMID:12213441  
PMID:12213839   PMID:12477932   PMID:12520002   PMID:12524425   PMID:12771155   PMID:12805219   PMID:12897243   PMID:12904583   PMID:12944407   PMID:14610273   PMID:14614988   PMID:14657280  
PMID:14657354   PMID:14697354   PMID:14726536   PMID:14966113   PMID:14966563   PMID:15071095   PMID:15085137   PMID:15093731   PMID:15102857   PMID:15146061   PMID:15151987   PMID:15169791  
PMID:15234347   PMID:15249579   PMID:15318166   PMID:15371459   PMID:15467718   PMID:15471984   PMID:15489334   PMID:15601830   PMID:15611087   PMID:15652341   PMID:15664190   PMID:15665004  
PMID:15668168   PMID:15670823   PMID:15710384   PMID:15741177   PMID:15747579   PMID:15761153   PMID:15775972   PMID:15782199   PMID:15797222   PMID:15798203   PMID:15817453   PMID:15845872  
PMID:15860730   PMID:15864301   PMID:15866170   PMID:15883643   PMID:15953360   PMID:15972668   PMID:15987744   PMID:16122906   PMID:16141072   PMID:16141073   PMID:16174757   PMID:16217026  
PMID:16254014   PMID:16291866   PMID:16298995   PMID:16308318   PMID:16317010   PMID:16362953   PMID:16378759   PMID:16391519   PMID:16432194   PMID:16448650   PMID:16452636   PMID:16467373  
PMID:16537894   PMID:16547516   PMID:16565087   PMID:16574652   PMID:16602821   PMID:16690620   PMID:16699960   PMID:16705092   PMID:16708475   PMID:16772297   PMID:16829523   PMID:16931773  
PMID:16996478   PMID:17102036   PMID:17143286   PMID:17229766   PMID:17265067   PMID:17267546   PMID:17267693   PMID:17272280   PMID:17272518   PMID:17284169   PMID:17299801   PMID:17307336  
PMID:17385722   PMID:17438139   PMID:17459090   PMID:17488776   PMID:17525371   PMID:17556652   PMID:17562701   PMID:17581634   PMID:17606864   PMID:17653061   PMID:17662312   PMID:17702745  
PMID:17716670   PMID:17846664   PMID:17934213   PMID:17942919   PMID:17947676   PMID:17993462   PMID:18060576   PMID:18078809   PMID:18083785   PMID:18084615   PMID:18187455   PMID:18207700  
PMID:18230650   PMID:18283662   PMID:18287559   PMID:18316486   PMID:18316594   PMID:18332105   PMID:18364514   PMID:18442487   PMID:18448676   PMID:18458160   PMID:18477564   PMID:18505823  
PMID:18571835   PMID:18604197   PMID:18614015   PMID:18688040   PMID:18690213   PMID:18757369   PMID:18794355   PMID:18799693   PMID:18802007   PMID:18824165   PMID:18824598   PMID:18829452  
PMID:18832717   PMID:18854161   PMID:18981818   PMID:19015235   PMID:19015276   PMID:19015318   PMID:19073150   PMID:19097191   PMID:19101507   PMID:19106222   PMID:19113908   PMID:19126596  
PMID:19144696   PMID:19147498   PMID:19184980   PMID:19286565   PMID:19286943   PMID:19289122   PMID:19331812   PMID:19334288   PMID:19342461   PMID:19346499   PMID:19361585   PMID:19363157  
PMID:19401298   PMID:19409875   PMID:19420112   PMID:19444895   PMID:19482078   PMID:19546217   PMID:19589776   PMID:19644046   PMID:19666843   PMID:19693013   PMID:19715691   PMID:19737918  
PMID:19812308   PMID:19940064   PMID:20004716   PMID:20035871   PMID:20041165   PMID:20067919   PMID:20067994   PMID:20086008   PMID:20097679   PMID:20208559   PMID:20348415   PMID:20360068  
PMID:20375066   PMID:20380579   PMID:20453885   PMID:20628200   PMID:20655874   PMID:20660154   PMID:20697357   PMID:20712988   PMID:20737513   PMID:20810787   PMID:20811643   PMID:20876660  
PMID:20938335   PMID:20974804   PMID:21029865   PMID:21051664   PMID:21061444   PMID:21087931   PMID:21148681   PMID:21177343   PMID:21187285   PMID:21209320   PMID:21219475   PMID:21262463  
PMID:21267068   PMID:21289175   PMID:21421844   PMID:21421853   PMID:21435554   PMID:21451048   PMID:21454503   PMID:21454546   PMID:21473788   PMID:21491542   PMID:21493898   PMID:21501827  
PMID:21502507   PMID:21525037   PMID:21533980   PMID:21543326   PMID:21558549   PMID:21575689   PMID:21576911   PMID:21618100   PMID:21624953   PMID:21645877   PMID:21677750   PMID:21678418  
PMID:21731611   PMID:21804090   PMID:21829547   PMID:21836084   PMID:21873635   PMID:21878647   PMID:21880919   PMID:21976490   PMID:22009749   PMID:22019888   PMID:22021442   PMID:22031541  
PMID:22045984   PMID:22150760   PMID:22194606   PMID:22210108   PMID:22228100   PMID:22244698   PMID:22275376   PMID:22333836   PMID:22357624   PMID:22405202   PMID:22420753   PMID:22438996  
PMID:22461561   PMID:22465314   PMID:22498500   PMID:22500016   PMID:22525349   PMID:22558255   PMID:22564682   PMID:22629471   PMID:22661927   PMID:22683701   PMID:22689267   PMID:22740689  
PMID:22749887   PMID:22836272   PMID:22883572   PMID:22918940   PMID:22955057   PMID:22956833   PMID:22984590   PMID:23022035   PMID:23040068   PMID:23066013   PMID:23195221   PMID:23195957  
PMID:23307872   PMID:23334894   PMID:23358651   PMID:23361851   PMID:23389455   PMID:23523587   PMID:23524873   PMID:23559363   PMID:23658012   PMID:23696743   PMID:23704088   PMID:23707391  
PMID:23771883   PMID:23773994   PMID:23776598   PMID:23825607   PMID:23861058   PMID:23871831   PMID:23935982   PMID:23963803   PMID:24004633   PMID:24038871   PMID:24101377   PMID:24178298  
PMID:24240172   PMID:24244167   PMID:24244596   PMID:24300375   PMID:24335996   PMID:24356971   PMID:24385487   PMID:24398689   PMID:24428713   PMID:24486510   PMID:24493591   PMID:24525234  
PMID:24535918   PMID:24572910   PMID:24637663   PMID:24639556   PMID:24691407   PMID:24698977   PMID:24744380   PMID:24782506   PMID:24790140   PMID:24872548   PMID:24906914   PMID:24949442  
PMID:24952961   PMID:25031021   PMID:25048084   PMID:25071083   PMID:25128586   PMID:25129107   PMID:25144196   PMID:25190059   PMID:25211221   PMID:25213860   PMID:25261755   PMID:25336613  
PMID:25398325   PMID:25445826   PMID:25574809   PMID:25588844   PMID:25733666   PMID:25857352   PMID:25908026   PMID:25911094   PMID:26030593   PMID:26035863   PMID:26083584   PMID:26146960  
PMID:26188246   PMID:26198811   PMID:26205718   PMID:26228485   PMID:26335717   PMID:26392029   PMID:26408665   PMID:26416580   PMID:26427649   PMID:26496610   PMID:26686473   PMID:26728616  
PMID:26728857   PMID:26752649   PMID:26755157   PMID:26782071   PMID:26845352   PMID:26859289   PMID:26875770   PMID:26883626   PMID:26969129   PMID:27094722   PMID:27126736   PMID:27218883  
PMID:27269051   PMID:27389190   PMID:27457035   PMID:27460990   PMID:27486147   PMID:27489999   PMID:27575935   PMID:27619816   PMID:27628094   PMID:27633771   PMID:27634010   PMID:27649495  
PMID:27664080   PMID:27680697   PMID:27803162   PMID:27892530   PMID:27917469   PMID:27927130   PMID:27974245   PMID:27986432   PMID:27992599   PMID:28019696   PMID:28303627   PMID:28378742  
PMID:28457749   PMID:28498971   PMID:28499918   PMID:28642362   PMID:28643773   PMID:28650466   PMID:28652571   PMID:28678840   PMID:28712859   PMID:28739254   PMID:28751650   PMID:28803695  
PMID:28929130   PMID:28947533   PMID:29059167   PMID:29070491   PMID:29088697   PMID:29129684   PMID:29133163   PMID:29208526   PMID:29255172   PMID:29330353   PMID:29363851   PMID:29398449  
PMID:29444209   PMID:29453251   PMID:29462287   PMID:29481523   PMID:29498307   PMID:29576115   PMID:29636380   PMID:29649639   PMID:29700112   PMID:29769144   PMID:29769264   PMID:29867343  
PMID:29904389   PMID:30068389   PMID:30071134   PMID:30120419   PMID:30148884   PMID:30177526   PMID:30185650   PMID:30194990   PMID:30196744   PMID:30220545   PMID:30254631   PMID:30266829  
PMID:30283008   PMID:30476019   PMID:30562941   PMID:30626696   PMID:30659117   PMID:30769001   PMID:30902550   PMID:30950395   PMID:30955841   PMID:30959374   PMID:30992372   PMID:31029634  
PMID:31073629   PMID:31237372   PMID:31260596   PMID:31262973   PMID:31302143   PMID:31323253   PMID:31361966   PMID:31366886   PMID:31406143   PMID:31461398   PMID:31462248   PMID:31467060  
PMID:31481470   PMID:31484924   PMID:31561853   PMID:31828132   PMID:32044971   PMID:32070020   PMID:32083022   PMID:32107212   PMID:32141548   PMID:32159914   PMID:32323368   PMID:32325033  
PMID:32493168   PMID:32511952   PMID:32523119   PMID:32554809   PMID:32579923   PMID:32583739   PMID:32724133   PMID:32725958   PMID:32960451   PMID:33303584   PMID:33361519   PMID:33385215  
PMID:33436060   PMID:33472844   PMID:33760136   PMID:33799579   PMID:33882318   PMID:33936062   PMID:33963279   PMID:33979620   PMID:34060267   PMID:34101619   PMID:34147507   PMID:34390950  
PMID:34508667   PMID:34654444   PMID:34721389   PMID:34759029   PMID:34884920   PMID:34988124   PMID:35074512   PMID:35103284   PMID:35132805   PMID:35371049   PMID:35413235   PMID:35443168  
PMID:35781329   PMID:36102736   PMID:36207400   PMID:36293380   PMID:36529281   PMID:36631535   PMID:36758801   PMID:36782228   PMID:36971019   PMID:37020186   PMID:37354721   PMID:37718806  
PMID:37806133   PMID:37863874   PMID:37907898   PMID:38022686   PMID:38113333  


Genomics

Comparative Map Data
Rhoa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,183,359 - 108,215,142 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,183,328 - 108,215,133 (+)EnsemblGRCm39 Ensembl
GRCm389108,306,160 - 108,337,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,306,129 - 108,337,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,208,536 - 108,240,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,164,298 - 108,196,026 (+)NCBIMGSCv36mm8
Celera9107,915,249 - 107,947,041 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.2NCBI
RHOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,359,145 - 49,411,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,359,139 - 49,412,998 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,396,578 - 49,449,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,371,582 - 49,424,530 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,371,584 - 49,424,530NCBI
Celera349,361,450 - 49,414,313 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,456,057 - 49,509,248 (-)NCBIHuRef
CHM1_1349,349,388 - 49,402,293 (-)NCBICHM1_1
T2T-CHM13v2.0349,388,518 - 49,441,355 (-)NCBIT2T-CHM13v2.0
Rhoa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,870,548 - 117,904,303 (+)NCBIGRCr8
mRatBN7.28108,991,926 - 109,025,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,991,954 - 109,025,746 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,643,315 - 114,651,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,842,642 - 112,851,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,685,281 - 110,693,860 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,082,440 - 117,116,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,106,576 - 117,116,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,431,244 - 116,464,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,319,010 - 108,327,586 (+)NCBICelera
Cytogenetic Map8q32NCBI
Rhoa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,300,462 - 1,347,451 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,300,821 - 1,347,453 (-)NCBIChiLan1.0ChiLan1.0
RHOA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,336,475 - 49,394,257 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,341,246 - 49,398,996 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,282,009 - 49,339,887 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,362,698 - 50,584,600 (-)NCBIpanpan1.1PanPan1.1panPan2
RHOA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,824,552 - 39,888,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,824,575 - 39,887,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,743,026 - 39,805,566 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,180,779 - 40,244,414 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,180,768 - 40,244,414 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,548,346 - 39,611,020 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,951,968 - 40,014,480 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,231,551 - 40,294,267 (+)NCBIUU_Cfam_GSD_1.0
Rhoa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,239,560 - 64,285,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529999,935 - 1,045,681 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,000,050 - 1,045,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,918,834 - 31,986,607 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,918,484 - 31,991,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,149,494 - 35,160,516 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,757,381 - 10,809,257 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,757,337 - 10,772,704 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,205,022 - 156,258,776 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rhoa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,316,122 - 3,361,820 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rhoa
851 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:276
Count of miRNA genes:239
Interacting mature miRNAs:252
Transcripts:ENSMUST00000007959
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959897283109089068Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974250230108250378Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976417989110418183Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985779563108518385Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994863354112701997Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse

Markers in Region
RH126696  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389108,335,931 - 108,336,141UniSTSGRCm38
MGSCv379108,238,262 - 108,238,472UniSTSGRCm37
Celera9107,945,033 - 107,945,243UniSTS
Cytogenetic Map9F2UniSTS
Whitehead/MRC_RH91110.61UniSTS
Arha2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38264,867,957 - 64,868,667UniSTSGRCm38
MGSCv37264,706,014 - 64,706,724UniSTSGRCm37
Celera266,538,829 - 66,539,539UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map2C1.3UniSTS
cM Map2 UniSTS
cM Map9 UniSTS
cM Map237.0UniSTS
Rhoa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389108,337,459 - 108,337,875UniSTSGRCm38
GRCm38264,866,865 - 64,867,364UniSTSGRCm38
Celera9107,946,561 - 107,946,977UniSTS
Celera266,537,733 - 66,538,236UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map9F1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001313961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC161260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF014371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF178958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF178959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF178960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF178961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE990465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP772032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX217831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX239124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX239638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN971019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000007959   ⟹   ENSMUSP00000007959
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,183,328 - 108,215,133 (+)Ensembl
GRCm38.p6 Ensembl9108,306,129 - 108,337,934 (+)Ensembl
RefSeq Acc Id: ENSMUST00000193424
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,207,759 - 108,213,950 (+)Ensembl
GRCm38.p6 Ensembl9108,330,560 - 108,336,751 (+)Ensembl
RefSeq Acc Id: ENSMUST00000193490   ⟹   ENSMUSP00000141572
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,184,028 - 108,208,115 (+)Ensembl
GRCm38.p6 Ensembl9108,306,829 - 108,330,916 (+)Ensembl
RefSeq Acc Id: ENSMUST00000193619
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,183,638 - 108,188,738 (+)Ensembl
GRCm38.p6 Ensembl9108,306,439 - 108,311,539 (+)Ensembl
RefSeq Acc Id: ENSMUST00000194701   ⟹   ENSMUSP00000141967
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9108,183,996 - 108,213,933 (+)Ensembl
GRCm38.p6 Ensembl9108,306,797 - 108,336,734 (+)Ensembl
RefSeq Acc Id: NM_001313961   ⟹   NP_001300890
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,183,996 - 108,215,142 (+)NCBI
GRCm389108,306,797 - 108,337,943 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001313962   ⟹   NP_001300891
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,183,996 - 108,215,142 (+)NCBI
GRCm389108,306,797 - 108,337,943 (+)NCBI
Sequence:
RefSeq Acc Id: NM_016802   ⟹   NP_058082
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,183,359 - 108,215,142 (+)NCBI
GRCm389108,306,160 - 108,337,943 (+)NCBI
MGSCv379108,208,536 - 108,240,270 (+)RGD
Celera9107,915,249 - 107,947,041 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_058082   ⟸   NM_016802
- Peptide Label: precursor
- UniProtKB: O88336 (UniProtKB/Swiss-Prot),   Q9QUI0 (UniProtKB/Swiss-Prot),   Q4VAE6 (UniProtKB/TrEMBL),   Q3TN61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300890   ⟸   NM_001313961
- Peptide Label: precursor
- UniProtKB: O88336 (UniProtKB/Swiss-Prot),   Q9QUI0 (UniProtKB/Swiss-Prot),   Q4VAE6 (UniProtKB/TrEMBL),   Q3TN61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300891   ⟸   NM_001313962
- Peptide Label: precursor
- UniProtKB: O88336 (UniProtKB/Swiss-Prot),   Q9QUI0 (UniProtKB/Swiss-Prot),   Q4VAE6 (UniProtKB/TrEMBL),   Q3TN61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000007959   ⟸   ENSMUST00000007959
RefSeq Acc Id: ENSMUSP00000141572   ⟸   ENSMUST00000193490
RefSeq Acc Id: ENSMUSP00000141967   ⟸   ENSMUST00000194701

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QUI0-F1-model_v2 AlphaFold Q9QUI0 1-193 view protein structure

Promoters
RGD ID:6845039
Promoter ID:MM_KWN:58785
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_016802,   NM_133986
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369108,207,666 - 108,209,322 (+)MPROMDB
RGD ID:8670878
Promoter ID:EPDNEW_M13470
Type:initiation region
Name:Rhoa_1
Description:Mus musculus ras homolog family member A , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13471  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389108,306,399 - 108,306,459EPDNEW
RGD ID:8670880
Promoter ID:EPDNEW_M13471
Type:initiation region
Name:Rhoa_2
Description:Mus musculus ras homolog family member A , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13470  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389108,306,839 - 108,306,899EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1096342 AgrOrtholog
Ensembl Genes ENSMUSG00000007815 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000007959 ENTREZGENE
  ENSMUST00000007959.14 UniProtKB/Swiss-Prot
  ENSMUST00000193490.2 UniProtKB/TrEMBL
  ENSMUST00000194701 ENTREZGENE
  ENSMUST00000194701.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1096342 ENTREZGENE
NCBI Gene 11848 ENTREZGENE
PANTHER PTHR24072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS-LIKE GTP-BINDING PROTEIN RHO1 UniProtKB/TrEMBL
  TRANSFORMING PROTEIN RHOA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rhoa PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A6YWJ1_MOUSE UniProtKB/TrEMBL
  A0A0A6YXF6_MOUSE UniProtKB/TrEMBL
  O88336 ENTREZGENE
  Q3TN61 ENTREZGENE, UniProtKB/TrEMBL
  Q4VAE6 ENTREZGENE, UniProtKB/TrEMBL
  Q9QUI0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O88336 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Rhoa  ras homolog family member A    ras homolog gene family, member A  Symbol and/or name change 5135510 APPROVED