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Gene: Akr1c18 (aldo-keto reductase family 1, member C18) Mus musculus
Symbol: Akr1c18
Name: aldo-keto reductase family 1, member C18
Description: Exhibits 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity. Involved in parturition and progesterone catabolic process. Predicted to localize to cytosol and nucleus. Is expressed in several structures, including brain; female reproductive system; and lung. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1,2-dichloroethane; 1-chloro-2,4-dinitrobenzene; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alpha-HSD; 20alpha-hydroxysteroid dehydrogenase; aldo-keto reductase family 1 member C18; AW146047
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl134,132,615 - 4,150,654 (-)EnsemblGRCm38mm10GRCm38
GRCm38134,132,615 - 4,150,646 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37134,131,873 - 4,149,877 (-)NCBIGRCm37mm9NCBIm37
MGSCv36134,131,873 - 4,149,877 (-)NCBImm8
Celera134,108,614 - 4,126,601 (-)NCBICelera
Cytogenetic Map13A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Akr1c18
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733290
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.