Stx1b (syntaxin 1B) - Rat Genome Database

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Gene: Stx1b (syntaxin 1B) Mus musculus
Analyze
Symbol: Stx1b
Name: syntaxin 1B
RGD ID: 736111
MGI Page MGI
Description: Enables protein kinase binding activity and signaling receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of synaptic vesicle recycling; and neurotransmitter secretion. Located in axon; plasma membrane; and presynapse. Is active in neuromuscular junction. Is expressed in forebrain and retina layer. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Orthologous to human STX1B (syntaxin 1B); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Stx1b1; Stx1b2; Stx1bl; Syn1b; syntaxin 1B1; syntaxin 1B2; syntaxin-1B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,403,072 - 127,423,703 (-)NCBIGRCm39mm39
GRCm39 Ensembl7127,403,072 - 127,423,721 (-)Ensembl
GRCm387127,803,900 - 127,824,531 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,803,900 - 127,824,549 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,950,358 - 134,968,045 (-)NCBIGRCm37mm9NCBIm37
MGSCv367127,598,364 - 127,615,438 (-)NCBImm8
Celera7127,641,815 - 127,659,486 (-)NCBICelera
Cytogenetic Map7F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10468580   PMID:12477932   PMID:12588844   PMID:12619134   PMID:12904583   PMID:14610273   PMID:15145078   PMID:15648052   PMID:15659226   PMID:15774481   PMID:15935055   PMID:17500595  
PMID:18224708   PMID:18507827   PMID:18703708   PMID:19546860   PMID:19723784   PMID:19892785   PMID:20114047   PMID:20881139   PMID:21138975   PMID:21307259   PMID:21424589   PMID:21873635  
PMID:21994363   PMID:22404429   PMID:22661231   PMID:23064108   PMID:23188083   PMID:23395379   PMID:23821748   PMID:23926259   PMID:24133272   PMID:24587181   PMID:24666284   PMID:24744148  
PMID:24885147   PMID:24908488   PMID:26203110   PMID:27063791   PMID:27160897   PMID:27418600   PMID:27466336   PMID:29139159   PMID:29191246   PMID:29912942   PMID:30562941   PMID:30870432  
PMID:31609468   PMID:32325033   PMID:32572454   PMID:32858780   PMID:34427183  


Genomics

Comparative Map Data
Stx1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,403,072 - 127,423,703 (-)NCBIGRCm39mm39
GRCm39 Ensembl7127,403,072 - 127,423,721 (-)Ensembl
GRCm387127,803,900 - 127,824,531 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,803,900 - 127,824,549 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,950,358 - 134,968,045 (-)NCBIGRCm37mm9NCBIm37
MGSCv367127,598,364 - 127,615,438 (-)NCBImm8
Celera7127,641,815 - 127,659,486 (-)NCBICelera
Cytogenetic Map7F3NCBI
STX1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1630,989,256 - 31,010,638 (-)EnsemblGRCh38hg38GRCh38
GRCh381630,989,256 - 31,010,638 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371631,000,577 - 31,021,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,910,869 - 30,929,276 (-)NCBINCBI36hg18NCBI36
Build 341630,910,868 - 30,929,276NCBI
Celera1629,275,546 - 29,296,879 (+)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1628,563,033 - 28,574,857 (-)NCBIHuRef
CHM1_11632,317,577 - 32,338,829 (-)NCBICHM1_1
Stx1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,415,544 - 182,434,385 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1182,415,546 - 182,441,280 (-)Ensembl
Rnor_6.01199,251,842 - 199,270,465 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,251,844 - 199,270,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,276,724 - 206,292,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,092,014 - 187,108,481 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11187,239,062 - 187,258,524 (-)NCBI
Celera1180,069,042 - 180,085,214 (-)NCBICelera
Cytogenetic Map1q37NCBI
Stx1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,838,684 - 7,857,700 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,838,684 - 7,857,700 (-)NCBIChiLan1.0ChiLan1.0
STX1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11631,356,907 - 31,378,864 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,356,907 - 31,378,870 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01623,956,426 - 23,979,646 (+)NCBIMhudiblu_PPA_v0panPan3
STX1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,209,972 - 17,219,903 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,210,433 - 17,241,363 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,777,682 - 18,795,209 (+)NCBI
ROS_Cfam_1.0617,332,948 - 17,350,471 (+)NCBI
UMICH_Zoey_3.1617,133,312 - 17,150,823 (+)NCBI
UNSW_CanFamBas_1.0617,052,453 - 17,069,975 (+)NCBI
UU_Cfam_GSD_1.0617,364,988 - 17,382,509 (+)NCBI
Stx1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,272,960 - 125,280,193 (-)NCBI
SpeTri2.0NW_00493650113,370,678 - 13,378,933 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STX1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,974,126 - 10,991,874 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,974,127 - 10,991,846 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,670,296 - 10,688,032 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STX1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,683,526 - 27,702,032 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl527,684,082 - 27,694,814 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660681,769,965 - 1,788,800 (+)NCBIVero_WHO_p1.0
Stx1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478214,054,762 - 14,073,890 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798565687132565775Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798795739132795739Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined7100238481134238481Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7101151499135151620Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7101394038135394119Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7102094158136094307Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7102094158136094307Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7102094158136094307Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102885996136886157Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105651440139651588Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105750785139750785Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7110108163144108163Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7110108163144108163Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7110108163144108163Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7111365511145365612Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7111365511145365612Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111564398145441459Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111564398145441459Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111564398145441459Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112950524145441459Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7113321003145441459Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7116100000128900000Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7117032360145441459Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117600000134500000Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7118151499128365612Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7119094158144844577Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119530844145441459Mouse
38501070Tip5_mtuberculosis immunophenotype 5, IFN-g level (mouse)7121000000130700000Mouse
1357613Bsbob2_mBSB obesity 2 (mouse)Not determined7122651440129217600Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122651440135569172Mouse
4141945Il4ppq_mIL-4 producing potential QTL (mouse)Not determined7124914439129217600Mouse
13207594Nigsq1_mneuroglucopenia-induced glucagon secretion QTL 1 (mouse)7127436844145441459Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127757504145441459Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2073
Count of miRNA genes:713
Interacting mature miRNAs:918
Transcripts:ENSMUST00000106267, ENSMUST00000156135
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000106267   ⟹   ENSMUSP00000101874
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,403,072 - 127,423,721 (-)Ensembl
GRCm38.p6 Ensembl7127,803,900 - 127,824,549 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156135   ⟹   ENSMUSP00000145698
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,406,544 - 127,410,096 (-)Ensembl
GRCm38.p6 Ensembl7127,807,372 - 127,810,924 (-)Ensembl
RefSeq Acc Id: NM_024414   ⟹   NP_077725
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,406,016 - 127,423,703 (-)NCBI
GRCm387127,806,844 - 127,824,531 (-)NCBI
MGSCv377134,950,358 - 134,968,045 (-)RGD
Celera7127,641,815 - 127,659,486 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006508044   ⟹   XP_006508107
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,403,072 - 127,415,701 (-)NCBI
GRCm387127,803,900 - 127,816,529 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241866   ⟹   XP_011240168
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,403,072 - 127,423,035 (-)NCBI
GRCm387127,803,900 - 127,823,863 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153269   ⟹   XP_036009162
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,403,072 - 127,415,205 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_077725   ⟸   NM_024414
- UniProtKB: P61264 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006508107   ⟸   XM_006508044
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011240168   ⟸   XM_011241866
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000101874   ⟸   ENSMUST00000106267
RefSeq Acc Id: ENSMUSP00000145698   ⟸   ENSMUST00000156135
RefSeq Acc Id: XP_036009162   ⟸   XM_036153269
- Peptide Label: isoform X3
Promoters
RGD ID:8665717
Promoter ID:EPDNEW_M10889
Type:initiation region
Name:Stx1b_1
Description:Mus musculus syntaxin 1B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387127,824,525 - 127,824,585EPDNEW
RGD ID:6842124
Promoter ID:MM_KWN:52815
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000077103
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367134,954,386 - 134,954,886 (-)MPROMDB
RGD ID:6842123
Promoter ID:MM_KWN:52816
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Brain,   Kidney,   Spleen
Transcripts:ENSMUST00000033076
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367134,959,354 - 134,959,854 (-)MPROMDB
RGD ID:6842125
Promoter ID:MM_KWN:52817
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000077102
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367134,968,086 - 134,968,586 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930705 AgrOrtholog
Ensembl Genes ENSMUSG00000030806 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000101874 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145698 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000106267 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000156135 UniProtKB/TrEMBL
InterPro SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin/epimorphin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T_SNARE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56216 UniProtKB/Swiss-Prot
MGD MGI:1930705 ENTREZGENE
NCBI Gene 56216 ENTREZGENE
PANTHER PTHR19957:SF334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stx1b PhenoGen
PROSITE SYNTAXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SynN UniProtKB/Swiss-Prot
  t_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47661 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNT8_MOUSE UniProtKB/TrEMBL
  P61264 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2RSB4 UniProtKB/Swiss-Prot
  O35525 UniProtKB/Swiss-Prot
  P32853 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-09 Stx1b  syntaxin 1B  Stx1b1  syntaxin 1B1  Data Merged 737654 PROVISIONAL