Akr1c18 (aldo-keto reductase family 1, member C18) - Rat Genome Database

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Gene: Akr1c18 (aldo-keto reductase family 1, member C18) Mus musculus
Analyze
Symbol: Akr1c18
Name: aldo-keto reductase family 1, member C18
RGD ID: 733290
MGI Page MGI
Description: Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity. Acts upstream of or within parturition and progesterone catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; brain; female reproductive system; and lung. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alph; 20alpha-HSD; 20alpha-hydroxysteroid dehydrogenase; aldo-keto reductase family 1 member C18; AW146047
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,182,614 - 4,200,645 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,182,614 - 4,200,653 (-)EnsemblGRCm39 Ensembl
GRCm38134,132,615 - 4,150,646 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,132,615 - 4,150,654 (-)EnsemblGRCm38mm10GRCm38
MGSCv37134,131,873 - 4,149,877 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,131,873 - 4,149,877 (-)NCBIMGSCv36mm8
Celera134,108,614 - 4,126,601 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-20-hydroxypregn-4-en-3-one  (ISO)
(E)-cinnamyl alcohol  (ISO)
(S)-naringenin  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,8-Dinitropyrene  (ISO)
1-Aminopyrene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
11-deoxycorticosterone  (EXP)
13-dihydrodaunorubicin  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (ISO)
20-hydroxypregn-4-en-3-one  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxybenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
5alpha-Pregnan-20alpha-ol-3-one  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
6-propyl-2-thiouracil  (ISO)
7-hydroxyflavone  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinal  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-hexylcinnamaldehyde  (EXP,ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
androst-4-ene-3,17-dione  (ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
Bandrowski's base  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Bromazepam  (ISO)
bromocriptine  (ISO)
butan-1-ol  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
Clofop  (ISO)
cloxazolam  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
cyclopentanol  (ISO)
cyclopentanone  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
daunorubicin  (ISO)
DDE  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
desogestrel  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazepam  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dinaciclib  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
dutasteride  (ISO)
dydrogesterone  (ISO)
emodin  (ISO)
enasidenib  (ISO)
estazolam  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
eugenol  (ISO)
farnesal  (ISO)
farnesoic acid  (ISO)
farnesol  (ISO)
fenamic acid  (ISO)
flufenamic acid  (ISO)
flunitrazepam  (ISO)
flurbiprofen  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
Frangulin A  (ISO)
Frangulin B  (ISO)
fructose  (EXP)
furan  (EXP)
geranylgeraniol  (ISO)
gliclazide  (ISO)
glimepiride  (ISO)
glipizide  (ISO)
glucose  (EXP)
glyburide  (ISO)
glycidyl methacrylate  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hexane  (ISO)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
inulin  (EXP)
isoeugenol  (ISO)
Isoxanthohumol  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
levonorgestrel  (ISO)
lithocholic acid  (ISO)
LY294002  (ISO)
meclofenamic acid  (ISO)
Medazepam  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methyl salicylate  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
midostaurin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalenes  (ISO)
naproxen  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrazepam  (ISO)
norethisterone  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
octyl gallate  (ISO)
oxaliplatin  (ISO)
oxcarbazepine  (ISO)
oxidopamine  (ISO)
oxycodone  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenolphthalein  (ISO)
phenylmercury acetate  (ISO)
phthalaldehyde  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
progesterone  (EXP,ISO)
propan-2-ol  (ISO)
prostaglandin D2  (ISO)
prostaglandin F2alpha  (ISO)
prostaglandin J2  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
salicylic acid  (ISO)
SB 431542  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulpiride  (ISO)
superoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
tolfenamic acid  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
umbelliferone  (ISO)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to calcium ion  (ISO)
cellular response to corticosteroid stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (IEA,ISO)
cellular response to forskolin  (IEA,ISO)
cellular response to gonadotropin-releasing hormone  (IEA,ISO)
cellular response to jasmonic acid stimulus  (ISO)
cellular response to prolactin  (IEA,ISO)
cellular response to prostaglandin D stimulus  (ISO)
cellular response to prostaglandin stimulus  (ISO)
cellular response to starvation  (ISO)
cellular response to testosterone stimulus  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
daunorubicin metabolic process  (IBA,ISO)
doxorubicin metabolic process  (IBA,ISO)
farnesol catabolic process  (ISO)
female pregnancy  (IEA,ISO)
G protein-coupled receptor signaling pathway  (ISO)
keratinocyte differentiation  (ISO)
male gonad development  (ISO)
negative regulation of retinoic acid biosynthetic process  (ISO)
parturition  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
progesterone catabolic process  (IDA,IMP)
progesterone metabolic process  (IBA,ISO)
prostaglandin metabolic process  (IBA,ISO)
regulation of retinoic acid receptor signaling pathway  (ISO)
regulation of steroid biosynthetic process  (IEA,ISO)
regulation of testosterone biosynthetic process  (ISO)
response to nutrient  (ISO)
retinal metabolic process  (ISO)
steroid metabolic process  (ISO)
testosterone biosynthetic process  (ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA,ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Paracrine-stimulated gene expression profile favors estradiol production in breast tumors. Amin SA, etal., Mol Cell Endocrinol. 2006 Jul 11;253(1-2):44-55. Epub 2006 Jun 2.
2. Steroidogenic enzyme activities in rat polycystic ovaries. Cooke GM, etal., Can J Physiol Pharmacol. 1993 Mar-Apr;71(3-4):247-53.
3. Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castration-resistant prostate cancer. Hamid AR, etal., Mol Med. 2013 Jan 22;18:1449-55. doi: 10.2119/molmed.2012.00296.
4. [Effects of AKR1C3 on kidney damage of preeclamptic rats]. Jin Y, etal., Zhonghua Yi Xue Za Zhi. 2015 Jan 6;95(1):30-3.
5. The roles of pregn-5-ene-3 beta, 20 alpha-diol and 20 alpha-hydroxy steroid dehydrogenase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat. Kuhn NJ and Briley MS, Biochem J. 1970 Apr;117(2):193-201.
6. Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia. Liu CY, etal., Carcinogenesis. 2008 May;29(5):984-90. doi: 10.1093/carcin/bgn071. Epub 2008 Mar 13.
7. 20 alpha-hydroxysteroid dehydrogenase expression in a murine virus-induced myeloproliferative syndrome. Marcovistz R, etal., Biochimie. 1991 Nov;73(11):1351-3.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia. Moradi Manesh D, etal., Blood. 2015 Sep 3;126(10):1193-202. doi: 10.1182/blood-2014-12-618900. Epub 2015 Jun 26.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Gene expression profiling of maternal blood in early onset severe preeclampsia: identification of novel biomarkers. Sun CJ, etal., J Perinat Med. 2009;37(6):609-16. doi: 10.1515/JPM.2009.103.
17. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
18. AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression. Tian Y, etal., Diagn Pathol. 2014 Feb 26;9:42. doi: 10.1186/1746-1596-9-42.
19. Prostaglandin F synthase. Watanabe K, Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:401-7.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12562828   PMID:14610273   PMID:14681479   PMID:14967952   PMID:15193432   PMID:15222881  
PMID:15471942   PMID:15489334   PMID:15860270   PMID:16141072   PMID:16141073   PMID:17122075   PMID:17255200   PMID:17272929   PMID:17629694   PMID:17872381   PMID:18667791   PMID:19273550  
PMID:19955443   PMID:21267068   PMID:21820362   PMID:21873635   PMID:22529366   PMID:23471215   PMID:23685333   PMID:24135228   PMID:24580729   PMID:24952961   PMID:26098214   PMID:28893949  
PMID:29107092   PMID:29212953   PMID:29879378   PMID:32243503   PMID:33127481   PMID:34288113   PMID:38355793   PMID:38788959  


Genomics

Comparative Map Data
Akr1c18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,182,614 - 4,200,645 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,182,614 - 4,200,653 (-)EnsemblGRCm39 Ensembl
GRCm38134,132,615 - 4,150,646 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,132,615 - 4,150,654 (-)EnsemblGRCm38mm10GRCm38
MGSCv37134,131,873 - 4,149,877 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,131,873 - 4,149,877 (-)NCBIMGSCv36mm8
Celera134,108,614 - 4,126,601 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.31NCBI
AKR1C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,048,781 - 5,107,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,035,354 - 5,107,686 (+)EnsemblGRCh38hg38GRCh38
GRCh37105,090,973 - 5,149,878 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,126,568 - 5,139,878 (+)NCBINCBI36Build 36hg18NCBI36
Build 34105,126,567 - 5,139,878NCBI
Celera105,076,549 - 5,089,836 (+)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,024,814 - 5,083,613 (+)NCBIHuRef
CHM1_1105,091,312 - 5,150,193 (+)NCBICHM1_1
T2T-CHM13v2.0105,049,294 - 5,108,188 (+)NCBIT2T-CHM13v2.0
Akr1c3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,020,884 - 71,037,779 (+)NCBIGRCr8
mRatBN7.21766,110,970 - 66,127,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,596,139 - 69,613,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,424,984 - 73,441,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,467,962 - 67,484,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,761,126 - 69,778,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,465,942 - 71,482,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,269,626 - 77,286,521 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,280,458 - 77,297,354 (+)NCBI
Celera1765,626,116 - 65,643,004 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
AKR1C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2817,590,820 - 17,668,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11017,660,905 - 17,732,534 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0105,079,580 - 5,157,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1105,061,119 - 5,139,818 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl105,081,214 - 5,139,812 (+)Ensemblpanpan1.1panPan2
AKR1C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,661,333 - 30,691,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,674,558 - 30,690,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha227,694,812 - 27,719,595 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0231,042,072 - 31,071,570 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl231,045,998 - 31,070,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1228,135,405 - 28,160,172 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,972,376 - 28,997,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,696,602 - 29,721,383 (+)NCBIUU_Cfam_GSD_1.0
AKR1C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,576,464 - 65,678,248 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,650,223 - 65,679,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,902,088 - 71,931,228 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

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Variants in Akr1c18
676 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:84
Interacting mature miRNAs:87
Transcripts:ENSMUST00000021635, ENSMUST00000110704
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301890Adip7_madiposity 7 (mouse)Not determined13123454672Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
1301227Skull19_mskull morphology 19 (mouse)Not determined13123454672Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
1301661Tshp13_mtooth shape 13 (mouse)Not determined13123454672Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse

Markers in Region
AW146047  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38134,132,675 - 4,132,754UniSTSGRCm38
MGSCv37134,131,921 - 4,132,000UniSTSGRCm37
Celera134,108,662 - 4,108,741UniSTS
Cytogenetic Map13A1UniSTS
Whitehead/MRC_RH13110.13UniSTS
Akr1c18  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A1UniSTS
cM Map13 UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000021635   ⟹   ENSMUSP00000021635
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl134,182,621 - 4,200,653 (-)Ensembl
GRCm38.p6 Ensembl134,132,622 - 4,150,654 (-)Ensembl
Ensembl Acc Id: ENSMUST00000110704   ⟹   ENSMUSP00000106332
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl134,182,614 - 4,200,627 (-)Ensembl
GRCm38.p6 Ensembl134,132,615 - 4,150,628 (-)Ensembl
RefSeq Acc Id: NM_001346535   ⟹   NP_001333464
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39134,182,614 - 4,200,645 (-)NCBI
GRCm38134,132,615 - 4,150,646 (-)NCBI
Sequence:
RefSeq Acc Id: NM_134066   ⟹   NP_598827
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39134,182,614 - 4,200,645 (-)NCBI
GRCm38134,132,615 - 4,150,646 (-)NCBI
MGSCv37134,131,873 - 4,149,877 (-)RGD
Celera134,108,614 - 4,126,601 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_598827   ⟸   NM_134066
- Peptide Label: isoform 1
- UniProtKB: Q99N44 (UniProtKB/Swiss-Prot),   Q8K023 (UniProtKB/Swiss-Prot),   Q3U538 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001333464   ⟸   NM_001346535
- Peptide Label: isoform 2
- UniProtKB: Q8K023 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000106332   ⟸   ENSMUST00000110704
Ensembl Acc Id: ENSMUSP00000021635   ⟸   ENSMUST00000021635
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K023-F1-model_v2 AlphaFold Q8K023 1-323 view protein structure

Promoters
RGD ID:8679520
Promoter ID:EPDNEW_M17791
Type:multiple initiation site
Name:Akr1c18_1
Description:Mus musculus aldo-keto reductase family 1, member C18 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38134,150,646 - 4,150,706EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2145420 AgrOrtholog
Ensembl Genes ENSMUSG00000021214 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021635 ENTREZGENE
  ENSMUST00000021635.9 UniProtKB/Swiss-Prot
  ENSMUST00000110704 ENTREZGENE
  ENSMUST00000110704.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AKR1C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:105349 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2145420 ENTREZGENE
NCBI Gene 105349 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER C18-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AKR1C3 RGD
PhenoGen Akr1c18 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AKC1H_MOUSE UniProtKB/Swiss-Prot
  Q3U538 ENTREZGENE, UniProtKB/TrEMBL
  Q8K023 ENTREZGENE
  Q99N44 ENTREZGENE
UniProt Secondary Q99N44 UniProtKB/Swiss-Prot