Kmt2a (lysine (K)-specific methyltransferase 2A) - Rat Genome Database

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Gene: Kmt2a (lysine (K)-specific methyltransferase 2A) Mus musculus
Analyze
Symbol: Kmt2a
Name: lysine (K)-specific methyltransferase 2A
RGD ID: 10900
MGI Page MGI
Description: Enables DNA binding activity; chromatin binding activity; and histone methyltransferase activity (H3-K4 specific). Involved in several processes, including definitive hemopoiesis; regulation of gene expression; and regulation of histone modification. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; macromolecule methylation; and regulation of histone modification. Located in nucleus. Is expressed in several structures, including extraembryonic component; genitourinary system; hematopoietic system; nervous system; and retina. Used to study acute lymphoblastic leukemia and acute myeloid leukemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A); PARTICIPATES IN DNA modification pathway; histone modification pathway; lysine degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6430520K01; A; AL; ALL-1; All1; Cxxc7; cysteine methyltransferase KMT2A; histone-lysine N-methyltransferase 2A; histone-lysine N-methyltransferase MLL; HRX; HTRX; HTRX1; KIAA4050; lysine N-methyltransferase 2A; M; mKIAA4050; Ml; Mll; Mll1; myeloid/lymphoid or mixed-lineage leukemia 1; myeloid/lymphoid or mixed-lineage leukemia protein 1; trithorax Drosophila; zinc finger protein HRX
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,714,652 - 44,793,492 (-)NCBIGRCm39mm39
GRCm39 Ensembl944,714,652 - 44,792,594 (-)Ensembl
GRCm38944,803,355 - 44,881,352 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,803,355 - 44,881,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv37944,611,438 - 44,689,357 (-)NCBIGRCm37mm9NCBIm37
MGSCv36944,554,350 - 44,632,269 (-)NCBImm8
Celera942,068,287 - 42,146,334 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
4-octylphenol  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
clozapine  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (ISO)
cytarabine  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
etoposide  (ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
haloperidol  (EXP)
kaempferol  (ISO)
malathion  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel dichloride  (ISO)
Nonylphenol  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
permethrin  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chloride  (ISO)
prednisolone  (ISO)
pyrvinium  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
testosterone enanthate  (ISO)
thimerosal  (ISO)
titanium dioxide  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal arcus anterior morphology  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal brain development  (IAGP)
abnormal cervical atlas morphology  (IAGP)
abnormal cervical axis morphology  (IAGP)
abnormal cervical vertebrae morphology  (IAGP)
abnormal common lymphocyte progenitor cell morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal facial morphology  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal liver development  (IAGP)
abnormal lymphocyte morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal myoblast differentiation  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal precursor cell migration  (IAGP)
abnormal paraxial mesoderm morphology  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal rib development  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal tail position or orientation  (IAGP)
abnormal vertebral arch morphology  (IAGP)
anemia  (IAGP)
ataxia  (IAGP)
big ears  (IAGP)
cervical vertebral fusion  (IAGP)
cervical vertebral transformation  (IAGP)
decreased B cell number  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased neuronal precursor cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased rib number  (IAGP)
early cellular replicative senescence  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
glossopharyngeal nerve hypoplasia  (IAGP)
hemorrhage  (IAGP)
hunched posture  (IAGP)
increased acute promyelocytic leukemia incidence  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased erythroblast number  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased hemolymphoid system tumor incidence  (IAGP)
increased incidence of induced tumors  (IAGP)
increased leukemia incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased malignant tumor incidence  (IAGP)
increased monocyte cell number  (IAGP)
increased mortality induced by gamma-irradiation  (IAGP)
increased neutrophil cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased spleen neoplasm incidence  (IAGP)
increased spleen red pulp amount  (IAGP)
increased sternebra number  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver hypoplasia  (IAGP)
lumbar vertebral transformation  (IAGP)
lymphoid hyperplasia  (IAGP)
myeloid hyperplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
pale kidney  (IAGP)
pale liver  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
pointed snout  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
reduced female fertility  (IAGP)
rib fusion  (IAGP)
rough coat  (IAGP)
sacral vertebral transformation  (IAGP)
short face  (IAGP)
short snout  (IAGP)
skin edema  (IAGP)
small olfactory bulb  (IAGP)
sternebra fusion  (IAGP)
thin cerebellar granule layer  (IAGP)
thoracic vertebral transformation  (IAGP)
thrombocytopenia  (IAGP)
vertebral transformation  (IAGP)
References

Additional References at PubMed
PMID:1303259   PMID:1423624   PMID:1423625   PMID:7477409   PMID:8327517   PMID:8681380   PMID:8791525   PMID:8889548   PMID:9153995   PMID:9639506   PMID:9724755   PMID:10349636  
PMID:10393173   PMID:10588712   PMID:10698926   PMID:11042159   PMID:11076861   PMID:11265751   PMID:11536426   PMID:12192052   PMID:12393557   PMID:12453418   PMID:12477932   PMID:12520002  
PMID:12642866   PMID:12781363   PMID:12789274   PMID:14610273   PMID:14615372   PMID:14636557   PMID:14681479   PMID:14970849   PMID:15030765   PMID:15033168   PMID:15070702   PMID:15132992  
PMID:15226823   PMID:15542854   PMID:15547684   PMID:15556871   PMID:15635450   PMID:15640349   PMID:15741318   PMID:16096649   PMID:16141072   PMID:16141073   PMID:16227968   PMID:16314519  
PMID:16551973   PMID:16618927   PMID:16713978   PMID:16888613   PMID:16951254   PMID:16981007   PMID:17259173   PMID:17895399   PMID:17906700   PMID:17942719   PMID:18022353   PMID:18287559  
PMID:18371366   PMID:18371367   PMID:18455126   PMID:18617636   PMID:18648005   PMID:18796627   PMID:18952898   PMID:18977325   PMID:19109563   PMID:19155294   PMID:19188669   PMID:19212323  
PMID:19463771   PMID:19703992   PMID:19710696   PMID:20010842   PMID:20133587   PMID:20159607   PMID:20219993   PMID:20506501   PMID:20541448   PMID:20541477   PMID:20716525   PMID:20724987  
PMID:20818375   PMID:21113167   PMID:21267068   PMID:21398221   PMID:21436082   PMID:21521783   PMID:21624810   PMID:21646476   PMID:21670200   PMID:21741597   PMID:21873635   PMID:21896721  
PMID:22012064   PMID:22037578   PMID:22396593   PMID:22427200   PMID:22469984   PMID:22516260   PMID:22623725   PMID:22674806   PMID:22740449   PMID:22863532   PMID:22988430   PMID:23074275  
PMID:23318960   PMID:23361907   PMID:23412334   PMID:23436574   PMID:23564351   PMID:23660685   PMID:23736260   PMID:23744037   PMID:23900238   PMID:23908472   PMID:23932714   PMID:23934123  
PMID:23974107   PMID:24040009   PMID:24085765   PMID:24122813   PMID:24176642   PMID:24183668   PMID:24423662   PMID:24509477   PMID:24619213   PMID:24813891   PMID:24824656   PMID:24831003  
PMID:24983772   PMID:24994068   PMID:25264566   PMID:25267403   PMID:25664857   PMID:25740828   PMID:25759025   PMID:25769952   PMID:25834037   PMID:25866973   PMID:26059830   PMID:26642852  
PMID:26657054   PMID:26691508   PMID:26725110   PMID:26847026   PMID:26927674   PMID:26996599   PMID:27071307   PMID:27151433   PMID:27256596   PMID:27396339   PMID:27485686   PMID:27607576  
PMID:27625305   PMID:27626377   PMID:27775550   PMID:27801610   PMID:27889185   PMID:27991934   PMID:28210005   PMID:28282266   PMID:28394257   PMID:28609655   PMID:28646023   PMID:28663191  
PMID:28663579   PMID:28723559   PMID:28733487   PMID:29249820   PMID:29351999   PMID:29754954   PMID:30093671   PMID:30315824   PMID:30625324   PMID:30710046   PMID:31337857   PMID:31395741  
PMID:31534153   PMID:31840352   PMID:32080306   PMID:32094205   PMID:32179751   PMID:32205424   PMID:32241942   PMID:32320749   PMID:32325033   PMID:32467231   PMID:32483278   PMID:32549410  
PMID:32763164   PMID:32768438   PMID:32968282   PMID:32999332   PMID:33477970   PMID:33589748  


Genomics

Comparative Map Data
Kmt2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,714,652 - 44,793,492 (-)NCBIGRCm39mm39
GRCm39 Ensembl944,714,652 - 44,792,594 (-)Ensembl
GRCm38944,803,355 - 44,881,352 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,803,355 - 44,881,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv37944,611,438 - 44,689,357 (-)NCBIGRCm37mm9NCBIm37
MGSCv36944,554,350 - 44,632,269 (-)NCBImm8
Celera942,068,287 - 42,146,334 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
KMT2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11118,436,490 - 118,526,832 (+)EnsemblGRCh38hg38GRCh38
GRCh3811118,436,492 - 118,526,832 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711118,307,207 - 118,397,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611117,812,415 - 117,901,146 (+)NCBINCBI36hg18NCBI36
Build 3411117,812,414 - 117,901,146NCBI
Celera11115,467,997 - 115,556,730 (+)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11114,244,065 - 114,334,229 (+)NCBIHuRef
CHM1_111118,193,852 - 118,284,190 (+)NCBICHM1_1
Kmt2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2845,116,771 - 45,193,320 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl845,118,814 - 45,193,181 (-)Ensembl
Rnor_6.0849,110,407 - 49,185,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl849,114,990 - 49,158,971 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,728,915 - 47,804,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,759,175 - 47,834,586 (-)NCBIRGSC3.4rn4RGSC3.4
Celera844,701,780 - 44,782,476 (-)NCBICelera
Cytogenetic Map8q22NCBI
Kmt2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541219,586,435 - 19,670,149 (+)NCBIChiLan1.0ChiLan1.0
KMT2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111117,203,337 - 117,294,755 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v011113,273,198 - 113,364,404 (+)NCBIMhudiblu_PPA_v0panPan3
KMT2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1515,212,559 - 15,302,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl515,217,348 - 15,270,971 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha515,263,739 - 15,351,690 (-)NCBI
ROS_Cfam_1.0515,154,723 - 15,242,720 (-)NCBI
UMICH_Zoey_3.1515,293,171 - 15,381,085 (-)NCBI
UNSW_CanFamBas_1.0515,196,657 - 15,284,731 (-)NCBI
UU_Cfam_GSD_1.0515,237,660 - 15,325,572 (-)NCBI
Kmt2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947100,558,662 - 100,644,258 (+)NCBI
SpeTri2.0NW_0049365423,480,071 - 3,566,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KMT2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1945,743,566 - 45,828,559 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2950,878,276 - 50,914,778 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KMT2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11109,819,748 - 109,912,763 (+)NCBI
Vero_WHO_p1.0NW_02366604316,125,381 - 16,218,277 (-)NCBI
Kmt2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478413,824,507 - 13,912,672 (+)NCBI

Position Markers
L17069  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,807,130 - 44,807,328UniSTSGRCm38
MGSCv37944,615,213 - 44,615,411UniSTSGRCm37
Celera942,072,061 - 42,072,259UniSTS
Cytogenetic Map9A5.2UniSTS
Whitehead_YAC9 UniSTS
PMC27946P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,848,376 - 44,849,216UniSTSGRCm38
MGSCv37944,656,459 - 44,657,299UniSTSGRCm37
Celera942,113,286 - 42,114,126UniSTS
Cytogenetic Map9A5.2UniSTS
MARC_12741-12742:1029349377:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,819,374 - 44,819,789UniSTSGRCm38
MGSCv37944,627,457 - 44,627,872UniSTSGRCm37
Celera942,084,294 - 42,084,709UniSTS
Cytogenetic Map9A5.2UniSTS
Mll  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A5.2UniSTS
cM Map926.0UniSTS
cM Map924.84UniSTS
Mll1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,842,649 - 44,843,399UniSTSGRCm38
MGSCv37944,650,732 - 44,651,482UniSTSGRCm37
Celera942,107,560 - 42,108,310UniSTS
Cytogenetic Map9A5.2UniSTS
cM Map926.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91245867446458818Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91347987947479879Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91550045549500594Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91550045549500594Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91550045549500594Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91550045549500594Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91583833149838331Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91583833149838331Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91583833149838331Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91610000050100000Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91610000050100000Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91679834550798345Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91706754451067647Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined92003211054032229Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92024206654242196Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92039490154395074Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92039490154395074Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92039490154395074Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92039490154395074Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92094144454941444Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92500000069000000Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92567618959676285Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92567618959676285Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92567618959676285Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92567618959676285Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92688512460885255Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92688512460885255Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92688512460885255Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92733989761340026Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92938163163381774Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92938163163381774Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93014186664141979Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93082861764828723Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93252326366523557Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93254112166541246Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93259987266600121Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93297840266978536Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93319972567199840Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93406754473531973Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93512317869123299Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93512317869123299Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93512317869123299Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93682494749509211Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93703211050199840Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93791224471912244Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93819229172192291Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93819229172192291Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93819229172192291Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93949260173492601Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94050829851897370Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94050829874700643Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94073407848440176Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94089776474897921Mouse
12738415Lfibq8_mliver fibrosis QTL 8 (mouse)94149086645432445Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94357343177573577Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94357343177573577Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94452089278520980Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir128-2mmu-miR-128-3pOncomiRDBexternal_infoNANA19749093
Mir128-1mmu-miR-128-3pOncomiRDBexternal_infoNANA19749093

Predicted Target Of
Summary Value
Count of predictions:3984
Count of miRNA genes:883
Interacting mature miRNAs:1178
Transcripts:ENSMUST00000002095, ENSMUST00000114689, ENSMUST00000128768, ENSMUST00000138119, ENSMUST00000152241
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC061963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC142113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L17069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000002095   ⟹   ENSMUSP00000002095
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,714,652 - 44,792,594 (-)Ensembl
GRCm38.p6 Ensembl944,803,355 - 44,881,296 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114689   ⟹   ENSMUSP00000110337
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,714,652 - 44,792,594 (-)Ensembl
GRCm38.p6 Ensembl944,803,355 - 44,881,296 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128768   ⟹   ENSMUSP00000122541
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,752,860 - 44,792,594 (-)Ensembl
GRCm38.p6 Ensembl944,841,563 - 44,881,296 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138119   ⟹   ENSMUSP00000138138
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,725,977 - 44,731,412 (-)Ensembl
GRCm38.p6 Ensembl944,814,680 - 44,820,115 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152241   ⟹   ENSMUSP00000138767
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,734,032 - 44,759,481 (-)Ensembl
GRCm38.p6 Ensembl944,822,735 - 44,848,184 (-)Ensembl
RefSeq Acc Id: ENSMUST00000215489   ⟹   ENSMUSP00000149173
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,758,729 - 44,792,164 (-)Ensembl
GRCm38.p6 Ensembl944,847,432 - 44,880,866 (-)Ensembl
RefSeq Acc Id: NM_001357549   ⟹   NP_001344478
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,714,652 - 44,792,587 (-)NCBI
GRCm38944,803,355 - 44,881,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006510128   ⟹   XP_006510191
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,714,652 - 44,793,492 (-)NCBI
GRCm38944,803,355 - 44,881,350 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242442   ⟹   XP_011240744
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,714,652 - 44,793,492 (-)NCBI
GRCm38944,803,355 - 44,881,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242443   ⟹   XP_011240745
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,714,652 - 44,793,492 (-)NCBI
GRCm38944,803,355 - 44,881,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242444   ⟹   XP_011240746
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,721,502 - 44,793,492 (-)NCBI
GRCm38944,810,205 - 44,881,352 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244217   ⟹   XP_030100077
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,714,652 - 44,793,492 (-)NCBI
GRCm38944,803,355 - 44,881,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154819   ⟹   XP_036010712
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,714,652 - 44,754,635 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_006510191   ⟸   XM_006510128
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011240745   ⟸   XM_011242443
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011240744   ⟸   XM_011242442
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011240746   ⟸   XM_011242444
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_030100077   ⟸   XM_030244217
- Peptide Label: isoform X4
RefSeq Acc Id: NP_001344478   ⟸   NM_001357549
RefSeq Acc Id: ENSMUSP00000138138   ⟸   ENSMUST00000138119
RefSeq Acc Id: ENSMUSP00000138767   ⟸   ENSMUST00000152241
RefSeq Acc Id: ENSMUSP00000002095   ⟸   ENSMUST00000002095
RefSeq Acc Id: ENSMUSP00000110337   ⟸   ENSMUST00000114689
RefSeq Acc Id: ENSMUSP00000122541   ⟸   ENSMUST00000128768
RefSeq Acc Id: ENSMUSP00000149173   ⟸   ENSMUST00000215489
RefSeq Acc Id: XP_036010712   ⟸   XM_036154819
- Peptide Label: isoform X6
Protein Domains
Bromo   CXXC-type   FYR C-terminal   FYR N-terminal   PHD-type   Post-SET   SET

Promoters
RGD ID:6844803
Promoter ID:MM_KWN:57159
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000049808
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36944,626,541 - 44,628,742 (-)MPROMDB
RGD ID:6844800
Promoter ID:MM_KWN:57160
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:OTTMUST00000049807
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36944,657,001 - 44,657,501 (-)MPROMDB
RGD ID:6844799
Promoter ID:MM_KWN:57161
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000098833,   ENSMUST00000114689,   NM_001081049,   OTTMUST00000049806,   UC009PEQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36944,689,251 - 44,690,317 (-)MPROMDB
RGD ID:8669416
Promoter ID:EPDNEW_M12739
Type:initiation region
Name:Kmt2a_1
Description:Mus musculus lysine -specific methyltransferase 2A , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38944,881,289 - 44,881,349EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96995 AgrOrtholog
Ensembl Genes ENSMUSG00000002028 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000002095 UniProtKB/Swiss-Prot
  ENSMUSP00000110337 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000122541 UniProtKB/TrEMBL
  ENSMUSP00000138138 UniProtKB/TrEMBL
  ENSMUSP00000138767 UniProtKB/TrEMBL
  ENSMUSP00000149173 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002095 UniProtKB/Swiss-Prot
  ENSMUST00000114689 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000128768 UniProtKB/TrEMBL
  ENSMUST00000138119 UniProtKB/TrEMBL
  ENSMUST00000152241 UniProtKB/TrEMBL
  ENSMUST00000215489 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Bromodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYrich_C UniProtKB/Swiss-Prot
  FYrich_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KMT2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KMT2A_ePHD UniProtKB/Swiss-Prot
  KMT2A_PHD1 UniProtKB/Swiss-Prot
  KMT2A_PHD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KMT2A_PHD3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MeTrfase_trithorax UniProtKB/Swiss-Prot
  Post-SET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96995 ENTREZGENE
NCBI Gene 214162 ENTREZGENE
PANTHER PTHR45838:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FYRC UniProtKB/Swiss-Prot
  FYRN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-CXXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MLL RGD
PhenoGen Kmt2a PhenoGen
PIRSF Methyltransferase_trithorax UniProtKB/Swiss-Prot
PROSITE BROMODOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYRC UniProtKB/Swiss-Prot
  FYRN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POST_SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_CXXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BROMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYRC UniProtKB/Swiss-Prot
  FYRN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PostSET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SQS9_MOUSE UniProtKB/TrEMBL
  D3Z5H5_MOUSE UniProtKB/TrEMBL
  KMT2A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5DTR3_MOUSE UniProtKB/TrEMBL
  Q80XM0_MOUSE UniProtKB/TrEMBL
  S4R199_MOUSE UniProtKB/TrEMBL
  S4R2S5_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QNE7 UniProtKB/Swiss-Prot
  Q3UEU1 UniProtKB/Swiss-Prot
  Q3USE7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-04 Kmt2a  lysine (K)-specific methyltransferase 2A  Mll1  myeloid/lymphoid or mixed-lineage leukemia 1  Symbol and/or name change 5135510 APPROVED