Kmt2a (lysine (K)-specific methyltransferase 2A) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Kmt2a (lysine (K)-specific methyltransferase 2A) Mus musculus
Analyze
Symbol: Kmt2a
Name: lysine (K)-specific methyltransferase 2A
RGD ID: 10900
MGI Page MGI
Description: Enables DNA binding activity; chromatin binding activity; and histone H3K4 methyltransferase activity. Involved in circadian regulation of gene expression; definitive hemopoiesis; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including peptidyl-lysine monomethylation; spleen development; and visual learning. Located in nucleus. Is expressed in several structures, including extraembryonic component; genitourinary system; nervous system; retina; and trunk mesenchyme. Used to study acute lymphoblastic leukemia; acute myeloid leukemia; and leukemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; myelofibrosis; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6430520K01; A; AL; ALL-1; All1; Cxxc7; cysteine methyltransferase KMT2A; histone-lysine N-methyltransferase 2A; histone-lysine N-methyltransferase MLL; HRX; HTRX; HTRX1; KIAA4050; lysine N-methyltransferase 2A; M; mKIAA4050; Ml; Mll; Mll1; myeloid/lymphoid or mixed-lineage leukemia 1; myeloid/lymphoid or mixed-lineage leukemia protein 1; trithorax Drosophila; zinc finger protein HRX
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,714,652 - 44,793,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,714,652 - 44,792,594 (-)EnsemblGRCm39 Ensembl
GRCm38944,803,355 - 44,881,352 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,803,355 - 44,881,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv37944,611,438 - 44,689,357 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36944,554,350 - 44,632,269 (-)NCBIMGSCv36mm8
Celera942,068,287 - 42,146,334 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-octylphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
amphetamine  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
clozapine  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (ISO)
cytarabine  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenthion  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
haloperidol  (EXP)
hydroquinone  (EXP)
kaempferol  (ISO)
malathion  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methimazole  (ISO)
methylmercury chloride  (ISO)
molibresib  (EXP)
morphine  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
nickel dichloride  (ISO)
Nonylphenol  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chloride  (ISO)
prednisolone  (ISO)
propiconazole  (ISO)
pyrvinium  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (ISO)
testosterone enanthate  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
histone methyltransferase complex  (IBA,ISO,ISS)
MLL1 complex  (ISO,ISS)
nucleoplasm  (ISO)
nucleus  (IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal arcus anterior morphology  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal brain development  (IAGP)
abnormal cervical atlas morphology  (IAGP)
abnormal cervical axis morphology  (IAGP)
abnormal cervical vertebrae morphology  (IAGP)
abnormal common lymphocyte progenitor cell morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal facial morphology  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal liver development  (IAGP)
abnormal lymphocyte morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal myoblast differentiation  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal precursor cell migration  (IAGP)
abnormal paraxial mesoderm morphology  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal rib development  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal tail position or orientation  (IAGP)
abnormal vertebral arch morphology  (IAGP)
anemia  (IAGP)
ataxia  (IAGP)
big ears  (IAGP)
cervical vertebral fusion  (IAGP)
cervical vertebral transformation  (IAGP)
decreased B cell number  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased neuronal precursor cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased rib number  (IAGP)
early cellular replicative senescence  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
glossopharyngeal nerve hypoplasia  (IAGP)
hemorrhage  (IAGP)
hunched posture  (IAGP)
increased acute promyelocytic leukemia incidence  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased erythroblast number  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased hemolymphoid system tumor incidence  (IAGP)
increased incidence of induced tumors  (IAGP)
increased leukemia incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased malignant tumor incidence  (IAGP)
increased monocyte cell number  (IAGP)
increased mortality induced by gamma-irradiation  (IAGP)
increased neutrophil cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased spleen neoplasm incidence  (IAGP)
increased spleen red pulp amount  (IAGP)
increased sternebra number  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver hypoplasia  (IAGP)
lumbar vertebral transformation  (IAGP)
lymphoid hyperplasia  (IAGP)
myeloid hyperplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
pale kidney  (IAGP)
pale liver  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
pointed snout  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
reduced female fertility  (IAGP)
rib fusion  (IAGP)
rough coat  (IAGP)
sacral vertebral transformation  (IAGP)
short face  (IAGP)
short snout  (IAGP)
skin edema  (IAGP)
small olfactory bulb  (IAGP)
sternebra fusion  (IAGP)
thin cerebellar granule layer  (IAGP)
thoracic vertebral transformation  (IAGP)
thrombocytopenia  (IAGP)
vertebral transformation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo. Ansari KI, etal., Oncogene. 2013 Jul 11;32(28):3359-70. doi: 10.1038/onc.2012.352. Epub 2012 Aug 27.
2. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
4. GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A) Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of Histone-3) Upregulates NCX3 (Na+-Ca2+ Exchanger 3) Transcription and Contributes to Ischemic Preconditioning Neuroprotection. Guida N, etal., Stroke. 2021 Nov;52(11):3680-3691. doi: 10.1161/STROKEAHA.121.034637. Epub 2021 Oct 25.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Menin is necessary for long term maintenance of meningioma-1 driven leukemia. Libbrecht C, etal., Leukemia. 2021 May;35(5):1405-1417. doi: 10.1038/s41375-021-01146-z. Epub 2021 Feb 4.
7. ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Long HK, etal., Biochem Soc Trans. 2013 Jun;41(3):727-40. doi: 10.1042/BST20130028.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. Riedel SS, etal., J Clin Invest. 2016 Apr 1;126(4):1438-50. doi: 10.1172/JCI80825. Epub 2016 Feb 29.
18. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Shilatifard A Annu Rev Biochem. 2012;81:65-95. doi: 10.1146/annurev-biochem-051710-134100.
19. Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16INK4a. Shimoda H, etal., Kidney Int. 2019 Nov;96(5):1162-1175. doi: 10.1016/j.kint.2019.06.021. Epub 2019 Aug 1.
20. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, etal., Hum Mol Genet 2001 Sep 1;10(18):1995-2011.
21. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. Thirman MJ, etal., N Engl J Med. 1993 Sep 23;329(13):909-14.
22. Deregulated expression of selected histone methylases and demethylases in prostate carcinoma. Vieira FQ, etal., Endocr Relat Cancer. 2013 Dec 16;21(1):51-61. doi: 10.1530/ERC-13-0375. Print 2014 Feb.
23. Clinical features and next-generation sequencing landscape of essential thrombocythemia, prefibrotic primary myelofibrosis, and overt fibrotic primary myelofibrosis: a Chinese monocentric retrospective study. Zhang L, etal., J Cancer Res Clin Oncol. 2022 Jun 22. doi: 10.1007/s00432-022-04067-1.
Additional References at PubMed
PMID:1303259   PMID:1423624   PMID:1423625   PMID:7477409   PMID:8327517   PMID:8681380   PMID:8791525   PMID:8889548   PMID:9153995   PMID:9639506   PMID:9724755   PMID:10349636  
PMID:10393173   PMID:10588712   PMID:10698926   PMID:11042159   PMID:11076861   PMID:11265751   PMID:11536426   PMID:12192052   PMID:12393557   PMID:12453418   PMID:12477932   PMID:12515728  
PMID:12520002   PMID:12642866   PMID:12781363   PMID:12789274   PMID:14610273   PMID:14615372   PMID:14636557   PMID:14681479   PMID:14970849   PMID:15030765   PMID:15033168   PMID:15070702  
PMID:15132992   PMID:15226823   PMID:15542854   PMID:15547684   PMID:15556871   PMID:15635450   PMID:15640349   PMID:15741318   PMID:16096649   PMID:16141072   PMID:16141073   PMID:16227968  
PMID:16314519   PMID:16551973   PMID:16607274   PMID:16618927   PMID:16713978   PMID:16888613   PMID:16951254   PMID:16981007   PMID:17259173   PMID:17895399   PMID:17906700   PMID:17942719  
PMID:18022353   PMID:18287559   PMID:18371366   PMID:18371367   PMID:18455126   PMID:18617636   PMID:18648005   PMID:18796627   PMID:18952898   PMID:18977325   PMID:19109563   PMID:19155294  
PMID:19188669   PMID:19212323   PMID:19463771   PMID:19703992   PMID:19710696   PMID:20010842   PMID:20133587   PMID:20159607   PMID:20219993   PMID:20506501   PMID:20541448   PMID:20541477  
PMID:20569692   PMID:20716525   PMID:20724987   PMID:20818375   PMID:21113167   PMID:21267068   PMID:21398221   PMID:21436082   PMID:21521783   PMID:21624810   PMID:21646476   PMID:21670200  
PMID:21741597   PMID:21873635   PMID:21896721   PMID:22012064   PMID:22037578   PMID:22396593   PMID:22427200   PMID:22469984   PMID:22516260   PMID:22623725   PMID:22674806   PMID:22740449  
PMID:22863532   PMID:22988430   PMID:23074275   PMID:23318960   PMID:23361907   PMID:23399917   PMID:23412334   PMID:23436574   PMID:23564351   PMID:23660685   PMID:23736260   PMID:23744037  
PMID:23900238   PMID:23908472   PMID:23932714   PMID:23934123   PMID:23974107   PMID:24040009   PMID:24085765   PMID:24122813   PMID:24176642   PMID:24183668   PMID:24423662   PMID:24509477  
PMID:24619213   PMID:24813891   PMID:24824656   PMID:24831003   PMID:24983772   PMID:24994068   PMID:25264566   PMID:25267403   PMID:25664857   PMID:25740828   PMID:25759025   PMID:25769952  
PMID:25834037   PMID:25866973   PMID:26059830   PMID:26642852   PMID:26657054   PMID:26691508   PMID:26725110   PMID:26847026   PMID:26996599   PMID:27071307   PMID:27151433   PMID:27256596  
PMID:27396339   PMID:27485686   PMID:27607576   PMID:27625305   PMID:27626377   PMID:27775550   PMID:27801610   PMID:27889185   PMID:27895715   PMID:27991934   PMID:28210005   PMID:28282266  
PMID:28394257   PMID:28609655   PMID:28646023   PMID:28663191   PMID:28663579   PMID:28723559   PMID:28733487   PMID:29249820   PMID:29351999   PMID:29445148   PMID:29754954   PMID:30093671  
PMID:30315824   PMID:30625324   PMID:30710046   PMID:31337857   PMID:31395741   PMID:31534153   PMID:31840352   PMID:32080306   PMID:32094205   PMID:32179751   PMID:32205424   PMID:32241942  
PMID:32320749   PMID:32325033   PMID:32467231   PMID:32483278   PMID:32549410   PMID:32763164   PMID:32768438   PMID:32968282   PMID:32999332   PMID:33230847   PMID:33349639   PMID:33477970  
PMID:33589748   PMID:34111112   PMID:34156981   PMID:34349066   PMID:34368113   PMID:34417259   PMID:34582559   PMID:34706236   PMID:34860830   PMID:34958665   PMID:35036869   PMID:35177813  
PMID:35412895   PMID:35727845   PMID:36052997   PMID:36098964   PMID:37074193   PMID:37142655   PMID:37167859   PMID:37253089   PMID:37587260   PMID:37712124   PMID:38363110   PMID:38413714  
PMID:38478601   PMID:38735046  


Genomics

Comparative Map Data
Kmt2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,714,652 - 44,793,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,714,652 - 44,792,594 (-)EnsemblGRCm39 Ensembl
GRCm38944,803,355 - 44,881,352 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,803,355 - 44,881,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv37944,611,438 - 44,689,357 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36944,554,350 - 44,632,269 (-)NCBIMGSCv36mm8
Celera942,068,287 - 42,146,334 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
KMT2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811118,436,492 - 118,526,832 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11118,436,456 - 118,526,832 (+)EnsemblGRCh38hg38GRCh38
GRCh3711118,307,207 - 118,397,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611117,812,415 - 117,901,146 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411117,812,414 - 117,901,146NCBI
Celera11115,467,997 - 115,556,730 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11114,244,065 - 114,334,229 (+)NCBIHuRef
CHM1_111118,193,852 - 118,284,190 (+)NCBICHM1_1
T2T-CHM13v2.011118,455,794 - 118,546,121 (+)NCBIT2T-CHM13v2.0
Kmt2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8854,013,547 - 54,089,219 (-)NCBIGRCr8
mRatBN7.2845,116,763 - 45,193,320 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl845,118,814 - 45,193,181 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0849,110,407 - 49,185,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl849,114,990 - 49,158,971 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,728,915 - 47,804,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,759,175 - 47,834,586 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera844,701,780 - 44,782,476 (-)NCBICelera
Cytogenetic Map8q22NCBI
Kmt2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541219,586,141 - 19,665,527 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541219,586,435 - 19,670,149 (+)NCBIChiLan1.0ChiLan1.0
KMT2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29119,139,884 - 119,230,967 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111120,244,773 - 120,335,992 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011113,273,198 - 113,364,404 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111117,203,337 - 117,294,755 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11117,204,820 - 117,290,100 (+)Ensemblpanpan1.1panPan2
KMT2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1515,212,559 - 15,302,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl515,217,348 - 15,270,971 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha515,263,739 - 15,351,690 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0515,154,723 - 15,242,720 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl515,155,965 - 15,242,720 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1515,293,171 - 15,381,085 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0515,196,657 - 15,284,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0515,237,660 - 15,325,572 (-)NCBIUU_Cfam_GSD_1.0
Kmt2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947100,558,662 - 100,644,258 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365423,391,774 - 3,562,147 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365423,480,071 - 3,566,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KMT2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl945,743,397 - 45,824,884 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1945,743,566 - 45,828,559 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2950,878,276 - 50,914,778 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KMT2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11109,819,748 - 109,912,763 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1109,853,758 - 109,908,113 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604316,125,381 - 16,218,277 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kmt2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478413,824,541 - 13,908,077 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478413,824,507 - 13,912,672 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kmt2a
2097 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3984
Count of miRNA genes:883
Interacting mature miRNAs:1178
Transcripts:ENSMUST00000002095, ENSMUST00000114689, ENSMUST00000128768, ENSMUST00000138119, ENSMUST00000152241
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
12738415Lfibq8_mliver fibrosis QTL 8 (mouse)94140216245343743Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
13432191Actrse4_mactivity response to saline/ethanol 4 (mouse)94370321448603195Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94064537448351476Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94041959451808670Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse

Markers in Region
L17069  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,807,130 - 44,807,328UniSTSGRCm38
MGSCv37944,615,213 - 44,615,411UniSTSGRCm37
Celera942,072,061 - 42,072,259UniSTS
Cytogenetic Map9A5.2UniSTS
Whitehead_YAC9 UniSTS
PMC27946P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,848,376 - 44,849,216UniSTSGRCm38
MGSCv37944,656,459 - 44,657,299UniSTSGRCm37
Celera942,113,286 - 42,114,126UniSTS
Cytogenetic Map9A5.2UniSTS
MARC_12741-12742:1029349377:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,819,374 - 44,819,789UniSTSGRCm38
MGSCv37944,627,457 - 44,627,872UniSTSGRCm37
Celera942,084,294 - 42,084,709UniSTS
Cytogenetic Map9A5.2UniSTS
Mll  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A5.2UniSTS
cM Map926.0UniSTS
cM Map924.84UniSTS
Mll1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,842,649 - 44,843,399UniSTSGRCm38
MGSCv37944,650,732 - 44,651,482UniSTSGRCm37
Celera942,107,560 - 42,108,310UniSTS
Cytogenetic Map9A5.2UniSTS
cM Map926.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC061963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC142113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L17069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000002095   ⟹   ENSMUSP00000002095
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,714,652 - 44,792,594 (-)Ensembl
GRCm38.p6 Ensembl944,803,355 - 44,881,296 (-)Ensembl
Ensembl Acc Id: ENSMUST00000114689   ⟹   ENSMUSP00000110337
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,714,652 - 44,792,594 (-)Ensembl
GRCm38.p6 Ensembl944,803,355 - 44,881,296 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128768   ⟹   ENSMUSP00000122541
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,752,860 - 44,792,594 (-)Ensembl
GRCm38.p6 Ensembl944,841,563 - 44,881,296 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138119   ⟹   ENSMUSP00000138138
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,725,977 - 44,731,412 (-)Ensembl
GRCm38.p6 Ensembl944,814,680 - 44,820,115 (-)Ensembl
Ensembl Acc Id: ENSMUST00000152241   ⟹   ENSMUSP00000138767
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,734,032 - 44,759,481 (-)Ensembl
GRCm38.p6 Ensembl944,822,735 - 44,848,184 (-)Ensembl
Ensembl Acc Id: ENSMUST00000215489   ⟹   ENSMUSP00000149173
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl944,758,729 - 44,792,164 (-)Ensembl
GRCm38.p6 Ensembl944,847,432 - 44,880,866 (-)Ensembl
RefSeq Acc Id: NM_001357549   ⟹   NP_001344478
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,714,652 - 44,792,587 (-)NCBI
GRCm38944,803,355 - 44,881,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006510128   ⟹   XP_006510191
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,714,652 - 44,793,492 (-)NCBI
GRCm38944,803,355 - 44,881,350 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242442   ⟹   XP_011240744
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,714,652 - 44,793,492 (-)NCBI
GRCm38944,803,355 - 44,881,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242443   ⟹   XP_011240745
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,714,652 - 44,793,492 (-)NCBI
GRCm38944,803,355 - 44,881,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242444   ⟹   XP_011240746
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,721,502 - 44,793,492 (-)NCBI
GRCm38944,810,205 - 44,881,352 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244217   ⟹   XP_030100077
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,714,652 - 44,793,492 (-)NCBI
GRCm38944,803,355 - 44,881,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154819   ⟹   XP_036010712
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,714,652 - 44,754,635 (-)NCBI
Sequence:
RefSeq Acc Id: XP_006510191   ⟸   XM_006510128
- Peptide Label: isoform X3
- UniProtKB: Q3USE7 (UniProtKB/Swiss-Prot),   Q3UEU1 (UniProtKB/Swiss-Prot),   P55200 (UniProtKB/Swiss-Prot),   E9QNE7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011240745   ⟸   XM_011242443
- Peptide Label: isoform X2
- UniProtKB: Q3USE7 (UniProtKB/Swiss-Prot),   Q3UEU1 (UniProtKB/Swiss-Prot),   P55200 (UniProtKB/Swiss-Prot),   E9QNE7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011240744   ⟸   XM_011242442
- Peptide Label: isoform X1
- UniProtKB: Q3USE7 (UniProtKB/Swiss-Prot),   Q3UEU1 (UniProtKB/Swiss-Prot),   P55200 (UniProtKB/Swiss-Prot),   E9QNE7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011240746   ⟸   XM_011242444
- Peptide Label: isoform X5
- UniProtKB: P55200 (UniProtKB/Swiss-Prot),   E9QNE7 (UniProtKB/Swiss-Prot),   Q3USE7 (UniProtKB/Swiss-Prot),   Q3UEU1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030100077   ⟸   XM_030244217
- Peptide Label: isoform X4
- UniProtKB: Q3USE7 (UniProtKB/Swiss-Prot),   Q3UEU1 (UniProtKB/Swiss-Prot),   P55200 (UniProtKB/Swiss-Prot),   E9QNE7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001344478   ⟸   NM_001357549
- UniProtKB: Q3USE7 (UniProtKB/Swiss-Prot),   Q3UEU1 (UniProtKB/Swiss-Prot),   P55200 (UniProtKB/Swiss-Prot),   E9QNE7 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000138138   ⟸   ENSMUST00000138119
Ensembl Acc Id: ENSMUSP00000138767   ⟸   ENSMUST00000152241
Ensembl Acc Id: ENSMUSP00000002095   ⟸   ENSMUST00000002095
Ensembl Acc Id: ENSMUSP00000110337   ⟸   ENSMUST00000114689
Ensembl Acc Id: ENSMUSP00000122541   ⟸   ENSMUST00000128768
Ensembl Acc Id: ENSMUSP00000149173   ⟸   ENSMUST00000215489
RefSeq Acc Id: XP_036010712   ⟸   XM_036154819
- Peptide Label: isoform X6
Protein Domains
Bromo   CXXC-type   FYR C-terminal   FYR N-terminal   PHD-type   Post-SET   SET

Promoters
RGD ID:6844803
Promoter ID:MM_KWN:57159
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000049808
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36944,626,541 - 44,628,742 (-)MPROMDB
RGD ID:6844800
Promoter ID:MM_KWN:57160
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:OTTMUST00000049807
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36944,657,001 - 44,657,501 (-)MPROMDB
RGD ID:6844799
Promoter ID:MM_KWN:57161
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000098833,   ENSMUST00000114689,   NM_001081049,   OTTMUST00000049806,   UC009PEQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36944,689,251 - 44,690,317 (-)MPROMDB
RGD ID:8669416
Promoter ID:EPDNEW_M12739
Type:initiation region
Name:Kmt2a_1
Description:Mus musculus lysine -specific methyltransferase 2A , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38944,881,289 - 44,881,349EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96995 AgrOrtholog
Ensembl Genes ENSMUSG00000002028 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002095.11 UniProtKB/Swiss-Prot
  ENSMUST00000114689 ENTREZGENE
  ENSMUST00000114689.8 UniProtKB/Swiss-Prot
  ENSMUST00000128768.3 UniProtKB/TrEMBL
  ENSMUST00000138119.2 UniProtKB/TrEMBL
  ENSMUST00000152241.8 UniProtKB/TrEMBL
  ENSMUST00000215489.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.920.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.170.270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.160.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Bromodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYrich_C UniProtKB/Swiss-Prot
  FYrich_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KMT2A_2B_SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KMT2A_ePHD UniProtKB/Swiss-Prot
  KMT2A_PHD1 UniProtKB/Swiss-Prot
  KMT2A_PHD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KMT2A_PHD3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MeTrfase_trithorax UniProtKB/Swiss-Prot
  Post-SET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96995 ENTREZGENE
NCBI Gene Kmt2a ENTREZGENE
PANTHER HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45838:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FYRC UniProtKB/Swiss-Prot
  FYRN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-CXXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-HC5HC2H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MLL RGD
PhenoGen Kmt2a PhenoGen
PIRSF Methyltransferase_trithorax UniProtKB/Swiss-Prot
PROSITE BROMODOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYRC UniProtKB/Swiss-Prot
  FYRN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POST_SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_CXXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BROMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYRC UniProtKB/Swiss-Prot
  FYRN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PostSET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82199 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SQS9_MOUSE UniProtKB/TrEMBL
  D3Z5H5_MOUSE UniProtKB/TrEMBL
  E9QNE7 ENTREZGENE
  KMT2A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UEU1 ENTREZGENE
  Q3USE7 ENTREZGENE
  Q5DTR3_MOUSE UniProtKB/TrEMBL
  Q80XM0_MOUSE UniProtKB/TrEMBL
  S4R199_MOUSE UniProtKB/TrEMBL
  S4R2S5_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QNE7 UniProtKB/Swiss-Prot
  Q3UEU1 UniProtKB/Swiss-Prot
  Q3USE7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Kmt2a  lysine (K)-specific methyltransferase 2A  Mll  myeloid/lymphoid or mixed-lineage leukemia  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Mll  myeloid/lymphoid or mixed-lineage leukemia  Kmt2a  lysine (K)-specific methyltransferase 2A  Symbol and/or name change 5135510 APPROVED
2013-06-04 Kmt2a  lysine (K)-specific methyltransferase 2A  Mll1  myeloid/lymphoid or mixed-lineage leukemia 1  Symbol and/or name change 5135510 APPROVED