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Gene: Kmt2a (lysine (K)-specific methyltransferase 2A) Mus musculus
Symbol: Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Description: Exhibits RNA polymerase II distal enhancer sequence-specific DNA binding activity and chromatin binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; macromolecule methylation; and regulation of histone modification. Localizes to the nucleus. Used to study acute lymphocytic leukemia and acute myeloid leukemia. Human ortholog(s) of this gene implicated in B- and T-cell mixed leukemia; acute myeloid leukemia; cervical cancer; and non-Hodgkin lymphoma. Is expressed in several structures, including extraembryonic component; genitourinary system; hematopoietic system; nervous system; and retina. Orthologous to human KMT2A (lysine methyltransferase 2A); PARTICIPATES IN DNA modification pathway; histone modification pathway; lysine degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6430520K01; ALL-1; All1; Cxxc7; histone-lysine N-methyltransferase 2A; histone-lysine N-methyltransferase MLL; HRX; HTRX1; KIAA4050; lysine N-methyltransferase 2A; mKIAA4050; Mll; Mll1; myeloid/lymphoid or mixed-lineage leukemia 1; myeloid/lymphoid or mixed-lineage leukemia protein 1; trithorax Drosophila; zinc finger protein HRX
Homo sapiens (human) : KMT2A (lysine methyltransferase 2A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kmt2a (lysine methyltransferase 2A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt2a (lysine methyltransferase 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT2A (lysine methyltransferase 2A)
Canis lupus familiaris (dog) : KMT2A (lysine methyltransferase 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt2a (lysine methyltransferase 2A)
Sus scrofa (pig) : KMT2A (lysine methyltransferase 2A)
Chlorocebus sabaeus (green monkey) : KMT2A (lysine methyltransferase 2A)
Heterocephalus glaber (naked mole-rat) : Kmt2a (lysine methyltransferase 2A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl944,803,355 - 44,881,296 (-)Ensembl
GRCm38944,803,355 - 44,881,352 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37944,611,438 - 44,689,357 (-)NCBIGRCm37mm9NCBIm37
MGSCv36944,554,350 - 44,632,269 (-)NCBImm8
Celera942,068,287 - 42,146,334 (-)NCBICelera
Cytogenetic Map9 A5.2NCBI
cM Map924.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Kmt2a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10900
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.